Amino acid dipepetide frequency for Monaibacterium marinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.873AlaAla: 15.873 ± 0.183	1.049AlaCys: 1.049 ± 0.039	7.767AlaAsp: 7.767 ± 0.135	7.631AlaGlu: 7.631 ± 0.116	4.045AlaPhe: 4.045 ± 0.067	10.539AlaGly: 10.539 ± 0.195	2.256AlaHis: 2.256 ± 0.054	6.44AlaIle: 6.44 ± 0.089	3.329AlaLys: 3.329 ± 0.073	13.142AlaLeu: 13.142 ± 0.135	3.797AlaMet: 3.797 ± 0.078	2.984AlaAsn: 2.984 ± 0.052	5.447AlaPro: 5.447 ± 0.104	5.372AlaGln: 5.372 ± 0.09	8.012AlaArg: 8.012 ± 0.119	5.754AlaSer: 5.754 ± 0.097	6.676AlaThr: 6.676 ± 0.138	8.411AlaVal: 8.411 ± 0.102	1.336AlaTrp: 1.336 ± 0.038	2.422AlaTyr: 2.422 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.046CysAla: 1.046 ± 0.033	0.109CysCys: 0.109 ± 0.01	0.615CysAsp: 0.615 ± 0.028	0.468CysGlu: 0.468 ± 0.024	0.323CysPhe: 0.323 ± 0.018	0.923CysGly: 0.923 ± 0.035	0.221CysHis: 0.221 ± 0.014	0.457CysIle: 0.457 ± 0.022	0.203CysLys: 0.203 ± 0.014	0.804CysLeu: 0.804 ± 0.031	0.189CysMet: 0.189 ± 0.013	0.221CysAsn: 0.221 ± 0.014	0.466CysPro: 0.466 ± 0.021	0.227CysGln: 0.227 ± 0.014	0.478CysArg: 0.478 ± 0.023	0.438CysSer: 0.438 ± 0.023	0.511CysThr: 0.511 ± 0.023	0.639CysVal: 0.639 ± 0.026	0.107CysTrp: 0.107 ± 0.011	0.234CysTyr: 0.234 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.273AspAla: 8.273 ± 0.122	0.503AspCys: 0.503 ± 0.025	3.648AspAsp: 3.648 ± 0.103	3.576AspGlu: 3.576 ± 0.066	2.273AspPhe: 2.273 ± 0.042	6.045AspGly: 6.045 ± 0.127	1.375AspHis: 1.375 ± 0.039	3.556AspIle: 3.556 ± 0.073	1.361AspLys: 1.361 ± 0.039	6.572AspLeu: 6.572 ± 0.088	1.861AspMet: 1.861 ± 0.04	1.42AspAsn: 1.42 ± 0.051	3.4AspPro: 3.4 ± 0.054	2.007AspGln: 2.007 ± 0.042	4.135AspArg: 4.135 ± 0.068	2.594AspSer: 2.594 ± 0.064	3.349AspThr: 3.349 ± 0.114	4.847AspVal: 4.847 ± 0.105	1.14AspTrp: 1.14 ± 0.035	1.532AspTyr: 1.532 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.837GluAla: 6.837 ± 0.1	0.379GluCys: 0.379 ± 0.019	2.926GluAsp: 2.926 ± 0.054	3.157GluGlu: 3.157 ± 0.076	1.857GluPhe: 1.857 ± 0.045	4.455GluGly: 4.455 ± 0.067	1.159GluHis: 1.159 ± 0.036	3.587GluIle: 3.587 ± 0.059	1.724GluLys: 1.724 ± 0.049	5.273GluLeu: 5.273 ± 0.076	1.823GluMet: 1.823 ± 0.049	1.732GluAsn: 1.732 ± 0.048	2.325GluPro: 2.325 ± 0.062	2.318GluGln: 2.318 ± 0.049	4.037GluArg: 4.037 ± 0.077	2.154GluSer: 2.154 ± 0.048	3.499GluThr: 3.499 ± 0.051	4.207GluVal: 4.207 ± 0.069	0.741GluTrp: 0.741 ± 0.027	1.136GluTyr: 1.136 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.526PheAla: 4.526 ± 0.069	0.43PheCys: 0.43 ± 0.019	2.844PheAsp: 2.844 ± 0.053	2.136PheGlu: 2.136 ± 0.043	1.267PhePhe: 1.267 ± 0.04	3.587PheGly: 3.587 ± 0.064	0.705PheHis: 0.705 ± 0.026	1.76PheIle: 1.76 ± 0.046	0.821PheLys: 0.821 ± 0.031	3.199PheLeu: 3.199 ± 0.072	0.866PheMet: 0.866 ± 0.028	1.023PheAsn: 1.023 ± 0.03	1.425PhePro: 1.425 ± 0.04	0.965PheGln: 0.965 ± 0.029	1.947PheArg: 1.947 ± 0.048	2.152PheSer: 2.152 ± 0.052	2.285PheThr: 2.285 ± 0.055	2.693PheVal: 2.693 ± 0.053	0.541PheTrp: 0.541 ± 0.024	0.886PheTyr: 0.886 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.05GlyAla: 10.05 ± 0.192	0.833GlyCys: 0.833 ± 0.029	5.18GlyAsp: 5.18 ± 0.207	4.534GlyGlu: 4.534 ± 0.071	3.483GlyPhe: 3.483 ± 0.06	7.679GlyGly: 7.679 ± 0.212	1.891GlyHis: 1.891 ± 0.047	4.761GlyIle: 4.761 ± 0.083	2.656GlyLys: 2.656 ± 0.057	8.732GlyLeu: 8.732 ± 0.099	2.603GlyMet: 2.603 ± 0.052	2.335GlyAsn: 2.335 ± 0.094	3.421GlyPro: 3.421 ± 0.062	3.28GlyGln: 3.28 ± 0.063	5.316GlyArg: 5.316 ± 0.089	4.487GlySer: 4.487 ± 0.149	5.196GlyThr: 5.196 ± 0.148	6.639GlyVal: 6.639 ± 0.099	1.455GlyTrp: 1.455 ± 0.039	2.275GlyTyr: 2.275 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.359HisAla: 2.359 ± 0.052	0.211HisCys: 0.211 ± 0.013	1.384HisAsp: 1.384 ± 0.042	1.045HisGlu: 1.045 ± 0.036	0.754HisPhe: 0.754 ± 0.026	1.869HisGly: 1.869 ± 0.045	0.538HisHis: 0.538 ± 0.026	1.025HisIle: 1.025 ± 0.032	0.445HisLys: 0.445 ± 0.021	2.065HisLeu: 2.065 ± 0.048	0.6HisMet: 0.6 ± 0.025	0.482HisAsn: 0.482 ± 0.019	1.245HisPro: 1.245 ± 0.036	0.655HisGln: 0.655 ± 0.023	1.303HisArg: 1.303 ± 0.045	1.029HisSer: 1.029 ± 0.036	0.89HisThr: 0.89 ± 0.031	1.551HisVal: 1.551 ± 0.039	0.349HisTrp: 0.349 ± 0.018	0.551HisTyr: 0.551 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.966IleAla: 7.966 ± 0.093	0.687IleCys: 0.687 ± 0.027	3.701IleAsp: 3.701 ± 0.077	3.433IleGlu: 3.433 ± 0.064	1.754IlePhe: 1.754 ± 0.047	5.287IleGly: 5.287 ± 0.084	0.911IleHis: 0.911 ± 0.033	2.647IleIle: 2.647 ± 0.057	1.266IleLys: 1.266 ± 0.041	4.988IleLeu: 4.988 ± 0.082	1.153IleMet: 1.153 ± 0.033	1.544IleAsn: 1.544 ± 0.056	2.535IlePro: 2.535 ± 0.056	1.279IleGln: 1.279 ± 0.033	3.166IleArg: 3.166 ± 0.065	3.421IleSer: 3.421 ± 0.072	3.569IleThr: 3.569 ± 0.088	4.19IleVal: 4.19 ± 0.074	0.774IleTrp: 0.774 ± 0.032	1.266IleTyr: 1.266 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	2.941LysAla: 2.941 ± 0.06	0.17LysCys: 0.17 ± 0.013	1.334LysAsp: 1.334 ± 0.039	1.139LysGlu: 1.139 ± 0.038	0.915LysPhe: 0.915 ± 0.028	2.123LysGly: 2.123 ± 0.045	0.558LysHis: 0.558 ± 0.023	1.518LysIle: 1.518 ± 0.039	0.964LysLys: 0.964 ± 0.036	2.715LysLeu: 2.715 ± 0.053	0.819LysMet: 0.819 ± 0.029	0.679LysAsn: 0.679 ± 0.026	1.501LysPro: 1.501 ± 0.043	0.875LysGln: 0.875 ± 0.028	1.963LysArg: 1.963 ± 0.044	1.739LysSer: 1.739 ± 0.044	1.673LysThr: 1.673 ± 0.044	2.008LysVal: 2.008 ± 0.049	0.356LysTrp: 0.356 ± 0.018	0.586LysTyr: 0.586 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	11.869LeuAla: 11.869 ± 0.135	0.889LeuCys: 0.889 ± 0.032	6.433LeuAsp: 6.433 ± 0.089	4.848LeuGlu: 4.848 ± 0.077	3.451LeuPhe: 3.451 ± 0.081	8.18LeuGly: 8.18 ± 0.111	2.081LeuHis: 2.081 ± 0.048	5.661LeuIle: 5.661 ± 0.087	2.594LeuLys: 2.594 ± 0.062	8.541LeuLeu: 8.541 ± 0.141	2.789LeuMet: 2.789 ± 0.058	3.16LeuAsn: 3.16 ± 0.053	5.163LeuPro: 5.163 ± 0.096	2.828LeuGln: 2.828 ± 0.054	7.065LeuArg: 7.065 ± 0.114	6.905LeuSer: 6.905 ± 0.08	6.387LeuThr: 6.387 ± 0.089	6.409LeuVal: 6.409 ± 0.088	1.148LeuTrp: 1.148 ± 0.039	1.953LeuTyr: 1.953 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.475MetAla: 3.475 ± 0.058	0.191MetCys: 0.191 ± 0.013	1.581MetAsp: 1.581 ± 0.042	1.287MetGlu: 1.287 ± 0.033	0.89MetPhe: 0.89 ± 0.033	2.313MetGly: 2.313 ± 0.052	0.52MetHis: 0.52 ± 0.022	1.732MetIle: 1.732 ± 0.042	0.919MetLys: 0.919 ± 0.029	2.835MetLeu: 2.835 ± 0.057	0.853MetMet: 0.853 ± 0.034	0.905MetAsn: 0.905 ± 0.032	1.543MetPro: 1.543 ± 0.041	1.186MetGln: 1.186 ± 0.035	2.022MetArg: 2.022 ± 0.051	1.881MetSer: 1.881 ± 0.045	2.144MetThr: 2.144 ± 0.05	1.908MetVal: 1.908 ± 0.041	0.282MetTrp: 0.282 ± 0.018	0.367MetTyr: 0.367 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.577AsnAla: 3.577 ± 0.088	0.242AsnCys: 0.242 ± 0.015	1.673AsnAsp: 1.673 ± 0.077	1.252AsnGlu: 1.252 ± 0.034	1.015AsnPhe: 1.015 ± 0.03	2.605AsnGly: 2.605 ± 0.06	0.543AsnHis: 0.543 ± 0.021	1.563AsnIle: 1.563 ± 0.051	0.633AsnLys: 0.633 ± 0.024	2.714AsnLeu: 2.714 ± 0.048	0.771AsnMet: 0.771 ± 0.024	0.801AsnAsn: 0.801 ± 0.034	1.813AsnPro: 1.813 ± 0.041	0.747AsnGln: 0.747 ± 0.033	1.788AsnArg: 1.788 ± 0.044	1.391AsnSer: 1.391 ± 0.046	1.531AsnThr: 1.531 ± 0.05	2.1AsnVal: 2.1 ± 0.056	0.487AsnTrp: 0.487 ± 0.024	0.737AsnTyr: 0.737 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.33ProAla: 5.33 ± 0.093	0.317ProCys: 0.317 ± 0.017	3.988ProAsp: 3.988 ± 0.073	3.482ProGlu: 3.482 ± 0.083	1.874ProPhe: 1.874 ± 0.046	3.389ProGly: 3.389 ± 0.072	1.062ProHis: 1.062 ± 0.033	2.296ProIle: 2.296 ± 0.049	1.303ProLys: 1.303 ± 0.04	4.386ProLeu: 4.386 ± 0.068	1.343ProMet: 1.343 ± 0.04	1.409ProAsn: 1.409 ± 0.03	1.922ProPro: 1.922 ± 0.055	1.823ProGln: 1.823 ± 0.045	2.67ProArg: 2.67 ± 0.061	2.475ProSer: 2.475 ± 0.061	2.661ProThr: 2.661 ± 0.06	4.22ProVal: 4.22 ± 0.081	0.64ProTrp: 0.64 ± 0.026	1.107ProTyr: 1.107 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.408GlnAla: 4.408 ± 0.068	0.268GlnCys: 0.268 ± 0.017	2.004GlnAsp: 2.004 ± 0.049	1.541GlnGlu: 1.541 ± 0.044	1.162GlnPhe: 1.162 ± 0.034	2.98GlnGly: 2.98 ± 0.053	0.74GlnHis: 0.74 ± 0.031	2.313GlnIle: 2.313 ± 0.048	0.88GlnLys: 0.88 ± 0.032	3.01GlnLeu: 3.01 ± 0.056	1.252GlnMet: 1.252 ± 0.038	1.051GlnAsn: 1.051 ± 0.03	1.711GlnPro: 1.711 ± 0.042	1.485GlnGln: 1.485 ± 0.039	2.5GlnArg: 2.5 ± 0.052	1.908GlnSer: 1.908 ± 0.041	1.925GlnThr: 1.925 ± 0.043	2.718GlnVal: 2.718 ± 0.058	0.415GlnTrp: 0.415 ± 0.02	0.584GlnTyr: 0.584 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.765ArgAla: 7.765 ± 0.099	0.486ArgCys: 0.486 ± 0.023	4.468ArgAsp: 4.468 ± 0.082	3.578ArgGlu: 3.578 ± 0.076	2.409ArgPhe: 2.409 ± 0.055	4.635ArgGly: 4.635 ± 0.077	1.416ArgHis: 1.416 ± 0.043	3.924ArgIle: 3.924 ± 0.066	1.961ArgLys: 1.961 ± 0.044	6.654ArgLeu: 6.654 ± 0.119	2.062ArgMet: 2.062 ± 0.053	1.896ArgAsn: 1.896 ± 0.047	2.912ArgPro: 2.912 ± 0.07	2.24ArgGln: 2.24 ± 0.051	4.447ArgArg: 4.447 ± 0.09	3.254ArgSer: 3.254 ± 0.055	3.319ArgThr: 3.319 ± 0.051	4.583ArgVal: 4.583 ± 0.073	0.832ArgTrp: 0.832 ± 0.028	1.478ArgTyr: 1.478 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.172SerAla: 6.172 ± 0.098	0.431SerCys: 0.431 ± 0.021	3.549SerAsp: 3.549 ± 0.076	2.685SerGlu: 2.685 ± 0.053	2.355SerPhe: 2.355 ± 0.043	5.732SerGly: 5.732 ± 0.131	1.051SerHis: 1.051 ± 0.034	3.015SerIle: 3.015 ± 0.066	1.378SerLys: 1.378 ± 0.038	5.129SerLeu: 5.129 ± 0.083	1.453SerMet: 1.453 ± 0.039	1.621SerAsn: 1.621 ± 0.057	2.399SerPro: 2.399 ± 0.045	1.729SerGln: 1.729 ± 0.039	3.206SerArg: 3.206 ± 0.051	2.856SerSer: 2.856 ± 0.066	3.044SerThr: 3.044 ± 0.096	4.088SerVal: 4.088 ± 0.09	0.695SerTrp: 0.695 ± 0.024	1.389SerTyr: 1.389 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.953ThrAla: 6.953 ± 0.139	0.572ThrCys: 0.572 ± 0.025	3.691ThrAsp: 3.691 ± 0.075	2.825ThrGlu: 2.825 ± 0.053	2.108ThrPhe: 2.108 ± 0.044	5.815ThrGly: 5.815 ± 0.182	1.147ThrHis: 1.147 ± 0.034	3.166ThrIle: 3.166 ± 0.088	1.358ThrLys: 1.358 ± 0.035	6.54ThrLeu: 6.54 ± 0.084	1.429ThrMet: 1.429 ± 0.04	1.517ThrAsn: 1.517 ± 0.057	3.437ThrPro: 3.437 ± 0.068	2.002ThrGln: 2.002 ± 0.043	3.374ThrArg: 3.374 ± 0.057	3.049ThrSer: 3.049 ± 0.092	3.444ThrThr: 3.444 ± 0.127	4.803ThrVal: 4.803 ± 0.121	0.659ThrTrp: 0.659 ± 0.027	1.359ThrTyr: 1.359 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.038ValAla: 9.038 ± 0.105	0.551ValCys: 0.551 ± 0.021	4.306ValAsp: 4.306 ± 0.068	4.941ValGlu: 4.941 ± 0.082	2.698ValPhe: 2.698 ± 0.062	5.676ValGly: 5.676 ± 0.089	1.342ValHis: 1.342 ± 0.035	4.358ValIle: 4.358 ± 0.078	1.904ValLys: 1.904 ± 0.046	7.374ValLeu: 7.374 ± 0.096	2.241ValMet: 2.241 ± 0.047	2.181ValAsn: 2.181 ± 0.055	3.355ValPro: 3.355 ± 0.059	2.464ValGln: 2.464 ± 0.045	4.33ValArg: 4.33 ± 0.066	4.383ValSer: 4.383 ± 0.101	5.064ValThr: 5.064 ± 0.153	5.754ValVal: 5.754 ± 0.08	0.851ValTrp: 0.851 ± 0.029	1.385ValTyr: 1.385 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.276TrpAla: 1.276 ± 0.038	0.132TrpCys: 0.132 ± 0.011	0.754TrpAsp: 0.754 ± 0.027	0.55TrpGlu: 0.55 ± 0.023	0.548TrpPhe: 0.548 ± 0.021	0.954TrpGly: 0.954 ± 0.034	0.356TrpHis: 0.356 ± 0.02	0.712TrpIle: 0.712 ± 0.025	0.369TrpLys: 0.369 ± 0.019	1.539TrpLeu: 1.539 ± 0.041	0.423TrpMet: 0.423 ± 0.02	0.405TrpAsn: 0.405 ± 0.021	0.65TrpPro: 0.65 ± 0.026	0.642TrpGln: 0.642 ± 0.03	1.053TrpArg: 1.053 ± 0.038	0.854TrpSer: 0.854 ± 0.031	0.774TrpThr: 0.774 ± 0.024	0.892TrpVal: 0.892 ± 0.029	0.237TrpTrp: 0.237 ± 0.014	0.268TrpTyr: 0.268 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.551TyrAla: 2.551 ± 0.049	0.228TyrCys: 0.228 ± 0.014	1.623TyrAsp: 1.623 ± 0.036	1.217TyrGlu: 1.217 ± 0.036	0.876TyrPhe: 0.876 ± 0.028	2.021TyrGly: 2.021 ± 0.052	0.48TyrHis: 0.48 ± 0.023	1.044TyrIle: 1.044 ± 0.032	0.505TyrLys: 0.505 ± 0.022	2.144TyrLeu: 2.144 ± 0.046	0.505TyrMet: 0.505 ± 0.021	0.615TyrAsn: 0.615 ± 0.027	1.024TyrPro: 1.024 ± 0.032	0.734TyrGln: 0.734 ± 0.025	1.506TyrArg: 1.506 ± 0.044	1.252TyrSer: 1.252 ± 0.039	1.31TyrThr: 1.31 ± 0.032	1.535TyrVal: 1.535 ± 0.038	0.343TyrTrp: 0.343 ± 0.018	0.548TyrTyr: 0.548 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3548 proteins (1142599 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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