Amino acid dipepetide frequency for Candidatus Nitrospira nitrosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.997AlaAla: 8.997 ± 0.112	1.036AlaCys: 1.036 ± 0.031	4.641AlaAsp: 4.641 ± 0.07	5.467AlaGlu: 5.467 ± 0.076	3.194AlaPhe: 3.194 ± 0.053	7.408AlaGly: 7.408 ± 0.096	2.099AlaHis: 2.099 ± 0.044	5.296AlaIle: 5.296 ± 0.059	4.216AlaLys: 4.216 ± 0.078	9.871AlaLeu: 9.871 ± 0.105	2.638AlaMet: 2.638 ± 0.045	2.425AlaAsn: 2.425 ± 0.049	3.626AlaPro: 3.626 ± 0.063	3.927AlaGln: 3.927 ± 0.064	5.587AlaArg: 5.587 ± 0.071	5.372AlaSer: 5.372 ± 0.069	5.18AlaThr: 5.18 ± 0.072	7.486AlaVal: 7.486 ± 0.094	1.248AlaTrp: 1.248 ± 0.034	2.297AlaTyr: 2.297 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.924CysAla: 0.924 ± 0.029	0.164CysCys: 0.164 ± 0.012	0.543CysAsp: 0.543 ± 0.024	0.505CysGlu: 0.505 ± 0.02	0.363CysPhe: 0.363 ± 0.015	0.967CysGly: 0.967 ± 0.029	0.376CysHis: 0.376 ± 0.021	0.458CysIle: 0.458 ± 0.019	0.366CysLys: 0.366 ± 0.019	1.095CysLeu: 1.095 ± 0.028	0.221CysMet: 0.221 ± 0.014	0.269CysAsn: 0.269 ± 0.016	0.557CysPro: 0.557 ± 0.025	0.406CysGln: 0.406 ± 0.018	0.805CysArg: 0.805 ± 0.027	0.675CysSer: 0.675 ± 0.025	0.549CysThr: 0.549 ± 0.023	0.731CysVal: 0.731 ± 0.025	0.139CysTrp: 0.139 ± 0.011	0.292CysTyr: 0.292 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.493AspAla: 4.493 ± 0.075	0.569AspCys: 0.569 ± 0.02	2.483AspAsp: 2.483 ± 0.066	3.23AspGlu: 3.23 ± 0.058	1.717AspPhe: 1.717 ± 0.039	4.245AspGly: 4.245 ± 0.081	1.413AspHis: 1.413 ± 0.034	2.713AspIle: 2.713 ± 0.051	1.676AspLys: 1.676 ± 0.046	5.9AspLeu: 5.9 ± 0.068	0.986AspMet: 0.986 ± 0.028	1.197AspAsn: 1.197 ± 0.037	3.093AspPro: 3.093 ± 0.057	2.327AspGln: 2.327 ± 0.046	4.051AspArg: 4.051 ± 0.061	2.684AspSer: 2.684 ± 0.062	2.617AspThr: 2.617 ± 0.071	4.047AspVal: 4.047 ± 0.067	0.816AspTrp: 0.816 ± 0.031	1.469AspTyr: 1.469 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	6.069GluAla: 6.069 ± 0.084	0.496GluCys: 0.496 ± 0.02	2.573GluAsp: 2.573 ± 0.047	3.781GluGlu: 3.781 ± 0.06	2.018GluPhe: 2.018 ± 0.04	4.207GluGly: 4.207 ± 0.069	1.456GluHis: 1.456 ± 0.033	3.326GluIle: 3.326 ± 0.053	2.591GluLys: 2.591 ± 0.061	6.087GluLeu: 6.087 ± 0.083	1.438GluMet: 1.438 ± 0.032	1.358GluAsn: 1.358 ± 0.031	2.485GluPro: 2.485 ± 0.049	3.364GluGln: 3.364 ± 0.065	4.84GluArg: 4.84 ± 0.087	3.539GluSer: 3.539 ± 0.061	3.287GluThr: 3.287 ± 0.049	4.209GluVal: 4.209 ± 0.07	0.864GluTrp: 0.864 ± 0.03	1.438GluTyr: 1.438 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.045PheAla: 3.045 ± 0.05	0.444PheCys: 0.444 ± 0.019	2.163PheAsp: 2.163 ± 0.049	2.008PheGlu: 2.008 ± 0.038	1.424PhePhe: 1.424 ± 0.035	3.025PheGly: 3.025 ± 0.058	0.935PheHis: 0.935 ± 0.028	1.731PheIle: 1.731 ± 0.036	1.267PheLys: 1.267 ± 0.035	3.924PheLeu: 3.924 ± 0.071	0.784PheMet: 0.784 ± 0.027	1.15PheAsn: 1.15 ± 0.038	1.73PhePro: 1.73 ± 0.041	1.314PheGln: 1.314 ± 0.033	2.257PheArg: 2.257 ± 0.046	2.542PheSer: 2.542 ± 0.047	2.228PheThr: 2.228 ± 0.052	2.675PheVal: 2.675 ± 0.044	0.496PheTrp: 0.496 ± 0.018	1.016PheTyr: 1.016 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	6.399GlyAla: 6.399 ± 0.094	1.0GlyCys: 1.0 ± 0.032	3.707GlyAsp: 3.707 ± 0.079	4.39GlyGlu: 4.39 ± 0.062	3.109GlyPhe: 3.109 ± 0.051	6.254GlyGly: 6.254 ± 0.108	1.91GlyHis: 1.91 ± 0.046	4.529GlyIle: 4.529 ± 0.067	3.703GlyLys: 3.703 ± 0.067	8.252GlyLeu: 8.252 ± 0.087	2.104GlyMet: 2.104 ± 0.043	2.509GlyAsn: 2.509 ± 0.1	2.907GlyPro: 2.907 ± 0.053	3.216GlyGln: 3.216 ± 0.057	4.99GlyArg: 4.99 ± 0.07	4.675GlySer: 4.675 ± 0.072	5.211GlyThr: 5.211 ± 0.116	5.832GlyVal: 5.832 ± 0.081	1.255GlyTrp: 1.255 ± 0.036	2.38GlyTyr: 2.38 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.267HisAla: 2.267 ± 0.04	0.323HisCys: 0.323 ± 0.018	1.328HisAsp: 1.328 ± 0.032	1.479HisGlu: 1.479 ± 0.038	0.85HisPhe: 0.85 ± 0.027	1.933HisGly: 1.933 ± 0.041	0.84HisHis: 0.84 ± 0.026	1.189HisIle: 1.189 ± 0.03	0.76HisLys: 0.76 ± 0.024	2.517HisLeu: 2.517 ± 0.049	0.516HisMet: 0.516 ± 0.021	0.605HisAsn: 0.605 ± 0.024	1.592HisPro: 1.592 ± 0.04	1.029HisGln: 1.029 ± 0.03	1.804HisArg: 1.804 ± 0.047	1.303HisSer: 1.303 ± 0.035	1.166HisThr: 1.166 ± 0.032	1.809HisVal: 1.809 ± 0.038	0.347HisTrp: 0.347 ± 0.016	0.703HisTyr: 0.703 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.119IleAla: 5.119 ± 0.068	0.517IleCys: 0.517 ± 0.019	3.149IleAsp: 3.149 ± 0.053	3.61IleGlu: 3.61 ± 0.057	1.687IlePhe: 1.687 ± 0.04	4.834IleGly: 4.834 ± 0.074	1.302IleHis: 1.302 ± 0.033	2.463IleIle: 2.463 ± 0.051	2.161IleLys: 2.161 ± 0.048	5.186IleLeu: 5.186 ± 0.073	0.999IleMet: 0.999 ± 0.029	1.572IleAsn: 1.572 ± 0.037	2.976IlePro: 2.976 ± 0.053	2.113IleGln: 2.113 ± 0.043	3.538IleArg: 3.538 ± 0.049	3.043IleSer: 3.043 ± 0.052	3.19IleThr: 3.19 ± 0.062	4.224IleVal: 4.224 ± 0.067	0.639IleTrp: 0.639 ± 0.023	1.169IleTyr: 1.169 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.926LysAla: 3.926 ± 0.076	0.265LysCys: 0.265 ± 0.017	2.343LysAsp: 2.343 ± 0.052	2.756LysGlu: 2.756 ± 0.06	1.132LysPhe: 1.132 ± 0.032	3.019LysGly: 3.019 ± 0.055	0.935LysHis: 0.935 ± 0.029	2.155LysIle: 2.155 ± 0.042	2.153LysLys: 2.153 ± 0.058	3.713LysLeu: 3.713 ± 0.068	0.98LysMet: 0.98 ± 0.032	1.19LysAsn: 1.19 ± 0.033	2.246LysPro: 2.246 ± 0.043	1.962LysGln: 1.962 ± 0.04	2.851LysArg: 2.851 ± 0.053	2.327LysSer: 2.327 ± 0.048	2.584LysThr: 2.584 ± 0.048	2.896LysVal: 2.896 ± 0.055	0.43LysTrp: 0.43 ± 0.019	0.913LysTyr: 0.913 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	10.425LeuAla: 10.425 ± 0.116	1.14LeuCys: 1.14 ± 0.031	5.532LeuAsp: 5.532 ± 0.076	5.921LeuGlu: 5.921 ± 0.076	3.884LeuPhe: 3.884 ± 0.066	7.512LeuGly: 7.512 ± 0.092	2.455LeuHis: 2.455 ± 0.048	5.305LeuIle: 5.305 ± 0.064	4.457LeuLys: 4.457 ± 0.063	11.05LeuLeu: 11.05 ± 0.135	2.391LeuMet: 2.391 ± 0.049	3.127LeuAsn: 3.127 ± 0.051	5.273LeuPro: 5.273 ± 0.069	3.966LeuGln: 3.966 ± 0.057	6.9LeuArg: 6.9 ± 0.09	7.252LeuSer: 7.252 ± 0.073	6.805LeuThr: 6.805 ± 0.103	7.897LeuVal: 7.897 ± 0.093	1.276LeuTrp: 1.276 ± 0.034	2.643LeuTyr: 2.643 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.565MetAla: 2.565 ± 0.049	0.174MetCys: 0.174 ± 0.011	1.161MetAsp: 1.161 ± 0.034	1.334MetGlu: 1.334 ± 0.033	0.698MetPhe: 0.698 ± 0.023	1.853MetGly: 1.853 ± 0.037	0.446MetHis: 0.446 ± 0.018	1.317MetIle: 1.317 ± 0.031	1.374MetLys: 1.374 ± 0.034	2.207MetLeu: 2.207 ± 0.042	0.685MetMet: 0.685 ± 0.025	0.898MetAsn: 0.898 ± 0.025	1.345MetPro: 1.345 ± 0.035	0.841MetGln: 0.841 ± 0.027	1.423MetArg: 1.423 ± 0.035	1.434MetSer: 1.434 ± 0.037	1.734MetThr: 1.734 ± 0.041	1.81MetVal: 1.81 ± 0.046	0.23MetTrp: 0.23 ± 0.013	0.452MetTyr: 0.452 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.36AsnAla: 2.36 ± 0.046	0.286AsnCys: 0.286 ± 0.015	1.514AsnAsp: 1.514 ± 0.069	1.423AsnGlu: 1.423 ± 0.033	1.01AsnPhe: 1.01 ± 0.032	2.637AsnGly: 2.637 ± 0.071	0.69AsnHis: 0.69 ± 0.024	1.382AsnIle: 1.382 ± 0.037	0.938AsnLys: 0.938 ± 0.028	3.029AsnLeu: 3.029 ± 0.054	0.61AsnMet: 0.61 ± 0.023	0.804AsnAsn: 0.804 ± 0.027	1.968AsnPro: 1.968 ± 0.041	1.253AsnGln: 1.253 ± 0.033	2.052AsnArg: 2.052 ± 0.037	1.531AsnSer: 1.531 ± 0.036	1.508AsnThr: 1.508 ± 0.04	2.115AsnVal: 2.115 ± 0.045	0.411AsnTrp: 0.411 ± 0.016	0.755AsnTyr: 0.755 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.19ProAla: 4.19 ± 0.061	0.452ProCys: 0.452 ± 0.02	2.962ProAsp: 2.962 ± 0.051	3.231ProGlu: 3.231 ± 0.054	1.986ProPhe: 1.986 ± 0.043	3.759ProGly: 3.759 ± 0.063	1.211ProHis: 1.211 ± 0.032	2.784ProIle: 2.784 ± 0.047	1.872ProLys: 1.872 ± 0.043	4.879ProLeu: 4.879 ± 0.07	1.205ProMet: 1.205 ± 0.027	1.564ProAsn: 1.564 ± 0.04	2.561ProPro: 2.561 ± 0.054	1.861ProGln: 1.861 ± 0.04	2.556ProArg: 2.556 ± 0.049	3.539ProSer: 3.539 ± 0.054	3.23ProThr: 3.23 ± 0.049	3.888ProVal: 3.888 ± 0.053	0.675ProTrp: 0.675 ± 0.026	1.318ProTyr: 1.318 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.651GlnAla: 4.651 ± 0.068	0.344GlnCys: 0.344 ± 0.019	2.068GlnAsp: 2.068 ± 0.04	2.614GlnGlu: 2.614 ± 0.051	1.453GlnPhe: 1.453 ± 0.039	3.049GlnGly: 3.049 ± 0.058	0.991GlnHis: 0.991 ± 0.024	2.152GlnIle: 2.152 ± 0.045	1.524GlnLys: 1.524 ± 0.04	4.279GlnLeu: 4.279 ± 0.067	0.925GlnMet: 0.925 ± 0.029	1.006GlnAsn: 1.006 ± 0.028	2.044GlnPro: 2.044 ± 0.037	2.13GlnGln: 2.13 ± 0.056	2.954GlnArg: 2.954 ± 0.058	2.484GlnSer: 2.484 ± 0.047	2.316GlnThr: 2.316 ± 0.044	3.214GlnVal: 3.214 ± 0.047	0.63GlnTrp: 0.63 ± 0.023	1.043GlnTyr: 1.043 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.509ArgAla: 5.509 ± 0.078	0.672ArgCys: 0.672 ± 0.023	3.313ArgAsp: 3.313 ± 0.048	4.337ArgGlu: 4.337 ± 0.069	2.701ArgPhe: 2.701 ± 0.048	4.112ArgGly: 4.112 ± 0.066	1.721ArgHis: 1.721 ± 0.041	3.752ArgIle: 3.752 ± 0.057	2.566ArgLys: 2.566 ± 0.048	7.687ArgLeu: 7.687 ± 0.094	1.809ArgMet: 1.809 ± 0.036	1.724ArgAsn: 1.724 ± 0.034	2.944ArgPro: 2.944 ± 0.045	3.049ArgGln: 3.049 ± 0.052	4.755ArgArg: 4.755 ± 0.08	3.922ArgSer: 3.922 ± 0.06	3.802ArgThr: 3.802 ± 0.059	4.979ArgVal: 4.979 ± 0.068	1.086ArgTrp: 1.086 ± 0.032	2.087ArgTyr: 2.087 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.24SerAla: 5.24 ± 0.072	0.658SerCys: 0.658 ± 0.027	3.148SerAsp: 3.148 ± 0.05	3.228SerGlu: 3.228 ± 0.058	2.331SerPhe: 2.331 ± 0.043	5.336SerGly: 5.336 ± 0.085	1.564SerHis: 1.564 ± 0.036	3.222SerIle: 3.222 ± 0.059	2.231SerLys: 2.231 ± 0.041	6.631SerLeu: 6.631 ± 0.082	1.573SerMet: 1.573 ± 0.037	1.665SerAsn: 1.665 ± 0.035	3.404SerPro: 3.404 ± 0.058	2.383SerGln: 2.383 ± 0.047	3.907SerArg: 3.907 ± 0.063	4.153SerSer: 4.153 ± 0.064	3.592SerThr: 3.592 ± 0.057	4.512SerVal: 4.512 ± 0.064	0.906SerTrp: 0.906 ± 0.025	1.526SerTyr: 1.526 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.477ThrAla: 5.477 ± 0.087	0.539ThrCys: 0.539 ± 0.019	3.065ThrAsp: 3.065 ± 0.066	3.097ThrGlu: 3.097 ± 0.052	2.341ThrPhe: 2.341 ± 0.052	5.181ThrGly: 5.181 ± 0.098	1.339ThrHis: 1.339 ± 0.035	3.728ThrIle: 3.728 ± 0.057	2.307ThrLys: 2.307 ± 0.044	6.388ThrLeu: 6.388 ± 0.093	1.371ThrMet: 1.371 ± 0.036	1.737ThrAsn: 1.737 ± 0.05	3.35ThrPro: 3.35 ± 0.056	2.06ThrGln: 2.06 ± 0.04	3.158ThrArg: 3.158 ± 0.053	3.511ThrSer: 3.511 ± 0.06	3.719ThrThr: 3.719 ± 0.066	5.293ThrVal: 5.293 ± 0.088	0.709ThrTrp: 0.709 ± 0.029	1.526ThrTyr: 1.526 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.08ValAla: 7.08 ± 0.075	0.821ValCys: 0.821 ± 0.027	3.837ValAsp: 3.837 ± 0.06	4.681ValGlu: 4.681 ± 0.075	2.604ValPhe: 2.604 ± 0.049	5.893ValGly: 5.893 ± 0.072	1.56ValHis: 1.56 ± 0.036	4.165ValIle: 4.165 ± 0.063	3.068ValLys: 3.068 ± 0.058	8.182ValLeu: 8.182 ± 0.084	1.932ValMet: 1.932 ± 0.033	2.239ValAsn: 2.239 ± 0.046	3.795ValPro: 3.795 ± 0.053	2.88ValGln: 2.88 ± 0.054	5.031ValArg: 5.031 ± 0.07	4.931ValSer: 4.931 ± 0.066	5.14ValThr: 5.14 ± 0.069	6.393ValVal: 6.393 ± 0.085	0.929ValTrp: 0.929 ± 0.03	1.716ValTyr: 1.716 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.089TrpAla: 1.089 ± 0.035	0.184TrpCys: 0.184 ± 0.011	0.667TrpAsp: 0.667 ± 0.027	0.799TrpGlu: 0.799 ± 0.028	0.576TrpPhe: 0.576 ± 0.021	0.927TrpGly: 0.927 ± 0.03	0.373TrpHis: 0.373 ± 0.017	0.768TrpIle: 0.768 ± 0.029	0.668TrpLys: 0.668 ± 0.024	1.537TrpLeu: 1.537 ± 0.038	0.36TrpMet: 0.36 ± 0.018	0.487TrpAsn: 0.487 ± 0.02	0.576TrpPro: 0.576 ± 0.023	0.575TrpGln: 0.575 ± 0.022	0.894TrpArg: 0.894 ± 0.028	0.867TrpSer: 0.867 ± 0.026	0.762TrpThr: 0.762 ± 0.028	0.991TrpVal: 0.991 ± 0.03	0.277TrpTrp: 0.277 ± 0.015	0.409TrpTyr: 0.409 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.188TyrAla: 2.188 ± 0.043	0.32TyrCys: 0.32 ± 0.015	1.527TyrAsp: 1.527 ± 0.04	1.533TyrGlu: 1.533 ± 0.04	1.079TyrPhe: 1.079 ± 0.031	2.179TyrGly: 2.179 ± 0.043	0.745TyrHis: 0.745 ± 0.024	1.055TyrIle: 1.055 ± 0.029	0.876TyrLys: 0.876 ± 0.031	2.797TyrLeu: 2.797 ± 0.048	0.455TyrMet: 0.455 ± 0.018	0.753TyrAsn: 0.753 ± 0.025	1.249TyrPro: 1.249 ± 0.035	1.218TyrGln: 1.218 ± 0.033	2.177TyrArg: 2.177 ± 0.041	1.428TyrSer: 1.428 ± 0.034	1.274TyrThr: 1.274 ± 0.038	1.877TyrVal: 1.877 ± 0.039	0.422TyrTrp: 0.422 ± 0.018	0.805TyrTyr: 0.805 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4245 proteins (1268829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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