Amino acid dipepetide frequency for Sneathiella sp. DP05

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.703AlaAla: 11.703 ± 0.14
0.974AlaCys: 0.974 ± 0.034
5.616AlaAsp: 5.616 ± 0.087
6.911AlaGlu: 6.911 ± 0.088
3.971AlaPhe: 3.971 ± 0.071
8.221AlaGly: 8.221 ± 0.091
1.795AlaHis: 1.795 ± 0.037
6.414AlaIle: 6.414 ± 0.079
4.54AlaLys: 4.54 ± 0.076
10.394AlaLeu: 10.394 ± 0.111
2.886AlaMet: 2.886 ± 0.047
3.088AlaAsn: 3.088 ± 0.056
3.847AlaPro: 3.847 ± 0.057
2.937AlaGln: 2.937 ± 0.053
5.669AlaArg: 5.669 ± 0.076
5.422AlaSer: 5.422 ± 0.07
5.076AlaThr: 5.076 ± 0.071
7.128AlaVal: 7.128 ± 0.078
0.969AlaTrp: 0.969 ± 0.031
2.496AlaTyr: 2.496 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.939CysAla: 0.939 ± 0.03
0.109CysCys: 0.109 ± 0.009
0.563CysAsp: 0.563 ± 0.026
0.488CysGlu: 0.488 ± 0.022
0.405CysPhe: 0.405 ± 0.019
0.906CysGly: 0.906 ± 0.034
0.266CysHis: 0.266 ± 0.017
0.516CysIle: 0.516 ± 0.021
0.291CysLys: 0.291 ± 0.015
0.896CysLeu: 0.896 ± 0.029
0.204CysMet: 0.204 ± 0.013
0.278CysAsn: 0.278 ± 0.018
0.431CysPro: 0.431 ± 0.023
0.262CysGln: 0.262 ± 0.016
0.547CysArg: 0.547 ± 0.024
0.484CysSer: 0.484 ± 0.02
0.452CysThr: 0.452 ± 0.019
0.583CysVal: 0.583 ± 0.022
0.116CysTrp: 0.116 ± 0.01
0.244CysTyr: 0.244 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
5.28AspAla: 5.28 ± 0.065
0.576AspCys: 0.576 ± 0.024
3.085AspAsp: 3.085 ± 0.063
3.775AspGlu: 3.775 ± 0.061
2.468AspPhe: 2.468 ± 0.052
4.569AspGly: 4.569 ± 0.082
1.247AspHis: 1.247 ± 0.036
4.315AspIle: 4.315 ± 0.066
2.635AspLys: 2.635 ± 0.048
5.906AspLeu: 5.906 ± 0.082
1.675AspMet: 1.675 ± 0.038
1.852AspAsn: 1.852 ± 0.036
2.976AspPro: 2.976 ± 0.059
1.784AspGln: 1.784 ± 0.035
3.32AspArg: 3.32 ± 0.058
2.518AspSer: 2.518 ± 0.048
2.642AspThr: 2.642 ± 0.052
4.139AspVal: 4.139 ± 0.062
0.925AspTrp: 0.925 ± 0.03
1.73AspTyr: 1.73 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
6.575GluAla: 6.575 ± 0.082
0.429GluCys: 0.429 ± 0.02
3.631GluAsp: 3.631 ± 0.062
4.838GluGlu: 4.838 ± 0.067
2.331GluPhe: 2.331 ± 0.045
4.592GluGly: 4.592 ± 0.068
1.15GluHis: 1.15 ± 0.037
4.844GluIle: 4.844 ± 0.069
4.323GluLys: 4.323 ± 0.065
5.905GluLeu: 5.905 ± 0.077
2.013GluMet: 2.013 ± 0.039
2.864GluAsn: 2.864 ± 0.053
2.404GluPro: 2.404 ± 0.049
2.285GluGln: 2.285 ± 0.048
3.782GluArg: 3.782 ± 0.065
2.848GluSer: 2.848 ± 0.051
3.907GluThr: 3.907 ± 0.062
4.294GluVal: 4.294 ± 0.061
0.673GluTrp: 0.673 ± 0.026
1.449GluTyr: 1.449 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.008PheAla: 4.008 ± 0.06
0.509PheCys: 0.509 ± 0.023
2.694PheAsp: 2.694 ± 0.047
2.505PheGlu: 2.505 ± 0.043
1.795PhePhe: 1.795 ± 0.044
3.749PheGly: 3.749 ± 0.068
0.823PheHis: 0.823 ± 0.026
2.386PheIle: 2.386 ± 0.051
1.558PheLys: 1.558 ± 0.039
4.056PheLeu: 4.056 ± 0.07
1.004PheMet: 1.004 ± 0.029
1.463PheAsn: 1.463 ± 0.038
1.66PhePro: 1.66 ± 0.037
1.05PheGln: 1.05 ± 0.03
1.966PheArg: 1.966 ± 0.043
2.839PheSer: 2.839 ± 0.053
2.234PheThr: 2.234 ± 0.043
2.902PheVal: 2.902 ± 0.052
0.57PheTrp: 0.57 ± 0.027
1.155PheTyr: 1.155 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
7.411GlyAla: 7.411 ± 0.1
0.79GlyCys: 0.79 ± 0.031
4.247GlyAsp: 4.247 ± 0.064
4.812GlyGlu: 4.812 ± 0.075
3.563GlyPhe: 3.563 ± 0.057
6.618GlyGly: 6.618 ± 0.104
1.731GlyHis: 1.731 ± 0.037
5.356GlyIle: 5.356 ± 0.088
4.116GlyLys: 4.116 ± 0.068
8.15GlyLeu: 8.15 ± 0.087
2.41GlyMet: 2.41 ± 0.047
2.576GlyAsn: 2.576 ± 0.052
2.942GlyPro: 2.942 ± 0.056
2.683GlyGln: 2.683 ± 0.056
4.581GlyArg: 4.581 ± 0.066
4.494GlySer: 4.494 ± 0.07
4.267GlyThr: 4.267 ± 0.064
5.801GlyVal: 5.801 ± 0.073
1.133GlyTrp: 1.133 ± 0.032
2.572GlyTyr: 2.572 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.708HisAla: 1.708 ± 0.039
0.243HisCys: 0.243 ± 0.015
1.061HisAsp: 1.061 ± 0.032
1.106HisGlu: 1.106 ± 0.029
0.918HisPhe: 0.918 ± 0.029
1.645HisGly: 1.645 ± 0.044
0.534HisHis: 0.534 ± 0.02
1.237HisIle: 1.237 ± 0.032
0.791HisLys: 0.791 ± 0.026
1.982HisLeu: 1.982 ± 0.042
0.555HisMet: 0.555 ± 0.022
0.631HisAsn: 0.631 ± 0.025
1.246HisPro: 1.246 ± 0.031
0.658HisGln: 0.658 ± 0.025
1.106HisArg: 1.106 ± 0.031
1.136HisSer: 1.136 ± 0.035
0.845HisThr: 0.845 ± 0.027
1.331HisVal: 1.331 ± 0.035
0.302HisTrp: 0.302 ± 0.019
0.61HisTyr: 0.61 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
7.169IleAla: 7.169 ± 0.095
0.683IleCys: 0.683 ± 0.026
4.092IleAsp: 4.092 ± 0.073
4.35IleGlu: 4.35 ± 0.058
2.642IlePhe: 2.642 ± 0.059
5.617IleGly: 5.617 ± 0.071
1.131IleHis: 1.131 ± 0.035
3.969IleIle: 3.969 ± 0.072
2.674IleLys: 2.674 ± 0.051
6.398IleLeu: 6.398 ± 0.095
1.447IleMet: 1.447 ± 0.034
2.271IleAsn: 2.271 ± 0.041
2.89IlePro: 2.89 ± 0.048
1.641IleGln: 1.641 ± 0.038
3.288IleArg: 3.288 ± 0.049
4.54IleSer: 4.54 ± 0.069
3.601IleThr: 3.601 ± 0.059
4.652IleVal: 4.652 ± 0.078
0.743IleTrp: 0.743 ± 0.03
1.626IleTyr: 1.626 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.76LysAla: 4.76 ± 0.064
0.29LysCys: 0.29 ± 0.018
2.697LysAsp: 2.697 ± 0.053
3.152LysGlu: 3.152 ± 0.056
1.571LysPhe: 1.571 ± 0.037
3.596LysGly: 3.596 ± 0.05
0.743LysHis: 0.743 ± 0.025
3.222LysIle: 3.222 ± 0.051
2.764LysLys: 2.764 ± 0.057
4.512LysLeu: 4.512 ± 0.065
1.321LysMet: 1.321 ± 0.033
1.771LysAsn: 1.771 ± 0.041
2.249LysPro: 2.249 ± 0.054
1.402LysGln: 1.402 ± 0.038
2.536LysArg: 2.536 ± 0.049
3.177LysSer: 3.177 ± 0.058
2.655LysThr: 2.655 ± 0.052
3.086LysVal: 3.086 ± 0.056
0.562LysTrp: 0.562 ± 0.024
1.22LysTyr: 1.22 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
10.654LeuAla: 10.654 ± 0.094
0.894LeuCys: 0.894 ± 0.032
5.772LeuAsp: 5.772 ± 0.071
6.014LeuGlu: 6.014 ± 0.069
4.03LeuPhe: 4.03 ± 0.076
7.747LeuGly: 7.747 ± 0.085
1.797LeuHis: 1.797 ± 0.042
6.332LeuIle: 6.332 ± 0.097
5.012LeuLys: 5.012 ± 0.065
9.721LeuLeu: 9.721 ± 0.114
2.526LeuMet: 2.526 ± 0.054
3.496LeuAsn: 3.496 ± 0.059
5.102LeuPro: 5.102 ± 0.072
2.938LeuGln: 2.938 ± 0.05
5.334LeuArg: 5.334 ± 0.075
6.964LeuSer: 6.964 ± 0.079
5.668LeuThr: 5.668 ± 0.077
6.858LeuVal: 6.858 ± 0.084
1.061LeuTrp: 1.061 ± 0.031
2.397LeuTyr: 2.397 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
3.023MetAla: 3.023 ± 0.054
0.187MetCys: 0.187 ± 0.015
1.4MetAsp: 1.4 ± 0.034
1.619MetGlu: 1.619 ± 0.036
0.864MetPhe: 0.864 ± 0.024
2.07MetGly: 2.07 ± 0.046
0.46MetHis: 0.46 ± 0.021
1.697MetIle: 1.697 ± 0.044
1.373MetLys: 1.373 ± 0.035
2.559MetLeu: 2.559 ± 0.043
0.837MetMet: 0.837 ± 0.03
0.942MetAsn: 0.942 ± 0.024
1.372MetPro: 1.372 ± 0.037
0.907MetGln: 0.907 ± 0.029
1.536MetArg: 1.536 ± 0.033
1.92MetSer: 1.92 ± 0.037
2.028MetThr: 2.028 ± 0.042
1.82MetVal: 1.82 ± 0.04
0.205MetTrp: 0.205 ± 0.016
0.452MetTyr: 0.452 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.337AsnAla: 3.337 ± 0.048
0.37AsnCys: 0.37 ± 0.019
1.756AsnAsp: 1.756 ± 0.037
1.918AsnGlu: 1.918 ± 0.043
1.489AsnPhe: 1.489 ± 0.036
2.809AsnGly: 2.809 ± 0.049
0.642AsnHis: 0.642 ± 0.024
2.452AsnIle: 2.452 ± 0.05
1.397AsnLys: 1.397 ± 0.037
3.567AsnLeu: 3.567 ± 0.062
1.03AsnMet: 1.03 ± 0.031
1.221AsnAsn: 1.221 ± 0.035
2.071AsnPro: 2.071 ± 0.046
0.986AsnGln: 0.986 ± 0.03
2.027AsnArg: 2.027 ± 0.042
2.075AsnSer: 2.075 ± 0.048
1.602AsnThr: 1.602 ± 0.038
2.386AsnVal: 2.386 ± 0.049
0.529AsnTrp: 0.529 ± 0.025
1.02AsnTyr: 1.02 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
4.254ProAla: 4.254 ± 0.069
0.309ProCys: 0.309 ± 0.023
3.235ProAsp: 3.235 ± 0.049
3.933ProGlu: 3.933 ± 0.066
1.991ProPhe: 1.991 ± 0.041
3.459ProGly: 3.459 ± 0.057
0.875ProHis: 0.875 ± 0.028
2.678ProIle: 2.678 ± 0.055
2.091ProLys: 2.091 ± 0.05
4.377ProLeu: 4.377 ± 0.061
1.186ProMet: 1.186 ± 0.034
1.494ProAsn: 1.494 ± 0.037
1.801ProPro: 1.801 ± 0.042
1.218ProGln: 1.218 ± 0.034
1.982ProArg: 1.982 ± 0.043
2.565ProSer: 2.565 ± 0.053
2.399ProThr: 2.399 ± 0.053
3.664ProVal: 3.664 ± 0.055
0.557ProTrp: 0.557 ± 0.023
1.247ProTyr: 1.247 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
2.995GlnAla: 2.995 ± 0.055
0.224GlnCys: 0.224 ± 0.013
1.565GlnAsp: 1.565 ± 0.037
2.036GlnGlu: 2.036 ± 0.039
1.157GlnPhe: 1.157 ± 0.03
2.103GlnGly: 2.103 ± 0.045
0.579GlnHis: 0.579 ± 0.02
2.225GlnIle: 2.225 ± 0.046
1.736GlnLys: 1.736 ± 0.035
2.952GlnLeu: 2.952 ± 0.054
0.926GlnMet: 0.926 ± 0.03
1.146GlnAsn: 1.146 ± 0.031
1.255GlnPro: 1.255 ± 0.032
1.216GlnGln: 1.216 ± 0.035
1.769GlnArg: 1.769 ± 0.042
1.933GlnSer: 1.933 ± 0.04
1.64GlnThr: 1.64 ± 0.038
2.076GlnVal: 2.076 ± 0.04
0.331GlnTrp: 0.331 ± 0.016
0.807GlnTyr: 0.807 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
4.978ArgAla: 4.978 ± 0.069
0.388ArgCys: 0.388 ± 0.019
3.231ArgAsp: 3.231 ± 0.055
3.889ArgGlu: 3.889 ± 0.061
2.284ArgPhe: 2.284 ± 0.048
3.519ArgGly: 3.519 ± 0.061
1.41ArgHis: 1.41 ± 0.037
3.727ArgIle: 3.727 ± 0.065
2.829ArgLys: 2.829 ± 0.053
6.052ArgLeu: 6.052 ± 0.089
1.454ArgMet: 1.454 ± 0.038
2.164ArgAsn: 2.164 ± 0.046
2.387ArgPro: 2.387 ± 0.048
2.115ArgGln: 2.115 ± 0.041
3.663ArgArg: 3.663 ± 0.077
2.989ArgSer: 2.989 ± 0.052
2.568ArgThr: 2.568 ± 0.05
3.487ArgVal: 3.487 ± 0.05
0.678ArgTrp: 0.678 ± 0.028
1.555ArgTyr: 1.555 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.551SerAla: 5.551 ± 0.07
0.477SerCys: 0.477 ± 0.02
3.493SerAsp: 3.493 ± 0.064
3.652SerGlu: 3.652 ± 0.06
2.758SerPhe: 2.758 ± 0.057
5.532SerGly: 5.532 ± 0.07
1.256SerHis: 1.256 ± 0.033
3.62SerIle: 3.62 ± 0.059
2.454SerLys: 2.454 ± 0.051
6.329SerLeu: 6.329 ± 0.074
1.666SerMet: 1.666 ± 0.037
1.909SerAsn: 1.909 ± 0.038
2.684SerPro: 2.684 ± 0.042
1.763SerGln: 1.763 ± 0.04
3.304SerArg: 3.304 ± 0.061
3.588SerSer: 3.588 ± 0.064
2.844SerThr: 2.844 ± 0.056
4.155SerVal: 4.155 ± 0.065
0.819SerTrp: 0.819 ± 0.027
1.608SerTyr: 1.608 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
5.462ThrAla: 5.462 ± 0.074
0.415ThrCys: 0.415 ± 0.019
3.076ThrAsp: 3.076 ± 0.057
3.409ThrGlu: 3.409 ± 0.052
2.082ThrPhe: 2.082 ± 0.048
4.894ThrGly: 4.894 ± 0.073
1.028ThrHis: 1.028 ± 0.031
3.324ThrIle: 3.324 ± 0.057
2.079ThrLys: 2.079 ± 0.046
5.623ThrLeu: 5.623 ± 0.076
1.233ThrMet: 1.233 ± 0.034
1.731ThrAsn: 1.731 ± 0.038
2.921ThrPro: 2.921 ± 0.055
1.461ThrGln: 1.461 ± 0.039
2.757ThrArg: 2.757 ± 0.052
3.113ThrSer: 3.113 ± 0.056
2.882ThrThr: 2.882 ± 0.059
4.091ThrVal: 4.091 ± 0.066
0.493ThrTrp: 0.493 ± 0.02
1.315ThrTyr: 1.315 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
7.037ValAla: 7.037 ± 0.094
0.656ValCys: 0.656 ± 0.025
3.998ValAsp: 3.998 ± 0.071
4.528ValGlu: 4.528 ± 0.068
2.829ValPhe: 2.829 ± 0.059
5.451ValGly: 5.451 ± 0.078
1.245ValHis: 1.245 ± 0.037
4.973ValIle: 4.973 ± 0.068
3.045ValLys: 3.045 ± 0.051
6.748ValLeu: 6.748 ± 0.082
1.96ValMet: 1.96 ± 0.043
2.495ValAsn: 2.495 ± 0.055
3.263ValPro: 3.263 ± 0.051
1.855ValGln: 1.855 ± 0.037
3.697ValArg: 3.697 ± 0.055
4.473ValSer: 4.473 ± 0.066
4.298ValThr: 4.298 ± 0.067
5.244ValVal: 5.244 ± 0.081
0.741ValTrp: 0.741 ± 0.027
1.641ValTyr: 1.641 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.919TrpAla: 0.919 ± 0.03
0.13TrpCys: 0.13 ± 0.01
0.595TrpAsp: 0.595 ± 0.024
0.637TrpGlu: 0.637 ± 0.023
0.493TrpPhe: 0.493 ± 0.022
0.826TrpGly: 0.826 ± 0.029
0.31TrpHis: 0.31 ± 0.017
0.742TrpIle: 0.742 ± 0.029
0.547TrpLys: 0.547 ± 0.02
1.4TrpLeu: 1.4 ± 0.039
0.319TrpMet: 0.319 ± 0.017
0.423TrpAsn: 0.423 ± 0.021
0.609TrpPro: 0.609 ± 0.026
0.606TrpGln: 0.606 ± 0.023
0.879TrpArg: 0.879 ± 0.027
0.703TrpSer: 0.703 ± 0.027
0.63TrpThr: 0.63 ± 0.023
0.764TrpVal: 0.764 ± 0.027
0.221TrpTrp: 0.221 ± 0.014
0.268TrpTyr: 0.268 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.294TyrAla: 2.294 ± 0.047
0.328TyrCys: 0.328 ± 0.018
1.612TyrAsp: 1.612 ± 0.041
1.564TyrGlu: 1.564 ± 0.039
1.287TyrPhe: 1.287 ± 0.03
2.33TyrGly: 2.33 ± 0.044
0.622TyrHis: 0.622 ± 0.023
1.398TyrIle: 1.398 ± 0.037
1.03TyrLys: 1.03 ± 0.035
2.787TyrLeu: 2.787 ± 0.048
0.617TyrMet: 0.617 ± 0.025
0.868TyrAsn: 0.868 ± 0.028
1.203TyrPro: 1.203 ± 0.034
0.904TyrGln: 0.904 ± 0.031
1.623TyrArg: 1.623 ± 0.036
1.684TyrSer: 1.684 ± 0.034
1.152TyrThr: 1.152 ± 0.033
1.714TyrVal: 1.714 ± 0.045
0.394TyrTrp: 0.394 ± 0.019
0.784TyrTyr: 0.784 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3523 proteins (1128886 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski