Amino acid dipepetide frequency for Idiomarina sp. A28L

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.225AlaAla: 10.225 ± 0.14
0.919AlaCys: 0.919 ± 0.037
5.397AlaAsp: 5.397 ± 0.08
7.85AlaGlu: 7.85 ± 0.1
3.545AlaPhe: 3.545 ± 0.071
7.175AlaGly: 7.175 ± 0.11
1.839AlaHis: 1.839 ± 0.047
5.969AlaIle: 5.969 ± 0.098
4.274AlaLys: 4.274 ± 0.094
10.823AlaLeu: 10.823 ± 0.13
2.652AlaMet: 2.652 ± 0.064
4.026AlaAsn: 4.026 ± 0.077
3.464AlaPro: 3.464 ± 0.064
4.225AlaGln: 4.225 ± 0.08
5.092AlaArg: 5.092 ± 0.08
5.505AlaSer: 5.505 ± 0.099
4.722AlaThr: 4.722 ± 0.083
6.729AlaVal: 6.729 ± 0.094
1.136AlaTrp: 1.136 ± 0.039
2.305AlaTyr: 2.305 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.772CysAla: 0.772 ± 0.032
0.105CysCys: 0.105 ± 0.012
0.481CysAsp: 0.481 ± 0.025
0.546CysGlu: 0.546 ± 0.027
0.338CysPhe: 0.338 ± 0.022
0.738CysGly: 0.738 ± 0.036
0.234CysHis: 0.234 ± 0.017
0.489CysIle: 0.489 ± 0.027
0.346CysLys: 0.346 ± 0.022
0.711CysLeu: 0.711 ± 0.03
0.185CysMet: 0.185 ± 0.015
0.285CysAsn: 0.285 ± 0.019
0.403CysPro: 0.403 ± 0.023
0.343CysGln: 0.343 ± 0.023
0.428CysArg: 0.428 ± 0.023
0.572CysSer: 0.572 ± 0.028
0.403CysThr: 0.403 ± 0.023
0.584CysVal: 0.584 ± 0.026
0.114CysTrp: 0.114 ± 0.013
0.268CysTyr: 0.268 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.695AspAla: 4.695 ± 0.08
0.426AspCys: 0.426 ± 0.024
2.887AspAsp: 2.887 ± 0.077
3.723AspGlu: 3.723 ± 0.08
2.517AspPhe: 2.517 ± 0.062
3.627AspGly: 3.627 ± 0.077
1.031AspHis: 1.031 ± 0.037
3.947AspIle: 3.947 ± 0.074
2.298AspLys: 2.298 ± 0.059
5.138AspLeu: 5.138 ± 0.073
1.364AspMet: 1.364 ± 0.051
2.136AspAsn: 2.136 ± 0.053
1.933AspPro: 1.933 ± 0.052
1.655AspGln: 1.655 ± 0.049
2.625AspArg: 2.625 ± 0.061
3.217AspSer: 3.217 ± 0.069
2.657AspThr: 2.657 ± 0.066
3.763AspVal: 3.763 ± 0.084
0.824AspTrp: 0.824 ± 0.034
1.963AspTyr: 1.963 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
6.135GluAla: 6.135 ± 0.107
0.421GluCys: 0.421 ± 0.022
2.794GluAsp: 2.794 ± 0.07
4.047GluGlu: 4.047 ± 0.081
2.813GluPhe: 2.813 ± 0.064
3.947GluGly: 3.947 ± 0.073
1.862GluHis: 1.862 ± 0.057
4.035GluIle: 4.035 ± 0.072
2.998GluLys: 2.998 ± 0.084
7.764GluLeu: 7.764 ± 0.102
1.713GluMet: 1.713 ± 0.048
2.988GluAsn: 2.988 ± 0.068
2.56GluPro: 2.56 ± 0.061
4.289GluGln: 4.289 ± 0.083
4.811GluArg: 4.811 ± 0.089
3.541GluSer: 3.541 ± 0.067
3.257GluThr: 3.257 ± 0.07
4.486GluVal: 4.486 ± 0.087
0.845GluTrp: 0.845 ± 0.034
1.893GluTyr: 1.893 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
4.209PheAla: 4.209 ± 0.075
0.382PheCys: 0.382 ± 0.024
2.389PheAsp: 2.389 ± 0.057
2.263PheGlu: 2.263 ± 0.062
1.645PhePhe: 1.645 ± 0.055
3.257PheGly: 3.257 ± 0.076
0.874PheHis: 0.874 ± 0.031
2.56PheIle: 2.56 ± 0.059
1.417PheLys: 1.417 ± 0.048
3.527PheLeu: 3.527 ± 0.077
0.929PheMet: 0.929 ± 0.033
1.853PheAsn: 1.853 ± 0.054
1.562PhePro: 1.562 ± 0.05
1.442PheGln: 1.442 ± 0.041
2.139PheArg: 2.139 ± 0.056
3.194PheSer: 3.194 ± 0.074
2.431PheThr: 2.431 ± 0.063
2.897PheVal: 2.897 ± 0.083
0.526PheTrp: 0.526 ± 0.027
1.298PheTyr: 1.298 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
5.962GlyAla: 5.962 ± 0.108
0.736GlyCys: 0.736 ± 0.032
3.702GlyAsp: 3.702 ± 0.068
4.806GlyGlu: 4.806 ± 0.088
3.413GlyPhe: 3.413 ± 0.075
5.165GlyGly: 5.165 ± 0.11
1.57GlyHis: 1.57 ± 0.047
4.569GlyIle: 4.569 ± 0.087
3.36GlyLys: 3.36 ± 0.075
6.944GlyLeu: 6.944 ± 0.098
2.041GlyMet: 2.041 ± 0.058
2.825GlyAsn: 2.825 ± 0.075
2.053GlyPro: 2.053 ± 0.047
2.666GlyGln: 2.666 ± 0.064
3.753GlyArg: 3.753 ± 0.073
4.357GlySer: 4.357 ± 0.077
3.644GlyThr: 3.644 ± 0.08
5.456GlyVal: 5.456 ± 0.095
0.983GlyTrp: 0.983 ± 0.039
2.512GlyTyr: 2.512 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.881HisAla: 1.881 ± 0.056
0.271HisCys: 0.271 ± 0.02
1.118HisAsp: 1.118 ± 0.038
1.498HisGlu: 1.498 ± 0.051
1.002HisPhe: 1.002 ± 0.035
1.752HisGly: 1.752 ± 0.056
0.616HisHis: 0.616 ± 0.034
1.378HisIle: 1.378 ± 0.041
0.826HisLys: 0.826 ± 0.035
2.163HisLeu: 2.163 ± 0.049
0.449HisMet: 0.449 ± 0.024
0.837HisAsn: 0.837 ± 0.035
1.206HisPro: 1.206 ± 0.042
0.983HisGln: 0.983 ± 0.036
1.272HisArg: 1.272 ± 0.046
1.396HisSer: 1.396 ± 0.043
1.086HisThr: 1.086 ± 0.038
1.367HisVal: 1.367 ± 0.044
0.371HisTrp: 0.371 ± 0.024
0.794HisTyr: 0.794 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.569IleAla: 6.569 ± 0.098
0.591IleCys: 0.591 ± 0.024
3.892IleAsp: 3.892 ± 0.074
4.325IleGlu: 4.325 ± 0.095
2.228IlePhe: 2.228 ± 0.062
4.537IleGly: 4.537 ± 0.089
1.312IleHis: 1.312 ± 0.04
3.474IleIle: 3.474 ± 0.083
2.226IleLys: 2.226 ± 0.061
5.188IleLeu: 5.188 ± 0.09
1.304IleMet: 1.304 ± 0.042
2.504IleAsn: 2.504 ± 0.06
2.61IlePro: 2.61 ± 0.064
2.291IleGln: 2.291 ± 0.049
3.258IleArg: 3.258 ± 0.071
4.114IleSer: 4.114 ± 0.083
3.635IleThr: 3.635 ± 0.068
3.966IleVal: 3.966 ± 0.082
0.673IleTrp: 0.673 ± 0.028
1.607IleTyr: 1.607 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.28LysAla: 4.28 ± 0.08
0.209LysCys: 0.209 ± 0.017
1.944LysAsp: 1.944 ± 0.052
2.589LysGlu: 2.589 ± 0.075
1.373LysPhe: 1.373 ± 0.041
2.509LysGly: 2.509 ± 0.07
1.09LysHis: 1.09 ± 0.04
2.344LysIle: 2.344 ± 0.066
2.213LysLys: 2.213 ± 0.075
4.34LysLeu: 4.34 ± 0.08
1.085LysMet: 1.085 ± 0.046
1.602LysAsn: 1.602 ± 0.053
2.136LysPro: 2.136 ± 0.066
2.226LysGln: 2.226 ± 0.057
2.528LysArg: 2.528 ± 0.061
2.282LysSer: 2.282 ± 0.061
2.181LysThr: 2.181 ± 0.054
2.893LysVal: 2.893 ± 0.076
0.416LysTrp: 0.416 ± 0.022
0.994LysTyr: 0.994 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
11.29LeuAla: 11.29 ± 0.143
0.826LeuCys: 0.826 ± 0.036
5.308LeuAsp: 5.308 ± 0.098
6.442LeuGlu: 6.442 ± 0.101
3.955LeuPhe: 3.955 ± 0.086
6.928LeuGly: 6.928 ± 0.1
2.311LeuHis: 2.311 ± 0.057
5.872LeuIle: 5.872 ± 0.102
4.066LeuLys: 4.066 ± 0.083
10.927LeuLeu: 10.927 ± 0.18
2.515LeuMet: 2.515 ± 0.061
4.43LeuAsn: 4.43 ± 0.076
5.075LeuPro: 5.075 ± 0.094
4.89LeuGln: 4.89 ± 0.102
5.985LeuArg: 5.985 ± 0.09
6.824LeuSer: 6.824 ± 0.098
5.739LeuThr: 5.739 ± 0.091
7.106LeuVal: 7.106 ± 0.117
1.183LeuTrp: 1.183 ± 0.039
2.435LeuTyr: 2.435 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.688MetAla: 2.688 ± 0.055
0.165MetCys: 0.165 ± 0.015
1.001MetAsp: 1.001 ± 0.037
1.246MetGlu: 1.246 ± 0.044
0.891MetPhe: 0.891 ± 0.035
1.663MetGly: 1.663 ± 0.054
0.606MetHis: 0.606 ± 0.027
1.311MetIle: 1.311 ± 0.04
1.18MetLys: 1.18 ± 0.037
2.88MetLeu: 2.88 ± 0.065
0.605MetMet: 0.605 ± 0.032
1.187MetAsn: 1.187 ± 0.042
1.322MetPro: 1.322 ± 0.047
1.45MetGln: 1.45 ± 0.04
1.418MetArg: 1.418 ± 0.048
1.704MetSer: 1.704 ± 0.053
1.108MetThr: 1.108 ± 0.04
1.714MetVal: 1.714 ± 0.046
0.211MetTrp: 0.211 ± 0.017
0.499MetTyr: 0.499 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.89AsnAla: 3.89 ± 0.081
0.337AsnCys: 0.337 ± 0.021
2.348AsnAsp: 2.348 ± 0.062
2.741AsnGlu: 2.741 ± 0.057
1.6AsnPhe: 1.6 ± 0.048
2.944AsnGly: 2.944 ± 0.061
0.865AsnHis: 0.865 ± 0.036
2.46AsnIle: 2.46 ± 0.062
1.637AsnLys: 1.637 ± 0.052
3.951AsnLeu: 3.951 ± 0.074
0.99AsnMet: 0.99 ± 0.035
1.796AsnAsn: 1.796 ± 0.054
2.238AsnPro: 2.238 ± 0.058
1.89AsnGln: 1.89 ± 0.058
2.281AsnArg: 2.281 ± 0.061
2.536AsnSer: 2.536 ± 0.057
2.223AsnThr: 2.223 ± 0.053
2.643AsnVal: 2.643 ± 0.063
0.579AsnTrp: 0.579 ± 0.031
1.274AsnTyr: 1.274 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
3.831ProAla: 3.831 ± 0.078
0.311ProCys: 0.311 ± 0.021
2.46ProAsp: 2.46 ± 0.06
3.979ProGlu: 3.979 ± 0.076
1.733ProPhe: 1.733 ± 0.048
2.974ProGly: 2.974 ± 0.075
0.812ProHis: 0.812 ± 0.034
2.434ProIle: 2.434 ± 0.059
1.771ProLys: 1.771 ± 0.046
4.228ProLeu: 4.228 ± 0.076
1.008ProMet: 1.008 ± 0.038
1.801ProAsn: 1.801 ± 0.054
1.317ProPro: 1.317 ± 0.048
1.662ProGln: 1.662 ± 0.046
1.85ProArg: 1.85 ± 0.05
2.292ProSer: 2.292 ± 0.057
2.057ProThr: 2.057 ± 0.052
3.337ProVal: 3.337 ± 0.073
0.576ProTrp: 0.576 ± 0.025
1.141ProTyr: 1.141 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
4.644GlnAla: 4.644 ± 0.081
0.288GlnCys: 0.288 ± 0.018
1.773GlnAsp: 1.773 ± 0.043
2.785GlnGlu: 2.785 ± 0.062
1.72GlnPhe: 1.72 ± 0.051
3.081GlnGly: 3.081 ± 0.065
1.247GlnHis: 1.247 ± 0.041
2.44GlnIle: 2.44 ± 0.057
1.805GlnLys: 1.805 ± 0.049
5.258GlnLeu: 5.258 ± 0.097
1.053GlnMet: 1.053 ± 0.035
1.702GlnAsn: 1.702 ± 0.052
1.997GlnPro: 1.997 ± 0.052
3.461GlnGln: 3.461 ± 0.113
3.22GlnArg: 3.22 ± 0.065
2.453GlnSer: 2.453 ± 0.063
2.057GlnThr: 2.057 ± 0.058
3.236GlnVal: 3.236 ± 0.065
0.68GlnTrp: 0.68 ± 0.033
1.183GlnTyr: 1.183 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
4.893ArgAla: 4.893 ± 0.082
0.422ArgCys: 0.422 ± 0.024
3.062ArgAsp: 3.062 ± 0.063
4.135ArgGlu: 4.135 ± 0.085
2.57ArgPhe: 2.57 ± 0.065
3.566ArgGly: 3.566 ± 0.074
1.187ArgHis: 1.187 ± 0.044
3.746ArgIle: 3.746 ± 0.082
2.454ArgLys: 2.454 ± 0.057
6.149ArgLeu: 6.149 ± 0.098
1.531ArgMet: 1.531 ± 0.048
2.304ArgAsn: 2.304 ± 0.052
1.939ArgPro: 1.939 ± 0.049
2.652ArgGln: 2.652 ± 0.062
3.238ArgArg: 3.238 ± 0.07
3.321ArgSer: 3.321 ± 0.075
2.495ArgThr: 2.495 ± 0.052
4.155ArgVal: 4.155 ± 0.072
0.91ArgTrp: 0.91 ± 0.034
2.016ArgTyr: 2.016 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
6.315SerAla: 6.315 ± 0.098
0.462SerCys: 0.462 ± 0.025
3.379SerAsp: 3.379 ± 0.073
4.261SerGlu: 4.261 ± 0.079
2.661SerPhe: 2.661 ± 0.06
5.157SerGly: 5.157 ± 0.091
1.212SerHis: 1.212 ± 0.042
3.573SerIle: 3.573 ± 0.07
2.506SerLys: 2.506 ± 0.06
6.214SerLeu: 6.214 ± 0.108
1.568SerMet: 1.568 ± 0.045
2.449SerAsn: 2.449 ± 0.061
2.353SerPro: 2.353 ± 0.055
2.395SerGln: 2.395 ± 0.063
3.321SerArg: 3.321 ± 0.063
3.983SerSer: 3.983 ± 0.081
2.814SerThr: 2.814 ± 0.056
4.342SerVal: 4.342 ± 0.078
0.815SerTrp: 0.815 ± 0.034
1.761SerTyr: 1.761 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.878ThrAla: 4.878 ± 0.1
0.41ThrCys: 0.41 ± 0.025
2.841ThrAsp: 2.841 ± 0.061
3.483ThrGlu: 3.483 ± 0.059
1.928ThrPhe: 1.928 ± 0.054
4.128ThrGly: 4.128 ± 0.082
1.152ThrHis: 1.152 ± 0.035
2.942ThrIle: 2.942 ± 0.062
1.792ThrLys: 1.792 ± 0.051
5.642ThrLeu: 5.642 ± 0.093
1.106ThrMet: 1.106 ± 0.036
1.992ThrAsn: 1.992 ± 0.056
2.654ThrPro: 2.654 ± 0.068
2.071ThrGln: 2.071 ± 0.055
2.726ThrArg: 2.726 ± 0.053
3.034ThrSer: 3.034 ± 0.067
2.734ThrThr: 2.734 ± 0.088
3.605ThrVal: 3.605 ± 0.079
0.62ThrTrp: 0.62 ± 0.031
1.401ThrTyr: 1.401 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
7.241ValAla: 7.241 ± 0.098
0.622ValCys: 0.622 ± 0.03
3.706ValAsp: 3.706 ± 0.078
4.325ValGlu: 4.325 ± 0.076
2.852ValPhe: 2.852 ± 0.065
4.631ValGly: 4.631 ± 0.097
1.36ValHis: 1.36 ± 0.04
4.587ValIle: 4.587 ± 0.084
2.787ValLys: 2.787 ± 0.068
7.319ValLeu: 7.319 ± 0.112
1.845ValMet: 1.845 ± 0.047
2.991ValAsn: 2.991 ± 0.072
2.931ValPro: 2.931 ± 0.061
2.648ValGln: 2.648 ± 0.054
4.001ValArg: 4.001 ± 0.079
4.679ValSer: 4.679 ± 0.089
3.996ValThr: 3.996 ± 0.074
5.414ValVal: 5.414 ± 0.098
0.803ValTrp: 0.803 ± 0.035
1.793ValTyr: 1.793 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.92TrpAla: 0.92 ± 0.039
0.139TrpCys: 0.139 ± 0.014
0.54TrpAsp: 0.54 ± 0.029
0.572TrpGlu: 0.572 ± 0.027
0.685TrpPhe: 0.685 ± 0.036
0.752TrpGly: 0.752 ± 0.035
0.393TrpHis: 0.393 ± 0.023
0.67TrpIle: 0.67 ± 0.033
0.351TrpLys: 0.351 ± 0.022
1.983TrpLeu: 1.983 ± 0.064
0.325TrpMet: 0.325 ± 0.021
0.462TrpAsn: 0.462 ± 0.028
0.542TrpPro: 0.542 ± 0.027
1.163TrpGln: 1.163 ± 0.051
0.844TrpArg: 0.844 ± 0.033
0.629TrpSer: 0.629 ± 0.028
0.394TrpThr: 0.394 ± 0.024
0.967TrpVal: 0.967 ± 0.038
0.209TrpTrp: 0.209 ± 0.018
0.37TrpTyr: 0.37 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.555TyrAla: 2.555 ± 0.056
0.302TyrCys: 0.302 ± 0.021
1.408TyrAsp: 1.408 ± 0.047
1.582TyrGlu: 1.582 ± 0.051
1.323TyrPhe: 1.323 ± 0.047
1.986TyrGly: 1.986 ± 0.063
0.693TyrHis: 0.693 ± 0.031
1.503TyrIle: 1.503 ± 0.042
0.928TyrLys: 0.928 ± 0.034
2.958TyrLeu: 2.958 ± 0.06
0.574TyrMet: 0.574 ± 0.03
1.055TyrAsn: 1.055 ± 0.038
1.276TyrPro: 1.276 ± 0.044
1.681TyrGln: 1.681 ± 0.045
1.954TyrArg: 1.954 ± 0.049
1.91TyrSer: 1.91 ± 0.063
1.507TyrThr: 1.507 ± 0.051
1.871TyrVal: 1.871 ± 0.053
0.438TyrTrp: 0.438 ± 0.022
0.835TyrTyr: 0.835 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2298 proteins (783584 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski