Amino acid dipepetide frequency for Cytobacillus depressus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.032AlaAla: 6.032 ± 0.089
0.587AlaCys: 0.587 ± 0.021
3.395AlaAsp: 3.395 ± 0.049
4.79AlaGlu: 4.79 ± 0.063
3.431AlaPhe: 3.431 ± 0.055
5.451AlaGly: 5.451 ± 0.072
1.25AlaHis: 1.25 ± 0.03
6.348AlaIle: 6.348 ± 0.081
4.845AlaLys: 4.845 ± 0.065
7.229AlaLeu: 7.229 ± 0.098
2.055AlaMet: 2.055 ± 0.037
2.99AlaAsn: 2.99 ± 0.045
2.04AlaPro: 2.04 ± 0.044
2.047AlaGln: 2.047 ± 0.043
2.567AlaArg: 2.567 ± 0.043
3.972AlaSer: 3.972 ± 0.049
3.358AlaThr: 3.358 ± 0.056
5.303AlaVal: 5.303 ± 0.072
0.584AlaTrp: 0.584 ± 0.021
2.215AlaTyr: 2.215 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.419CysAla: 0.419 ± 0.021
0.083CysCys: 0.083 ± 0.008
0.389CysAsp: 0.389 ± 0.019
0.455CysGlu: 0.455 ± 0.018
0.324CysPhe: 0.324 ± 0.016
0.694CysGly: 0.694 ± 0.028
0.197CysHis: 0.197 ± 0.013
0.584CysIle: 0.584 ± 0.019
0.406CysLys: 0.406 ± 0.016
0.689CysLeu: 0.689 ± 0.023
0.171CysMet: 0.171 ± 0.011
0.277CysAsn: 0.277 ± 0.013
0.337CysPro: 0.337 ± 0.017
0.227CysGln: 0.227 ± 0.014
0.295CysArg: 0.295 ± 0.015
0.523CysSer: 0.523 ± 0.021
0.402CysThr: 0.402 ± 0.017
0.394CysVal: 0.394 ± 0.015
0.068CysTrp: 0.068 ± 0.007
0.242CysTyr: 0.242 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.055AspAla: 3.055 ± 0.045
0.35AspCys: 0.35 ± 0.015
2.226AspAsp: 2.226 ± 0.047
4.123AspGlu: 4.123 ± 0.059
2.513AspPhe: 2.513 ± 0.048
3.242AspGly: 3.242 ± 0.052
1.137AspHis: 1.137 ± 0.03
3.996AspIle: 3.996 ± 0.06
3.039AspLys: 3.039 ± 0.059
4.962AspLeu: 4.962 ± 0.064
1.31AspMet: 1.31 ± 0.033
1.626AspAsn: 1.626 ± 0.039
2.009AspPro: 2.009 ± 0.035
1.964AspGln: 1.964 ± 0.039
2.141AspArg: 2.141 ± 0.038
2.529AspSer: 2.529 ± 0.046
2.164AspThr: 2.164 ± 0.041
3.495AspVal: 3.495 ± 0.049
0.631AspTrp: 0.631 ± 0.023
2.0AspTyr: 2.0 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
5.252GluAla: 5.252 ± 0.073
0.382GluCys: 0.382 ± 0.016
3.44GluAsp: 3.44 ± 0.05
6.575GluGlu: 6.575 ± 0.077
2.708GluPhe: 2.708 ± 0.041
4.274GluGly: 4.274 ± 0.064
1.404GluHis: 1.404 ± 0.032
6.094GluIle: 6.094 ± 0.074
7.049GluLys: 7.049 ± 0.086
7.047GluLeu: 7.047 ± 0.077
2.359GluMet: 2.359 ± 0.039
3.818GluAsn: 3.818 ± 0.058
1.94GluPro: 1.94 ± 0.036
2.989GluGln: 2.989 ± 0.058
3.32GluArg: 3.32 ± 0.059
3.468GluSer: 3.468 ± 0.048
3.627GluThr: 3.627 ± 0.051
4.912GluVal: 4.912 ± 0.065
0.857GluTrp: 0.857 ± 0.025
2.269GluTyr: 2.269 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.209PheAla: 3.209 ± 0.049
0.362PheCys: 0.362 ± 0.016
2.343PheAsp: 2.343 ± 0.038
2.928PheGlu: 2.928 ± 0.055
2.43PhePhe: 2.43 ± 0.054
3.602PheGly: 3.602 ± 0.062
1.074PheHis: 1.074 ± 0.028
4.225PheIle: 4.225 ± 0.062
2.547PheLys: 2.547 ± 0.043
4.627PheLeu: 4.627 ± 0.07
1.225PheMet: 1.225 ± 0.035
2.076PheAsn: 2.076 ± 0.04
1.811PhePro: 1.811 ± 0.034
1.661PheGln: 1.661 ± 0.037
1.533PheArg: 1.533 ± 0.03
3.418PheSer: 3.418 ± 0.048
2.632PheThr: 2.632 ± 0.043
3.084PheVal: 3.084 ± 0.057
0.522PheTrp: 0.522 ± 0.02
1.713PheTyr: 1.713 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
4.946GlyAla: 4.946 ± 0.075
0.665GlyCys: 0.665 ± 0.023
3.073GlyAsp: 3.073 ± 0.072
4.567GlyGlu: 4.567 ± 0.059
3.622GlyPhe: 3.622 ± 0.057
4.99GlyGly: 4.99 ± 0.069
1.43GlyHis: 1.43 ± 0.03
6.457GlyIle: 6.457 ± 0.079
5.393GlyLys: 5.393 ± 0.067
6.811GlyLeu: 6.811 ± 0.079
2.176GlyMet: 2.176 ± 0.044
2.95GlyAsn: 2.95 ± 0.056
1.887GlyPro: 1.887 ± 0.042
2.198GlyGln: 2.198 ± 0.041
2.622GlyArg: 2.622 ± 0.045
4.125GlySer: 4.125 ± 0.054
4.078GlyThr: 4.078 ± 0.058
5.041GlyVal: 5.041 ± 0.059
0.785GlyTrp: 0.785 ± 0.025
2.726GlyTyr: 2.726 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
1.281HisAla: 1.281 ± 0.028
0.187HisCys: 0.187 ± 0.012
1.005HisAsp: 1.005 ± 0.029
1.355HisGlu: 1.355 ± 0.03
1.069HisPhe: 1.069 ± 0.031
1.388HisGly: 1.388 ± 0.032
0.622HisHis: 0.622 ± 0.024
1.593HisIle: 1.593 ± 0.033
1.046HisLys: 1.046 ± 0.028
2.142HisLeu: 2.142 ± 0.043
0.495HisMet: 0.495 ± 0.02
0.785HisAsn: 0.785 ± 0.023
1.139HisPro: 1.139 ± 0.028
0.775HisGln: 0.775 ± 0.023
0.827HisArg: 0.827 ± 0.023
1.318HisSer: 1.318 ± 0.028
1.018HisThr: 1.018 ± 0.025
1.323HisVal: 1.323 ± 0.035
0.217HisTrp: 0.217 ± 0.014
0.858HisTyr: 0.858 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.428IleAla: 6.428 ± 0.085
0.68IleCys: 0.68 ± 0.023
4.361IleAsp: 4.361 ± 0.057
6.004IleGlu: 6.004 ± 0.068
3.696IlePhe: 3.696 ± 0.06
6.425IleGly: 6.425 ± 0.07
1.809IleHis: 1.809 ± 0.035
6.801IleIle: 6.801 ± 0.091
5.035IleLys: 5.035 ± 0.065
7.652IleLeu: 7.652 ± 0.097
1.972IleMet: 1.972 ± 0.04
3.69IleAsn: 3.69 ± 0.052
3.715IlePro: 3.715 ± 0.052
3.091IleGln: 3.091 ± 0.051
3.196IleArg: 3.196 ± 0.046
5.491IleSer: 5.491 ± 0.061
4.533IleThr: 4.533 ± 0.058
5.802IleVal: 5.802 ± 0.071
0.677IleTrp: 0.677 ± 0.021
2.567IleTyr: 2.567 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.849LysAla: 4.849 ± 0.061
0.355LysCys: 0.355 ± 0.015
3.886LysAsp: 3.886 ± 0.064
6.922LysGlu: 6.922 ± 0.084
2.121LysPhe: 2.121 ± 0.034
4.894LysGly: 4.894 ± 0.072
1.272LysHis: 1.272 ± 0.028
5.071LysIle: 5.071 ± 0.061
6.063LysLys: 6.063 ± 0.081
6.07LysLeu: 6.07 ± 0.064
2.263LysMet: 2.263 ± 0.033
3.701LysAsn: 3.701 ± 0.058
2.27LysPro: 2.27 ± 0.042
2.92LysGln: 2.92 ± 0.05
3.199LysArg: 3.199 ± 0.048
3.616LysSer: 3.616 ± 0.056
3.596LysThr: 3.596 ± 0.052
4.871LysVal: 4.871 ± 0.053
0.872LysTrp: 0.872 ± 0.027
2.283LysTyr: 2.283 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
7.254LeuAla: 7.254 ± 0.075
0.701LeuCys: 0.701 ± 0.023
4.611LeuAsp: 4.611 ± 0.055
6.664LeuGlu: 6.664 ± 0.067
4.898LeuPhe: 4.898 ± 0.085
6.568LeuGly: 6.568 ± 0.077
1.887LeuHis: 1.887 ± 0.039
7.759LeuIle: 7.759 ± 0.095
6.84LeuLys: 6.84 ± 0.076
10.018LeuLeu: 10.018 ± 0.124
2.484LeuMet: 2.484 ± 0.041
4.46LeuAsn: 4.46 ± 0.05
3.914LeuPro: 3.914 ± 0.053
3.492LeuGln: 3.492 ± 0.055
3.552LeuArg: 3.552 ± 0.056
6.871LeuSer: 6.871 ± 0.074
5.631LeuThr: 5.631 ± 0.055
5.971LeuVal: 5.971 ± 0.071
0.771LeuTrp: 0.771 ± 0.024
3.057LeuTyr: 3.057 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.085MetAla: 2.085 ± 0.043
0.16MetCys: 0.16 ± 0.01
1.399MetAsp: 1.399 ± 0.029
2.001MetGlu: 2.001 ± 0.036
1.09MetPhe: 1.09 ± 0.028
1.885MetGly: 1.885 ± 0.046
0.447MetHis: 0.447 ± 0.017
2.325MetIle: 2.325 ± 0.044
2.585MetLys: 2.585 ± 0.039
2.518MetLeu: 2.518 ± 0.043
0.824MetMet: 0.824 ± 0.022
1.673MetAsn: 1.673 ± 0.034
1.016MetPro: 1.016 ± 0.039
0.823MetGln: 0.823 ± 0.025
1.035MetArg: 1.035 ± 0.032
1.615MetSer: 1.615 ± 0.034
1.584MetThr: 1.584 ± 0.031
1.711MetVal: 1.711 ± 0.03
0.193MetTrp: 0.193 ± 0.012
0.725MetTyr: 0.725 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.824AsnAla: 2.824 ± 0.048
0.303AsnCys: 0.303 ± 0.014
2.276AsnAsp: 2.276 ± 0.04
3.694AsnGlu: 3.694 ± 0.057
1.78AsnPhe: 1.78 ± 0.042
3.602AsnGly: 3.602 ± 0.06
1.09AsnHis: 1.09 ± 0.029
3.775AsnIle: 3.775 ± 0.057
3.248AsnLys: 3.248 ± 0.046
4.055AsnLeu: 4.055 ± 0.053
1.232AsnMet: 1.232 ± 0.031
2.183AsnAsn: 2.183 ± 0.05
2.278AsnPro: 2.278 ± 0.043
1.933AsnGln: 1.933 ± 0.037
2.029AsnArg: 2.029 ± 0.038
2.445AsnSer: 2.445 ± 0.046
2.127AsnThr: 2.127 ± 0.044
3.026AsnVal: 3.026 ± 0.046
0.562AsnTrp: 0.562 ± 0.02
1.516AsnTyr: 1.516 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
2.349ProAla: 2.349 ± 0.043
0.213ProCys: 0.213 ± 0.013
1.885ProAsp: 1.885 ± 0.041
2.886ProGlu: 2.886 ± 0.05
2.109ProPhe: 2.109 ± 0.038
2.504ProGly: 2.504 ± 0.051
0.815ProHis: 0.815 ± 0.027
3.135ProIle: 3.135 ± 0.048
2.324ProLys: 2.324 ± 0.048
3.522ProLeu: 3.522 ± 0.049
0.865ProMet: 0.865 ± 0.025
1.815ProAsn: 1.815 ± 0.036
1.108ProPro: 1.108 ± 0.036
1.176ProGln: 1.176 ± 0.034
1.098ProArg: 1.098 ± 0.033
2.439ProSer: 2.439 ± 0.036
1.918ProThr: 1.918 ± 0.038
2.765ProVal: 2.765 ± 0.046
0.344ProTrp: 0.344 ± 0.017
1.395ProTyr: 1.395 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
2.704GlnAla: 2.704 ± 0.051
0.199GlnCys: 0.199 ± 0.012
1.533GlnAsp: 1.533 ± 0.032
2.69GlnGlu: 2.69 ± 0.046
1.646GlnPhe: 1.646 ± 0.032
2.031GlnGly: 2.031 ± 0.041
0.702GlnHis: 0.702 ± 0.025
2.784GlnIle: 2.784 ± 0.047
2.64GlnLys: 2.64 ± 0.039
3.78GlnLeu: 3.78 ± 0.055
1.142GlnMet: 1.142 ± 0.035
1.699GlnAsn: 1.699 ± 0.034
1.208GlnPro: 1.208 ± 0.029
1.588GlnGln: 1.588 ± 0.041
1.388GlnArg: 1.388 ± 0.036
2.114GlnSer: 2.114 ± 0.041
1.916GlnThr: 1.916 ± 0.032
2.264GlnVal: 2.264 ± 0.041
0.359GlnTrp: 0.359 ± 0.018
1.299GlnTyr: 1.299 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
2.462ArgAla: 2.462 ± 0.043
0.268ArgCys: 0.268 ± 0.016
1.923ArgAsp: 1.923 ± 0.036
3.035ArgGlu: 3.035 ± 0.049
1.919ArgPhe: 1.919 ± 0.039
2.321ArgGly: 2.321 ± 0.044
0.764ArgHis: 0.764 ± 0.028
3.226ArgIle: 3.226 ± 0.048
3.202ArgLys: 3.202 ± 0.05
3.822ArgLeu: 3.822 ± 0.059
1.19ArgMet: 1.19 ± 0.031
1.956ArgAsn: 1.956 ± 0.039
1.268ArgPro: 1.268 ± 0.03
1.444ArgGln: 1.444 ± 0.03
1.708ArgArg: 1.708 ± 0.041
2.078ArgSer: 2.078 ± 0.037
1.993ArgThr: 1.993 ± 0.036
2.523ArgVal: 2.523 ± 0.041
0.397ArgTrp: 0.397 ± 0.017
1.37ArgTyr: 1.37 ± 0.027
0.0ArgXaa: 0.0 ± 0.0
Ser
3.846SerAla: 3.846 ± 0.059
0.415SerCys: 0.415 ± 0.018
2.674SerAsp: 2.674 ± 0.046
3.998SerGlu: 3.998 ± 0.059
3.448SerPhe: 3.448 ± 0.052
4.564SerGly: 4.564 ± 0.056
1.245SerHis: 1.245 ± 0.031
5.399SerIle: 5.399 ± 0.068
3.938SerLys: 3.938 ± 0.055
6.208SerLeu: 6.208 ± 0.06
1.705SerMet: 1.705 ± 0.035
2.633SerAsn: 2.633 ± 0.046
2.194SerPro: 2.194 ± 0.039
1.973SerGln: 1.973 ± 0.037
2.215SerArg: 2.215 ± 0.045
3.926SerSer: 3.926 ± 0.057
3.016SerThr: 3.016 ± 0.043
3.982SerVal: 3.982 ± 0.057
0.652SerTrp: 0.652 ± 0.023
2.236SerTyr: 2.236 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
3.975ThrAla: 3.975 ± 0.051
0.353ThrCys: 0.353 ± 0.016
2.483ThrAsp: 2.483 ± 0.047
3.333ThrGlu: 3.333 ± 0.051
2.611ThrPhe: 2.611 ± 0.047
4.28ThrGly: 4.28 ± 0.056
1.002ThrHis: 1.002 ± 0.024
4.667ThrIle: 4.667 ± 0.058
3.3ThrLys: 3.3 ± 0.048
5.074ThrLeu: 5.074 ± 0.057
1.278ThrMet: 1.278 ± 0.027
2.45ThrAsn: 2.45 ± 0.042
2.189ThrPro: 2.189 ± 0.043
1.348ThrGln: 1.348 ± 0.034
1.809ThrArg: 1.809 ± 0.036
3.13ThrSer: 3.13 ± 0.046
2.773ThrThr: 2.773 ± 0.051
4.17ThrVal: 4.17 ± 0.058
0.482ThrTrp: 0.482 ± 0.023
1.76ThrTyr: 1.76 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
4.83ValAla: 4.83 ± 0.066
0.546ValCys: 0.546 ± 0.022
3.312ValAsp: 3.312 ± 0.05
4.605ValGlu: 4.605 ± 0.053
3.209ValPhe: 3.209 ± 0.054
4.669ValGly: 4.669 ± 0.062
1.346ValHis: 1.346 ± 0.026
6.03ValIle: 6.03 ± 0.071
4.707ValLys: 4.707 ± 0.064
6.621ValLeu: 6.621 ± 0.073
1.79ValMet: 1.79 ± 0.035
3.218ValAsn: 3.218 ± 0.047
2.692ValPro: 2.692 ± 0.044
2.354ValGln: 2.354 ± 0.041
2.417ValArg: 2.417 ± 0.043
4.429ValSer: 4.429 ± 0.057
3.837ValThr: 3.837 ± 0.056
4.658ValVal: 4.658 ± 0.063
0.569ValTrp: 0.569 ± 0.018
2.205ValTyr: 2.205 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.64TrpAla: 0.64 ± 0.019
0.079TrpCys: 0.079 ± 0.007
0.54TrpAsp: 0.54 ± 0.021
0.661TrpGlu: 0.661 ± 0.023
0.537TrpPhe: 0.537 ± 0.023
0.711TrpGly: 0.711 ± 0.026
0.186TrpHis: 0.186 ± 0.012
0.817TrpIle: 0.817 ± 0.027
0.766TrpLys: 0.766 ± 0.022
1.132TrpLeu: 1.132 ± 0.03
0.328TrpMet: 0.328 ± 0.015
0.511TrpAsn: 0.511 ± 0.017
0.27TrpPro: 0.27 ± 0.014
0.343TrpGln: 0.343 ± 0.016
0.4TrpArg: 0.4 ± 0.018
0.584TrpSer: 0.584 ± 0.019
0.488TrpThr: 0.488 ± 0.018
0.632TrpVal: 0.632 ± 0.022
0.136TrpTrp: 0.136 ± 0.01
0.325TrpTyr: 0.325 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.049TyrAla: 2.049 ± 0.035
0.286TyrCys: 0.286 ± 0.015
1.759TyrAsp: 1.759 ± 0.04
2.497TyrGlu: 2.497 ± 0.05
1.858TyrPhe: 1.858 ± 0.038
2.445TyrGly: 2.445 ± 0.04
0.764TyrHis: 0.764 ± 0.021
2.539TyrIle: 2.539 ± 0.049
2.124TyrLys: 2.124 ± 0.04
3.425TyrLeu: 3.425 ± 0.05
0.829TyrMet: 0.829 ± 0.02
1.466TyrAsn: 1.466 ± 0.034
1.381TyrPro: 1.381 ± 0.033
1.343TyrGln: 1.343 ± 0.031
1.518TyrArg: 1.518 ± 0.032
2.176TyrSer: 2.176 ± 0.039
1.775TyrThr: 1.775 ± 0.035
2.118TyrVal: 2.118 ± 0.043
0.411TyrTrp: 0.411 ± 0.017
1.395TyrTyr: 1.395 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4971 proteins (1449228 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski