Amino acid dipepetide frequency for Petrocella atlantisensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.176AlaAla: 4.176 ± 0.101
0.688AlaCys: 0.688 ± 0.03
3.108AlaAsp: 3.108 ± 0.051
3.64AlaGlu: 3.64 ± 0.059
2.997AlaPhe: 2.997 ± 0.058
4.246AlaGly: 4.246 ± 0.077
1.235AlaHis: 1.235 ± 0.037
6.352AlaIle: 6.352 ± 0.09
4.527AlaLys: 4.527 ± 0.071
7.138AlaLeu: 7.138 ± 0.093
2.251AlaMet: 2.251 ± 0.048
2.545AlaAsn: 2.545 ± 0.048
1.598AlaPro: 1.598 ± 0.039
1.787AlaGln: 1.787 ± 0.045
2.289AlaArg: 2.289 ± 0.048
3.963AlaSer: 3.963 ± 0.065
3.635AlaThr: 3.635 ± 0.057
4.379AlaVal: 4.379 ± 0.063
0.427AlaTrp: 0.427 ± 0.022
2.988AlaTyr: 2.988 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.49CysAla: 0.49 ± 0.021
0.114CysCys: 0.114 ± 0.011
0.6CysAsp: 0.6 ± 0.024
0.582CysGlu: 0.582 ± 0.026
0.366CysPhe: 0.366 ± 0.021
0.807CysGly: 0.807 ± 0.031
0.277CysHis: 0.277 ± 0.017
0.74CysIle: 0.74 ± 0.026
0.565CysLys: 0.565 ± 0.027
0.754CysLeu: 0.754 ± 0.028
0.264CysMet: 0.264 ± 0.018
0.466CysAsn: 0.466 ± 0.025
0.397CysPro: 0.397 ± 0.022
0.297CysGln: 0.297 ± 0.017
0.348CysArg: 0.348 ± 0.018
0.545CysSer: 0.545 ± 0.024
0.443CysThr: 0.443 ± 0.023
0.556CysVal: 0.556 ± 0.022
0.049CysTrp: 0.049 ± 0.006
0.378CysTyr: 0.378 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.62AspAla: 3.62 ± 0.07
0.514AspCys: 0.514 ± 0.021
3.187AspAsp: 3.187 ± 0.095
4.713AspGlu: 4.713 ± 0.077
2.915AspPhe: 2.915 ± 0.059
3.652AspGly: 3.652 ± 0.06
1.448AspHis: 1.448 ± 0.037
5.369AspIle: 5.369 ± 0.077
3.684AspLys: 3.684 ± 0.054
5.724AspLeu: 5.724 ± 0.076
1.963AspMet: 1.963 ± 0.043
2.323AspAsn: 2.323 ± 0.051
1.715AspPro: 1.715 ± 0.049
2.279AspGln: 2.279 ± 0.049
2.286AspArg: 2.286 ± 0.047
2.661AspSer: 2.661 ± 0.058
2.897AspThr: 2.897 ± 0.064
4.152AspVal: 4.152 ± 0.067
0.483AspTrp: 0.483 ± 0.024
2.963AspTyr: 2.963 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
5.97GluAla: 5.97 ± 0.086
0.421GluCys: 0.421 ± 0.021
4.695GluAsp: 4.695 ± 0.076
6.192GluGlu: 6.192 ± 0.099
2.349GluPhe: 2.349 ± 0.049
4.625GluGly: 4.625 ± 0.071
1.416GluHis: 1.416 ± 0.038
6.075GluIle: 6.075 ± 0.086
6.158GluLys: 6.158 ± 0.093
6.483GluLeu: 6.483 ± 0.087
2.355GluMet: 2.355 ± 0.052
3.633GluAsn: 3.633 ± 0.066
1.851GluPro: 1.851 ± 0.054
2.433GluGln: 2.433 ± 0.05
2.717GluArg: 2.717 ± 0.066
3.712GluSer: 3.712 ± 0.064
3.777GluThr: 3.777 ± 0.065
5.503GluVal: 5.503 ± 0.084
0.535GluTrp: 0.535 ± 0.022
2.338GluTyr: 2.338 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
2.391PheAla: 2.391 ± 0.059
0.452PheCys: 0.452 ± 0.024
2.828PheAsp: 2.828 ± 0.055
3.19PheGlu: 3.19 ± 0.062
1.889PhePhe: 1.889 ± 0.049
2.981PheGly: 2.981 ± 0.06
0.731PheHis: 0.731 ± 0.028
3.855PheIle: 3.855 ± 0.071
2.622PheLys: 2.622 ± 0.055
3.786PheLeu: 3.786 ± 0.079
1.273PheMet: 1.273 ± 0.037
2.035PheAsn: 2.035 ± 0.046
1.093PhePro: 1.093 ± 0.033
0.928PheGln: 0.928 ± 0.028
1.38PheArg: 1.38 ± 0.034
2.777PheSer: 2.777 ± 0.055
2.259PheThr: 2.259 ± 0.049
2.883PheVal: 2.883 ± 0.055
0.301PheTrp: 0.301 ± 0.019
1.614PheTyr: 1.614 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
4.115GlyAla: 4.115 ± 0.075
0.799GlyCys: 0.799 ± 0.031
3.431GlyAsp: 3.431 ± 0.064
4.027GlyGlu: 4.027 ± 0.071
3.224GlyPhe: 3.224 ± 0.056
4.271GlyGly: 4.271 ± 0.095
1.507GlyHis: 1.507 ± 0.034
6.508GlyIle: 6.508 ± 0.103
4.506GlyLys: 4.506 ± 0.072
6.314GlyLeu: 6.314 ± 0.085
2.184GlyMet: 2.184 ± 0.05
2.724GlyAsn: 2.724 ± 0.063
1.381GlyPro: 1.381 ± 0.039
2.026GlyGln: 2.026 ± 0.046
2.465GlyArg: 2.465 ± 0.055
3.714GlySer: 3.714 ± 0.058
3.665GlyThr: 3.665 ± 0.064
4.603GlyVal: 4.603 ± 0.082
0.539GlyTrp: 0.539 ± 0.026
3.226GlyTyr: 3.226 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.119HisAla: 1.119 ± 0.033
0.251HisCys: 0.251 ± 0.017
1.133HisAsp: 1.133 ± 0.038
1.409HisGlu: 1.409 ± 0.042
0.852HisPhe: 0.852 ± 0.033
1.236HisGly: 1.236 ± 0.038
0.623HisHis: 0.623 ± 0.03
1.916HisIle: 1.916 ± 0.046
1.381HisLys: 1.381 ± 0.038
2.001HisLeu: 2.001 ± 0.047
0.645HisMet: 0.645 ± 0.023
0.953HisAsn: 0.953 ± 0.03
0.832HisPro: 0.832 ± 0.029
0.822HisGln: 0.822 ± 0.03
0.815HisArg: 0.815 ± 0.031
1.143HisSer: 1.143 ± 0.032
1.043HisThr: 1.043 ± 0.031
1.301HisVal: 1.301 ± 0.033
0.196HisTrp: 0.196 ± 0.013
0.987HisTyr: 0.987 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.843IleAla: 5.843 ± 0.081
0.863IleCys: 0.863 ± 0.031
5.428IleAsp: 5.428 ± 0.068
7.033IleGlu: 7.033 ± 0.09
3.449IlePhe: 3.449 ± 0.07
6.36IleGly: 6.36 ± 0.082
1.921IleHis: 1.921 ± 0.045
7.828IleIle: 7.828 ± 0.118
6.549IleLys: 6.549 ± 0.074
8.047IleLeu: 8.047 ± 0.118
2.565IleMet: 2.565 ± 0.045
4.129IleAsn: 4.129 ± 0.065
3.081IlePro: 3.081 ± 0.061
2.835IleGln: 2.835 ± 0.052
3.743IleArg: 3.743 ± 0.061
5.488IleSer: 5.488 ± 0.085
4.886IleThr: 4.886 ± 0.074
5.637IleVal: 5.637 ± 0.081
0.544IleTrp: 0.544 ± 0.022
3.209IleTyr: 3.209 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
5.186LysAla: 5.186 ± 0.072
0.48LysCys: 0.48 ± 0.023
4.549LysAsp: 4.549 ± 0.07
6.377LysGlu: 6.377 ± 0.095
1.91LysPhe: 1.91 ± 0.045
4.282LysGly: 4.282 ± 0.073
1.469LysHis: 1.469 ± 0.037
5.931LysIle: 5.931 ± 0.079
6.227LysLys: 6.227 ± 0.095
5.802LysLeu: 5.802 ± 0.079
2.283LysMet: 2.283 ± 0.05
3.955LysAsn: 3.955 ± 0.067
2.121LysPro: 2.121 ± 0.049
2.268LysGln: 2.268 ± 0.053
2.995LysArg: 2.995 ± 0.065
4.275LysSer: 4.275 ± 0.063
4.167LysThr: 4.167 ± 0.058
5.027LysVal: 5.027 ± 0.076
0.559LysTrp: 0.559 ± 0.021
2.795LysTyr: 2.795 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
6.026LeuAla: 6.026 ± 0.08
0.842LeuCys: 0.842 ± 0.03
5.646LeuAsp: 5.646 ± 0.078
7.346LeuGlu: 7.346 ± 0.086
3.958LeuPhe: 3.958 ± 0.082
6.11LeuGly: 6.11 ± 0.095
1.536LeuHis: 1.536 ± 0.045
7.915LeuIle: 7.915 ± 0.097
7.089LeuLys: 7.089 ± 0.096
9.26LeuLeu: 9.26 ± 0.138
3.15LeuMet: 3.15 ± 0.058
4.579LeuAsn: 4.579 ± 0.065
3.155LeuPro: 3.155 ± 0.062
2.507LeuGln: 2.507 ± 0.05
3.54LeuArg: 3.54 ± 0.058
6.973LeuSer: 6.973 ± 0.084
5.282LeuThr: 5.282 ± 0.081
6.076LeuVal: 6.076 ± 0.087
0.691LeuTrp: 0.691 ± 0.031
3.405LeuTyr: 3.405 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.39MetAla: 2.39 ± 0.052
0.213MetCys: 0.213 ± 0.017
2.207MetAsp: 2.207 ± 0.053
2.07MetGlu: 2.07 ± 0.053
0.999MetPhe: 0.999 ± 0.03
2.137MetGly: 2.137 ± 0.045
0.561MetHis: 0.561 ± 0.024
2.749MetIle: 2.749 ± 0.048
2.696MetLys: 2.696 ± 0.044
2.638MetLeu: 2.638 ± 0.05
1.193MetMet: 1.193 ± 0.038
1.925MetAsn: 1.925 ± 0.046
1.136MetPro: 1.136 ± 0.034
0.769MetGln: 0.769 ± 0.031
1.09MetArg: 1.09 ± 0.031
1.952MetSer: 1.952 ± 0.046
2.011MetThr: 2.011 ± 0.046
2.279MetVal: 2.279 ± 0.056
0.181MetTrp: 0.181 ± 0.014
0.862MetTyr: 0.862 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.817AsnAla: 2.817 ± 0.049
0.423AsnCys: 0.423 ± 0.021
2.439AsnAsp: 2.439 ± 0.051
3.353AsnGlu: 3.353 ± 0.066
1.693AsnPhe: 1.693 ± 0.045
2.872AsnGly: 2.872 ± 0.06
1.283AsnHis: 1.283 ± 0.037
4.389AsnIle: 4.389 ± 0.078
3.485AsnLys: 3.485 ± 0.069
4.443AsnLeu: 4.443 ± 0.062
1.496AsnMet: 1.496 ± 0.034
2.493AsnAsn: 2.493 ± 0.06
2.005AsnPro: 2.005 ± 0.037
2.099AsnGln: 2.099 ± 0.052
2.073AsnArg: 2.073 ± 0.043
2.347AsnSer: 2.347 ± 0.057
2.525AsnThr: 2.525 ± 0.046
2.865AsnVal: 2.865 ± 0.062
0.383AsnTrp: 0.383 ± 0.021
2.009AsnTyr: 2.009 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
1.545ProAla: 1.545 ± 0.039
0.284ProCys: 0.284 ± 0.016
1.876ProAsp: 1.876 ± 0.046
2.429ProGlu: 2.429 ± 0.058
1.398ProPhe: 1.398 ± 0.044
1.743ProGly: 1.743 ± 0.048
0.606ProHis: 0.606 ± 0.025
2.934ProIle: 2.934 ± 0.062
2.006ProLys: 2.006 ± 0.051
2.834ProLeu: 2.834 ± 0.061
0.952ProMet: 0.952 ± 0.034
1.462ProAsn: 1.462 ± 0.039
0.693ProPro: 0.693 ± 0.026
0.794ProGln: 0.794 ± 0.03
0.923ProArg: 0.923 ± 0.031
2.187ProSer: 2.187 ± 0.044
1.833ProThr: 1.833 ± 0.048
2.286ProVal: 2.286 ± 0.053
0.267ProTrp: 0.267 ± 0.016
1.446ProTyr: 1.446 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
2.065GlnAla: 2.065 ± 0.045
0.245GlnCys: 0.245 ± 0.017
1.608GlnAsp: 1.608 ± 0.04
2.326GlnGlu: 2.326 ± 0.048
1.164GlnPhe: 1.164 ± 0.037
1.894GlnGly: 1.894 ± 0.048
0.573GlnHis: 0.573 ± 0.023
2.706GlnIle: 2.706 ± 0.052
2.402GlnLys: 2.402 ± 0.053
3.236GlnLeu: 3.236 ± 0.051
1.086GlnMet: 1.086 ± 0.031
1.535GlnAsn: 1.535 ± 0.041
0.892GlnPro: 0.892 ± 0.031
1.062GlnGln: 1.062 ± 0.036
1.177GlnArg: 1.177 ± 0.035
1.943GlnSer: 1.943 ± 0.049
1.508GlnThr: 1.508 ± 0.037
2.411GlnVal: 2.411 ± 0.048
0.287GlnTrp: 0.287 ± 0.017
1.147GlnTyr: 1.147 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.18ArgAla: 2.18 ± 0.043
0.353ArgCys: 0.353 ± 0.02
2.047ArgAsp: 2.047 ± 0.046
2.686ArgGlu: 2.686 ± 0.052
1.759ArgPhe: 1.759 ± 0.043
2.04ArgGly: 2.04 ± 0.043
0.838ArgHis: 0.838 ± 0.029
3.485ArgIle: 3.485 ± 0.059
2.835ArgLys: 2.835 ± 0.052
4.028ArgLeu: 4.028 ± 0.073
1.234ArgMet: 1.234 ± 0.034
1.804ArgAsn: 1.804 ± 0.039
1.182ArgPro: 1.182 ± 0.033
1.378ArgGln: 1.378 ± 0.037
1.753ArgArg: 1.753 ± 0.046
2.133ArgSer: 2.133 ± 0.05
2.045ArgThr: 2.045 ± 0.053
2.451ArgVal: 2.451 ± 0.05
0.342ArgTrp: 0.342 ± 0.018
1.695ArgTyr: 1.695 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.353SerAla: 3.353 ± 0.055
0.499SerCys: 0.499 ± 0.023
3.343SerAsp: 3.343 ± 0.065
3.877SerGlu: 3.877 ± 0.068
2.686SerPhe: 2.686 ± 0.052
4.347SerGly: 4.347 ± 0.072
1.253SerHis: 1.253 ± 0.037
5.664SerIle: 5.664 ± 0.079
4.439SerLys: 4.439 ± 0.065
5.731SerLeu: 5.731 ± 0.084
1.91SerMet: 1.91 ± 0.043
2.8SerAsn: 2.8 ± 0.051
1.612SerPro: 1.612 ± 0.041
1.911SerGln: 1.911 ± 0.041
2.392SerArg: 2.392 ± 0.051
3.571SerSer: 3.571 ± 0.073
3.155SerThr: 3.155 ± 0.052
4.002SerVal: 4.002 ± 0.059
0.459SerTrp: 0.459 ± 0.024
2.483SerTyr: 2.483 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
3.213ThrAla: 3.213 ± 0.069
0.468ThrCys: 0.468 ± 0.02
2.922ThrAsp: 2.922 ± 0.059
3.335ThrGlu: 3.335 ± 0.062
2.458ThrPhe: 2.458 ± 0.053
3.943ThrGly: 3.943 ± 0.067
1.096ThrHis: 1.096 ± 0.033
4.951ThrIle: 4.951 ± 0.069
3.622ThrLys: 3.622 ± 0.054
5.634ThrLeu: 5.634 ± 0.077
1.695ThrMet: 1.695 ± 0.042
2.452ThrAsn: 2.452 ± 0.059
2.017ThrPro: 2.017 ± 0.051
1.608ThrGln: 1.608 ± 0.044
1.933ThrArg: 1.933 ± 0.05
3.367ThrSer: 3.367 ± 0.063
3.286ThrThr: 3.286 ± 0.067
3.81ThrVal: 3.81 ± 0.076
0.439ThrTrp: 0.439 ± 0.022
2.564ThrTyr: 2.564 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
4.732ValAla: 4.732 ± 0.078
0.625ValCys: 0.625 ± 0.027
4.31ValAsp: 4.31 ± 0.07
4.927ValGlu: 4.927 ± 0.072
3.01ValPhe: 3.01 ± 0.053
4.487ValGly: 4.487 ± 0.085
1.23ValHis: 1.23 ± 0.036
6.148ValIle: 6.148 ± 0.077
4.485ValLys: 4.485 ± 0.068
6.747ValLeu: 6.747 ± 0.082
2.146ValMet: 2.146 ± 0.047
3.12ValAsn: 3.12 ± 0.06
2.194ValPro: 2.194 ± 0.049
1.741ValGln: 1.741 ± 0.04
2.299ValArg: 2.299 ± 0.05
4.116ValSer: 4.116 ± 0.064
3.902ValThr: 3.902 ± 0.065
5.194ValVal: 5.194 ± 0.085
0.443ValTrp: 0.443 ± 0.02
2.626ValTyr: 2.626 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.437TrpAla: 0.437 ± 0.022
0.081TrpCys: 0.081 ± 0.01
0.439TrpAsp: 0.439 ± 0.024
0.488TrpGlu: 0.488 ± 0.021
0.337TrpPhe: 0.337 ± 0.017
0.461TrpGly: 0.461 ± 0.024
0.178TrpHis: 0.178 ± 0.014
0.656TrpIle: 0.656 ± 0.028
0.452TrpLys: 0.452 ± 0.021
0.806TrpLeu: 0.806 ± 0.027
0.251TrpMet: 0.251 ± 0.014
0.361TrpAsn: 0.361 ± 0.018
0.19TrpPro: 0.19 ± 0.015
0.291TrpGln: 0.291 ± 0.017
0.309TrpArg: 0.309 ± 0.018
0.437TrpSer: 0.437 ± 0.021
0.37TrpThr: 0.37 ± 0.022
0.56TrpVal: 0.56 ± 0.026
0.079TrpTrp: 0.079 ± 0.009
0.319TrpTyr: 0.319 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.304TyrAla: 2.304 ± 0.049
0.421TyrCys: 0.421 ± 0.024
2.752TyrAsp: 2.752 ± 0.062
3.237TyrGlu: 3.237 ± 0.061
1.853TyrPhe: 1.853 ± 0.047
2.733TyrGly: 2.733 ± 0.056
0.877TyrHis: 0.877 ± 0.031
3.27TyrIle: 3.27 ± 0.057
2.929TyrLys: 2.929 ± 0.059
3.682TyrLeu: 3.682 ± 0.072
1.163TyrMet: 1.163 ± 0.034
2.199TyrAsn: 2.199 ± 0.046
1.351TyrPro: 1.351 ± 0.039
1.43TyrGln: 1.43 ± 0.038
1.741TyrArg: 1.741 ± 0.043
2.184TyrSer: 2.184 ± 0.048
2.123TyrThr: 2.123 ± 0.048
2.509TyrVal: 2.509 ± 0.055
0.297TyrTrp: 0.297 ± 0.019
1.948TyrTyr: 1.948 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3381 proteins (1030731 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski