Amino acid dipepetide frequency for Novosphingobium pentaromativorans US6-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.735AlaAla: 16.735 ± 0.136	1.201AlaCys: 1.201 ± 0.028	7.007AlaAsp: 7.007 ± 0.077	7.394AlaGlu: 7.394 ± 0.08	4.208AlaPhe: 4.208 ± 0.058	10.703AlaGly: 10.703 ± 0.104	2.339AlaHis: 2.339 ± 0.042	6.668AlaIle: 6.668 ± 0.065	3.931AlaLys: 3.931 ± 0.065	13.172AlaLeu: 13.172 ± 0.112	4.045AlaMet: 4.045 ± 0.059	3.094AlaAsn: 3.094 ± 0.045	5.729AlaPro: 5.729 ± 0.077	4.641AlaGln: 4.641 ± 0.067	9.529AlaArg: 9.529 ± 0.09	7.159AlaSer: 7.159 ± 0.088	5.727AlaThr: 5.727 ± 0.068	8.143AlaVal: 8.143 ± 0.076	1.671AlaTrp: 1.671 ± 0.037	2.508AlaTyr: 2.508 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.142CysAla: 1.142 ± 0.028	0.132CysCys: 0.132 ± 0.011	0.628CysAsp: 0.628 ± 0.023	0.572CysGlu: 0.572 ± 0.02	0.338CysPhe: 0.338 ± 0.017	1.014CysGly: 1.014 ± 0.029	0.255CysHis: 0.255 ± 0.015	0.399CysIle: 0.399 ± 0.014	0.217CysLys: 0.217 ± 0.012	0.812CysLeu: 0.812 ± 0.026	0.183CysMet: 0.183 ± 0.012	0.27CysAsn: 0.27 ± 0.015	0.52CysPro: 0.52 ± 0.023	0.24CysGln: 0.24 ± 0.013	0.683CysArg: 0.683 ± 0.023	0.576CysSer: 0.576 ± 0.019	0.415CysThr: 0.415 ± 0.018	0.584CysVal: 0.584 ± 0.021	0.148CysTrp: 0.148 ± 0.011	0.196CysTyr: 0.196 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.177AspAla: 7.177 ± 0.069	0.596AspCys: 0.596 ± 0.021	3.385AspAsp: 3.385 ± 0.049	3.872AspGlu: 3.872 ± 0.056	2.221AspPhe: 2.221 ± 0.036	5.193AspGly: 5.193 ± 0.069	1.37AspHis: 1.37 ± 0.03	2.892AspIle: 2.892 ± 0.049	1.913AspLys: 1.913 ± 0.041	5.956AspLeu: 5.956 ± 0.069	1.471AspMet: 1.471 ± 0.032	1.411AspAsn: 1.411 ± 0.035	3.717AspPro: 3.717 ± 0.052	1.69AspGln: 1.69 ± 0.03	4.579AspArg: 4.579 ± 0.06	2.428AspSer: 2.428 ± 0.044	2.672AspThr: 2.672 ± 0.041	3.996AspVal: 3.996 ± 0.058	1.132AspTrp: 1.132 ± 0.03	1.611AspTyr: 1.611 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.099GluAla: 8.099 ± 0.088	0.446GluCys: 0.446 ± 0.018	3.12GluAsp: 3.12 ± 0.05	3.393GluGlu: 3.393 ± 0.05	1.801GluPhe: 1.801 ± 0.035	4.843GluGly: 4.843 ± 0.061	1.256GluHis: 1.256 ± 0.032	3.261GluIle: 3.261 ± 0.047	2.256GluLys: 2.256 ± 0.044	5.521GluLeu: 5.521 ± 0.069	1.583GluMet: 1.583 ± 0.03	1.552GluAsn: 1.552 ± 0.037	2.721GluPro: 2.721 ± 0.051	2.344GluGln: 2.344 ± 0.035	5.196GluArg: 5.196 ± 0.06	2.592GluSer: 2.592 ± 0.044	3.397GluThr: 3.397 ± 0.055	3.963GluVal: 3.963 ± 0.051	0.859GluTrp: 0.859 ± 0.026	1.035GluTyr: 1.035 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.691PheAla: 4.691 ± 0.062	0.378PheCys: 0.378 ± 0.015	2.705PheAsp: 2.705 ± 0.042	2.27PheGlu: 2.27 ± 0.034	1.255PhePhe: 1.255 ± 0.033	3.602PheGly: 3.602 ± 0.055	0.792PheHis: 0.792 ± 0.026	1.492PheIle: 1.492 ± 0.033	0.905PheLys: 0.905 ± 0.027	3.185PheLeu: 3.185 ± 0.051	0.809PheMet: 0.809 ± 0.024	1.018PheAsn: 1.018 ± 0.027	1.562PhePro: 1.562 ± 0.03	0.912PheGln: 0.912 ± 0.022	2.155PheArg: 2.155 ± 0.039	2.246PheSer: 2.246 ± 0.038	1.952PheThr: 1.952 ± 0.038	2.637PheVal: 2.637 ± 0.045	0.579PheTrp: 0.579 ± 0.022	0.903PheTyr: 0.903 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.267GlyAla: 9.267 ± 0.092	0.875GlyCys: 0.875 ± 0.023	4.76GlyAsp: 4.76 ± 0.065	5.207GlyGlu: 5.207 ± 0.052	3.532GlyPhe: 3.532 ± 0.048	7.543GlyGly: 7.543 ± 0.124	1.905GlyHis: 1.905 ± 0.04	4.536GlyIle: 4.536 ± 0.062	3.634GlyLys: 3.634 ± 0.049	8.506GlyLeu: 8.506 ± 0.07	2.447GlyMet: 2.447 ± 0.045	2.41GlyAsn: 2.41 ± 0.056	3.639GlyPro: 3.639 ± 0.053	3.01GlyGln: 3.01 ± 0.045	6.097GlyArg: 6.097 ± 0.072	5.109GlySer: 5.109 ± 0.073	4.693GlyThr: 4.693 ± 0.068	5.904GlyVal: 5.904 ± 0.061	1.447GlyTrp: 1.447 ± 0.029	2.347GlyTyr: 2.347 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.429HisAla: 2.429 ± 0.048	0.256HisCys: 0.256 ± 0.013	1.278HisAsp: 1.278 ± 0.031	1.17HisGlu: 1.17 ± 0.032	0.886HisPhe: 0.886 ± 0.023	2.008HisGly: 2.008 ± 0.04	0.578HisHis: 0.578 ± 0.022	0.965HisIle: 0.965 ± 0.026	0.509HisLys: 0.509 ± 0.019	1.984HisLeu: 1.984 ± 0.037	0.514HisMet: 0.514 ± 0.02	0.443HisAsn: 0.443 ± 0.017	1.308HisPro: 1.308 ± 0.03	0.55HisGln: 0.55 ± 0.019	1.552HisArg: 1.552 ± 0.036	1.05HisSer: 1.05 ± 0.025	0.759HisThr: 0.759 ± 0.023	1.548HisVal: 1.548 ± 0.034	0.355HisTrp: 0.355 ± 0.016	0.631HisTyr: 0.631 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.609IleAla: 7.609 ± 0.085	0.508IleCys: 0.508 ± 0.019	3.844IleAsp: 3.844 ± 0.055	3.764IleGlu: 3.764 ± 0.052	1.573IlePhe: 1.573 ± 0.03	4.975IleGly: 4.975 ± 0.054	0.942IleHis: 0.942 ± 0.027	1.884IleIle: 1.884 ± 0.046	1.247IleLys: 1.247 ± 0.03	4.001IleLeu: 4.001 ± 0.054	0.998IleMet: 0.998 ± 0.025	1.306IleAsn: 1.306 ± 0.032	2.292IlePro: 2.292 ± 0.039	1.177IleGln: 1.177 ± 0.03	3.157IleArg: 3.157 ± 0.041	2.859IleSer: 2.859 ± 0.047	2.46IleThr: 2.46 ± 0.038	4.144IleVal: 4.144 ± 0.053	0.601IleTrp: 0.601 ± 0.022	1.138IleTyr: 1.138 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.259LysAla: 4.259 ± 0.064	0.205LysCys: 0.205 ± 0.013	1.667LysAsp: 1.667 ± 0.037	1.457LysGlu: 1.457 ± 0.038	0.91LysPhe: 0.91 ± 0.024	2.758LysGly: 2.758 ± 0.046	0.622LysHis: 0.622 ± 0.025	1.466LysIle: 1.466 ± 0.033	1.052LysLys: 1.052 ± 0.033	3.296LysLeu: 3.296 ± 0.043	0.809LysMet: 0.809 ± 0.027	0.746LysAsn: 0.746 ± 0.023	1.983LysPro: 1.983 ± 0.04	1.035LysGln: 1.035 ± 0.029	2.311LysArg: 2.311 ± 0.046	1.759LysSer: 1.759 ± 0.033	1.629LysThr: 1.629 ± 0.034	2.438LysVal: 2.438 ± 0.038	0.408LysTrp: 0.408 ± 0.02	0.595LysTyr: 0.595 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.737LeuAla: 13.737 ± 0.119	0.911LeuCys: 0.911 ± 0.025	6.141LeuAsp: 6.141 ± 0.075	5.505LeuGlu: 5.505 ± 0.069	3.548LeuPhe: 3.548 ± 0.054	8.358LeuGly: 8.358 ± 0.075	1.905LeuHis: 1.905 ± 0.039	4.627LeuIle: 4.627 ± 0.064	3.006LeuLys: 3.006 ± 0.046	9.163LeuLeu: 9.163 ± 0.114	2.128LeuMet: 2.128 ± 0.042	2.365LeuAsn: 2.365 ± 0.039	5.582LeuPro: 5.582 ± 0.06	2.654LeuGln: 2.654 ± 0.041	7.013LeuArg: 7.013 ± 0.076	6.33LeuSer: 6.33 ± 0.068	5.326LeuThr: 5.326 ± 0.064	7.128LeuVal: 7.128 ± 0.079	1.098LeuTrp: 1.098 ± 0.023	1.869LeuTyr: 1.869 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	3.481MetAla: 3.481 ± 0.048	0.181MetCys: 0.181 ± 0.011	1.242MetAsp: 1.242 ± 0.029	1.211MetGlu: 1.211 ± 0.026	0.728MetPhe: 0.728 ± 0.022	1.929MetGly: 1.929 ± 0.038	0.526MetHis: 0.526 ± 0.019	1.413MetIle: 1.413 ± 0.03	0.966MetLys: 0.966 ± 0.026	2.662MetLeu: 2.662 ± 0.04	0.712MetMet: 0.712 ± 0.024	0.725MetAsn: 0.725 ± 0.02	1.567MetPro: 1.567 ± 0.029	0.858MetGln: 0.858 ± 0.023	1.89MetArg: 1.89 ± 0.035	1.591MetSer: 1.591 ± 0.034	1.736MetThr: 1.736 ± 0.038	1.671MetVal: 1.671 ± 0.037	0.236MetTrp: 0.236 ± 0.013	0.279MetTyr: 0.279 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.258AsnAla: 3.258 ± 0.055	0.268AsnCys: 0.268 ± 0.015	1.483AsnAsp: 1.483 ± 0.034	1.236AsnGlu: 1.236 ± 0.029	0.98AsnPhe: 0.98 ± 0.028	2.487AsnGly: 2.487 ± 0.044	0.483AsnHis: 0.483 ± 0.017	1.285AsnIle: 1.285 ± 0.031	0.616AsnLys: 0.616 ± 0.022	2.6AsnLeu: 2.6 ± 0.049	0.593AsnMet: 0.593 ± 0.02	0.629AsnAsn: 0.629 ± 0.024	1.774AsnPro: 1.774 ± 0.036	0.712AsnGln: 0.712 ± 0.022	1.965AsnArg: 1.965 ± 0.038	1.301AsnSer: 1.301 ± 0.031	1.128AsnThr: 1.128 ± 0.033	1.883AsnVal: 1.883 ± 0.039	0.47AsnTrp: 0.47 ± 0.02	0.732AsnTyr: 0.732 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.329ProAla: 6.329 ± 0.079	0.409ProCys: 0.409 ± 0.014	3.663ProAsp: 3.663 ± 0.047	3.892ProGlu: 3.892 ± 0.058	1.92ProPhe: 1.92 ± 0.035	4.743ProGly: 4.743 ± 0.063	1.068ProHis: 1.068 ± 0.028	2.398ProIle: 2.398 ± 0.038	1.497ProLys: 1.497 ± 0.033	4.84ProLeu: 4.84 ± 0.06	1.271ProMet: 1.271 ± 0.031	1.249ProAsn: 1.249 ± 0.029	2.497ProPro: 2.497 ± 0.055	1.803ProGln: 1.803 ± 0.032	3.129ProArg: 3.129 ± 0.054	2.875ProSer: 2.875 ± 0.04	2.325ProThr: 2.325 ± 0.039	4.25ProVal: 4.25 ± 0.051	0.683ProTrp: 0.683 ± 0.021	1.067ProTyr: 1.067 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.254GlnAla: 4.254 ± 0.063	0.264GlnCys: 0.264 ± 0.015	1.579GlnAsp: 1.579 ± 0.036	1.58GlnGlu: 1.58 ± 0.031	1.191GlnPhe: 1.191 ± 0.025	2.547GlnGly: 2.547 ± 0.041	0.633GlnHis: 0.633 ± 0.022	1.779GlnIle: 1.779 ± 0.035	0.943GlnLys: 0.943 ± 0.026	3.156GlnLeu: 3.156 ± 0.04	0.91GlnMet: 0.91 ± 0.025	0.781GlnAsn: 0.781 ± 0.024	1.73GlnPro: 1.73 ± 0.033	1.129GlnGln: 1.129 ± 0.03	2.453GlnArg: 2.453 ± 0.048	1.815GlnSer: 1.815 ± 0.039	1.604GlnThr: 1.604 ± 0.036	2.563GlnVal: 2.563 ± 0.044	0.48GlnTrp: 0.48 ± 0.016	0.648GlnTyr: 0.648 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.948ArgAla: 7.948 ± 0.084	0.572ArgCys: 0.572 ± 0.02	4.187ArgAsp: 4.187 ± 0.057	4.674ArgGlu: 4.674 ± 0.062	3.104ArgPhe: 3.104 ± 0.042	4.886ArgGly: 4.886 ± 0.053	1.812ArgHis: 1.812 ± 0.04	4.297ArgIle: 4.297 ± 0.05	2.677ArgLys: 2.677 ± 0.044	7.818ArgLeu: 7.818 ± 0.095	1.921ArgMet: 1.921 ± 0.037	2.05ArgAsn: 2.05 ± 0.04	3.547ArgPro: 3.547 ± 0.053	2.664ArgGln: 2.664 ± 0.042	5.731ArgArg: 5.731 ± 0.087	4.109ArgSer: 4.109 ± 0.056	3.493ArgThr: 3.493 ± 0.044	4.557ArgVal: 4.557 ± 0.054	1.105ArgTrp: 1.105 ± 0.028	1.811ArgTyr: 1.811 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.672SerAla: 6.672 ± 0.077	0.553SerCys: 0.553 ± 0.02	3.356SerAsp: 3.356 ± 0.048	3.107SerGlu: 3.107 ± 0.044	2.19SerPhe: 2.19 ± 0.039	5.791SerGly: 5.791 ± 0.071	1.131SerHis: 1.131 ± 0.027	2.78SerIle: 2.78 ± 0.038	1.6SerLys: 1.6 ± 0.039	5.623SerLeu: 5.623 ± 0.066	1.394SerMet: 1.394 ± 0.03	1.461SerAsn: 1.461 ± 0.036	2.942SerPro: 2.942 ± 0.041	1.901SerGln: 1.901 ± 0.04	3.943SerArg: 3.943 ± 0.048	3.234SerSer: 3.234 ± 0.057	2.7SerThr: 2.7 ± 0.045	3.812SerVal: 3.812 ± 0.05	0.842SerTrp: 0.842 ± 0.024	1.431SerTyr: 1.431 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.931ThrAla: 5.931 ± 0.075	0.5ThrCys: 0.5 ± 0.017	2.825ThrAsp: 2.825 ± 0.046	2.458ThrGlu: 2.458 ± 0.04	1.848ThrPhe: 1.848 ± 0.033	5.126ThrGly: 5.126 ± 0.085	0.913ThrHis: 0.913 ± 0.027	2.88ThrIle: 2.88 ± 0.044	1.292ThrLys: 1.292 ± 0.032	5.228ThrLeu: 5.228 ± 0.059	1.287ThrMet: 1.287 ± 0.03	1.246ThrAsn: 1.246 ± 0.037	3.078ThrPro: 3.078 ± 0.039	1.412ThrGln: 1.412 ± 0.03	3.429ThrArg: 3.429 ± 0.048	2.859ThrSer: 2.859 ± 0.053	2.425ThrThr: 2.425 ± 0.046	3.999ThrVal: 3.999 ± 0.052	0.66ThrTrp: 0.66 ± 0.02	1.186ThrTyr: 1.186 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	8.713ValAla: 8.713 ± 0.078	0.632ValCys: 0.632 ± 0.022	4.231ValAsp: 4.231 ± 0.05	4.627ValGlu: 4.627 ± 0.056	2.377ValPhe: 2.377 ± 0.043	5.335ValGly: 5.335 ± 0.057	1.382ValHis: 1.382 ± 0.032	3.804ValIle: 3.804 ± 0.051	1.974ValLys: 1.974 ± 0.041	6.899ValLeu: 6.899 ± 0.078	1.7ValMet: 1.7 ± 0.036	1.966ValAsn: 1.966 ± 0.043	3.986ValPro: 3.986 ± 0.045	1.993ValGln: 1.993 ± 0.037	5.009ValArg: 5.009 ± 0.057	4.357ValSer: 4.357 ± 0.055	4.308ValThr: 4.308 ± 0.063	5.126ValVal: 5.126 ± 0.066	0.865ValTrp: 0.865 ± 0.024	1.342ValTyr: 1.342 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.304TrpAla: 1.304 ± 0.034	0.164TrpCys: 0.164 ± 0.01	0.719TrpAsp: 0.719 ± 0.023	0.623TrpGlu: 0.623 ± 0.021	0.574TrpPhe: 0.574 ± 0.022	0.953TrpGly: 0.953 ± 0.029	0.372TrpHis: 0.372 ± 0.016	0.742TrpIle: 0.742 ± 0.022	0.537TrpLys: 0.537 ± 0.018	1.767TrpLeu: 1.767 ± 0.037	0.386TrpMet: 0.386 ± 0.016	0.51TrpAsn: 0.51 ± 0.017	0.689TrpPro: 0.689 ± 0.019	0.637TrpGln: 0.637 ± 0.019	1.278TrpArg: 1.278 ± 0.028	0.928TrpSer: 0.928 ± 0.024	0.765TrpThr: 0.765 ± 0.02	0.761TrpVal: 0.761 ± 0.024	0.237TrpTrp: 0.237 ± 0.014	0.306TrpTyr: 0.306 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.572TyrAla: 2.572 ± 0.043	0.271TyrCys: 0.271 ± 0.014	1.462TyrAsp: 1.462 ± 0.031	1.226TyrGlu: 1.226 ± 0.027	0.867TyrPhe: 0.867 ± 0.024	2.074TyrGly: 2.074 ± 0.044	0.492TyrHis: 0.492 ± 0.018	0.91TyrIle: 0.91 ± 0.021	0.631TyrLys: 0.631 ± 0.024	2.209TyrLeu: 2.209 ± 0.039	0.442TyrMet: 0.442 ± 0.017	0.652TyrAsn: 0.652 ± 0.021	1.043TyrPro: 1.043 ± 0.026	0.676TyrGln: 0.676 ± 0.02	1.864TyrArg: 1.864 ± 0.036	1.286TyrSer: 1.286 ± 0.03	1.066TyrThr: 1.066 ± 0.029	1.517TyrVal: 1.517 ± 0.032	0.376TyrTrp: 0.376 ± 0.015	0.636TyrTyr: 0.636 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5229 proteins (1570680 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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