Amino acid dipepetide frequency for Parry s Lagoon virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.289AlaAla: 6.289 ± 1.705
0.497AlaCys: 0.497 ± 0.194
4.138AlaAsp: 4.138 ± 0.782
4.469AlaGlu: 4.469 ± 0.884
1.49AlaPhe: 1.49 ± 0.377
3.641AlaGly: 3.641 ± 1.252
2.152AlaHis: 2.152 ± 0.804
6.62AlaIle: 6.62 ± 1.37
3.972AlaLys: 3.972 ± 0.761
7.944AlaLeu: 7.944 ± 1.358
2.648AlaMet: 2.648 ± 0.904
2.317AlaAsn: 2.317 ± 0.492
3.31AlaPro: 3.31 ± 0.654
1.159AlaGln: 1.159 ± 0.508
4.303AlaArg: 4.303 ± 0.524
4.8AlaSer: 4.8 ± 0.726
4.634AlaThr: 4.634 ± 0.927
5.627AlaVal: 5.627 ± 1.13
1.159AlaTrp: 1.159 ± 0.523
1.986AlaTyr: 1.986 ± 0.41
0.0AlaXaa: 0.0 ± 0.0
Cys
0.662CysAla: 0.662 ± 0.373
0.0CysCys: 0.0 ± 0.0
0.331CysAsp: 0.331 ± 0.319
0.662CysGlu: 0.662 ± 0.365
0.166CysPhe: 0.166 ± 0.203
1.159CysGly: 1.159 ± 0.37
0.331CysHis: 0.331 ± 0.247
0.828CysIle: 0.828 ± 0.383
0.331CysLys: 0.331 ± 0.262
1.324CysLeu: 1.324 ± 0.644
0.331CysMet: 0.331 ± 0.214
0.497CysAsn: 0.497 ± 0.354
0.166CysPro: 0.166 ± 0.16
0.993CysGln: 0.993 ± 0.676
0.497CysArg: 0.497 ± 0.22
0.331CysSer: 0.331 ± 0.186
0.828CysThr: 0.828 ± 0.35
0.662CysVal: 0.662 ± 0.397
0.331CysTrp: 0.331 ± 0.203
0.497CysTyr: 0.497 ± 0.194
0.0CysXaa: 0.0 ± 0.0
Asp
4.138AspAla: 4.138 ± 0.715
0.828AspCys: 0.828 ± 0.325
5.296AspAsp: 5.296 ± 0.934
3.972AspGlu: 3.972 ± 0.977
2.317AspPhe: 2.317 ± 0.732
4.303AspGly: 4.303 ± 0.939
1.324AspHis: 1.324 ± 0.616
4.634AspIle: 4.634 ± 0.974
3.641AspLys: 3.641 ± 0.772
5.627AspLeu: 5.627 ± 0.817
2.814AspMet: 2.814 ± 0.807
1.49AspAsn: 1.49 ± 0.439
2.814AspPro: 2.814 ± 0.661
1.49AspGln: 1.49 ± 0.738
4.965AspArg: 4.965 ± 0.756
3.476AspSer: 3.476 ± 1.204
2.979AspThr: 2.979 ± 0.534
6.951AspVal: 6.951 ± 1.47
0.828AspTrp: 0.828 ± 0.489
2.317AspTyr: 2.317 ± 0.417
0.0AspXaa: 0.0 ± 0.0
Glu
4.138GluAla: 4.138 ± 1.038
0.331GluCys: 0.331 ± 0.209
4.634GluAsp: 4.634 ± 0.417
6.455GluGlu: 6.455 ± 1.36
1.986GluPhe: 1.986 ± 1.065
3.145GluGly: 3.145 ± 0.571
1.324GluHis: 1.324 ± 0.672
4.965GluIle: 4.965 ± 1.05
6.289GluLys: 6.289 ± 1.048
4.965GluLeu: 4.965 ± 0.866
1.655GluMet: 1.655 ± 0.347
1.324GluAsn: 1.324 ± 0.512
2.979GluPro: 2.979 ± 0.87
1.821GluGln: 1.821 ± 0.409
4.138GluArg: 4.138 ± 1.369
3.145GluSer: 3.145 ± 0.647
2.483GluThr: 2.483 ± 0.482
4.469GluVal: 4.469 ± 0.746
0.662GluTrp: 0.662 ± 0.407
2.648GluTyr: 2.648 ± 0.548
0.0GluXaa: 0.0 ± 0.0
Phe
2.483PheAla: 2.483 ± 0.769
1.159PheCys: 1.159 ± 0.403
1.821PheAsp: 1.821 ± 0.559
1.986PheGlu: 1.986 ± 0.356
1.655PhePhe: 1.655 ± 0.351
1.821PheGly: 1.821 ± 0.455
0.331PheHis: 0.331 ± 0.157
0.993PheIle: 0.993 ± 0.369
1.821PheLys: 1.821 ± 0.498
2.814PheLeu: 2.814 ± 0.656
0.828PheMet: 0.828 ± 0.311
1.159PheAsn: 1.159 ± 0.332
0.993PhePro: 0.993 ± 0.318
1.49PheGln: 1.49 ± 0.507
2.483PheArg: 2.483 ± 0.769
3.31PheSer: 3.31 ± 1.007
1.821PheThr: 1.821 ± 0.474
2.648PheVal: 2.648 ± 0.457
0.166PheTrp: 0.166 ± 0.203
1.986PheTyr: 1.986 ± 0.421
0.0PheXaa: 0.0 ± 0.0
Gly
3.476GlyAla: 3.476 ± 1.133
0.662GlyCys: 0.662 ± 0.284
4.469GlyAsp: 4.469 ± 1.025
4.138GlyGlu: 4.138 ± 0.968
2.152GlyPhe: 2.152 ± 0.599
3.641GlyGly: 3.641 ± 0.747
2.152GlyHis: 2.152 ± 0.963
2.648GlyIle: 2.648 ± 0.791
4.469GlyLys: 4.469 ± 0.964
4.138GlyLeu: 4.138 ± 0.403
2.648GlyMet: 2.648 ± 0.579
0.993GlyAsn: 0.993 ± 0.538
2.152GlyPro: 2.152 ± 0.788
1.324GlyGln: 1.324 ± 0.386
3.476GlyArg: 3.476 ± 1.027
4.8GlySer: 4.8 ± 0.982
2.483GlyThr: 2.483 ± 0.549
4.965GlyVal: 4.965 ± 1.217
0.331GlyTrp: 0.331 ± 0.203
3.807GlyTyr: 3.807 ± 0.835
0.0GlyXaa: 0.0 ± 0.0
His
2.648HisAla: 2.648 ± 0.513
0.166HisCys: 0.166 ± 0.162
1.821HisAsp: 1.821 ± 0.429
2.152HisGlu: 2.152 ± 0.678
0.497HisPhe: 0.497 ± 0.233
1.655HisGly: 1.655 ± 0.426
1.159HisHis: 1.159 ± 0.472
2.152HisIle: 2.152 ± 0.607
0.828HisLys: 0.828 ± 0.358
2.317HisLeu: 2.317 ± 0.71
0.497HisMet: 0.497 ± 0.281
1.49HisAsn: 1.49 ± 0.552
0.662HisPro: 0.662 ± 0.337
0.993HisGln: 0.993 ± 0.339
1.821HisArg: 1.821 ± 0.418
1.159HisSer: 1.159 ± 0.584
1.821HisThr: 1.821 ± 0.573
1.821HisVal: 1.821 ± 0.661
0.662HisTrp: 0.662 ± 0.256
0.331HisTyr: 0.331 ± 0.157
0.0HisXaa: 0.0 ± 0.0
Ile
3.641IleAla: 3.641 ± 1.061
0.993IleCys: 0.993 ± 0.321
4.303IleAsp: 4.303 ± 0.921
5.793IleGlu: 5.793 ± 0.703
1.655IlePhe: 1.655 ± 0.691
3.145IleGly: 3.145 ± 0.742
1.49IleHis: 1.49 ± 0.608
3.145IleIle: 3.145 ± 0.754
2.483IleLys: 2.483 ± 0.791
5.296IleLeu: 5.296 ± 0.828
1.821IleMet: 1.821 ± 0.507
2.152IleAsn: 2.152 ± 0.664
2.814IlePro: 2.814 ± 0.895
1.655IleGln: 1.655 ± 0.584
5.793IleArg: 5.793 ± 1.186
5.131IleSer: 5.131 ± 0.92
4.138IleThr: 4.138 ± 0.809
4.469IleVal: 4.469 ± 0.666
0.662IleTrp: 0.662 ± 0.237
1.986IleTyr: 1.986 ± 0.688
0.166IleXaa: 0.166 ± 0.203
Lys
3.972LysAla: 3.972 ± 1.173
0.497LysCys: 0.497 ± 0.244
3.807LysAsp: 3.807 ± 0.803
5.627LysGlu: 5.627 ± 1.132
1.986LysPhe: 1.986 ± 0.492
2.814LysGly: 2.814 ± 0.494
1.49LysHis: 1.49 ± 0.312
3.972LysIle: 3.972 ± 0.713
4.8LysLys: 4.8 ± 1.077
4.965LysLeu: 4.965 ± 1.07
1.159LysMet: 1.159 ± 0.439
3.145LysAsn: 3.145 ± 0.664
1.821LysPro: 1.821 ± 0.847
1.821LysGln: 1.821 ± 0.503
4.469LysArg: 4.469 ± 1.234
2.814LysSer: 2.814 ± 0.574
3.807LysThr: 3.807 ± 1.277
3.145LysVal: 3.145 ± 1.01
0.828LysTrp: 0.828 ± 0.422
1.986LysTyr: 1.986 ± 0.444
0.0LysXaa: 0.0 ± 0.0
Leu
6.786LeuAla: 6.786 ± 1.36
0.993LeuCys: 0.993 ± 0.484
4.138LeuAsp: 4.138 ± 0.933
4.303LeuGlu: 4.303 ± 0.751
2.979LeuPhe: 2.979 ± 0.719
3.972LeuGly: 3.972 ± 0.585
2.317LeuHis: 2.317 ± 0.321
4.469LeuIle: 4.469 ± 0.793
5.131LeuLys: 5.131 ± 0.869
6.786LeuLeu: 6.786 ± 1.097
2.317LeuMet: 2.317 ± 0.707
4.469LeuAsn: 4.469 ± 0.835
6.124LeuPro: 6.124 ± 0.908
3.476LeuGln: 3.476 ± 0.731
8.275LeuArg: 8.275 ± 1.482
6.951LeuSer: 6.951 ± 0.961
6.289LeuThr: 6.289 ± 0.678
3.641LeuVal: 3.641 ± 0.478
1.49LeuTrp: 1.49 ± 0.34
2.979LeuTyr: 2.979 ± 0.87
0.0LeuXaa: 0.0 ± 0.0
Met
3.31MetAla: 3.31 ± 0.828
0.497MetCys: 0.497 ± 0.194
2.317MetAsp: 2.317 ± 0.717
0.828MetGlu: 0.828 ± 0.324
0.993MetPhe: 0.993 ± 0.57
1.655MetGly: 1.655 ± 0.275
1.159MetHis: 1.159 ± 0.465
1.49MetIle: 1.49 ± 0.397
2.317MetLys: 2.317 ± 0.562
3.145MetLeu: 3.145 ± 0.5
1.324MetMet: 1.324 ± 0.491
1.159MetAsn: 1.159 ± 0.364
0.828MetPro: 0.828 ± 0.317
0.828MetGln: 0.828 ± 0.333
2.152MetArg: 2.152 ± 0.655
1.655MetSer: 1.655 ± 0.655
2.317MetThr: 2.317 ± 0.515
1.655MetVal: 1.655 ± 0.489
0.331MetTrp: 0.331 ± 0.35
1.655MetTyr: 1.655 ± 0.565
0.0MetXaa: 0.0 ± 0.0
Asn
3.807AsnAla: 3.807 ± 1.146
0.331AsnCys: 0.331 ± 0.186
1.655AsnAsp: 1.655 ± 0.454
1.986AsnGlu: 1.986 ± 0.534
2.648AsnPhe: 2.648 ± 0.733
2.152AsnGly: 2.152 ± 0.916
0.497AsnHis: 0.497 ± 0.297
3.145AsnIle: 3.145 ± 0.596
1.986AsnLys: 1.986 ± 0.541
2.648AsnLeu: 2.648 ± 0.542
0.993AsnMet: 0.993 ± 0.318
0.662AsnAsn: 0.662 ± 0.337
1.986AsnPro: 1.986 ± 0.83
1.821AsnGln: 1.821 ± 0.675
1.986AsnArg: 1.986 ± 0.595
1.986AsnSer: 1.986 ± 0.491
2.648AsnThr: 2.648 ± 0.841
2.979AsnVal: 2.979 ± 0.514
0.331AsnTrp: 0.331 ± 0.271
1.324AsnTyr: 1.324 ± 0.521
0.0AsnXaa: 0.0 ± 0.0
Pro
2.152ProAla: 2.152 ± 0.41
0.166ProCys: 0.166 ± 0.131
2.483ProAsp: 2.483 ± 0.526
3.807ProGlu: 3.807 ± 0.326
1.159ProPhe: 1.159 ± 0.465
2.814ProGly: 2.814 ± 0.502
1.324ProHis: 1.324 ± 0.405
2.483ProIle: 2.483 ± 0.687
2.152ProLys: 2.152 ± 1.568
3.807ProLeu: 3.807 ± 0.847
1.324ProMet: 1.324 ± 0.435
1.986ProAsn: 1.986 ± 0.707
2.648ProPro: 2.648 ± 0.735
1.655ProGln: 1.655 ± 0.844
1.986ProArg: 1.986 ± 0.414
1.324ProSer: 1.324 ± 0.322
3.641ProThr: 3.641 ± 0.613
1.49ProVal: 1.49 ± 0.599
0.662ProTrp: 0.662 ± 0.237
2.483ProTyr: 2.483 ± 0.605
0.0ProXaa: 0.0 ± 0.0
Gln
2.648GlnAla: 2.648 ± 0.513
0.662GlnCys: 0.662 ± 0.338
1.986GlnAsp: 1.986 ± 0.389
1.821GlnGlu: 1.821 ± 0.799
0.993GlnPhe: 0.993 ± 0.435
1.655GlnGly: 1.655 ± 0.571
1.49GlnHis: 1.49 ± 0.385
2.483GlnIle: 2.483 ± 0.579
2.483GlnLys: 2.483 ± 0.726
2.483GlnLeu: 2.483 ± 0.485
1.159GlnMet: 1.159 ± 0.254
1.324GlnAsn: 1.324 ± 0.399
1.324GlnPro: 1.324 ± 0.469
0.828GlnGln: 0.828 ± 0.492
2.483GlnArg: 2.483 ± 0.654
1.821GlnSer: 1.821 ± 0.641
1.159GlnThr: 1.159 ± 0.525
2.152GlnVal: 2.152 ± 0.461
0.662GlnTrp: 0.662 ± 0.491
0.662GlnTyr: 0.662 ± 0.507
0.0GlnXaa: 0.0 ± 0.0
Arg
5.462ArgAla: 5.462 ± 0.784
0.166ArgCys: 0.166 ± 0.16
5.131ArgAsp: 5.131 ± 0.987
3.145ArgGlu: 3.145 ± 0.981
2.648ArgPhe: 2.648 ± 0.645
4.8ArgGly: 4.8 ± 0.659
1.821ArgHis: 1.821 ± 0.462
3.972ArgIle: 3.972 ± 1.012
3.31ArgLys: 3.31 ± 0.553
5.296ArgLeu: 5.296 ± 0.818
2.648ArgMet: 2.648 ± 0.694
3.145ArgAsn: 3.145 ± 0.72
1.159ArgPro: 1.159 ± 0.305
2.317ArgGln: 2.317 ± 0.67
4.138ArgArg: 4.138 ± 0.804
6.124ArgSer: 6.124 ± 1.466
4.469ArgThr: 4.469 ± 0.407
5.958ArgVal: 5.958 ± 0.932
0.331ArgTrp: 0.331 ± 0.252
2.483ArgTyr: 2.483 ± 0.788
0.0ArgXaa: 0.0 ± 0.0
Ser
4.8SerAla: 4.8 ± 0.865
0.828SerCys: 0.828 ± 0.41
5.296SerAsp: 5.296 ± 0.863
3.972SerGlu: 3.972 ± 1.069
2.648SerPhe: 2.648 ± 0.734
3.807SerGly: 3.807 ± 1.019
1.821SerHis: 1.821 ± 0.505
4.965SerIle: 4.965 ± 0.452
4.303SerLys: 4.303 ± 0.622
7.117SerLeu: 7.117 ± 0.918
1.159SerMet: 1.159 ± 0.42
2.648SerAsn: 2.648 ± 0.579
0.828SerPro: 0.828 ± 0.477
1.986SerGln: 1.986 ± 0.665
3.807SerArg: 3.807 ± 0.963
3.641SerSer: 3.641 ± 1.104
3.641SerThr: 3.641 ± 0.652
4.469SerVal: 4.469 ± 0.661
0.662SerTrp: 0.662 ± 0.34
2.317SerTyr: 2.317 ± 0.463
0.0SerXaa: 0.0 ± 0.0
Thr
4.8ThrAla: 4.8 ± 1.417
1.159ThrCys: 1.159 ± 0.514
4.138ThrAsp: 4.138 ± 0.943
2.152ThrGlu: 2.152 ± 0.49
2.483ThrPhe: 2.483 ± 0.768
4.634ThrGly: 4.634 ± 0.738
1.159ThrHis: 1.159 ± 0.385
4.138ThrIle: 4.138 ± 0.933
2.814ThrLys: 2.814 ± 0.695
4.634ThrLeu: 4.634 ± 1.443
1.821ThrMet: 1.821 ± 0.646
2.317ThrAsn: 2.317 ± 1.03
3.641ThrPro: 3.641 ± 0.931
2.979ThrGln: 2.979 ± 0.712
4.303ThrArg: 4.303 ± 0.795
3.972ThrSer: 3.972 ± 0.892
2.152ThrThr: 2.152 ± 0.961
2.814ThrVal: 2.814 ± 0.717
0.993ThrTrp: 0.993 ± 0.672
2.317ThrTyr: 2.317 ± 1.03
0.0ThrXaa: 0.0 ± 0.0
Val
4.8ValAla: 4.8 ± 0.651
0.497ValCys: 0.497 ± 0.304
3.972ValAsp: 3.972 ± 0.532
3.641ValGlu: 3.641 ± 0.754
1.821ValPhe: 1.821 ± 0.317
4.8ValGly: 4.8 ± 1.239
1.655ValHis: 1.655 ± 0.513
3.476ValIle: 3.476 ± 0.645
3.972ValLys: 3.972 ± 1.199
7.117ValLeu: 7.117 ± 1.235
2.814ValMet: 2.814 ± 0.698
2.979ValAsn: 2.979 ± 0.533
3.807ValPro: 3.807 ± 0.669
2.317ValGln: 2.317 ± 0.524
4.303ValArg: 4.303 ± 0.832
4.8ValSer: 4.8 ± 1.022
4.8ValThr: 4.8 ± 0.726
6.124ValVal: 6.124 ± 1.228
0.331ValTrp: 0.331 ± 0.215
2.814ValTyr: 2.814 ± 0.718
0.0ValXaa: 0.0 ± 0.0
Trp
0.331TrpAla: 0.331 ± 0.217
0.166TrpCys: 0.166 ± 0.159
1.159TrpAsp: 1.159 ± 0.428
0.497TrpGlu: 0.497 ± 0.363
0.331TrpPhe: 0.331 ± 0.205
0.331TrpGly: 0.331 ± 0.324
0.828TrpHis: 0.828 ± 0.394
0.166TrpIle: 0.166 ± 0.175
1.159TrpLys: 1.159 ± 0.356
1.159TrpLeu: 1.159 ± 0.646
0.497TrpMet: 0.497 ± 0.346
0.662TrpAsn: 0.662 ± 0.479
0.497TrpPro: 0.497 ± 0.428
0.662TrpGln: 0.662 ± 0.325
0.662TrpArg: 0.662 ± 0.247
0.662TrpSer: 0.662 ± 0.402
0.331TrpThr: 0.331 ± 0.186
0.828TrpVal: 0.828 ± 0.465
0.166TrpTrp: 0.166 ± 0.175
0.828TrpTyr: 0.828 ± 0.24
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.814TyrAla: 2.814 ± 0.546
0.331TyrCys: 0.331 ± 0.217
3.31TyrAsp: 3.31 ± 0.582
2.152TyrGlu: 2.152 ± 0.64
1.159TyrPhe: 1.159 ± 0.324
2.979TyrGly: 2.979 ± 0.623
0.828TyrHis: 0.828 ± 0.23
1.821TyrIle: 1.821 ± 0.579
0.662TyrLys: 0.662 ± 0.446
4.469TyrLeu: 4.469 ± 0.856
0.993TyrMet: 0.993 ± 0.25
1.655TyrAsn: 1.655 ± 0.667
0.993TyrPro: 0.993 ± 0.418
0.662TyrGln: 0.662 ± 0.371
2.483TyrArg: 2.483 ± 0.592
2.814TyrSer: 2.814 ± 0.503
2.979TyrThr: 2.979 ± 0.799
3.972TyrVal: 3.972 ± 0.397
0.331TyrTrp: 0.331 ± 0.217
1.324TyrTyr: 1.324 ± 0.588
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.166XaaIle: 0.166 ± 0.203
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (6043 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski