Amino acid dipepetide frequency for Emmonsia crescens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.272AlaAla: 8.272 ± 0.053	0.931AlaCys: 0.931 ± 0.016	3.956AlaAsp: 3.956 ± 0.028	4.965AlaGlu: 4.965 ± 0.045	2.87AlaPhe: 2.87 ± 0.03	5.567AlaGly: 5.567 ± 0.041	1.689AlaHis: 1.689 ± 0.02	4.123AlaIle: 4.123 ± 0.04	4.027AlaLys: 4.027 ± 0.038	7.166AlaLeu: 7.166 ± 0.047	1.739AlaMet: 1.739 ± 0.023	2.936AlaAsn: 2.936 ± 0.029	4.411AlaPro: 4.411 ± 0.038	3.099AlaGln: 3.099 ± 0.035	4.716AlaArg: 4.716 ± 0.034	6.898AlaSer: 6.898 ± 0.043	5.038AlaThr: 5.038 ± 0.039	4.896AlaVal: 4.896 ± 0.038	0.953AlaTrp: 0.953 ± 0.018	1.912AlaTyr: 1.912 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.84CysAla: 0.84 ± 0.014	0.236CysCys: 0.236 ± 0.009	0.64CysAsp: 0.64 ± 0.012	0.61CysGlu: 0.61 ± 0.011	0.499CysPhe: 0.499 ± 0.009	0.897CysGly: 0.897 ± 0.017	0.335CysHis: 0.335 ± 0.01	0.686CysIle: 0.686 ± 0.012	0.535CysLys: 0.535 ± 0.015	1.221CysLeu: 1.221 ± 0.018	0.254CysMet: 0.254 ± 0.009	0.425CysAsn: 0.425 ± 0.01	0.659CysPro: 0.659 ± 0.016	0.469CysGln: 0.469 ± 0.01	0.756CysArg: 0.756 ± 0.014	0.913CysSer: 0.913 ± 0.015	0.63CysThr: 0.63 ± 0.012	0.737CysVal: 0.737 ± 0.013	0.186CysTrp: 0.186 ± 0.007	0.346CysTyr: 0.346 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.225AspAla: 4.225 ± 0.029	0.598AspCys: 0.598 ± 0.011	4.423AspAsp: 4.423 ± 0.054	4.506AspGlu: 4.506 ± 0.043	2.131AspPhe: 2.131 ± 0.024	4.146AspGly: 4.146 ± 0.035	1.221AspHis: 1.221 ± 0.017	3.433AspIle: 3.433 ± 0.032	2.421AspLys: 2.421 ± 0.025	4.86AspLeu: 4.86 ± 0.035	1.282AspMet: 1.282 ± 0.017	2.098AspAsn: 2.098 ± 0.026	3.306AspPro: 3.306 ± 0.034	1.804AspGln: 1.804 ± 0.02	3.1AspArg: 3.1 ± 0.032	4.224AspSer: 4.224 ± 0.035	2.9AspThr: 2.9 ± 0.028	3.533AspVal: 3.533 ± 0.031	0.785AspTrp: 0.785 ± 0.014	1.554AspTyr: 1.554 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	4.976GluAla: 4.976 ± 0.044	0.643GluCys: 0.643 ± 0.012	4.18GluAsp: 4.18 ± 0.041	5.691GluGlu: 5.691 ± 0.065	1.99GluPhe: 1.99 ± 0.021	3.903GluGly: 3.903 ± 0.031	1.378GluHis: 1.378 ± 0.017	3.242GluIle: 3.242 ± 0.03	3.885GluLys: 3.885 ± 0.04	5.225GluLeu: 5.225 ± 0.044	1.525GluMet: 1.525 ± 0.02	2.598GluAsn: 2.598 ± 0.026	2.858GluPro: 2.858 ± 0.041	2.473GluGln: 2.473 ± 0.023	4.157GluArg: 4.157 ± 0.04	4.373GluSer: 4.373 ± 0.04	3.417GluThr: 3.417 ± 0.03	3.419GluVal: 3.419 ± 0.033	0.851GluTrp: 0.851 ± 0.016	1.718GluTyr: 1.718 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.822PheAla: 2.822 ± 0.03	0.539PheCys: 0.539 ± 0.011	2.227PheAsp: 2.227 ± 0.027	2.174PheGlu: 2.174 ± 0.024	1.502PhePhe: 1.502 ± 0.024	2.689PheGly: 2.689 ± 0.032	0.928PheHis: 0.928 ± 0.014	1.805PheIle: 1.805 ± 0.023	1.542PheLys: 1.542 ± 0.02	3.403PheLeu: 3.403 ± 0.03	0.745PheMet: 0.745 ± 0.016	1.454PheAsn: 1.454 ± 0.018	2.059PhePro: 2.059 ± 0.023	1.383PheGln: 1.383 ± 0.017	2.047PheArg: 2.047 ± 0.024	3.162PheSer: 3.162 ± 0.034	2.103PheThr: 2.103 ± 0.024	2.236PheVal: 2.236 ± 0.025	0.576PheTrp: 0.576 ± 0.012	1.081PheTyr: 1.081 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.002GlyAla: 5.002 ± 0.044	0.824GlyCys: 0.824 ± 0.015	3.815GlyAsp: 3.815 ± 0.034	3.906GlyGlu: 3.906 ± 0.033	2.656GlyPhe: 2.656 ± 0.026	6.463GlyGly: 6.463 ± 0.079	1.636GlyHis: 1.636 ± 0.022	3.497GlyIle: 3.497 ± 0.032	3.649GlyLys: 3.649 ± 0.03	5.654GlyLeu: 5.654 ± 0.042	1.607GlyMet: 1.607 ± 0.021	2.773GlyAsn: 2.773 ± 0.028	3.268GlyPro: 3.268 ± 0.035	2.47GlyGln: 2.47 ± 0.028	4.227GlyArg: 4.227 ± 0.035	5.74GlySer: 5.74 ± 0.037	3.751GlyThr: 3.751 ± 0.031	4.2GlyVal: 4.2 ± 0.039	1.078GlyTrp: 1.078 ± 0.016	2.03GlyTyr: 2.03 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	1.799HisAla: 1.799 ± 0.022	0.319HisCys: 0.319 ± 0.009	1.31HisAsp: 1.31 ± 0.017	1.307HisGlu: 1.307 ± 0.018	0.928HisPhe: 0.928 ± 0.016	1.682HisGly: 1.682 ± 0.022	0.995HisHis: 0.995 ± 0.025	1.324HisIle: 1.324 ± 0.017	0.925HisLys: 0.925 ± 0.017	2.276HisLeu: 2.276 ± 0.025	0.494HisMet: 0.494 ± 0.01	0.948HisAsn: 0.948 ± 0.017	1.857HisPro: 1.857 ± 0.024	1.109HisGln: 1.109 ± 0.018	1.584HisArg: 1.584 ± 0.019	2.075HisSer: 2.075 ± 0.024	1.29HisThr: 1.29 ± 0.018	1.367HisVal: 1.367 ± 0.019	0.293HisTrp: 0.293 ± 0.009	0.669HisTyr: 0.669 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.98IleAla: 3.98 ± 0.034	0.773IleCys: 0.773 ± 0.016	3.021IleAsp: 3.021 ± 0.031	2.967IleGlu: 2.967 ± 0.029	2.125IlePhe: 2.125 ± 0.026	3.12IleGly: 3.12 ± 0.031	1.296IleHis: 1.296 ± 0.017	2.714IleIle: 2.714 ± 0.035	2.283IleLys: 2.283 ± 0.025	4.796IleLeu: 4.796 ± 0.04	0.998IleMet: 0.998 ± 0.016	1.943IleAsn: 1.943 ± 0.021	3.409IlePro: 3.409 ± 0.029	1.954IleGln: 1.954 ± 0.022	2.965IleArg: 2.965 ± 0.029	4.456IleSer: 4.456 ± 0.035	2.872IleThr: 2.872 ± 0.029	3.077IleVal: 3.077 ± 0.032	0.683IleTrp: 0.683 ± 0.014	1.497IleTyr: 1.497 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.048LysAla: 4.048 ± 0.035	0.553LysCys: 0.553 ± 0.013	2.724LysAsp: 2.724 ± 0.023	3.57LysGlu: 3.57 ± 0.037	1.594LysPhe: 1.594 ± 0.018	3.13LysGly: 3.13 ± 0.029	1.174LysHis: 1.174 ± 0.016	2.483LysIle: 2.483 ± 0.026	3.508LysLys: 3.508 ± 0.056	4.305LysLeu: 4.305 ± 0.039	1.057LysMet: 1.057 ± 0.018	1.918LysAsn: 1.918 ± 0.023	2.976LysPro: 2.976 ± 0.032	2.004LysGln: 2.004 ± 0.022	3.695LysArg: 3.695 ± 0.039	3.798LysSer: 3.798 ± 0.033	2.758LysThr: 2.758 ± 0.029	2.765LysVal: 2.765 ± 0.026	0.652LysTrp: 0.652 ± 0.012	1.453LysTyr: 1.453 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	7.259LeuAla: 7.259 ± 0.05	1.184LeuCys: 1.184 ± 0.017	5.064LeuAsp: 5.064 ± 0.04	5.541LeuGlu: 5.541 ± 0.048	3.294LeuPhe: 3.294 ± 0.035	5.611LeuGly: 5.611 ± 0.042	2.257LeuHis: 2.257 ± 0.027	3.998LeuIle: 3.998 ± 0.037	4.49LeuLys: 4.49 ± 0.04	8.338LeuLeu: 8.338 ± 0.065	1.697LeuMet: 1.697 ± 0.019	3.295LeuAsn: 3.295 ± 0.029	5.558LeuPro: 5.558 ± 0.038	3.792LeuGln: 3.792 ± 0.033	5.823LeuArg: 5.823 ± 0.041	7.658LeuSer: 7.658 ± 0.045	4.728LeuThr: 4.728 ± 0.036	5.053LeuVal: 5.053 ± 0.038	1.084LeuTrp: 1.084 ± 0.018	2.295LeuTyr: 2.295 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.072MetAla: 2.072 ± 0.022	0.232MetCys: 0.232 ± 0.008	1.241MetAsp: 1.241 ± 0.018	1.39MetGlu: 1.39 ± 0.019	0.717MetPhe: 0.717 ± 0.014	1.436MetGly: 1.436 ± 0.018	0.436MetHis: 0.436 ± 0.011	1.004MetIle: 1.004 ± 0.018	1.087MetLys: 1.087 ± 0.017	1.782MetLeu: 1.782 ± 0.021	0.532MetMet: 0.532 ± 0.013	0.823MetAsn: 0.823 ± 0.016	1.187MetPro: 1.187 ± 0.016	0.823MetGln: 0.823 ± 0.015	1.229MetArg: 1.229 ± 0.019	1.83MetSer: 1.83 ± 0.019	1.223MetThr: 1.223 ± 0.017	1.239MetVal: 1.239 ± 0.02	0.253MetTrp: 0.253 ± 0.007	0.479MetTyr: 0.479 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.044AsnAla: 3.044 ± 0.03	0.465AsnCys: 0.465 ± 0.011	2.177AsnAsp: 2.177 ± 0.027	2.222AsnGlu: 2.222 ± 0.023	1.394AsnPhe: 1.394 ± 0.019	3.191AsnGly: 3.191 ± 0.034	0.965AsnHis: 0.965 ± 0.016	2.349AsnIle: 2.349 ± 0.025	1.755AsnLys: 1.755 ± 0.022	3.377AsnLeu: 3.377 ± 0.027	0.869AsnMet: 0.869 ± 0.014	2.25AsnAsn: 2.25 ± 0.039	2.752AsnPro: 2.752 ± 0.025	1.44AsnGln: 1.44 ± 0.02	2.16AsnArg: 2.16 ± 0.024	3.165AsnSer: 3.165 ± 0.03	2.376AsnThr: 2.376 ± 0.025	2.28AsnVal: 2.28 ± 0.024	0.51AsnTrp: 0.51 ± 0.01	1.057AsnTyr: 1.057 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.024ProAla: 5.024 ± 0.042	0.53ProCys: 0.53 ± 0.012	3.208ProAsp: 3.208 ± 0.027	3.773ProGlu: 3.773 ± 0.034	2.146ProPhe: 2.146 ± 0.023	3.864ProGly: 3.864 ± 0.038	1.512ProHis: 1.512 ± 0.018	2.786ProIle: 2.786 ± 0.029	2.8ProLys: 2.8 ± 0.03	5.031ProLeu: 5.031 ± 0.039	1.045ProMet: 1.045 ± 0.017	2.485ProAsn: 2.485 ± 0.029	6.114ProPro: 6.114 ± 0.087	2.732ProGln: 2.732 ± 0.039	3.547ProArg: 3.547 ± 0.041	6.62ProSer: 6.62 ± 0.051	4.353ProThr: 4.353 ± 0.04	3.372ProVal: 3.372 ± 0.034	0.671ProTrp: 0.671 ± 0.012	1.56ProTyr: 1.56 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.121GlnAla: 3.121 ± 0.038	0.419GlnCys: 0.419 ± 0.009	1.966GlnAsp: 1.966 ± 0.023	2.378GlnGlu: 2.378 ± 0.028	1.301GlnPhe: 1.301 ± 0.017	2.322GlnGly: 2.322 ± 0.028	1.214GlnHis: 1.214 ± 0.02	1.942GlnIle: 1.942 ± 0.025	2.093GlnLys: 2.093 ± 0.027	3.522GlnLeu: 3.522 ± 0.032	0.843GlnMet: 0.843 ± 0.014	1.73GlnAsn: 1.73 ± 0.021	2.803GlnPro: 2.803 ± 0.039	3.189GlnGln: 3.189 ± 0.068	2.742GlnArg: 2.742 ± 0.028	3.268GlnSer: 3.268 ± 0.034	2.278GlnThr: 2.278 ± 0.024	2.001GlnVal: 2.001 ± 0.022	0.499GlnTrp: 0.499 ± 0.01	1.126GlnTyr: 1.126 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.574ArgAla: 4.574 ± 0.034	0.725ArgCys: 0.725 ± 0.015	3.478ArgAsp: 3.478 ± 0.036	4.072ArgGlu: 4.072 ± 0.044	2.168ArgPhe: 2.168 ± 0.025	4.015ArgGly: 4.015 ± 0.039	1.63ArgHis: 1.63 ± 0.019	3.055ArgIle: 3.055 ± 0.026	3.692ArgLys: 3.692 ± 0.035	5.495ArgLeu: 5.495 ± 0.041	1.297ArgMet: 1.297 ± 0.019	2.51ArgAsn: 2.51 ± 0.022	3.614ArgPro: 3.614 ± 0.034	2.699ArgGln: 2.699 ± 0.029	5.414ArgArg: 5.414 ± 0.045	5.008ArgSer: 5.008 ± 0.042	3.337ArgThr: 3.337 ± 0.028	3.334ArgVal: 3.334 ± 0.033	0.878ArgTrp: 0.878 ± 0.016	1.692ArgTyr: 1.692 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.539SerAla: 6.539 ± 0.042	0.863SerCys: 0.863 ± 0.016	4.198SerAsp: 4.198 ± 0.036	4.214SerGlu: 4.214 ± 0.038	3.083SerPhe: 3.083 ± 0.028	5.633SerGly: 5.633 ± 0.043	2.166SerHis: 2.166 ± 0.028	4.237SerIle: 4.237 ± 0.032	4.05SerLys: 4.05 ± 0.032	7.449SerLeu: 7.449 ± 0.054	1.742SerMet: 1.742 ± 0.02	3.436SerAsn: 3.436 ± 0.032	6.287SerPro: 6.287 ± 0.065	3.513SerGln: 3.513 ± 0.035	5.516SerArg: 5.516 ± 0.043	10.104SerSer: 10.104 ± 0.091	5.981SerThr: 5.981 ± 0.043	4.348SerVal: 4.348 ± 0.037	1.039SerTrp: 1.039 ± 0.015	2.066SerTyr: 2.066 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	4.967ThrAla: 4.967 ± 0.038	0.715ThrCys: 0.715 ± 0.014	2.819ThrAsp: 2.819 ± 0.025	3.043ThrGlu: 3.043 ± 0.029	2.165ThrPhe: 2.165 ± 0.02	3.962ThrGly: 3.962 ± 0.04	1.358ThrHis: 1.358 ± 0.017	3.113ThrIle: 3.113 ± 0.029	2.658ThrLys: 2.658 ± 0.03	5.149ThrLeu: 5.149 ± 0.037	1.123ThrMet: 1.123 ± 0.017	2.287ThrAsn: 2.287 ± 0.022	4.604ThrPro: 4.604 ± 0.043	2.065ThrGln: 2.065 ± 0.024	3.206ThrArg: 3.206 ± 0.029	5.661ThrSer: 5.661 ± 0.045	4.701ThrThr: 4.701 ± 0.05	3.405ThrVal: 3.405 ± 0.032	0.715ThrTrp: 0.715 ± 0.014	1.505ThrTyr: 1.505 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.643ValAla: 4.643 ± 0.033	0.751ValCys: 0.751 ± 0.014	3.678ValAsp: 3.678 ± 0.03	3.834ValGlu: 3.834 ± 0.036	2.25ValPhe: 2.25 ± 0.026	3.849ValGly: 3.849 ± 0.035	1.304ValHis: 1.304 ± 0.018	2.948ValIle: 2.948 ± 0.031	2.9ValLys: 2.9 ± 0.03	5.164ValLeu: 5.164 ± 0.042	1.234ValMet: 1.234 ± 0.016	2.201ValAsn: 2.201 ± 0.025	3.337ValPro: 3.337 ± 0.03	2.17ValGln: 2.17 ± 0.023	3.308ValArg: 3.308 ± 0.028	4.501ValSer: 4.501 ± 0.036	3.194ValThr: 3.194 ± 0.028	3.919ValVal: 3.919 ± 0.034	0.76ValTrp: 0.76 ± 0.014	1.538ValTyr: 1.538 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.005TrpAla: 1.005 ± 0.016	0.171TrpCys: 0.171 ± 0.006	0.815TrpAsp: 0.815 ± 0.016	0.838TrpGlu: 0.838 ± 0.015	0.467TrpPhe: 0.467 ± 0.011	0.839TrpGly: 0.839 ± 0.016	0.315TrpHis: 0.315 ± 0.009	0.708TrpIle: 0.708 ± 0.014	0.774TrpLys: 0.774 ± 0.014	1.211TrpLeu: 1.211 ± 0.018	0.344TrpMet: 0.344 ± 0.008	0.585TrpAsn: 0.585 ± 0.012	0.538TrpPro: 0.538 ± 0.011	0.486TrpGln: 0.486 ± 0.01	0.909TrpArg: 0.909 ± 0.015	0.925TrpSer: 0.925 ± 0.015	0.768TrpThr: 0.768 ± 0.015	0.789TrpVal: 0.789 ± 0.013	0.24TrpTrp: 0.24 ± 0.009	0.362TrpTyr: 0.362 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.949TyrAla: 1.949 ± 0.023	0.402TyrCys: 0.402 ± 0.01	1.61TyrAsp: 1.61 ± 0.022	1.502TyrGlu: 1.502 ± 0.021	1.195TyrPhe: 1.195 ± 0.018	1.928TyrGly: 1.928 ± 0.025	0.743TyrHis: 0.743 ± 0.013	1.482TyrIle: 1.482 ± 0.019	1.091TyrLys: 1.091 ± 0.016	2.595TyrLeu: 2.595 ± 0.026	0.588TyrMet: 0.588 ± 0.013	1.1TyrAsn: 1.1 ± 0.015	1.578TyrPro: 1.578 ± 0.025	1.085TyrGln: 1.085 ± 0.015	1.587TyrArg: 1.587 ± 0.018	2.086TyrSer: 2.086 ± 0.03	1.524TyrThr: 1.524 ± 0.019	1.513TyrVal: 1.513 ± 0.019	0.383TyrTrp: 0.383 ± 0.008	0.896TyrTyr: 0.896 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8899 proteins (4332052 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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