Amino acid dipepetide frequency for Microbacterium mangrovi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.853AlaAla: 21.853 ± 0.228	0.723AlaCys: 0.723 ± 0.029	8.682AlaAsp: 8.682 ± 0.095	7.734AlaGlu: 7.734 ± 0.126	4.061AlaPhe: 4.061 ± 0.06	13.164AlaGly: 13.164 ± 0.189	2.673AlaHis: 2.673 ± 0.048	5.934AlaIle: 5.934 ± 0.081	2.668AlaLys: 2.668 ± 0.061	14.022AlaLeu: 14.022 ± 0.113	2.707AlaMet: 2.707 ± 0.055	2.385AlaAsn: 2.385 ± 0.048	6.523AlaPro: 6.523 ± 0.112	4.018AlaGln: 4.018 ± 0.068	9.472AlaArg: 9.472 ± 0.139	7.9AlaSer: 7.9 ± 0.09	7.485AlaThr: 7.485 ± 0.128	12.517AlaVal: 12.517 ± 0.128	2.011AlaTrp: 2.011 ± 0.047	2.467AlaTyr: 2.467 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.709CysAla: 0.709 ± 0.027	0.047CysCys: 0.047 ± 0.007	0.323CysAsp: 0.323 ± 0.018	0.24CysGlu: 0.24 ± 0.014	0.177CysPhe: 0.177 ± 0.012	0.572CysGly: 0.572 ± 0.025	0.115CysHis: 0.115 ± 0.01	0.217CysIle: 0.217 ± 0.014	0.074CysLys: 0.074 ± 0.007	0.465CysLeu: 0.465 ± 0.017	0.102CysMet: 0.102 ± 0.011	0.106CysAsn: 0.106 ± 0.01	0.301CysPro: 0.301 ± 0.016	0.118CysGln: 0.118 ± 0.011	0.329CysArg: 0.329 ± 0.019	0.318CysSer: 0.318 ± 0.015	0.378CysThr: 0.378 ± 0.02	0.441CysVal: 0.441 ± 0.022	0.086CysTrp: 0.086 ± 0.009	0.095CysTyr: 0.095 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	10.151AspAla: 10.151 ± 0.131	0.23AspCys: 0.23 ± 0.015	4.244AspAsp: 4.244 ± 0.078	4.048AspGlu: 4.048 ± 0.083	1.709AspPhe: 1.709 ± 0.04	5.889AspGly: 5.889 ± 0.093	1.222AspHis: 1.222 ± 0.034	2.448AspIle: 2.448 ± 0.05	1.026AspLys: 1.026 ± 0.033	6.343AspLeu: 6.343 ± 0.078	0.857AspMet: 0.857 ± 0.029	0.868AspAsn: 0.868 ± 0.035	4.282AspPro: 4.282 ± 0.062	1.518AspGln: 1.518 ± 0.039	4.529AspArg: 4.529 ± 0.078	2.357AspSer: 2.357 ± 0.046	2.842AspThr: 2.842 ± 0.062	5.47AspVal: 5.47 ± 0.074	0.947AspTrp: 0.947 ± 0.031	1.219AspTyr: 1.219 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.481GluAla: 6.481 ± 0.091	0.226GluCys: 0.226 ± 0.015	2.521GluAsp: 2.521 ± 0.059	2.446GluGlu: 2.446 ± 0.062	1.672GluPhe: 1.672 ± 0.042	3.389GluGly: 3.389 ± 0.059	1.416GluHis: 1.416 ± 0.041	2.486GluIle: 2.486 ± 0.049	1.175GluLys: 1.175 ± 0.041	6.101GluLeu: 6.101 ± 0.1	0.853GluMet: 0.853 ± 0.031	1.075GluAsn: 1.075 ± 0.031	2.807GluPro: 2.807 ± 0.065	2.067GluGln: 2.067 ± 0.049	4.717GluArg: 4.717 ± 0.091	2.509GluSer: 2.509 ± 0.047	2.764GluThr: 2.764 ± 0.044	4.275GluVal: 4.275 ± 0.081	0.802GluTrp: 0.802 ± 0.031	1.104GluTyr: 1.104 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.57PheAla: 4.57 ± 0.067	0.185PheCys: 0.185 ± 0.013	2.416PheAsp: 2.416 ± 0.05	1.65PheGlu: 1.65 ± 0.039	1.08PhePhe: 1.08 ± 0.039	3.566PheGly: 3.566 ± 0.063	0.575PheHis: 0.575 ± 0.023	1.179PheIle: 1.179 ± 0.033	0.443PheLys: 0.443 ± 0.02	2.961PheLeu: 2.961 ± 0.063	0.422PheMet: 0.422 ± 0.019	0.668PheAsn: 0.668 ± 0.025	1.443PhePro: 1.443 ± 0.037	0.812PheGln: 0.812 ± 0.028	1.807PheArg: 1.807 ± 0.044	1.672PheSer: 1.672 ± 0.043	2.274PheThr: 2.274 ± 0.061	2.943PheVal: 2.943 ± 0.05	0.504PheTrp: 0.504 ± 0.019	0.649PheTyr: 0.649 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.063GlyAla: 11.063 ± 0.133	0.575GlyCys: 0.575 ± 0.023	5.118GlyAsp: 5.118 ± 0.094	4.401GlyGlu: 4.401 ± 0.08	3.365GlyPhe: 3.365 ± 0.063	7.87GlyGly: 7.87 ± 0.159	1.943GlyHis: 1.943 ± 0.04	5.329GlyIle: 5.329 ± 0.079	2.089GlyLys: 2.089 ± 0.049	8.826GlyLeu: 8.826 ± 0.082	2.094GlyMet: 2.094 ± 0.042	1.681GlyAsn: 1.681 ± 0.042	3.991GlyPro: 3.991 ± 0.067	2.556GlyGln: 2.556 ± 0.056	6.468GlyArg: 6.468 ± 0.087	5.349GlySer: 5.349 ± 0.131	5.861GlyThr: 5.861 ± 0.171	8.028GlyVal: 8.028 ± 0.099	1.704GlyTrp: 1.704 ± 0.043	2.26GlyTyr: 2.26 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.502HisAla: 2.502 ± 0.047	0.114HisCys: 0.114 ± 0.01	1.336HisAsp: 1.336 ± 0.036	1.109HisGlu: 1.109 ± 0.032	0.565HisPhe: 0.565 ± 0.022	2.177HisGly: 2.177 ± 0.04	0.535HisHis: 0.535 ± 0.029	0.765HisIle: 0.765 ± 0.028	0.287HisLys: 0.287 ± 0.018	2.094HisLeu: 2.094 ± 0.043	0.319HisMet: 0.319 ± 0.015	0.384HisAsn: 0.384 ± 0.02	1.66HisPro: 1.66 ± 0.036	0.497HisGln: 0.497 ± 0.021	1.61HisArg: 1.61 ± 0.037	0.933HisSer: 0.933 ± 0.028	1.087HisThr: 1.087 ± 0.03	1.837HisVal: 1.837 ± 0.042	0.291HisTrp: 0.291 ± 0.016	0.417HisTyr: 0.417 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.291IleAla: 7.291 ± 0.098	0.236IleCys: 0.236 ± 0.015	3.378IleAsp: 3.378 ± 0.049	2.581IleGlu: 2.581 ± 0.051	1.168IlePhe: 1.168 ± 0.036	4.707IleGly: 4.707 ± 0.066	0.781IleHis: 0.781 ± 0.025	1.827IleIle: 1.827 ± 0.052	0.769IleLys: 0.769 ± 0.027	3.901IleLeu: 3.901 ± 0.055	0.639IleMet: 0.639 ± 0.022	0.913IleAsn: 0.913 ± 0.028	2.599IlePro: 2.599 ± 0.049	1.046IleGln: 1.046 ± 0.035	2.841IleArg: 2.841 ± 0.052	2.274IleSer: 2.274 ± 0.048	2.838IleThr: 2.838 ± 0.071	4.908IleVal: 4.908 ± 0.068	0.531IleTrp: 0.531 ± 0.023	0.719IleTyr: 0.719 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.464LysAla: 2.464 ± 0.06	0.073LysCys: 0.073 ± 0.008	1.138LysAsp: 1.138 ± 0.036	0.786LysGlu: 0.786 ± 0.035	0.481LysPhe: 0.481 ± 0.02	1.495LysGly: 1.495 ± 0.042	0.443LysHis: 0.443 ± 0.022	0.924LysIle: 0.924 ± 0.031	0.674LysLys: 0.674 ± 0.031	1.794LysLeu: 1.794 ± 0.043	0.389LysMet: 0.389 ± 0.019	0.523LysAsn: 0.523 ± 0.025	1.187LysPro: 1.187 ± 0.032	0.734LysGln: 0.734 ± 0.029	1.338LysArg: 1.338 ± 0.034	1.113LysSer: 1.113 ± 0.037	1.341LysThr: 1.341 ± 0.038	1.664LysVal: 1.664 ± 0.049	0.253LysTrp: 0.253 ± 0.014	0.479LysTyr: 0.479 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.613LeuAla: 14.613 ± 0.128	0.573LeuCys: 0.573 ± 0.022	6.598LeuAsp: 6.598 ± 0.091	4.694LeuGlu: 4.694 ± 0.077	3.057LeuPhe: 3.057 ± 0.06	9.373LeuGly: 9.373 ± 0.1	1.977LeuHis: 1.977 ± 0.042	4.399LeuIle: 4.399 ± 0.074	1.697LeuLys: 1.697 ± 0.041	9.79LeuLeu: 9.79 ± 0.118	1.64LeuMet: 1.64 ± 0.044	1.794LeuAsn: 1.794 ± 0.042	5.494LeuPro: 5.494 ± 0.066	2.851LeuGln: 2.851 ± 0.046	7.376LeuArg: 7.376 ± 0.105	5.402LeuSer: 5.402 ± 0.077	6.491LeuThr: 6.491 ± 0.135	9.307LeuVal: 9.307 ± 0.098	1.346LeuTrp: 1.346 ± 0.041	1.692LeuTyr: 1.692 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.135MetAla: 2.135 ± 0.05	0.117MetCys: 0.117 ± 0.011	0.85MetAsp: 0.85 ± 0.028	0.585MetGlu: 0.585 ± 0.023	0.55MetPhe: 0.55 ± 0.024	1.298MetGly: 1.298 ± 0.036	0.346MetHis: 0.346 ± 0.019	0.904MetIle: 0.904 ± 0.031	0.419MetLys: 0.419 ± 0.022	2.085MetLeu: 2.085 ± 0.044	0.345MetMet: 0.345 ± 0.02	0.454MetAsn: 0.454 ± 0.02	1.295MetPro: 1.295 ± 0.039	0.529MetGln: 0.529 ± 0.022	1.412MetArg: 1.412 ± 0.041	1.435MetSer: 1.435 ± 0.038	1.734MetThr: 1.734 ± 0.044	1.359MetVal: 1.359 ± 0.038	0.225MetTrp: 0.225 ± 0.014	0.276MetTyr: 0.276 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.523AsnAla: 2.523 ± 0.05	0.115AsnCys: 0.115 ± 0.011	1.133AsnAsp: 1.133 ± 0.034	0.844AsnGlu: 0.844 ± 0.028	0.6AsnPhe: 0.6 ± 0.025	1.858AsnGly: 1.858 ± 0.043	0.338AsnHis: 0.338 ± 0.019	0.83AsnIle: 0.83 ± 0.028	0.404AsnLys: 0.404 ± 0.02	1.879AsnLeu: 1.879 ± 0.045	0.337AsnMet: 0.337 ± 0.02	0.446AsnAsn: 0.446 ± 0.022	1.603AsnPro: 1.603 ± 0.039	0.602AsnGln: 0.602 ± 0.027	1.187AsnArg: 1.187 ± 0.04	0.942AsnSer: 0.942 ± 0.034	1.211AsnThr: 1.211 ± 0.044	1.689AsnVal: 1.689 ± 0.039	0.309AsnTrp: 0.309 ± 0.017	0.461AsnTyr: 0.461 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.772ProAla: 7.772 ± 0.124	0.186ProCys: 0.186 ± 0.013	4.101ProAsp: 4.101 ± 0.072	3.388ProGlu: 3.388 ± 0.058	1.83ProPhe: 1.83 ± 0.041	5.298ProGly: 5.298 ± 0.077	1.209ProHis: 1.209 ± 0.032	2.145ProIle: 2.145 ± 0.042	1.087ProLys: 1.087 ± 0.034	4.823ProLeu: 4.823 ± 0.081	0.94ProMet: 0.94 ± 0.031	1.057ProAsn: 1.057 ± 0.032	2.323ProPro: 2.323 ± 0.059	1.631ProGln: 1.631 ± 0.046	3.352ProArg: 3.352 ± 0.074	2.905ProSer: 2.905 ± 0.052	3.319ProThr: 3.319 ± 0.05	5.102ProVal: 5.102 ± 0.071	0.894ProTrp: 0.894 ± 0.033	1.093ProTyr: 1.093 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.659GlnAla: 3.659 ± 0.062	0.14GlnCys: 0.14 ± 0.011	1.415GlnAsp: 1.415 ± 0.037	1.086GlnGlu: 1.086 ± 0.031	0.853GlnPhe: 0.853 ± 0.027	2.052GlnGly: 2.052 ± 0.048	0.657GlnHis: 0.657 ± 0.028	1.486GlnIle: 1.486 ± 0.038	0.721GlnLys: 0.721 ± 0.027	3.341GlnLeu: 3.341 ± 0.06	0.519GlnMet: 0.519 ± 0.022	0.714GlnAsn: 0.714 ± 0.029	1.555GlnPro: 1.555 ± 0.04	1.213GlnGln: 1.213 ± 0.042	2.377GlnArg: 2.377 ± 0.052	1.481GlnSer: 1.481 ± 0.04	1.671GlnThr: 1.671 ± 0.043	2.462GlnVal: 2.462 ± 0.05	0.468GlnTrp: 0.468 ± 0.02	0.647GlnTyr: 0.647 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	9.144ArgAla: 9.144 ± 0.12	0.305ArgCys: 0.305 ± 0.018	4.373ArgAsp: 4.373 ± 0.079	4.1ArgGlu: 4.1 ± 0.086	2.357ArgPhe: 2.357 ± 0.051	5.468ArgGly: 5.468 ± 0.081	1.592ArgHis: 1.592 ± 0.041	3.727ArgIle: 3.727 ± 0.06	1.249ArgLys: 1.249 ± 0.042	7.322ArgLeu: 7.322 ± 0.107	1.804ArgMet: 1.804 ± 0.046	1.26ArgAsn: 1.26 ± 0.033	3.602ArgPro: 3.602 ± 0.067	1.93ArgGln: 1.93 ± 0.042	6.529ArgArg: 6.529 ± 0.117	3.878ArgSer: 3.878 ± 0.059	4.418ArgThr: 4.418 ± 0.066	6.162ArgVal: 6.162 ± 0.088	1.197ArgTrp: 1.197 ± 0.036	1.606ArgTyr: 1.606 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	7.102SerAla: 7.102 ± 0.085	0.3SerCys: 0.3 ± 0.016	3.09SerAsp: 3.09 ± 0.055	2.373SerGlu: 2.373 ± 0.048	1.937SerPhe: 1.937 ± 0.048	5.729SerGly: 5.729 ± 0.103	0.97SerHis: 0.97 ± 0.029	2.518SerIle: 2.518 ± 0.046	1.043SerLys: 1.043 ± 0.033	5.185SerLeu: 5.185 ± 0.073	1.125SerMet: 1.125 ± 0.03	1.049SerAsn: 1.049 ± 0.038	3.076SerPro: 3.076 ± 0.054	1.408SerGln: 1.408 ± 0.036	3.612SerArg: 3.612 ± 0.054	3.253SerSer: 3.253 ± 0.067	3.515SerThr: 3.515 ± 0.076	4.658SerVal: 4.658 ± 0.068	0.903SerTrp: 0.903 ± 0.029	1.131SerTyr: 1.131 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	8.18ThrAla: 8.18 ± 0.133	0.287ThrCys: 0.287 ± 0.016	3.633ThrAsp: 3.633 ± 0.058	2.795ThrGlu: 2.795 ± 0.051	2.024ThrPhe: 2.024 ± 0.064	6.282ThrGly: 6.282 ± 0.184	1.15ThrHis: 1.15 ± 0.031	2.924ThrIle: 2.924 ± 0.074	1.189ThrLys: 1.189 ± 0.038	5.969ThrLeu: 5.969 ± 0.142	1.052ThrMet: 1.052 ± 0.032	1.177ThrAsn: 1.177 ± 0.037	3.949ThrPro: 3.949 ± 0.06	1.457ThrGln: 1.457 ± 0.04	3.836ThrArg: 3.836 ± 0.061	3.196ThrSer: 3.196 ± 0.066	3.971ThrThr: 3.971 ± 0.112	6.21ThrVal: 6.21 ± 0.163	0.921ThrTrp: 0.921 ± 0.028	1.253ThrTyr: 1.253 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	12.504ValAla: 12.504 ± 0.128	0.559ValCys: 0.559 ± 0.023	5.638ValAsp: 5.638 ± 0.066	4.42ValGlu: 4.42 ± 0.077	3.006ValPhe: 3.006 ± 0.065	7.296ValGly: 7.296 ± 0.084	1.907ValHis: 1.907 ± 0.042	4.414ValIle: 4.414 ± 0.07	1.642ValLys: 1.642 ± 0.044	9.476ValLeu: 9.476 ± 0.114	1.554ValMet: 1.554 ± 0.039	1.823ValAsn: 1.823 ± 0.05	4.999ValPro: 4.999 ± 0.063	2.363ValGln: 2.363 ± 0.051	6.346ValArg: 6.346 ± 0.09	5.017ValSer: 5.017 ± 0.089	6.013ValThr: 6.013 ± 0.143	9.238ValVal: 9.238 ± 0.105	1.226ValTrp: 1.226 ± 0.033	1.602ValTyr: 1.602 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.714TrpAla: 1.714 ± 0.04	0.114TrpCys: 0.114 ± 0.009	0.846TrpAsp: 0.846 ± 0.029	0.598TrpGlu: 0.598 ± 0.023	0.599TrpPhe: 0.599 ± 0.025	1.138TrpGly: 1.138 ± 0.036	0.378TrpHis: 0.378 ± 0.018	0.773TrpIle: 0.773 ± 0.028	0.288TrpLys: 0.288 ± 0.016	1.649TrpLeu: 1.649 ± 0.043	0.406TrpMet: 0.406 ± 0.02	0.453TrpAsn: 0.453 ± 0.023	0.743TrpPro: 0.743 ± 0.029	0.601TrpGln: 0.601 ± 0.026	1.253TrpArg: 1.253 ± 0.04	0.945TrpSer: 0.945 ± 0.028	0.99TrpThr: 0.99 ± 0.03	1.162TrpVal: 1.162 ± 0.032	0.363TrpTrp: 0.363 ± 0.019	0.301TrpTyr: 0.301 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.569TyrAla: 2.569 ± 0.049	0.109TyrCys: 0.109 ± 0.01	1.367TyrAsp: 1.367 ± 0.036	1.008TyrGlu: 1.008 ± 0.028	0.726TyrPhe: 0.726 ± 0.027	1.948TyrGly: 1.948 ± 0.046	0.293TyrHis: 0.293 ± 0.016	0.719TyrIle: 0.719 ± 0.027	0.347TyrLys: 0.347 ± 0.02	2.141TyrLeu: 2.141 ± 0.045	0.249TyrMet: 0.249 ± 0.016	0.482TyrAsn: 0.482 ± 0.022	1.023TyrPro: 1.023 ± 0.036	0.564TyrGln: 0.564 ± 0.025	1.631TyrArg: 1.631 ± 0.041	1.098TyrSer: 1.098 ± 0.035	1.252TyrThr: 1.252 ± 0.039	1.611TyrVal: 1.611 ± 0.039	0.332TyrTrp: 0.332 ± 0.018	0.474TyrTyr: 0.474 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3509 proteins (1144491 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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