Amino acid dipepetide frequency for Streptomyces xiamenensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.48AlaAla: 22.48 ± 0.163
0.92AlaCys: 0.92 ± 0.022
8.313AlaAsp: 8.313 ± 0.082
9.104AlaGlu: 9.104 ± 0.081
3.335AlaPhe: 3.335 ± 0.05
14.344AlaGly: 14.344 ± 0.109
3.003AlaHis: 3.003 ± 0.049
3.701AlaIle: 3.701 ± 0.052
2.032AlaLys: 2.032 ± 0.045
15.406AlaLeu: 15.406 ± 0.148
2.451AlaMet: 2.451 ± 0.043
1.77AlaAsn: 1.77 ± 0.037
7.797AlaPro: 7.797 ± 0.104
3.761AlaGln: 3.761 ± 0.05
10.571AlaArg: 10.571 ± 0.093
5.232AlaSer: 5.232 ± 0.055
7.251AlaThr: 7.251 ± 0.075
11.769AlaVal: 11.769 ± 0.112
1.728AlaTrp: 1.728 ± 0.034
2.618AlaTyr: 2.618 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
1.113CysAla: 1.113 ± 0.027
0.098CysCys: 0.098 ± 0.008
0.472CysAsp: 0.472 ± 0.018
0.378CysGlu: 0.378 ± 0.017
0.198CysPhe: 0.198 ± 0.012
0.937CysGly: 0.937 ± 0.024
0.183CysHis: 0.183 ± 0.012
0.131CysIle: 0.131 ± 0.009
0.079CysLys: 0.079 ± 0.007
0.632CysLeu: 0.632 ± 0.021
0.106CysMet: 0.106 ± 0.009
0.111CysAsn: 0.111 ± 0.009
0.464CysPro: 0.464 ± 0.019
0.16CysGln: 0.16 ± 0.01
0.596CysArg: 0.596 ± 0.021
0.386CysSer: 0.386 ± 0.015
0.453CysThr: 0.453 ± 0.016
0.651CysVal: 0.651 ± 0.02
0.127CysTrp: 0.127 ± 0.009
0.158CysTyr: 0.158 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.653AspAla: 7.653 ± 0.071
0.388AspCys: 0.388 ± 0.015
3.167AspAsp: 3.167 ± 0.055
3.697AspGlu: 3.697 ± 0.05
1.597AspPhe: 1.597 ± 0.031
6.408AspGly: 6.408 ± 0.072
1.407AspHis: 1.407 ± 0.028
2.145AspIle: 2.145 ± 0.042
0.86AspLys: 0.86 ± 0.03
6.061AspLeu: 6.061 ± 0.06
0.756AspMet: 0.756 ± 0.021
0.898AspAsn: 0.898 ± 0.03
4.879AspPro: 4.879 ± 0.056
1.518AspGln: 1.518 ± 0.032
4.895AspArg: 4.895 ± 0.059
2.499AspSer: 2.499 ± 0.043
3.335AspThr: 3.335 ± 0.037
4.064AspVal: 4.064 ± 0.051
0.939AspTrp: 0.939 ± 0.021
1.082AspTyr: 1.082 ± 0.026
0.0AspXaa: 0.0 ± 0.0
Glu
7.498GluAla: 7.498 ± 0.091
0.347GluCys: 0.347 ± 0.014
3.055GluAsp: 3.055 ± 0.046
4.021GluGlu: 4.021 ± 0.075
1.508GluPhe: 1.508 ± 0.031
4.653GluGly: 4.653 ± 0.059
1.661GluHis: 1.661 ± 0.035
2.397GluIle: 2.397 ± 0.036
1.086GluLys: 1.086 ± 0.028
7.343GluLeu: 7.343 ± 0.076
0.894GluMet: 0.894 ± 0.024
1.133GluAsn: 1.133 ± 0.027
3.783GluPro: 3.783 ± 0.054
2.189GluGln: 2.189 ± 0.035
6.366GluArg: 6.366 ± 0.079
2.658GluSer: 2.658 ± 0.046
2.935GluThr: 2.935 ± 0.042
4.645GluVal: 4.645 ± 0.047
0.803GluTrp: 0.803 ± 0.02
1.08GluTyr: 1.08 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
3.616PheAla: 3.616 ± 0.05
0.234PheCys: 0.234 ± 0.011
1.876PheAsp: 1.876 ± 0.035
1.416PheGlu: 1.416 ± 0.033
0.861PhePhe: 0.861 ± 0.027
2.915PheGly: 2.915 ± 0.046
0.645PheHis: 0.645 ± 0.019
0.791PheIle: 0.791 ± 0.021
0.382PheLys: 0.382 ± 0.015
2.53PheLeu: 2.53 ± 0.044
0.403PheMet: 0.403 ± 0.017
0.529PheAsn: 0.529 ± 0.02
1.396PhePro: 1.396 ± 0.029
0.714PheGln: 0.714 ± 0.019
1.801PheArg: 1.801 ± 0.034
1.462PheSer: 1.462 ± 0.033
2.082PheThr: 2.082 ± 0.036
1.968PheVal: 1.968 ± 0.033
0.408PheTrp: 0.408 ± 0.015
0.532PheTyr: 0.532 ± 0.019
0.0PheXaa: 0.0 ± 0.0
Gly
11.876GlyAla: 11.876 ± 0.1
0.854GlyCys: 0.854 ± 0.024
5.348GlyAsp: 5.348 ± 0.058
6.065GlyGlu: 6.065 ± 0.069
2.831GlyPhe: 2.831 ± 0.045
9.599GlyGly: 9.599 ± 0.124
2.43GlyHis: 2.43 ± 0.04
3.533GlyIle: 3.533 ± 0.048
1.923GlyLys: 1.923 ± 0.033
9.318GlyLeu: 9.318 ± 0.077
2.092GlyMet: 2.092 ± 0.033
1.774GlyAsn: 1.774 ± 0.046
5.661GlyPro: 5.661 ± 0.074
2.795GlyGln: 2.795 ± 0.043
7.951GlyArg: 7.951 ± 0.077
5.28GlySer: 5.28 ± 0.06
6.622GlyThr: 6.622 ± 0.072
7.451GlyVal: 7.451 ± 0.074
1.76GlyTrp: 1.76 ± 0.03
2.376GlyTyr: 2.376 ± 0.035
0.0GlyXaa: 0.0 ± 0.0
His
2.684HisAla: 2.684 ± 0.043
0.201HisCys: 0.201 ± 0.01
1.31HisAsp: 1.31 ± 0.029
1.248HisGlu: 1.248 ± 0.03
0.639HisPhe: 0.639 ± 0.022
2.521HisGly: 2.521 ± 0.039
0.782HisHis: 0.782 ± 0.025
0.709HisIle: 0.709 ± 0.023
0.265HisLys: 0.265 ± 0.013
2.432HisLeu: 2.432 ± 0.045
0.333HisMet: 0.333 ± 0.014
0.394HisAsn: 0.394 ± 0.017
1.934HisPro: 1.934 ± 0.037
0.72HisGln: 0.72 ± 0.019
2.401HisArg: 2.401 ± 0.041
1.06HisSer: 1.06 ± 0.028
1.461HisThr: 1.461 ± 0.031
1.448HisVal: 1.448 ± 0.026
0.385HisTrp: 0.385 ± 0.016
0.482HisTyr: 0.482 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
4.995IleAla: 4.995 ± 0.061
0.299IleCys: 0.299 ± 0.014
2.382IleAsp: 2.382 ± 0.044
2.087IleGlu: 2.087 ± 0.04
0.806IlePhe: 0.806 ± 0.02
3.829IleGly: 3.829 ± 0.052
0.658IleHis: 0.658 ± 0.017
1.05IleIle: 1.05 ± 0.029
0.632IleLys: 0.632 ± 0.023
2.402IleLeu: 2.402 ± 0.04
0.473IleMet: 0.473 ± 0.017
0.746IleAsn: 0.746 ± 0.023
1.925IlePro: 1.925 ± 0.031
0.707IleGln: 0.707 ± 0.022
2.338IleArg: 2.338 ± 0.036
1.857IleSer: 1.857 ± 0.033
2.519IleThr: 2.519 ± 0.047
2.654IleVal: 2.654 ± 0.043
0.388IleTrp: 0.388 ± 0.015
0.526IleTyr: 0.526 ± 0.019
0.0IleXaa: 0.0 ± 0.0
Lys
1.956LysAla: 1.956 ± 0.04
0.076LysCys: 0.076 ± 0.007
0.969LysAsp: 0.969 ± 0.024
1.009LysGlu: 1.009 ± 0.027
0.338LysPhe: 0.338 ± 0.013
1.309LysGly: 1.309 ± 0.032
0.323LysHis: 0.323 ± 0.014
0.747LysIle: 0.747 ± 0.024
0.568LysLys: 0.568 ± 0.026
1.546LysLeu: 1.546 ± 0.033
0.305LysMet: 0.305 ± 0.016
0.387LysAsn: 0.387 ± 0.015
0.984LysPro: 0.984 ± 0.027
0.5LysGln: 0.5 ± 0.018
1.202LysArg: 1.202 ± 0.029
0.854LysSer: 0.854 ± 0.027
0.934LysThr: 0.934 ± 0.029
1.379LysVal: 1.379 ± 0.03
0.189LysTrp: 0.189 ± 0.01
0.311LysTyr: 0.311 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
15.609LeuAla: 15.609 ± 0.11
0.827LeuCys: 0.827 ± 0.024
6.407LeuAsp: 6.407 ± 0.063
5.056LeuGlu: 5.056 ± 0.069
2.556LeuPhe: 2.556 ± 0.046
9.398LeuGly: 9.398 ± 0.088
2.308LeuHis: 2.308 ± 0.046
3.8LeuIle: 3.8 ± 0.049
1.475LeuLys: 1.475 ± 0.032
12.19LeuLeu: 12.19 ± 0.118
1.68LeuMet: 1.68 ± 0.033
1.716LeuAsn: 1.716 ± 0.034
6.987LeuPro: 6.987 ± 0.078
1.944LeuGln: 1.944 ± 0.037
9.423LeuArg: 9.423 ± 0.089
5.54LeuSer: 5.54 ± 0.06
7.467LeuThr: 7.467 ± 0.076
8.18LeuVal: 8.18 ± 0.084
1.404LeuTrp: 1.404 ± 0.035
1.909LeuTyr: 1.909 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
2.294MetAla: 2.294 ± 0.039
0.128MetCys: 0.128 ± 0.008
0.859MetAsp: 0.859 ± 0.021
0.783MetGlu: 0.783 ± 0.02
0.426MetPhe: 0.426 ± 0.018
1.345MetGly: 1.345 ± 0.028
0.318MetHis: 0.318 ± 0.015
0.664MetIle: 0.664 ± 0.023
0.347MetLys: 0.347 ± 0.016
1.694MetLeu: 1.694 ± 0.037
0.327MetMet: 0.327 ± 0.013
0.446MetAsn: 0.446 ± 0.014
1.046MetPro: 1.046 ± 0.026
0.376MetGln: 0.376 ± 0.015
1.415MetArg: 1.415 ± 0.028
1.251MetSer: 1.251 ± 0.024
1.612MetThr: 1.612 ± 0.032
1.296MetVal: 1.296 ± 0.026
0.221MetTrp: 0.221 ± 0.01
0.34MetTyr: 0.34 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.08AsnAla: 2.08 ± 0.042
0.151AsnCys: 0.151 ± 0.009
0.963AsnAsp: 0.963 ± 0.023
0.846AsnGlu: 0.846 ± 0.026
0.477AsnPhe: 0.477 ± 0.018
1.841AsnGly: 1.841 ± 0.034
0.377AsnHis: 0.377 ± 0.016
0.658AsnIle: 0.658 ± 0.023
0.302AsnLys: 0.302 ± 0.013
1.564AsnLeu: 1.564 ± 0.039
0.304AsnMet: 0.304 ± 0.013
0.41AsnAsn: 0.41 ± 0.02
1.357AsnPro: 1.357 ± 0.032
0.483AsnGln: 0.483 ± 0.017
1.209AsnArg: 1.209 ± 0.026
0.887AsnSer: 0.887 ± 0.027
1.1AsnThr: 1.1 ± 0.028
1.248AsnVal: 1.248 ± 0.027
0.283AsnTrp: 0.283 ± 0.011
0.383AsnTyr: 0.383 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
9.579ProAla: 9.579 ± 0.117
0.335ProCys: 0.335 ± 0.014
4.538ProAsp: 4.538 ± 0.053
4.693ProGlu: 4.693 ± 0.053
1.562ProPhe: 1.562 ± 0.03
7.567ProGly: 7.567 ± 0.092
1.528ProHis: 1.528 ± 0.036
1.296ProIle: 1.296 ± 0.026
0.839ProLys: 0.839 ± 0.021
5.785ProLeu: 5.785 ± 0.069
1.032ProMet: 1.032 ± 0.025
0.832ProAsn: 0.832 ± 0.022
4.14ProPro: 4.14 ± 0.076
1.993ProGln: 1.993 ± 0.045
4.278ProArg: 4.278 ± 0.053
2.858ProSer: 2.858 ± 0.041
3.029ProThr: 3.029 ± 0.044
5.509ProVal: 5.509 ± 0.058
0.939ProTrp: 0.939 ± 0.023
1.39ProTyr: 1.39 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.364GlnAla: 3.364 ± 0.047
0.145GlnCys: 0.145 ± 0.011
1.469GlnAsp: 1.469 ± 0.028
1.658GlnGlu: 1.658 ± 0.031
0.651GlnPhe: 0.651 ± 0.019
2.228GlnGly: 2.228 ± 0.046
0.703GlnHis: 0.703 ± 0.021
1.055GlnIle: 1.055 ± 0.026
0.4GlnLys: 0.4 ± 0.017
3.279GlnLeu: 3.279 ± 0.045
0.444GlnMet: 0.444 ± 0.017
0.505GlnAsn: 0.505 ± 0.017
1.75GlnPro: 1.75 ± 0.047
1.25GlnGln: 1.25 ± 0.041
2.616GlnArg: 2.616 ± 0.046
1.172GlnSer: 1.172 ± 0.027
1.236GlnThr: 1.236 ± 0.027
2.253GlnVal: 2.253 ± 0.038
0.462GlnTrp: 0.462 ± 0.016
0.555GlnTyr: 0.555 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
10.653ArgAla: 10.653 ± 0.111
0.616ArgCys: 0.616 ± 0.022
4.477ArgAsp: 4.477 ± 0.06
5.53ArgGlu: 5.53 ± 0.062
2.274ArgPhe: 2.274 ± 0.037
6.246ArgGly: 6.246 ± 0.071
2.215ArgHis: 2.215 ± 0.041
3.235ArgIle: 3.235 ± 0.041
1.305ArgLys: 1.305 ± 0.031
9.2ArgLeu: 9.2 ± 0.093
1.788ArgMet: 1.788 ± 0.034
1.275ArgAsn: 1.275 ± 0.029
5.146ArgPro: 5.146 ± 0.07
2.431ArgGln: 2.431 ± 0.041
8.143ArgArg: 8.143 ± 0.103
3.831ArgSer: 3.831 ± 0.056
5.488ArgThr: 5.488 ± 0.066
6.04ArgVal: 6.04 ± 0.067
1.459ArgTrp: 1.459 ± 0.031
1.909ArgTyr: 1.909 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.356SerAla: 6.356 ± 0.061
0.4SerCys: 0.4 ± 0.015
2.513SerAsp: 2.513 ± 0.039
2.451SerGlu: 2.451 ± 0.041
1.495SerPhe: 1.495 ± 0.034
6.074SerGly: 6.074 ± 0.066
1.025SerHis: 1.025 ± 0.026
1.357SerIle: 1.357 ± 0.03
0.726SerLys: 0.726 ± 0.02
4.704SerLeu: 4.704 ± 0.052
1.013SerMet: 1.013 ± 0.024
0.782SerAsn: 0.782 ± 0.023
3.11SerPro: 3.11 ± 0.049
1.168SerGln: 1.168 ± 0.028
3.535SerArg: 3.535 ± 0.044
2.526SerSer: 2.526 ± 0.043
2.907SerThr: 2.907 ± 0.041
3.999SerVal: 3.999 ± 0.05
0.904SerTrp: 0.904 ± 0.024
1.119SerTyr: 1.119 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
9.315ThrAla: 9.315 ± 0.088
0.368ThrCys: 0.368 ± 0.017
3.629ThrAsp: 3.629 ± 0.045
3.541ThrGlu: 3.541 ± 0.058
1.643ThrPhe: 1.643 ± 0.032
7.162ThrGly: 7.162 ± 0.069
1.224ThrHis: 1.224 ± 0.029
1.757ThrIle: 1.757 ± 0.038
0.862ThrLys: 0.862 ± 0.022
6.08ThrLeu: 6.08 ± 0.072
0.937ThrMet: 0.937 ± 0.024
0.902ThrAsn: 0.902 ± 0.024
4.193ThrPro: 4.193 ± 0.065
1.326ThrGln: 1.326 ± 0.029
4.089ThrArg: 4.089 ± 0.045
2.859ThrSer: 2.859 ± 0.044
3.902ThrThr: 3.902 ± 0.055
6.297ThrVal: 6.297 ± 0.06
0.848ThrTrp: 0.848 ± 0.024
1.223ThrTyr: 1.223 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
10.088ValAla: 10.088 ± 0.09
0.733ValCys: 0.733 ± 0.021
4.284ValAsp: 4.284 ± 0.05
4.374ValGlu: 4.374 ± 0.055
2.293ValPhe: 2.293 ± 0.04
5.898ValGly: 5.898 ± 0.069
1.829ValHis: 1.829 ± 0.032
3.215ValIle: 3.215 ± 0.046
1.266ValLys: 1.266 ± 0.031
9.757ValLeu: 9.757 ± 0.091
1.336ValMet: 1.336 ± 0.03
1.567ValAsn: 1.567 ± 0.035
5.303ValPro: 5.303 ± 0.066
1.874ValGln: 1.874 ± 0.039
7.159ValArg: 7.159 ± 0.074
4.145ValSer: 4.145 ± 0.053
5.641ValThr: 5.641 ± 0.062
6.925ValVal: 6.925 ± 0.08
1.071ValTrp: 1.071 ± 0.027
1.467ValTyr: 1.467 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.626TrpAla: 1.626 ± 0.033
0.157TrpCys: 0.157 ± 0.009
0.823TrpAsp: 0.823 ± 0.02
0.822TrpGlu: 0.822 ± 0.024
0.471TrpPhe: 0.471 ± 0.016
1.053TrpGly: 1.053 ± 0.026
0.388TrpHis: 0.388 ± 0.016
0.523TrpIle: 0.523 ± 0.019
0.266TrpLys: 0.266 ± 0.014
1.817TrpLeu: 1.817 ± 0.037
0.294TrpMet: 0.294 ± 0.012
0.366TrpAsn: 0.366 ± 0.013
0.788TrpPro: 0.788 ± 0.023
0.64TrpGln: 0.64 ± 0.018
1.381TrpArg: 1.381 ± 0.033
0.951TrpSer: 0.951 ± 0.027
0.988TrpThr: 0.988 ± 0.022
0.975TrpVal: 0.975 ± 0.026
0.367TrpTrp: 0.367 ± 0.014
0.344TrpTyr: 0.344 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.751TyrAla: 2.751 ± 0.039
0.154TyrCys: 0.154 ± 0.009
1.394TyrAsp: 1.394 ± 0.033
1.275TyrGlu: 1.275 ± 0.026
0.599TyrPhe: 0.599 ± 0.017
2.212TyrGly: 2.212 ± 0.036
0.404TyrHis: 0.404 ± 0.014
0.509TyrIle: 0.509 ± 0.015
0.273TyrLys: 0.273 ± 0.012
2.136TyrLeu: 2.136 ± 0.039
0.217TyrMet: 0.217 ± 0.012
0.38TyrAsn: 0.38 ± 0.016
1.079TyrPro: 1.079 ± 0.024
0.646TyrGln: 0.646 ± 0.019
1.894TyrArg: 1.894 ± 0.034
0.856TyrSer: 0.856 ± 0.023
1.196TyrThr: 1.196 ± 0.031
1.476TyrVal: 1.476 ± 0.033
0.354TyrTrp: 0.354 ± 0.014
0.448TyrTyr: 0.448 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5490 proteins (1750436 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski