Amino acid dipepetide frequency for Bilophila wadsworthia (strain 3_1_6)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.049AlaAla: 12.049 ± 0.149	1.673AlaCys: 1.673 ± 0.037	5.317AlaAsp: 5.317 ± 0.075	6.588AlaGlu: 6.588 ± 0.097	4.379AlaPhe: 4.379 ± 0.068	8.334AlaGly: 8.334 ± 0.095	1.877AlaHis: 1.877 ± 0.04	5.042AlaIle: 5.042 ± 0.075	4.156AlaLys: 4.156 ± 0.063	11.824AlaLeu: 11.824 ± 0.118	2.893AlaMet: 2.893 ± 0.05	2.551AlaAsn: 2.551 ± 0.045	4.441AlaPro: 4.441 ± 0.08	3.351AlaGln: 3.351 ± 0.056	6.095AlaArg: 6.095 ± 0.085	6.093AlaSer: 6.093 ± 0.091	4.426AlaThr: 4.426 ± 0.068	7.903AlaVal: 7.903 ± 0.093	1.301AlaTrp: 1.301 ± 0.034	2.568AlaTyr: 2.568 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.482CysAla: 1.482 ± 0.037	0.306CysCys: 0.306 ± 0.017	0.643CysAsp: 0.643 ± 0.024	0.714CysGlu: 0.714 ± 0.026	0.585CysPhe: 0.585 ± 0.024	1.666CysGly: 1.666 ± 0.045	0.368CysHis: 0.368 ± 0.029	0.785CysIle: 0.785 ± 0.028	0.474CysLys: 0.474 ± 0.02	1.497CysLeu: 1.497 ± 0.042	0.386CysMet: 0.386 ± 0.021	0.399CysAsn: 0.399 ± 0.019	1.009CysPro: 1.009 ± 0.033	0.349CysGln: 0.349 ± 0.018	1.025CysArg: 1.025 ± 0.03	0.889CysSer: 0.889 ± 0.027	0.762CysThr: 0.762 ± 0.029	1.079CysVal: 1.079 ± 0.038	0.188CysTrp: 0.188 ± 0.012	0.383CysTyr: 0.383 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.953AspAla: 5.953 ± 0.091	0.678AspCys: 0.678 ± 0.027	2.497AspAsp: 2.497 ± 0.058	3.341AspGlu: 3.341 ± 0.055	2.092AspPhe: 2.092 ± 0.042	4.53AspGly: 4.53 ± 0.091	0.834AspHis: 0.834 ± 0.024	3.27AspIle: 3.27 ± 0.057	2.288AspLys: 2.288 ± 0.051	4.817AspLeu: 4.817 ± 0.059	1.74AspMet: 1.74 ± 0.034	1.473AspAsn: 1.473 ± 0.034	2.73AspPro: 2.73 ± 0.055	1.177AspGln: 1.177 ± 0.03	2.945AspArg: 2.945 ± 0.062	2.404AspSer: 2.404 ± 0.044	2.728AspThr: 2.728 ± 0.078	4.119AspVal: 4.119 ± 0.057	0.804AspTrp: 0.804 ± 0.025	1.417AspTyr: 1.417 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.214GluAla: 7.214 ± 0.102	0.707GluCys: 0.707 ± 0.024	3.007GluAsp: 3.007 ± 0.061	4.333GluGlu: 4.333 ± 0.082	1.782GluPhe: 1.782 ± 0.045	4.646GluGly: 4.646 ± 0.077	1.435GluHis: 1.435 ± 0.037	3.141GluIle: 3.141 ± 0.06	3.359GluLys: 3.359 ± 0.061	6.388GluLeu: 6.388 ± 0.093	1.698GluMet: 1.698 ± 0.037	2.149GluAsn: 2.149 ± 0.039	2.542GluPro: 2.542 ± 0.057	2.578GluGln: 2.578 ± 0.046	4.814GluArg: 4.814 ± 0.097	3.135GluSer: 3.135 ± 0.051	3.448GluThr: 3.448 ± 0.062	3.652GluVal: 3.652 ± 0.056	0.775GluTrp: 0.775 ± 0.024	1.579GluTyr: 1.579 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.826PheAla: 3.826 ± 0.068	0.691PheCys: 0.691 ± 0.024	2.184PheAsp: 2.184 ± 0.043	2.025PheGlu: 2.025 ± 0.039	1.937PhePhe: 1.937 ± 0.06	3.537PheGly: 3.537 ± 0.056	0.829PheHis: 0.829 ± 0.027	2.124PheIle: 2.124 ± 0.053	1.351PheLys: 1.351 ± 0.037	4.211PheLeu: 4.211 ± 0.075	1.199PheMet: 1.199 ± 0.035	1.198PheAsn: 1.198 ± 0.029	2.026PhePro: 2.026 ± 0.041	1.079PheGln: 1.079 ± 0.027	2.449PheArg: 2.449 ± 0.046	2.886PheSer: 2.886 ± 0.056	2.325PheThr: 2.325 ± 0.055	2.757PheVal: 2.757 ± 0.05	0.589PheTrp: 0.589 ± 0.024	1.032PheTyr: 1.032 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	7.137GlyAla: 7.137 ± 0.11	1.458GlyCys: 1.458 ± 0.045	3.976GlyAsp: 3.976 ± 0.061	4.783GlyGlu: 4.783 ± 0.065	3.534GlyPhe: 3.534 ± 0.067	6.943GlyGly: 6.943 ± 0.111	1.704GlyHis: 1.704 ± 0.04	5.277GlyIle: 5.277 ± 0.083	4.577GlyLys: 4.577 ± 0.065	8.438GlyLeu: 8.438 ± 0.101	2.858GlyMet: 2.858 ± 0.048	2.714GlyAsn: 2.714 ± 0.063	2.744GlyPro: 2.744 ± 0.056	2.577GlyGln: 2.577 ± 0.052	4.811GlyArg: 4.811 ± 0.067	4.581GlySer: 4.581 ± 0.084	4.937GlyThr: 4.937 ± 0.119	6.284GlyVal: 6.284 ± 0.087	1.169GlyTrp: 1.169 ± 0.033	2.631GlyTyr: 2.631 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.927HisAla: 1.927 ± 0.035	0.354HisCys: 0.354 ± 0.019	1.091HisAsp: 1.091 ± 0.033	1.121HisGlu: 1.121 ± 0.035	0.892HisPhe: 0.892 ± 0.025	1.767HisGly: 1.767 ± 0.047	0.478HisHis: 0.478 ± 0.022	1.222HisIle: 1.222 ± 0.035	0.748HisLys: 0.748 ± 0.029	1.947HisLeu: 1.947 ± 0.04	0.563HisMet: 0.563 ± 0.023	0.627HisAsn: 0.627 ± 0.023	1.42HisPro: 1.42 ± 0.035	0.562HisGln: 0.562 ± 0.024	1.089HisArg: 1.089 ± 0.026	1.049HisSer: 1.049 ± 0.033	1.082HisThr: 1.082 ± 0.034	1.402HisVal: 1.402 ± 0.035	0.299HisTrp: 0.299 ± 0.015	0.582HisTyr: 0.582 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.504IleAla: 5.504 ± 0.074	0.789IleCys: 0.789 ± 0.026	2.661IleAsp: 2.661 ± 0.045	2.897IleGlu: 2.897 ± 0.057	1.896IlePhe: 1.896 ± 0.044	4.535IleGly: 4.535 ± 0.072	1.035IleHis: 1.035 ± 0.032	2.929IleIle: 2.929 ± 0.06	1.984IleLys: 1.984 ± 0.044	5.486IleLeu: 5.486 ± 0.07	1.428IleMet: 1.428 ± 0.037	1.744IleAsn: 1.744 ± 0.041	3.168IlePro: 3.168 ± 0.047	1.508IleGln: 1.508 ± 0.039	3.611IleArg: 3.611 ± 0.066	3.234IleSer: 3.234 ± 0.058	2.848IleThr: 2.848 ± 0.056	4.007IleVal: 4.007 ± 0.069	0.64IleTrp: 0.64 ± 0.024	1.245IleTyr: 1.245 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.894LysAla: 4.894 ± 0.069	0.4LysCys: 0.4 ± 0.02	2.471LysAsp: 2.471 ± 0.058	3.042LysGlu: 3.042 ± 0.056	1.031LysPhe: 1.031 ± 0.031	3.603LysGly: 3.603 ± 0.057	0.844LysHis: 0.844 ± 0.031	2.067LysIle: 2.067 ± 0.051	2.56LysLys: 2.56 ± 0.068	3.934LysLeu: 3.934 ± 0.059	1.253LysMet: 1.253 ± 0.037	1.526LysAsn: 1.526 ± 0.039	2.188LysPro: 2.188 ± 0.045	1.426LysGln: 1.426 ± 0.044	2.745LysArg: 2.745 ± 0.051	2.002LysSer: 2.002 ± 0.044	2.483LysThr: 2.483 ± 0.047	2.778LysVal: 2.778 ± 0.05	0.425LysTrp: 0.425 ± 0.019	1.122LysTyr: 1.122 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	11.208LeuAla: 11.208 ± 0.11	1.774LeuCys: 1.774 ± 0.043	5.644LeuAsp: 5.644 ± 0.092	6.542LeuGlu: 6.542 ± 0.099	4.679LeuPhe: 4.679 ± 0.079	8.14LeuGly: 8.14 ± 0.091	2.144LeuHis: 2.144 ± 0.043	4.917LeuIle: 4.917 ± 0.072	4.134LeuLys: 4.134 ± 0.06	11.2LeuLeu: 11.2 ± 0.13	2.669LeuMet: 2.669 ± 0.051	3.045LeuAsn: 3.045 ± 0.063	6.34LeuPro: 6.34 ± 0.089	2.823LeuGln: 2.823 ± 0.058	6.835LeuArg: 6.835 ± 0.091	7.171LeuSer: 7.171 ± 0.09	5.385LeuThr: 5.385 ± 0.102	6.782LeuVal: 6.782 ± 0.083	1.287LeuTrp: 1.287 ± 0.04	2.764LeuTyr: 2.764 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.876MetAla: 2.876 ± 0.051	0.281MetCys: 0.281 ± 0.016	1.66MetAsp: 1.66 ± 0.036	1.749MetGlu: 1.749 ± 0.033	0.887MetPhe: 0.887 ± 0.03	2.23MetGly: 2.23 ± 0.044	0.541MetHis: 0.541 ± 0.021	1.284MetIle: 1.284 ± 0.035	1.367MetLys: 1.367 ± 0.034	2.966MetLeu: 2.966 ± 0.053	0.717MetMet: 0.717 ± 0.029	1.029MetAsn: 1.029 ± 0.028	1.63MetPro: 1.63 ± 0.038	1.009MetGln: 1.009 ± 0.031	1.839MetArg: 1.839 ± 0.047	1.76MetSer: 1.76 ± 0.04	1.66MetThr: 1.66 ± 0.038	1.617MetVal: 1.617 ± 0.038	0.225MetTrp: 0.225 ± 0.013	0.56MetTyr: 0.56 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.286AsnAla: 3.286 ± 0.061	0.401AsnCys: 0.401 ± 0.019	1.439AsnAsp: 1.439 ± 0.044	1.535AsnGlu: 1.535 ± 0.035	1.009AsnPhe: 1.009 ± 0.029	2.663AsnGly: 2.663 ± 0.065	0.554AsnHis: 0.554 ± 0.021	2.076AsnIle: 2.076 ± 0.045	1.247AsnLys: 1.247 ± 0.037	2.985AsnLeu: 2.985 ± 0.047	0.986AsnMet: 0.986 ± 0.027	0.949AsnAsn: 0.949 ± 0.042	2.049AsnPro: 2.049 ± 0.043	0.75AsnGln: 0.75 ± 0.026	1.814AsnArg: 1.814 ± 0.04	1.353AsnSer: 1.353 ± 0.038	1.712AsnThr: 1.712 ± 0.044	2.234AsnVal: 2.234 ± 0.046	0.433AsnTrp: 0.433 ± 0.018	0.792AsnTyr: 0.792 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.118ProAla: 5.118 ± 0.089	0.692ProCys: 0.692 ± 0.026	3.535ProAsp: 3.535 ± 0.063	4.474ProGlu: 4.474 ± 0.059	2.224ProPhe: 2.224 ± 0.048	4.351ProGly: 4.351 ± 0.067	1.058ProHis: 1.058 ± 0.028	2.083ProIle: 2.083 ± 0.044	1.807ProLys: 1.807 ± 0.039	5.346ProLeu: 5.346 ± 0.086	1.123ProMet: 1.123 ± 0.03	1.305ProAsn: 1.305 ± 0.03	2.242ProPro: 2.242 ± 0.049	1.764ProGln: 1.764 ± 0.045	2.425ProArg: 2.425 ± 0.051	3.152ProSer: 3.152 ± 0.054	2.225ProThr: 2.225 ± 0.048	4.26ProVal: 4.26 ± 0.07	0.692ProTrp: 0.692 ± 0.026	1.437ProTyr: 1.437 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.456GlnAla: 3.456 ± 0.056	0.397GlnCys: 0.397 ± 0.021	1.499GlnAsp: 1.499 ± 0.036	2.085GlnGlu: 2.085 ± 0.045	1.036GlnPhe: 1.036 ± 0.028	2.618GlnGly: 2.618 ± 0.052	0.635GlnHis: 0.635 ± 0.025	1.612GlnIle: 1.612 ± 0.038	1.552GlnLys: 1.552 ± 0.04	2.86GlnLeu: 2.86 ± 0.048	0.815GlnMet: 0.815 ± 0.023	1.035GlnAsn: 1.035 ± 0.029	1.531GlnPro: 1.531 ± 0.044	1.228GlnGln: 1.228 ± 0.039	1.997GlnArg: 1.997 ± 0.039	1.72GlnSer: 1.72 ± 0.039	1.572GlnThr: 1.572 ± 0.043	1.946GlnVal: 1.946 ± 0.043	0.387GlnTrp: 0.387 ± 0.02	0.837GlnTyr: 0.837 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	5.372ArgAla: 5.372 ± 0.078	0.881ArgCys: 0.881 ± 0.031	3.137ArgAsp: 3.137 ± 0.062	4.724ArgGlu: 4.724 ± 0.083	2.677ArgPhe: 2.677 ± 0.048	4.04ArgGly: 4.04 ± 0.067	1.56ArgHis: 1.56 ± 0.043	3.689ArgIle: 3.689 ± 0.06	3.195ArgLys: 3.195 ± 0.055	6.87ArgLeu: 6.87 ± 0.095	1.897ArgMet: 1.897 ± 0.037	2.147ArgAsn: 2.147 ± 0.038	2.827ArgPro: 2.827 ± 0.055	2.293ArgGln: 2.293 ± 0.048	4.317ArgArg: 4.317 ± 0.074	3.194ArgSer: 3.194 ± 0.054	3.116ArgThr: 3.116 ± 0.059	4.033ArgVal: 4.033 ± 0.055	0.78ArgTrp: 0.78 ± 0.024	1.828ArgTyr: 1.828 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.526SerAla: 5.526 ± 0.078	0.905SerCys: 0.905 ± 0.03	2.742SerAsp: 2.742 ± 0.049	3.139SerGlu: 3.139 ± 0.048	2.523SerPhe: 2.523 ± 0.051	5.845SerGly: 5.845 ± 0.077	1.141SerHis: 1.141 ± 0.03	3.114SerIle: 3.114 ± 0.064	1.954SerLys: 1.954 ± 0.044	6.643SerLeu: 6.643 ± 0.083	1.585SerMet: 1.585 ± 0.037	1.467SerAsn: 1.467 ± 0.035	3.081SerPro: 3.081 ± 0.061	1.573SerGln: 1.573 ± 0.036	3.627SerArg: 3.627 ± 0.061	3.525SerSer: 3.525 ± 0.064	2.68SerThr: 2.68 ± 0.055	4.349SerVal: 4.349 ± 0.065	0.734SerTrp: 0.734 ± 0.025	1.458SerTyr: 1.458 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.271ThrAla: 5.271 ± 0.073	0.716ThrCys: 0.716 ± 0.028	2.597ThrAsp: 2.597 ± 0.069	2.796ThrGlu: 2.796 ± 0.044	2.275ThrPhe: 2.275 ± 0.052	4.982ThrGly: 4.982 ± 0.075	1.006ThrHis: 1.006 ± 0.029	2.781ThrIle: 2.781 ± 0.061	1.666ThrLys: 1.666 ± 0.04	6.243ThrLeu: 6.243 ± 0.148	1.104ThrMet: 1.104 ± 0.029	1.354ThrAsn: 1.354 ± 0.045	3.608ThrPro: 3.608 ± 0.051	1.387ThrGln: 1.387 ± 0.032	2.737ThrArg: 2.737 ± 0.05	2.703ThrSer: 2.703 ± 0.051	2.528ThrThr: 2.528 ± 0.048	4.222ThrVal: 4.222 ± 0.09	0.604ThrTrp: 0.604 ± 0.022	1.459ThrTyr: 1.459 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	6.886ValAla: 6.886 ± 0.087	1.244ValCys: 1.244 ± 0.033	3.694ValAsp: 3.694 ± 0.057	4.202ValGlu: 4.202 ± 0.062	3.182ValPhe: 3.182 ± 0.06	5.186ValGly: 5.186 ± 0.076	1.349ValHis: 1.349 ± 0.03	3.787ValIle: 3.787 ± 0.06	2.658ValLys: 2.658 ± 0.049	7.77ValLeu: 7.77 ± 0.083	1.946ValMet: 1.946 ± 0.036	2.174ValAsn: 2.174 ± 0.045	3.719ValPro: 3.719 ± 0.055	2.129ValGln: 2.129 ± 0.042	4.773ValArg: 4.773 ± 0.076	4.584ValSer: 4.584 ± 0.065	3.946ValThr: 3.946 ± 0.076	5.154ValVal: 5.154 ± 0.084	0.845ValTrp: 0.845 ± 0.03	1.805ValTyr: 1.805 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.03TrpAla: 1.03 ± 0.031	0.207TrpCys: 0.207 ± 0.013	0.626TrpAsp: 0.626 ± 0.024	0.789TrpGlu: 0.789 ± 0.026	0.564TrpPhe: 0.564 ± 0.023	0.976TrpGly: 0.976 ± 0.032	0.302TrpHis: 0.302 ± 0.017	0.687TrpIle: 0.687 ± 0.025	0.723TrpLys: 0.723 ± 0.025	1.459TrpLeu: 1.459 ± 0.041	0.369TrpMet: 0.369 ± 0.017	0.506TrpAsn: 0.506 ± 0.02	0.612TrpPro: 0.612 ± 0.025	0.464TrpGln: 0.464 ± 0.018	0.866TrpArg: 0.866 ± 0.027	0.687TrpSer: 0.687 ± 0.023	0.601TrpThr: 0.601 ± 0.024	0.722TrpVal: 0.722 ± 0.025	0.211TrpTrp: 0.211 ± 0.012	0.349TrpTyr: 0.349 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.846TyrAla: 2.846 ± 0.05	0.434TyrCys: 0.434 ± 0.021	1.418TyrAsp: 1.418 ± 0.035	1.504TyrGlu: 1.504 ± 0.037	1.071TyrPhe: 1.071 ± 0.034	2.541TyrGly: 2.541 ± 0.051	0.525TyrHis: 0.525 ± 0.02	1.262TyrIle: 1.262 ± 0.042	0.994TyrLys: 0.994 ± 0.029	2.6TyrLeu: 2.6 ± 0.049	0.657TyrMet: 0.657 ± 0.025	0.873TyrAsn: 0.873 ± 0.032	1.404TyrPro: 1.404 ± 0.036	0.791TyrGln: 0.791 ± 0.027	1.76TyrArg: 1.76 ± 0.046	1.492TyrSer: 1.492 ± 0.037	1.574TyrThr: 1.574 ± 0.07	1.738TyrVal: 1.738 ± 0.039	0.363TyrTrp: 0.363 ± 0.017	0.76TyrTyr: 0.76 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3779 proteins (1220490 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---