Amino acid dipepetide frequency for Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.383AlaAla: 11.383 ± 0.184
1.466AlaCys: 1.466 ± 0.046
4.939AlaAsp: 4.939 ± 0.091
6.109AlaGlu: 6.109 ± 0.102
3.495AlaPhe: 3.495 ± 0.082
7.968AlaGly: 7.968 ± 0.133
1.602AlaHis: 1.602 ± 0.04
4.247AlaIle: 4.247 ± 0.084
3.402AlaLys: 3.402 ± 0.073
9.845AlaLeu: 9.845 ± 0.132
2.658AlaMet: 2.658 ± 0.056
2.632AlaAsn: 2.632 ± 0.071
4.48AlaPro: 4.48 ± 0.091
2.907AlaGln: 2.907 ± 0.067
6.303AlaArg: 6.303 ± 0.109
5.931AlaSer: 5.931 ± 0.112
3.744AlaThr: 3.744 ± 0.085
7.231AlaVal: 7.231 ± 0.109
1.401AlaTrp: 1.401 ± 0.047
2.608AlaTyr: 2.608 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
1.276CysAla: 1.276 ± 0.043
0.271CysCys: 0.271 ± 0.021
0.634CysAsp: 0.634 ± 0.028
0.615CysGlu: 0.615 ± 0.03
0.622CysPhe: 0.622 ± 0.027
1.359CysGly: 1.359 ± 0.045
0.315CysHis: 0.315 ± 0.024
0.792CysIle: 0.792 ± 0.03
0.428CysLys: 0.428 ± 0.021
1.416CysLeu: 1.416 ± 0.041
0.427CysMet: 0.427 ± 0.022
0.393CysAsn: 0.393 ± 0.022
0.796CysPro: 0.796 ± 0.039
0.316CysGln: 0.316 ± 0.021
1.06CysArg: 1.06 ± 0.039
1.072CysSer: 1.072 ± 0.046
0.664CysThr: 0.664 ± 0.033
0.974CysVal: 0.974 ± 0.043
0.187CysTrp: 0.187 ± 0.016
0.469CysTyr: 0.469 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
5.038AspAla: 5.038 ± 0.081
0.678AspCys: 0.678 ± 0.027
2.162AspAsp: 2.162 ± 0.063
3.106AspGlu: 3.106 ± 0.068
2.306AspPhe: 2.306 ± 0.057
4.653AspGly: 4.653 ± 0.11
0.983AspHis: 0.983 ± 0.033
3.136AspIle: 3.136 ± 0.062
2.402AspLys: 2.402 ± 0.075
4.602AspLeu: 4.602 ± 0.08
1.635AspMet: 1.635 ± 0.049
1.656AspAsn: 1.656 ± 0.051
2.525AspPro: 2.525 ± 0.063
1.469AspGln: 1.469 ± 0.057
3.105AspArg: 3.105 ± 0.069
3.104AspSer: 3.104 ± 0.07
2.387AspThr: 2.387 ± 0.057
3.424AspVal: 3.424 ± 0.082
0.849AspTrp: 0.849 ± 0.034
1.853AspTyr: 1.853 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
6.1GluAla: 6.1 ± 0.121
0.76GluCys: 0.76 ± 0.034
3.227GluAsp: 3.227 ± 0.077
5.39GluGlu: 5.39 ± 0.113
2.208GluPhe: 2.208 ± 0.052
4.862GluGly: 4.862 ± 0.088
1.447GluHis: 1.447 ± 0.043
3.33GluIle: 3.33 ± 0.069
4.015GluLys: 4.015 ± 0.078
6.118GluLeu: 6.118 ± 0.107
1.797GluMet: 1.797 ± 0.055
2.489GluAsn: 2.489 ± 0.052
2.468GluPro: 2.468 ± 0.073
2.812GluGln: 2.812 ± 0.065
4.038GluArg: 4.038 ± 0.096
3.01GluSer: 3.01 ± 0.056
3.469GluThr: 3.469 ± 0.079
3.539GluVal: 3.539 ± 0.075
0.998GluTrp: 0.998 ± 0.038
1.741GluTyr: 1.741 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.097PheAla: 3.097 ± 0.076
0.732PheCys: 0.732 ± 0.033
2.019PheAsp: 2.019 ± 0.054
1.834PheGlu: 1.834 ± 0.048
1.877PhePhe: 1.877 ± 0.065
3.018PheGly: 3.018 ± 0.064
0.926PheHis: 0.926 ± 0.039
2.262PheIle: 2.262 ± 0.063
1.46PheLys: 1.46 ± 0.043
4.396PheLeu: 4.396 ± 0.087
1.098PheMet: 1.098 ± 0.041
1.468PheAsn: 1.468 ± 0.052
2.126PhePro: 2.126 ± 0.058
1.207PheGln: 1.207 ± 0.039
2.621PheArg: 2.621 ± 0.058
3.341PheSer: 3.341 ± 0.075
2.1PheThr: 2.1 ± 0.051
2.226PheVal: 2.226 ± 0.053
0.613PheTrp: 0.613 ± 0.032
1.325PheTyr: 1.325 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
6.778GlyAla: 6.778 ± 0.125
1.181GlyCys: 1.181 ± 0.044
3.989GlyAsp: 3.989 ± 0.081
4.657GlyGlu: 4.657 ± 0.081
3.232GlyPhe: 3.232 ± 0.067
6.38GlyGly: 6.38 ± 0.144
1.649GlyHis: 1.649 ± 0.055
5.008GlyIle: 5.008 ± 0.089
4.83GlyLys: 4.83 ± 0.079
7.054GlyLeu: 7.054 ± 0.107
2.668GlyMet: 2.668 ± 0.059
3.341GlyAsn: 3.341 ± 0.127
2.369GlyPro: 2.369 ± 0.058
2.348GlyGln: 2.348 ± 0.054
4.881GlyArg: 4.881 ± 0.088
5.012GlySer: 5.012 ± 0.145
5.079GlyThr: 5.079 ± 0.178
5.531GlyVal: 5.531 ± 0.098
1.321GlyTrp: 1.321 ± 0.048
2.542GlyTyr: 2.542 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.981HisAla: 1.981 ± 0.056
0.293HisCys: 0.293 ± 0.021
0.98HisAsp: 0.98 ± 0.037
1.212HisGlu: 1.212 ± 0.045
0.878HisPhe: 0.878 ± 0.036
1.754HisGly: 1.754 ± 0.054
0.515HisHis: 0.515 ± 0.025
1.203HisIle: 1.203 ± 0.042
0.665HisLys: 0.665 ± 0.024
2.168HisLeu: 2.168 ± 0.054
0.559HisMet: 0.559 ± 0.028
0.63HisAsn: 0.63 ± 0.027
1.404HisPro: 1.404 ± 0.053
0.648HisGln: 0.648 ± 0.027
1.237HisArg: 1.237 ± 0.042
1.191HisSer: 1.191 ± 0.04
1.053HisThr: 1.053 ± 0.037
1.369HisVal: 1.369 ± 0.048
0.31HisTrp: 0.31 ± 0.021
0.696HisTyr: 0.696 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
4.878IleAla: 4.878 ± 0.086
0.863IleCys: 0.863 ± 0.033
2.607IleAsp: 2.607 ± 0.067
2.518IleGlu: 2.518 ± 0.071
2.17IlePhe: 2.17 ± 0.059
3.85IleGly: 3.85 ± 0.072
1.141IleHis: 1.141 ± 0.037
2.962IleIle: 2.962 ± 0.077
2.056IleLys: 2.056 ± 0.054
5.486IleLeu: 5.486 ± 0.101
1.293IleMet: 1.293 ± 0.044
1.959IleAsn: 1.959 ± 0.061
3.557IlePro: 3.557 ± 0.086
1.749IleGln: 1.749 ± 0.046
3.709IleArg: 3.709 ± 0.077
3.893IleSer: 3.893 ± 0.076
3.062IleThr: 3.062 ± 0.079
3.555IleVal: 3.555 ± 0.078
0.64IleTrp: 0.64 ± 0.028
1.536IleTyr: 1.536 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.628LysAla: 4.628 ± 0.095
0.446LysCys: 0.446 ± 0.027
2.737LysAsp: 2.737 ± 0.081
3.561LysGlu: 3.561 ± 0.087
1.41LysPhe: 1.41 ± 0.052
3.46LysGly: 3.46 ± 0.077
0.876LysHis: 0.876 ± 0.04
2.458LysIle: 2.458 ± 0.061
3.433LysLys: 3.433 ± 0.08
4.158LysLeu: 4.158 ± 0.075
1.374LysMet: 1.374 ± 0.038
2.201LysAsn: 2.201 ± 0.056
2.195LysPro: 2.195 ± 0.059
1.521LysGln: 1.521 ± 0.048
2.741LysArg: 2.741 ± 0.06
2.575LysSer: 2.575 ± 0.058
3.035LysThr: 3.035 ± 0.06
2.76LysVal: 2.76 ± 0.072
0.66LysTrp: 0.66 ± 0.033
1.388LysTyr: 1.388 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
9.731LeuAla: 9.731 ± 0.142
1.519LeuCys: 1.519 ± 0.048
5.239LeuAsp: 5.239 ± 0.081
6.059LeuGlu: 6.059 ± 0.091
4.094LeuPhe: 4.094 ± 0.09
7.243LeuGly: 7.243 ± 0.115
2.152LeuHis: 2.152 ± 0.052
4.64LeuIle: 4.64 ± 0.094
5.203LeuLys: 5.203 ± 0.111
10.126LeuLeu: 10.126 ± 0.192
2.654LeuMet: 2.654 ± 0.06
3.77LeuAsn: 3.77 ± 0.092
5.663LeuPro: 5.663 ± 0.111
3.063LeuGln: 3.063 ± 0.07
5.765LeuArg: 5.765 ± 0.097
6.64LeuSer: 6.64 ± 0.087
5.301LeuThr: 5.301 ± 0.12
6.26LeuVal: 6.26 ± 0.11
1.243LeuTrp: 1.243 ± 0.046
2.717LeuTyr: 2.717 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.73MetAla: 2.73 ± 0.063
0.287MetCys: 0.287 ± 0.018
1.7MetAsp: 1.7 ± 0.049
2.117MetGlu: 2.117 ± 0.059
0.884MetPhe: 0.884 ± 0.038
2.218MetGly: 2.218 ± 0.066
0.515MetHis: 0.515 ± 0.028
1.364MetIle: 1.364 ± 0.043
1.999MetLys: 1.999 ± 0.051
2.607MetLeu: 2.607 ± 0.055
0.885MetMet: 0.885 ± 0.037
1.412MetAsn: 1.412 ± 0.046
1.505MetPro: 1.505 ± 0.042
0.931MetGln: 0.931 ± 0.039
1.536MetArg: 1.536 ± 0.045
1.705MetSer: 1.705 ± 0.046
1.628MetThr: 1.628 ± 0.041
1.666MetVal: 1.666 ± 0.046
0.257MetTrp: 0.257 ± 0.018
0.517MetTyr: 0.517 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.391AsnAla: 3.391 ± 0.081
0.441AsnCys: 0.441 ± 0.024
1.578AsnAsp: 1.578 ± 0.049
1.748AsnGlu: 1.748 ± 0.048
1.221AsnPhe: 1.221 ± 0.045
3.338AsnGly: 3.338 ± 0.091
0.761AsnHis: 0.761 ± 0.029
2.441AsnIle: 2.441 ± 0.064
1.627AsnLys: 1.627 ± 0.058
3.477AsnLeu: 3.477 ± 0.075
1.095AsnMet: 1.095 ± 0.034
1.457AsnAsn: 1.457 ± 0.055
2.393AsnPro: 2.393 ± 0.059
1.027AsnGln: 1.027 ± 0.039
2.245AsnArg: 2.245 ± 0.053
2.107AsnSer: 2.107 ± 0.06
2.015AsnThr: 2.015 ± 0.068
2.327AsnVal: 2.327 ± 0.063
0.504AsnTrp: 0.504 ± 0.027
1.173AsnTyr: 1.173 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
5.309ProAla: 5.309 ± 0.112
0.664ProCys: 0.664 ± 0.03
3.323ProAsp: 3.323 ± 0.074
4.869ProGlu: 4.869 ± 0.096
2.02ProPhe: 2.02 ± 0.049
4.412ProGly: 4.412 ± 0.099
1.102ProHis: 1.102 ± 0.036
1.999ProIle: 1.999 ± 0.062
1.587ProLys: 1.587 ± 0.052
4.627ProLeu: 4.627 ± 0.09
1.204ProMet: 1.204 ± 0.04
1.409ProAsn: 1.409 ± 0.048
2.318ProPro: 2.318 ± 0.069
1.545ProGln: 1.545 ± 0.046
2.577ProArg: 2.577 ± 0.066
3.498ProSer: 3.498 ± 0.073
1.881ProThr: 1.881 ± 0.051
4.438ProVal: 4.438 ± 0.086
0.747ProTrp: 0.747 ± 0.036
1.439ProTyr: 1.439 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
3.368GlnAla: 3.368 ± 0.069
0.349GlnCys: 0.349 ± 0.021
1.648GlnAsp: 1.648 ± 0.051
2.475GlnGlu: 2.475 ± 0.062
1.208GlnPhe: 1.208 ± 0.041
2.418GlnGly: 2.418 ± 0.058
0.594GlnHis: 0.594 ± 0.026
1.732GlnIle: 1.732 ± 0.05
1.688GlnLys: 1.688 ± 0.048
2.908GlnLeu: 2.908 ± 0.07
0.975GlnMet: 0.975 ± 0.036
1.16GlnAsn: 1.16 ± 0.049
1.6GlnPro: 1.6 ± 0.056
1.318GlnGln: 1.318 ± 0.045
1.658GlnArg: 1.658 ± 0.055
1.741GlnSer: 1.741 ± 0.045
1.675GlnThr: 1.675 ± 0.048
2.004GlnVal: 2.004 ± 0.053
0.52GlnTrp: 0.52 ± 0.027
1.02GlnTyr: 1.02 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
4.623ArgAla: 4.623 ± 0.09
0.717ArgCys: 0.717 ± 0.033
3.144ArgAsp: 3.144 ± 0.072
5.078ArgGlu: 5.078 ± 0.1
2.58ArgPhe: 2.58 ± 0.055
3.993ArgGly: 3.993 ± 0.076
1.588ArgHis: 1.588 ± 0.042
3.617ArgIle: 3.617 ± 0.074
3.697ArgLys: 3.697 ± 0.077
6.435ArgLeu: 6.435 ± 0.109
2.041ArgMet: 2.041 ± 0.056
2.424ArgAsn: 2.424 ± 0.054
2.859ArgPro: 2.859 ± 0.077
2.432ArgGln: 2.432 ± 0.061
4.497ArgArg: 4.497 ± 0.104
3.175ArgSer: 3.175 ± 0.066
3.114ArgThr: 3.114 ± 0.059
3.683ArgVal: 3.683 ± 0.082
0.841ArgTrp: 0.841 ± 0.032
1.899ArgTyr: 1.899 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
5.471SerAla: 5.471 ± 0.09
1.063SerCys: 1.063 ± 0.035
2.512SerAsp: 2.512 ± 0.055
2.571SerGlu: 2.571 ± 0.061
2.842SerPhe: 2.842 ± 0.075
6.116SerGly: 6.116 ± 0.148
1.27SerHis: 1.27 ± 0.039
3.631SerIle: 3.631 ± 0.075
2.16SerLys: 2.16 ± 0.052
6.809SerLeu: 6.809 ± 0.102
1.86SerMet: 1.86 ± 0.048
1.832SerAsn: 1.832 ± 0.053
3.472SerPro: 3.472 ± 0.071
1.767SerGln: 1.767 ± 0.056
4.373SerArg: 4.373 ± 0.083
4.798SerSer: 4.798 ± 0.106
2.936SerThr: 2.936 ± 0.076
4.486SerVal: 4.486 ± 0.083
1.079SerTrp: 1.079 ± 0.04
1.877SerTyr: 1.877 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
5.243ThrAla: 5.243 ± 0.109
0.631ThrCys: 0.631 ± 0.028
2.765ThrAsp: 2.765 ± 0.066
3.123ThrGlu: 3.123 ± 0.067
1.949ThrPhe: 1.949 ± 0.052
4.961ThrGly: 4.961 ± 0.139
0.961ThrHis: 0.961 ± 0.036
2.738ThrIle: 2.738 ± 0.075
1.649ThrLys: 1.649 ± 0.046
5.702ThrLeu: 5.702 ± 0.14
1.21ThrMet: 1.21 ± 0.04
1.528ThrAsn: 1.528 ± 0.049
3.468ThrPro: 3.468 ± 0.077
1.39ThrGln: 1.39 ± 0.042
2.965ThrArg: 2.965 ± 0.069
2.952ThrSer: 2.952 ± 0.073
2.503ThrThr: 2.503 ± 0.092
4.146ThrVal: 4.146 ± 0.097
0.745ThrTrp: 0.745 ± 0.036
1.44ThrTyr: 1.44 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
5.529ValAla: 5.529 ± 0.101
1.075ValCys: 1.075 ± 0.04
3.426ValAsp: 3.426 ± 0.072
4.252ValGlu: 4.252 ± 0.083
2.809ValPhe: 2.809 ± 0.064
4.115ValGly: 4.115 ± 0.091
1.347ValHis: 1.347 ± 0.048
3.804ValIle: 3.804 ± 0.079
3.218ValLys: 3.218 ± 0.07
6.78ValLeu: 6.78 ± 0.098
1.811ValMet: 1.811 ± 0.052
2.629ValAsn: 2.629 ± 0.069
3.753ValPro: 3.753 ± 0.073
2.12ValGln: 2.12 ± 0.053
4.257ValArg: 4.257 ± 0.079
4.502ValSer: 4.502 ± 0.077
4.041ValThr: 4.041 ± 0.096
4.495ValVal: 4.495 ± 0.087
0.878ValTrp: 0.878 ± 0.039
1.919ValTyr: 1.919 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
1.099TrpAla: 1.099 ± 0.043
0.231TrpCys: 0.231 ± 0.018
0.726TrpAsp: 0.726 ± 0.029
0.892TrpGlu: 0.892 ± 0.035
0.618TrpPhe: 0.618 ± 0.032
1.089TrpGly: 1.089 ± 0.042
0.362TrpHis: 0.362 ± 0.023
0.748TrpIle: 0.748 ± 0.031
0.981TrpLys: 0.981 ± 0.037
1.495TrpLeu: 1.495 ± 0.05
0.491TrpMet: 0.491 ± 0.022
0.821TrpAsn: 0.821 ± 0.031
0.53TrpPro: 0.53 ± 0.029
0.476TrpGln: 0.476 ± 0.028
0.836TrpArg: 0.836 ± 0.033
0.882TrpSer: 0.882 ± 0.03
0.769TrpThr: 0.769 ± 0.032
0.809TrpVal: 0.809 ± 0.032
0.254TrpTrp: 0.254 ± 0.019
0.38TrpTyr: 0.38 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.699TyrAla: 2.699 ± 0.058
0.417TyrCys: 0.417 ± 0.025
1.718TyrAsp: 1.718 ± 0.068
1.633TyrGlu: 1.633 ± 0.048
1.322TyrPhe: 1.322 ± 0.047
2.642TyrGly: 2.642 ± 0.067
0.64TyrHis: 0.64 ± 0.03
1.373TyrIle: 1.373 ± 0.044
1.118TyrLys: 1.118 ± 0.039
2.875TyrLeu: 2.875 ± 0.059
0.727TyrMet: 0.727 ± 0.032
1.156TyrAsn: 1.156 ± 0.046
1.486TyrPro: 1.486 ± 0.05
1.014TyrGln: 1.014 ± 0.039
2.031TyrArg: 2.031 ± 0.053
1.797TyrSer: 1.797 ± 0.065
1.613TyrThr: 1.613 ± 0.056
1.838TyrVal: 1.838 ± 0.052
0.441TyrTrp: 0.441 ± 0.028
1.066TyrTyr: 1.066 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2137 proteins (771359 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski