Amino acid dipepetide frequency for Helicobacter canadensis MIT 98-5491

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.585AlaAla: 3.585 ± 0.106
0.894AlaCys: 0.894 ± 0.05
2.294AlaAsp: 2.294 ± 0.074
3.007AlaGlu: 3.007 ± 0.088
3.568AlaPhe: 3.568 ± 0.087
3.674AlaGly: 3.674 ± 0.108
1.131AlaHis: 1.131 ± 0.051
6.144AlaIle: 6.144 ± 0.128
6.494AlaLys: 6.494 ± 0.119
8.559AlaLeu: 8.559 ± 0.147
1.937AlaMet: 1.937 ± 0.057
3.696AlaAsn: 3.696 ± 0.1
1.951AlaPro: 1.951 ± 0.066
2.827AlaGln: 2.827 ± 0.08
2.567AlaArg: 2.567 ± 0.077
3.836AlaSer: 3.836 ± 0.093
3.25AlaThr: 3.25 ± 0.083
3.072AlaVal: 3.072 ± 0.085
0.446AlaTrp: 0.446 ± 0.031
2.64AlaTyr: 2.64 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.938CysAla: 0.938 ± 0.046
0.136CysCys: 0.136 ± 0.017
0.671CysAsp: 0.671 ± 0.038
0.936CysGlu: 0.936 ± 0.048
0.689CysPhe: 0.689 ± 0.037
1.086CysGly: 1.086 ± 0.054
0.227CysHis: 0.227 ± 0.028
0.902CysIle: 0.902 ± 0.044
0.865CysLys: 0.865 ± 0.049
1.096CysLeu: 1.096 ± 0.051
0.265CysMet: 0.265 ± 0.021
0.577CysAsn: 0.577 ± 0.037
0.407CysPro: 0.407 ± 0.029
0.415CysGln: 0.415 ± 0.029
0.302CysArg: 0.302 ± 0.024
0.628CysSer: 0.628 ± 0.039
0.351CysThr: 0.351 ± 0.027
0.932CysVal: 0.932 ± 0.053
0.081CysTrp: 0.081 ± 0.014
0.466CysTyr: 0.466 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
2.393AspAla: 2.393 ± 0.076
0.758AspCys: 0.758 ± 0.039
1.901AspAsp: 1.901 ± 0.058
3.457AspGlu: 3.457 ± 0.095
3.901AspPhe: 3.901 ± 0.099
2.46AspGly: 2.46 ± 0.077
0.529AspHis: 0.529 ± 0.035
4.18AspIle: 4.18 ± 0.094
3.844AspLys: 3.844 ± 0.098
5.195AspLeu: 5.195 ± 0.109
1.106AspMet: 1.106 ± 0.042
2.336AspAsn: 2.336 ± 0.075
1.224AspPro: 1.224 ± 0.059
0.91AspGln: 0.91 ± 0.037
1.574AspArg: 1.574 ± 0.064
4.527AspSer: 4.527 ± 0.096
2.101AspThr: 2.101 ± 0.072
2.134AspVal: 2.134 ± 0.074
0.338AspTrp: 0.338 ± 0.026
2.164AspTyr: 2.164 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
5.027GluAla: 5.027 ± 0.11
0.849GluCys: 0.849 ± 0.046
3.106GluAsp: 3.106 ± 0.089
5.595GluGlu: 5.595 ± 0.129
3.793GluPhe: 3.793 ± 0.09
3.688GluGly: 3.688 ± 0.098
1.003GluHis: 1.003 ± 0.055
8.0GluIle: 8.0 ± 0.143
5.978GluLys: 5.978 ± 0.123
6.458GluLeu: 6.458 ± 0.118
1.724GluMet: 1.724 ± 0.06
4.887GluAsn: 4.887 ± 0.108
1.321GluPro: 1.321 ± 0.053
2.249GluGln: 2.249 ± 0.076
2.488GluArg: 2.488 ± 0.087
5.037GluSer: 5.037 ± 0.112
2.879GluThr: 2.879 ± 0.08
4.833GluVal: 4.833 ± 0.111
0.561GluTrp: 0.561 ± 0.035
2.367GluTyr: 2.367 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
3.552PheAla: 3.552 ± 0.093
0.944PheCys: 0.944 ± 0.051
2.851PheAsp: 2.851 ± 0.071
3.487PheGlu: 3.487 ± 0.086
3.155PhePhe: 3.155 ± 0.091
3.996PheGly: 3.996 ± 0.102
0.831PheHis: 0.831 ± 0.043
4.213PheIle: 4.213 ± 0.095
3.765PheLys: 3.765 ± 0.094
6.377PheLeu: 6.377 ± 0.179
1.293PheMet: 1.293 ± 0.056
2.691PheAsn: 2.691 ± 0.072
1.418PhePro: 1.418 ± 0.055
1.406PheGln: 1.406 ± 0.052
1.566PheArg: 1.566 ± 0.051
4.312PheSer: 4.312 ± 0.096
2.101PheThr: 2.101 ± 0.064
3.242PheVal: 3.242 ± 0.102
0.521PheTrp: 0.521 ± 0.04
2.371PheTyr: 2.371 ± 0.077
0.0PheXaa: 0.0 ± 0.0
Gly
4.194GlyAla: 4.194 ± 0.106
0.748GlyCys: 0.748 ± 0.045
3.161GlyAsp: 3.161 ± 0.083
4.379GlyGlu: 4.379 ± 0.097
3.664GlyPhe: 3.664 ± 0.099
4.573GlyGly: 4.573 ± 0.129
0.954GlyHis: 0.954 ± 0.043
6.737GlyIle: 6.737 ± 0.137
4.654GlyLys: 4.654 ± 0.122
5.274GlyLeu: 5.274 ± 0.11
1.607GlyMet: 1.607 ± 0.059
2.898GlyAsn: 2.898 ± 0.079
0.896GlyPro: 0.896 ± 0.049
1.617GlyGln: 1.617 ± 0.058
2.146GlyArg: 2.146 ± 0.08
3.68GlySer: 3.68 ± 0.098
2.231GlyThr: 2.231 ± 0.072
4.533GlyVal: 4.533 ± 0.108
0.458GlyTrp: 0.458 ± 0.035
2.614GlyTyr: 2.614 ± 0.077
0.0GlyXaa: 0.0 ± 0.0
His
0.731HisAla: 0.731 ± 0.044
0.3HisCys: 0.3 ± 0.025
0.565HisAsp: 0.565 ± 0.036
0.58HisGlu: 0.58 ± 0.034
1.309HisPhe: 1.309 ± 0.05
0.802HisGly: 0.802 ± 0.046
0.462HisHis: 0.462 ± 0.035
1.589HisIle: 1.589 ± 0.052
1.52HisLys: 1.52 ± 0.056
2.061HisLeu: 2.061 ± 0.064
0.318HisMet: 0.318 ± 0.026
1.033HisAsn: 1.033 ± 0.049
0.758HisPro: 0.758 ± 0.043
0.78HisGln: 0.78 ± 0.038
0.58HisArg: 0.58 ± 0.034
1.327HisSer: 1.327 ± 0.054
1.017HisThr: 1.017 ± 0.049
0.342HisVal: 0.342 ± 0.03
0.164HisTrp: 0.164 ± 0.019
0.863HisTyr: 0.863 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
7.08IleAla: 7.08 ± 0.138
1.108IleCys: 1.108 ± 0.051
4.324IleAsp: 4.324 ± 0.085
5.696IleGlu: 5.696 ± 0.103
4.606IlePhe: 4.606 ± 0.134
5.424IleGly: 5.424 ± 0.118
1.55IleHis: 1.55 ± 0.053
6.592IleIle: 6.592 ± 0.126
6.737IleLys: 6.737 ± 0.134
10.587IleLeu: 10.587 ± 0.171
1.508IleMet: 1.508 ± 0.058
4.259IleAsn: 4.259 ± 0.093
3.688IlePro: 3.688 ± 0.083
3.495IleGln: 3.495 ± 0.088
2.543IleArg: 2.543 ± 0.069
5.568IleSer: 5.568 ± 0.114
4.456IleThr: 4.456 ± 0.115
4.778IleVal: 4.778 ± 0.11
0.553IleTrp: 0.553 ± 0.034
3.064IleTyr: 3.064 ± 0.086
0.002IleXaa: 0.002 ± 0.002
Lys
5.501LysAla: 5.501 ± 0.108
0.582LysCys: 0.582 ± 0.043
4.608LysAsp: 4.608 ± 0.103
9.216LysGlu: 9.216 ± 0.157
2.774LysPhe: 2.774 ± 0.071
4.407LysGly: 4.407 ± 0.102
1.234LysHis: 1.234 ± 0.047
8.66LysIle: 8.66 ± 0.146
7.116LysLys: 7.116 ± 0.133
6.488LysLeu: 6.488 ± 0.113
2.117LysMet: 2.117 ± 0.064
6.251LysAsn: 6.251 ± 0.123
2.456LysPro: 2.456 ± 0.074
3.297LysGln: 3.297 ± 0.092
2.922LysArg: 2.922 ± 0.089
4.509LysSer: 4.509 ± 0.09
4.055LysThr: 4.055 ± 0.097
4.265LysVal: 4.265 ± 0.092
0.505LysTrp: 0.505 ± 0.036
2.634LysTyr: 2.634 ± 0.082
0.002LysXaa: 0.002 ± 0.002
Leu
7.147LeuAla: 7.147 ± 0.127
1.445LeuCys: 1.445 ± 0.056
5.629LeuAsp: 5.629 ± 0.108
9.564LeuGlu: 9.564 ± 0.162
5.366LeuPhe: 5.366 ± 0.13
6.958LeuGly: 6.958 ± 0.154
1.722LeuHis: 1.722 ± 0.063
7.212LeuIle: 7.212 ± 0.163
9.773LeuLys: 9.773 ± 0.151
10.747LeuLeu: 10.747 ± 0.21
2.249LeuMet: 2.249 ± 0.071
5.68LeuAsn: 5.68 ± 0.127
3.854LeuPro: 3.854 ± 0.101
5.031LeuGln: 5.031 ± 0.142
3.595LeuArg: 3.595 ± 0.087
7.505LeuSer: 7.505 ± 0.148
4.186LeuThr: 4.186 ± 0.084
5.246LeuVal: 5.246 ± 0.099
0.843LeuTrp: 0.843 ± 0.045
3.605LeuTyr: 3.605 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
1.672MetAla: 1.672 ± 0.06
0.215MetCys: 0.215 ± 0.022
1.068MetAsp: 1.068 ± 0.048
1.641MetGlu: 1.641 ± 0.058
0.782MetPhe: 0.782 ± 0.042
1.587MetGly: 1.587 ± 0.06
0.346MetHis: 0.346 ± 0.03
1.826MetIle: 1.826 ± 0.063
1.481MetLys: 1.481 ± 0.056
2.594MetLeu: 2.594 ± 0.069
0.507MetMet: 0.507 ± 0.033
0.989MetAsn: 0.989 ± 0.044
1.068MetPro: 1.068 ± 0.042
1.508MetGln: 1.508 ± 0.056
1.009MetArg: 1.009 ± 0.044
1.323MetSer: 1.323 ± 0.054
0.731MetThr: 0.731 ± 0.036
1.362MetVal: 1.362 ± 0.057
0.128MetTrp: 0.128 ± 0.017
0.476MetTyr: 0.476 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
4.332AsnAla: 4.332 ± 0.111
0.515AsnCys: 0.515 ± 0.036
2.316AsnAsp: 2.316 ± 0.071
3.518AsnGlu: 3.518 ± 0.084
3.171AsnPhe: 3.171 ± 0.088
3.372AsnGly: 3.372 ± 0.105
1.151AsnHis: 1.151 ± 0.048
4.784AsnIle: 4.784 ± 0.103
4.008AsnLys: 4.008 ± 0.09
6.9AsnLeu: 6.9 ± 0.146
1.003AsnMet: 1.003 ± 0.047
2.892AsnAsn: 2.892 ± 0.091
2.928AsnPro: 2.928 ± 0.082
2.49AsnGln: 2.49 ± 0.074
1.724AsnArg: 1.724 ± 0.063
3.386AsnSer: 3.386 ± 0.097
2.687AsnThr: 2.687 ± 0.071
2.703AsnVal: 2.703 ± 0.081
0.355AsnTrp: 0.355 ± 0.028
2.174AsnTyr: 2.174 ± 0.08
0.0AsnXaa: 0.0 ± 0.0
Pro
1.467ProAla: 1.467 ± 0.053
0.322ProCys: 0.322 ± 0.028
1.198ProAsp: 1.198 ± 0.052
1.585ProGlu: 1.585 ± 0.066
1.99ProPhe: 1.99 ± 0.067
1.119ProGly: 1.119 ± 0.057
0.719ProHis: 0.719 ± 0.036
2.995ProIle: 2.995 ± 0.073
3.595ProLys: 3.595 ± 0.097
3.838ProLeu: 3.838 ± 0.094
0.665ProMet: 0.665 ± 0.035
2.316ProAsn: 2.316 ± 0.089
0.906ProPro: 0.906 ± 0.05
1.643ProGln: 1.643 ± 0.062
0.881ProArg: 0.881 ± 0.05
2.097ProSer: 2.097 ± 0.057
1.828ProThr: 1.828 ± 0.074
1.356ProVal: 1.356 ± 0.064
0.261ProTrp: 0.261 ± 0.021
1.475ProTyr: 1.475 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
2.43GlnAla: 2.43 ± 0.083
0.342GlnCys: 0.342 ± 0.027
2.111GlnAsp: 2.111 ± 0.072
4.024GlnGlu: 4.024 ± 0.132
1.281GlnPhe: 1.281 ± 0.055
2.034GlnGly: 2.034 ± 0.056
0.472GlnHis: 0.472 ± 0.028
3.562GlnIle: 3.562 ± 0.106
4.928GlnLys: 4.928 ± 0.119
2.492GlnLeu: 2.492 ± 0.079
0.924GlnMet: 0.924 ± 0.04
3.508GlnAsn: 3.508 ± 0.099
0.729GlnPro: 0.729 ± 0.037
1.305GlnGln: 1.305 ± 0.05
1.441GlnArg: 1.441 ± 0.054
2.78GlnSer: 2.78 ± 0.079
2.276GlnThr: 2.276 ± 0.065
1.662GlnVal: 1.662 ± 0.066
0.282GlnTrp: 0.282 ± 0.026
1.218GlnTyr: 1.218 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
2.093ArgAla: 2.093 ± 0.066
0.269ArgCys: 0.269 ± 0.023
1.923ArgAsp: 1.923 ± 0.059
3.023ArgGlu: 3.023 ± 0.072
2.018ArgPhe: 2.018 ± 0.074
2.026ArgGly: 2.026 ± 0.068
0.598ArgHis: 0.598 ± 0.035
3.351ArgIle: 3.351 ± 0.088
2.464ArgLys: 2.464 ± 0.075
3.216ArgLeu: 3.216 ± 0.088
0.798ArgMet: 0.798 ± 0.044
1.82ArgAsn: 1.82 ± 0.062
0.877ArgPro: 0.877 ± 0.05
1.165ArgGln: 1.165 ± 0.047
1.139ArgArg: 1.139 ± 0.054
1.793ArgSer: 1.793 ± 0.067
1.149ArgThr: 1.149 ± 0.054
2.178ArgVal: 2.178 ± 0.076
0.215ArgTrp: 0.215 ± 0.02
1.512ArgTyr: 1.512 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
3.874SerAla: 3.874 ± 0.099
0.677SerCys: 0.677 ± 0.044
2.592SerAsp: 2.592 ± 0.073
3.289SerGlu: 3.289 ± 0.077
3.907SerPhe: 3.907 ± 0.106
4.405SerGly: 4.405 ± 0.102
1.394SerHis: 1.394 ± 0.055
5.281SerIle: 5.281 ± 0.115
5.755SerLys: 5.755 ± 0.109
8.296SerLeu: 8.296 ± 0.155
1.382SerMet: 1.382 ± 0.055
3.491SerAsn: 3.491 ± 0.107
2.267SerPro: 2.267 ± 0.06
3.123SerGln: 3.123 ± 0.084
1.99SerArg: 1.99 ± 0.069
4.093SerSer: 4.093 ± 0.107
2.843SerThr: 2.843 ± 0.079
3.726SerVal: 3.726 ± 0.103
0.47SerTrp: 0.47 ± 0.03
2.75SerTyr: 2.75 ± 0.08
0.0SerXaa: 0.0 ± 0.0
Thr
2.509ThrAla: 2.509 ± 0.076
0.369ThrCys: 0.369 ± 0.028
1.668ThrAsp: 1.668 ± 0.06
1.923ThrGlu: 1.923 ± 0.067
2.363ThrPhe: 2.363 ± 0.07
2.306ThrGly: 2.306 ± 0.083
1.066ThrHis: 1.066 ± 0.049
3.901ThrIle: 3.901 ± 0.088
3.897ThrLys: 3.897 ± 0.092
6.411ThrLeu: 6.411 ± 0.106
0.9ThrMet: 0.9 ± 0.044
2.351ThrAsn: 2.351 ± 0.08
2.515ThrPro: 2.515 ± 0.085
2.892ThrGln: 2.892 ± 0.085
1.479ThrArg: 1.479 ± 0.056
2.815ThrSer: 2.815 ± 0.081
2.525ThrThr: 2.525 ± 0.077
0.685ThrVal: 0.685 ± 0.04
0.284ThrTrp: 0.284 ± 0.021
1.643ThrTyr: 1.643 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
4.091ValAla: 4.091 ± 0.11
0.861ValCys: 0.861 ± 0.044
2.719ValAsp: 2.719 ± 0.08
3.73ValGlu: 3.73 ± 0.105
2.946ValPhe: 2.946 ± 0.08
3.927ValGly: 3.927 ± 0.112
0.746ValHis: 0.746 ± 0.047
4.586ValIle: 4.586 ± 0.097
3.323ValLys: 3.323 ± 0.09
5.886ValLeu: 5.886 ± 0.132
1.244ValMet: 1.244 ± 0.048
2.407ValAsn: 2.407 ± 0.085
1.335ValPro: 1.335 ± 0.057
1.451ValGln: 1.451 ± 0.06
1.972ValArg: 1.972 ± 0.066
3.724ValSer: 3.724 ± 0.099
1.945ValThr: 1.945 ± 0.069
3.86ValVal: 3.86 ± 0.122
0.44ValTrp: 0.44 ± 0.028
1.809ValTyr: 1.809 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.444TrpAla: 0.444 ± 0.027
0.111TrpCys: 0.111 ± 0.015
0.411TrpAsp: 0.411 ± 0.027
0.531TrpGlu: 0.531 ± 0.034
0.346TrpPhe: 0.346 ± 0.031
0.549TrpGly: 0.549 ± 0.033
0.18TrpHis: 0.18 ± 0.018
0.744TrpIle: 0.744 ± 0.045
0.436TrpLys: 0.436 ± 0.03
0.9TrpLeu: 0.9 ± 0.049
0.174TrpMet: 0.174 ± 0.018
0.401TrpAsn: 0.401 ± 0.027
0.085TrpPro: 0.085 ± 0.012
0.361TrpGln: 0.361 ± 0.029
0.29TrpArg: 0.29 ± 0.025
0.357TrpSer: 0.357 ± 0.025
0.201TrpThr: 0.201 ± 0.023
0.46TrpVal: 0.46 ± 0.031
0.093TrpTrp: 0.093 ± 0.014
0.237TrpTyr: 0.237 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.511TyrAla: 2.511 ± 0.064
0.527TyrCys: 0.527 ± 0.037
1.917TyrAsp: 1.917 ± 0.061
2.665TyrGlu: 2.665 ± 0.07
2.464TyrPhe: 2.464 ± 0.081
2.624TyrGly: 2.624 ± 0.069
0.786TyrHis: 0.786 ± 0.036
2.363TyrIle: 2.363 ± 0.074
2.966TyrLys: 2.966 ± 0.084
3.984TyrLeu: 3.984 ± 0.097
0.588TyrMet: 0.588 ± 0.035
1.925TyrAsn: 1.925 ± 0.065
1.57TyrPro: 1.57 ± 0.058
1.834TyrGln: 1.834 ± 0.069
1.42TyrArg: 1.42 ± 0.054
2.304TyrSer: 2.304 ± 0.076
1.686TyrThr: 1.686 ± 0.063
1.635TyrVal: 1.635 ± 0.065
0.314TyrTrp: 0.314 ± 0.025
1.67TyrTyr: 1.67 ± 0.066
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.002XaaGln: 0.002 ± 0.002
0.0XaaArg: 0.0 ± 0.0
0.002XaaSer: 0.002 ± 0.002
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.219XaaXaa: 0.219 ± 0.187
Statistics based on 1535 proteins (493512 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski