Amino acid dipepetide frequency for Coriobacteriales bacterium OH1046

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.373AlaAla: 14.373 ± 0.225	2.153AlaCys: 2.153 ± 0.062	7.223AlaAsp: 7.223 ± 0.13	7.385AlaGlu: 7.385 ± 0.123	4.232AlaPhe: 4.232 ± 0.078	9.814AlaGly: 9.814 ± 0.132	2.38AlaHis: 2.38 ± 0.063	6.422AlaIle: 6.422 ± 0.109	3.755AlaLys: 3.755 ± 0.081	12.083AlaLeu: 12.083 ± 0.182	2.928AlaMet: 2.928 ± 0.076	2.757AlaAsn: 2.757 ± 0.07	4.194AlaPro: 4.194 ± 0.099	3.117AlaGln: 3.117 ± 0.074	7.497AlaArg: 7.497 ± 0.142	6.638AlaSer: 6.638 ± 0.125	5.059AlaThr: 5.059 ± 0.116	8.334AlaVal: 8.334 ± 0.126	1.313AlaTrp: 1.313 ± 0.046	3.422AlaTyr: 3.422 ± 0.07	0.0AlaXaa: 0.0 ± 0.0
Cys	1.936CysAla: 1.936 ± 0.051	0.296CysCys: 0.296 ± 0.024	1.025CysAsp: 1.025 ± 0.044	0.987CysGlu: 0.987 ± 0.042	0.565CysPhe: 0.565 ± 0.028	1.82CysGly: 1.82 ± 0.053	0.36CysHis: 0.36 ± 0.022	0.986CysIle: 0.986 ± 0.041	0.38CysLys: 0.38 ± 0.023	1.229CysLeu: 1.229 ± 0.047	0.408CysMet: 0.408 ± 0.026	0.387CysAsn: 0.387 ± 0.024	0.824CysPro: 0.824 ± 0.042	0.315CysGln: 0.315 ± 0.021	0.881CysArg: 0.881 ± 0.035	0.967CysSer: 0.967 ± 0.04	0.917CysThr: 0.917 ± 0.036	1.226CysVal: 1.226 ± 0.045	0.149CysTrp: 0.149 ± 0.015	0.442CysTyr: 0.442 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	7.737AspAla: 7.737 ± 0.13	0.821AspCys: 0.821 ± 0.034	3.918AspAsp: 3.918 ± 0.093	5.308AspGlu: 5.308 ± 0.101	2.351AspPhe: 2.351 ± 0.054	6.046AspGly: 6.046 ± 0.132	1.129AspHis: 1.129 ± 0.046	3.693AspIle: 3.693 ± 0.073	1.803AspLys: 1.803 ± 0.054	5.53AspLeu: 5.53 ± 0.086	1.514AspMet: 1.514 ± 0.047	1.375AspAsn: 1.375 ± 0.05	3.256AspPro: 3.256 ± 0.071	1.356AspGln: 1.356 ± 0.048	3.722AspArg: 3.722 ± 0.073	2.816AspSer: 2.816 ± 0.076	2.961AspThr: 2.961 ± 0.067	4.478AspVal: 4.478 ± 0.074	0.782AspTrp: 0.782 ± 0.036	1.935AspTyr: 1.935 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	7.207GluAla: 7.207 ± 0.122	0.765GluCys: 0.765 ± 0.034	3.94GluAsp: 3.94 ± 0.078	4.391GluGlu: 4.391 ± 0.096	1.903GluPhe: 1.903 ± 0.055	5.351GluGly: 5.351 ± 0.096	1.631GluHis: 1.631 ± 0.048	3.596GluIle: 3.596 ± 0.08	2.655GluLys: 2.655 ± 0.073	7.045GluLeu: 7.045 ± 0.102	1.845GluMet: 1.845 ± 0.055	1.913GluAsn: 1.913 ± 0.055	2.535GluPro: 2.535 ± 0.067	2.173GluGln: 2.173 ± 0.056	5.326GluArg: 5.326 ± 0.119	3.022GluSer: 3.022 ± 0.062	3.082GluThr: 3.082 ± 0.074	4.34GluVal: 4.34 ± 0.09	0.591GluTrp: 0.591 ± 0.032	1.683GluTyr: 1.683 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	4.037PheAla: 4.037 ± 0.084	0.72PheCys: 0.72 ± 0.034	2.757PheAsp: 2.757 ± 0.056	2.445PheGlu: 2.445 ± 0.054	1.528PhePhe: 1.528 ± 0.055	3.406PheGly: 3.406 ± 0.077	0.69PheHis: 0.69 ± 0.031	1.942PheIle: 1.942 ± 0.066	1.134PheLys: 1.134 ± 0.045	3.172PheLeu: 3.172 ± 0.082	1.005PheMet: 1.005 ± 0.039	1.022PheAsn: 1.022 ± 0.044	1.431PhePro: 1.431 ± 0.037	0.837PheGln: 0.837 ± 0.035	1.702PheArg: 1.702 ± 0.049	2.858PheSer: 2.858 ± 0.065	1.908PheThr: 1.908 ± 0.061	2.705PheVal: 2.705 ± 0.07	0.437PheTrp: 0.437 ± 0.027	1.126PheTyr: 1.126 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	8.9GlyAla: 8.9 ± 0.134	1.595GlyCys: 1.595 ± 0.056	4.802GlyAsp: 4.802 ± 0.092	5.284GlyGlu: 5.284 ± 0.086	3.531GlyPhe: 3.531 ± 0.069	7.22GlyGly: 7.22 ± 0.123	1.683GlyHis: 1.683 ± 0.048	6.094GlyIle: 6.094 ± 0.099	3.519GlyLys: 3.519 ± 0.092	7.825GlyLeu: 7.825 ± 0.124	2.822GlyMet: 2.822 ± 0.065	2.37GlyAsn: 2.37 ± 0.066	2.467GlyPro: 2.467 ± 0.065	2.146GlyGln: 2.146 ± 0.055	5.577GlyArg: 5.577 ± 0.108	5.585GlySer: 5.585 ± 0.097	5.339GlyThr: 5.339 ± 0.133	6.044GlyVal: 6.044 ± 0.092	0.985GlyTrp: 0.985 ± 0.043	2.977GlyTyr: 2.977 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	2.42HisAla: 2.42 ± 0.064	0.269HisCys: 0.269 ± 0.019	1.269HisAsp: 1.269 ± 0.044	1.42HisGlu: 1.42 ± 0.054	0.645HisPhe: 0.645 ± 0.028	2.001HisGly: 2.001 ± 0.055	0.428HisHis: 0.428 ± 0.026	1.112HisIle: 1.112 ± 0.042	0.506HisLys: 0.506 ± 0.029	1.869HisLeu: 1.869 ± 0.054	0.467HisMet: 0.467 ± 0.025	0.489HisAsn: 0.489 ± 0.026	1.183HisPro: 1.183 ± 0.04	0.383HisGln: 0.383 ± 0.024	1.175HisArg: 1.175 ± 0.042	0.867HisSer: 0.867 ± 0.034	0.951HisThr: 0.951 ± 0.036	1.495HisVal: 1.495 ± 0.046	0.181HisTrp: 0.181 ± 0.017	0.606HisTyr: 0.606 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	7.323IleAla: 7.323 ± 0.098	1.138IleCys: 1.138 ± 0.046	4.395IleAsp: 4.395 ± 0.075	4.19IleGlu: 4.19 ± 0.068	1.875IlePhe: 1.875 ± 0.054	4.887IleGly: 4.887 ± 0.085	0.992IleHis: 0.992 ± 0.046	3.273IleIle: 3.273 ± 0.078	1.67IleLys: 1.67 ± 0.058	4.773IleLeu: 4.773 ± 0.086	1.483IleMet: 1.483 ± 0.048	1.457IleAsn: 1.457 ± 0.049	2.973IlePro: 2.973 ± 0.065	1.319IleGln: 1.319 ± 0.044	3.282IleArg: 3.282 ± 0.074	3.68IleSer: 3.68 ± 0.077	2.834IleThr: 2.834 ± 0.078	4.903IleVal: 4.903 ± 0.1	0.552IleTrp: 0.552 ± 0.027	1.588IleTyr: 1.588 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	3.732LysAla: 3.732 ± 0.085	0.305LysCys: 0.305 ± 0.022	1.901LysAsp: 1.901 ± 0.052	1.881LysGlu: 1.881 ± 0.062	0.71LysPhe: 0.71 ± 0.032	2.63LysGly: 2.63 ± 0.066	0.704LysHis: 0.704 ± 0.034	1.841LysIle: 1.841 ± 0.06	1.508LysLys: 1.508 ± 0.055	3.169LysLeu: 3.169 ± 0.08	0.792LysMet: 0.792 ± 0.037	1.04LysAsn: 1.04 ± 0.045	1.541LysPro: 1.541 ± 0.051	0.891LysGln: 0.891 ± 0.04	2.649LysArg: 2.649 ± 0.067	1.723LysSer: 1.723 ± 0.048	2.008LysThr: 2.008 ± 0.058	2.439LysVal: 2.439 ± 0.068	0.246LysTrp: 0.246 ± 0.02	0.82LysTyr: 0.82 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	12.599LeuAla: 12.599 ± 0.161	1.495LeuCys: 1.495 ± 0.045	6.495LeuAsp: 6.495 ± 0.106	5.909LeuGlu: 5.909 ± 0.111	3.557LeuPhe: 3.557 ± 0.086	8.292LeuGly: 8.292 ± 0.122	1.729LeuHis: 1.729 ± 0.054	5.151LeuIle: 5.151 ± 0.1	2.912LeuLys: 2.912 ± 0.067	8.95LeuLeu: 8.95 ± 0.126	2.691LeuMet: 2.691 ± 0.065	2.108LeuAsn: 2.108 ± 0.059	4.45LeuPro: 4.45 ± 0.082	1.956LeuGln: 1.956 ± 0.053	5.501LeuArg: 5.501 ± 0.111	6.677LeuSer: 6.677 ± 0.111	4.426LeuThr: 4.426 ± 0.084	7.475LeuVal: 7.475 ± 0.113	0.928LeuTrp: 0.928 ± 0.038	2.459LeuTyr: 2.459 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	3.152MetAla: 3.152 ± 0.066	0.366MetCys: 0.366 ± 0.02	1.625MetAsp: 1.625 ± 0.046	1.534MetGlu: 1.534 ± 0.047	0.758MetPhe: 0.758 ± 0.032	2.571MetGly: 2.571 ± 0.073	0.502MetHis: 0.502 ± 0.025	1.324MetIle: 1.324 ± 0.048	0.849MetLys: 0.849 ± 0.035	2.64MetLeu: 2.64 ± 0.065	0.73MetMet: 0.73 ± 0.034	0.826MetAsn: 0.826 ± 0.035	1.512MetPro: 1.512 ± 0.044	0.823MetGln: 0.823 ± 0.033	2.206MetArg: 2.206 ± 0.058	1.635MetSer: 1.635 ± 0.046	1.402MetThr: 1.402 ± 0.045	1.943MetVal: 1.943 ± 0.05	0.201MetTrp: 0.201 ± 0.016	0.538MetTyr: 0.538 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.855AsnAla: 2.855 ± 0.07	0.327AsnCys: 0.327 ± 0.023	1.496AsnAsp: 1.496 ± 0.054	1.489AsnGlu: 1.489 ± 0.049	0.85AsnPhe: 0.85 ± 0.03	2.313AsnGly: 2.313 ± 0.07	0.555AsnHis: 0.555 ± 0.027	1.653AsnIle: 1.653 ± 0.047	0.749AsnLys: 0.749 ± 0.031	2.459AsnLeu: 2.459 ± 0.057	0.72AsnMet: 0.72 ± 0.033	0.698AsnAsn: 0.698 ± 0.038	1.642AsnPro: 1.642 ± 0.05	0.707AsnGln: 0.707 ± 0.04	1.554AsnArg: 1.554 ± 0.057	1.254AsnSer: 1.254 ± 0.049	1.355AsnThr: 1.355 ± 0.05	2.13AsnVal: 2.13 ± 0.058	0.292AsnTrp: 0.292 ± 0.023	0.788AsnTyr: 0.788 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.018ProAla: 5.018 ± 0.105	0.567ProCys: 0.567 ± 0.031	2.951ProAsp: 2.951 ± 0.076	3.486ProGlu: 3.486 ± 0.068	1.738ProPhe: 1.738 ± 0.054	3.469ProGly: 3.469 ± 0.08	0.881ProHis: 0.881 ± 0.037	2.329ProIle: 2.329 ± 0.052	1.421ProLys: 1.421 ± 0.052	3.986ProLeu: 3.986 ± 0.073	0.982ProMet: 0.982 ± 0.043	1.128ProAsn: 1.128 ± 0.047	1.236ProPro: 1.236 ± 0.042	1.301ProGln: 1.301 ± 0.043	2.216ProArg: 2.216 ± 0.059	2.766ProSer: 2.766 ± 0.061	2.157ProThr: 2.157 ± 0.055	3.372ProVal: 3.372 ± 0.077	0.479ProTrp: 0.479 ± 0.025	1.452ProTyr: 1.452 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	2.958GlnAla: 2.958 ± 0.073	0.28GlnCys: 0.28 ± 0.02	1.337GlnAsp: 1.337 ± 0.043	1.492GlnGlu: 1.492 ± 0.052	0.782GlnPhe: 0.782 ± 0.038	2.277GlnGly: 2.277 ± 0.061	0.421GlnHis: 0.421 ± 0.026	1.667GlnIle: 1.667 ± 0.052	0.856GlnLys: 0.856 ± 0.037	2.698GlnLeu: 2.698 ± 0.056	0.83GlnMet: 0.83 ± 0.033	0.671GlnAsn: 0.671 ± 0.031	0.956GlnPro: 0.956 ± 0.037	0.795GlnGln: 0.795 ± 0.044	1.721GlnArg: 1.721 ± 0.051	1.371GlnSer: 1.371 ± 0.05	1.374GlnThr: 1.374 ± 0.05	1.919GlnVal: 1.919 ± 0.053	0.285GlnTrp: 0.285 ± 0.023	0.684GlnTyr: 0.684 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	7.051ArgAla: 7.051 ± 0.122	0.961ArgCys: 0.961 ± 0.039	3.512ArgAsp: 3.512 ± 0.079	4.376ArgGlu: 4.376 ± 0.086	2.591ArgPhe: 2.591 ± 0.068	4.586ArgGly: 4.586 ± 0.09	1.271ArgHis: 1.271 ± 0.038	4.21ArgIle: 4.21 ± 0.083	2.387ArgLys: 2.387 ± 0.062	6.062ArgLeu: 6.062 ± 0.118	2.105ArgMet: 2.105 ± 0.052	1.693ArgAsn: 1.693 ± 0.05	2.303ArgPro: 2.303 ± 0.053	1.684ArgGln: 1.684 ± 0.064	4.651ArgArg: 4.651 ± 0.096	3.923ArgSer: 3.923 ± 0.088	3.33ArgThr: 3.33 ± 0.072	4.403ArgVal: 4.403 ± 0.093	0.759ArgTrp: 0.759 ± 0.032	2.007ArgTyr: 2.007 ± 0.061	0.0ArgXaa: 0.0 ± 0.0
Ser	6.341SerAla: 6.341 ± 0.1	1.121SerCys: 1.121 ± 0.039	3.576SerAsp: 3.576 ± 0.071	3.479SerGlu: 3.479 ± 0.079	2.798SerPhe: 2.798 ± 0.06	5.564SerGly: 5.564 ± 0.105	1.142SerHis: 1.142 ± 0.04	3.667SerIle: 3.667 ± 0.08	1.8SerLys: 1.8 ± 0.051	5.54SerLeu: 5.54 ± 0.104	1.664SerMet: 1.664 ± 0.062	1.434SerAsn: 1.434 ± 0.05	2.452SerPro: 2.452 ± 0.063	1.443SerGln: 1.443 ± 0.046	3.563SerArg: 3.563 ± 0.074	3.86SerSer: 3.86 ± 0.08	3.061SerThr: 3.061 ± 0.068	4.369SerVal: 4.369 ± 0.084	0.844SerTrp: 0.844 ± 0.033	2.101SerTyr: 2.101 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.11ThrAla: 5.11 ± 0.103	0.844ThrCys: 0.844 ± 0.036	2.858ThrAsp: 2.858 ± 0.068	2.589ThrGlu: 2.589 ± 0.077	2.06ThrPhe: 2.06 ± 0.067	4.916ThrGly: 4.916 ± 0.101	1.089ThrHis: 1.089 ± 0.042	3.204ThrIle: 3.204 ± 0.084	1.381ThrLys: 1.381 ± 0.053	5.172ThrLeu: 5.172 ± 0.083	1.275ThrMet: 1.275 ± 0.045	1.298ThrAsn: 1.298 ± 0.067	2.623ThrPro: 2.623 ± 0.073	1.2ThrGln: 1.2 ± 0.042	2.783ThrArg: 2.783 ± 0.059	2.905ThrSer: 2.905 ± 0.07	2.668ThrThr: 2.668 ± 0.081	4.676ThrVal: 4.676 ± 0.137	0.577ThrTrp: 0.577 ± 0.027	1.708ThrTyr: 1.708 ± 0.085	0.0ThrXaa: 0.0 ± 0.0
Val	8.136ValAla: 8.136 ± 0.131	1.394ValCys: 1.394 ± 0.043	4.666ValAsp: 4.666 ± 0.087	4.66ValGlu: 4.66 ± 0.089	2.88ValPhe: 2.88 ± 0.069	6.044ValGly: 6.044 ± 0.102	1.34ValHis: 1.34 ± 0.039	4.416ValIle: 4.416 ± 0.091	2.115ValLys: 2.115 ± 0.058	7.421ValLeu: 7.421 ± 0.111	1.94ValMet: 1.94 ± 0.053	1.988ValAsn: 1.988 ± 0.056	3.615ValPro: 3.615 ± 0.075	1.775ValGln: 1.775 ± 0.048	4.975ValArg: 4.975 ± 0.085	5.095ValSer: 5.095 ± 0.097	3.857ValThr: 3.857 ± 0.14	5.707ValVal: 5.707 ± 0.092	0.81ValTrp: 0.81 ± 0.035	1.897ValTyr: 1.897 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.972TrpAla: 0.972 ± 0.037	0.214TrpCys: 0.214 ± 0.017	0.717TrpAsp: 0.717 ± 0.036	0.695TrpGlu: 0.695 ± 0.034	0.434TrpPhe: 0.434 ± 0.025	0.898TrpGly: 0.898 ± 0.04	0.214TrpHis: 0.214 ± 0.018	0.574TrpIle: 0.574 ± 0.035	0.36TrpLys: 0.36 ± 0.02	1.112TrpLeu: 1.112 ± 0.044	0.34TrpMet: 0.34 ± 0.021	0.37TrpAsn: 0.37 ± 0.021	0.455TrpPro: 0.455 ± 0.027	0.341TrpGln: 0.341 ± 0.022	0.733TrpArg: 0.733 ± 0.032	0.707TrpSer: 0.707 ± 0.037	0.574TrpThr: 0.574 ± 0.03	0.655TrpVal: 0.655 ± 0.032	0.166TrpTrp: 0.166 ± 0.017	0.337TrpTyr: 0.337 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.221TyrAla: 3.221 ± 0.074	0.471TyrCys: 0.471 ± 0.029	2.066TyrAsp: 2.066 ± 0.059	1.994TyrGlu: 1.994 ± 0.052	1.076TyrPhe: 1.076 ± 0.042	2.659TyrGly: 2.659 ± 0.06	0.597TyrHis: 0.597 ± 0.026	1.433TyrIle: 1.433 ± 0.051	0.771TyrLys: 0.771 ± 0.03	3.023TyrLeu: 3.023 ± 0.077	0.594TyrMet: 0.594 ± 0.032	0.863TyrAsn: 0.863 ± 0.032	1.285TyrPro: 1.285 ± 0.041	0.81TyrGln: 0.81 ± 0.039	2.153TyrArg: 2.153 ± 0.062	1.469TyrSer: 1.469 ± 0.055	1.671TyrThr: 1.671 ± 0.083	2.12TyrVal: 2.12 ± 0.054	0.292TyrTrp: 0.292 ± 0.019	0.941TyrTyr: 0.941 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2118 proteins (691650 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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