Amino acid dipepetide frequency for Legionella jordanis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.886AlaAla: 6.886 ± 0.122	1.134AlaCys: 1.134 ± 0.04	3.527AlaAsp: 3.527 ± 0.065	4.856AlaGlu: 4.856 ± 0.078	3.543AlaPhe: 3.543 ± 0.066	5.101AlaGly: 5.101 ± 0.106	1.844AlaHis: 1.844 ± 0.042	6.338AlaIle: 6.338 ± 0.092	5.073AlaLys: 5.073 ± 0.08	9.665AlaLeu: 9.665 ± 0.128	2.235AlaMet: 2.235 ± 0.051	3.671AlaAsn: 3.671 ± 0.075	2.525AlaPro: 2.525 ± 0.058	3.756AlaGln: 3.756 ± 0.085	3.537AlaArg: 3.537 ± 0.064	5.157AlaSer: 5.157 ± 0.091	3.644AlaThr: 3.644 ± 0.071	5.211AlaVal: 5.211 ± 0.081	0.835AlaTrp: 0.835 ± 0.032	2.582AlaTyr: 2.582 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.843CysAla: 0.843 ± 0.034	0.222CysCys: 0.222 ± 0.015	0.573CysAsp: 0.573 ± 0.025	0.697CysGlu: 0.697 ± 0.03	0.729CysPhe: 0.729 ± 0.03	0.897CysGly: 0.897 ± 0.034	0.365CysHis: 0.365 ± 0.019	0.811CysIle: 0.811 ± 0.029	0.562CysLys: 0.562 ± 0.028	1.457CysLeu: 1.457 ± 0.039	0.277CysMet: 0.277 ± 0.018	0.451CysAsn: 0.451 ± 0.022	0.528CysPro: 0.528 ± 0.027	0.588CysGln: 0.588 ± 0.024	0.534CysArg: 0.534 ± 0.023	0.826CysSer: 0.826 ± 0.036	0.487CysThr: 0.487 ± 0.025	0.659CysVal: 0.659 ± 0.029	0.139CysTrp: 0.139 ± 0.013	0.49CysTyr: 0.49 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	3.484AspAla: 3.484 ± 0.073	0.638AspCys: 0.638 ± 0.026	2.219AspAsp: 2.219 ± 0.057	3.627AspGlu: 3.627 ± 0.065	2.481AspPhe: 2.481 ± 0.053	2.504AspGly: 2.504 ± 0.056	1.015AspHis: 1.015 ± 0.037	3.228AspIle: 3.228 ± 0.061	3.054AspLys: 3.054 ± 0.068	5.196AspLeu: 5.196 ± 0.061	1.047AspMet: 1.047 ± 0.035	2.181AspAsn: 2.181 ± 0.044	1.863AspPro: 1.863 ± 0.042	1.482AspGln: 1.482 ± 0.045	1.927AspArg: 1.927 ± 0.043	3.079AspSer: 3.079 ± 0.058	1.592AspThr: 1.592 ± 0.043	3.0AspVal: 3.0 ± 0.061	0.722AspTrp: 0.722 ± 0.027	2.07AspTyr: 2.07 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	4.973GluAla: 4.973 ± 0.082	0.595GluCys: 0.595 ± 0.023	2.724GluAsp: 2.724 ± 0.052	4.627GluGlu: 4.627 ± 0.109	2.515GluPhe: 2.515 ± 0.055	3.216GluGly: 3.216 ± 0.06	1.754GluHis: 1.754 ± 0.044	4.452GluIle: 4.452 ± 0.075	4.242GluLys: 4.242 ± 0.085	7.032GluLeu: 7.032 ± 0.111	1.481GluMet: 1.481 ± 0.047	2.872GluAsn: 2.872 ± 0.055	1.963GluPro: 1.963 ± 0.049	3.906GluGln: 3.906 ± 0.067	3.192GluArg: 3.192 ± 0.072	3.311GluSer: 3.311 ± 0.062	2.911GluThr: 2.911 ± 0.054	3.66GluVal: 3.66 ± 0.072	0.652GluTrp: 0.652 ± 0.028	1.728GluTyr: 1.728 ± 0.043	0.001GluXaa: 0.001 ± 0.001
Phe	3.642PheAla: 3.642 ± 0.063	0.688PheCys: 0.688 ± 0.027	2.312PheAsp: 2.312 ± 0.052	2.512PheGlu: 2.512 ± 0.059	2.557PhePhe: 2.557 ± 0.064	2.747PheGly: 2.747 ± 0.06	1.065PheHis: 1.065 ± 0.04	3.447PheIle: 3.447 ± 0.066	2.605PheLys: 2.605 ± 0.055	5.108PheLeu: 5.108 ± 0.091	1.035PheMet: 1.035 ± 0.036	2.49PheAsn: 2.49 ± 0.062	1.91PhePro: 1.91 ± 0.04	1.695PheGln: 1.695 ± 0.038	1.779PheArg: 1.779 ± 0.043	3.685PheSer: 3.685 ± 0.07	2.161PheThr: 2.161 ± 0.05	2.426PheVal: 2.426 ± 0.053	0.594PheTrp: 0.594 ± 0.027	1.732PheTyr: 1.732 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.168GlyAla: 4.168 ± 0.091	0.808GlyCys: 0.808 ± 0.035	2.675GlyAsp: 2.675 ± 0.056	3.433GlyGlu: 3.433 ± 0.066	3.353GlyPhe: 3.353 ± 0.069	3.921GlyGly: 3.921 ± 0.094	1.623GlyHis: 1.623 ± 0.041	4.671GlyIle: 4.671 ± 0.075	3.824GlyLys: 3.824 ± 0.072	6.873GlyLeu: 6.873 ± 0.104	1.534GlyMet: 1.534 ± 0.043	2.43GlyAsn: 2.43 ± 0.054	1.729GlyPro: 1.729 ± 0.048	2.728GlyGln: 2.728 ± 0.065	2.729GlyArg: 2.729 ± 0.063	3.768GlySer: 3.768 ± 0.077	2.832GlyThr: 2.832 ± 0.071	3.874GlyVal: 3.874 ± 0.076	0.863GlyTrp: 0.863 ± 0.033	2.336GlyTyr: 2.336 ± 0.051	0.001GlyXaa: 0.001 ± 0.001
His	1.881HisAla: 1.881 ± 0.047	0.417HisCys: 0.417 ± 0.023	1.094HisAsp: 1.094 ± 0.031	1.496HisGlu: 1.496 ± 0.036	1.459HisPhe: 1.459 ± 0.042	1.609HisGly: 1.609 ± 0.044	0.915HisHis: 0.915 ± 0.036	1.474HisIle: 1.474 ± 0.039	1.115HisLys: 1.115 ± 0.037	3.053HisLeu: 3.053 ± 0.059	0.519HisMet: 0.519 ± 0.025	0.953HisAsn: 0.953 ± 0.033	1.392HisPro: 1.392 ± 0.046	1.309HisGln: 1.309 ± 0.039	1.271HisArg: 1.271 ± 0.042	1.802HisSer: 1.802 ± 0.053	0.883HisThr: 0.883 ± 0.031	1.308HisVal: 1.308 ± 0.037	0.469HisTrp: 0.469 ± 0.026	1.138HisTyr: 1.138 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	6.368IleAla: 6.368 ± 0.093	0.887IleCys: 0.887 ± 0.033	3.778IleAsp: 3.778 ± 0.062	4.472IleGlu: 4.472 ± 0.085	2.765IlePhe: 2.765 ± 0.064	4.233IleGly: 4.233 ± 0.088	1.767IleHis: 1.767 ± 0.053	4.694IleIle: 4.694 ± 0.08	4.377IleLys: 4.377 ± 0.078	7.097IleLeu: 7.097 ± 0.095	1.388IleMet: 1.388 ± 0.046	3.629IleAsn: 3.629 ± 0.072	3.288IlePro: 3.288 ± 0.064	2.761IleGln: 2.761 ± 0.048	3.126IleArg: 3.126 ± 0.069	4.872IleSer: 4.872 ± 0.083	3.546IleThr: 3.546 ± 0.068	3.855IleVal: 3.855 ± 0.071	0.616IleTrp: 0.616 ± 0.028	2.09IleTyr: 2.09 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	5.048LysAla: 5.048 ± 0.073	0.394LysCys: 0.394 ± 0.023	2.945LysAsp: 2.945 ± 0.056	4.352LysGlu: 4.352 ± 0.085	1.715LysPhe: 1.715 ± 0.048	3.083LysGly: 3.083 ± 0.058	1.516LysHis: 1.516 ± 0.045	4.159LysIle: 4.159 ± 0.08	4.148LysLys: 4.148 ± 0.082	5.947LysLeu: 5.947 ± 0.084	1.388LysMet: 1.388 ± 0.039	3.18LysAsn: 3.18 ± 0.069	2.907LysPro: 2.907 ± 0.057	3.61LysGln: 3.61 ± 0.067	3.124LysArg: 3.124 ± 0.065	3.507LysSer: 3.507 ± 0.07	3.479LysThr: 3.479 ± 0.069	3.027LysVal: 3.027 ± 0.06	0.566LysTrp: 0.566 ± 0.025	1.504LysTyr: 1.504 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	10.231LeuAla: 10.231 ± 0.112	1.405LeuCys: 1.405 ± 0.04	5.184LeuAsp: 5.184 ± 0.079	6.285LeuGlu: 6.285 ± 0.101	5.368LeuPhe: 5.368 ± 0.085	6.778LeuGly: 6.778 ± 0.093	2.57LeuHis: 2.57 ± 0.054	7.983LeuIle: 7.983 ± 0.11	7.024LeuLys: 7.024 ± 0.101	13.014LeuLeu: 13.014 ± 0.164	2.688LeuMet: 2.688 ± 0.053	5.735LeuAsn: 5.735 ± 0.081	5.105LeuPro: 5.105 ± 0.079	5.135LeuGln: 5.135 ± 0.087	4.95LeuArg: 4.95 ± 0.083	8.793LeuSer: 8.793 ± 0.118	5.768LeuThr: 5.768 ± 0.079	6.028LeuVal: 6.028 ± 0.078	1.137LeuTrp: 1.137 ± 0.04	3.183LeuTyr: 3.183 ± 0.061	0.001LeuXaa: 0.001 ± 0.001
Met	2.238MetAla: 2.238 ± 0.049	0.145MetCys: 0.145 ± 0.013	1.153MetAsp: 1.153 ± 0.037	1.252MetGlu: 1.252 ± 0.043	0.753MetPhe: 0.753 ± 0.03	1.485MetGly: 1.485 ± 0.045	0.58MetHis: 0.58 ± 0.025	1.428MetIle: 1.428 ± 0.04	1.527MetLys: 1.527 ± 0.039	2.616MetLeu: 2.616 ± 0.054	0.622MetMet: 0.622 ± 0.029	1.138MetAsn: 1.138 ± 0.033	1.113MetPro: 1.113 ± 0.039	1.226MetGln: 1.226 ± 0.039	1.16MetArg: 1.16 ± 0.033	1.548MetSer: 1.548 ± 0.042	1.32MetThr: 1.32 ± 0.042	1.401MetVal: 1.401 ± 0.038	0.175MetTrp: 0.175 ± 0.015	0.487MetTyr: 0.487 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.438AsnAla: 3.438 ± 0.068	0.607AsnCys: 0.607 ± 0.027	2.057AsnAsp: 2.057 ± 0.05	2.81AsnGlu: 2.81 ± 0.058	2.006AsnPhe: 2.006 ± 0.051	2.543AsnGly: 2.543 ± 0.058	1.407AsnHis: 1.407 ± 0.039	3.005AsnIle: 3.005 ± 0.058	2.737AsnLys: 2.737 ± 0.058	5.197AsnLeu: 5.197 ± 0.088	0.888AsnMet: 0.888 ± 0.03	2.401AsnAsn: 2.401 ± 0.058	2.807AsnPro: 2.807 ± 0.069	2.699AsnGln: 2.699 ± 0.06	2.206AsnArg: 2.206 ± 0.045	3.166AsnSer: 3.166 ± 0.064	2.034AsnThr: 2.034 ± 0.056	2.215AsnVal: 2.215 ± 0.05	0.647AsnTrp: 0.647 ± 0.026	1.824AsnTyr: 1.824 ± 0.048	0.001AsnXaa: 0.001 ± 0.001
Pro	3.188ProAla: 3.188 ± 0.065	0.452ProCys: 0.452 ± 0.024	2.094ProAsp: 2.094 ± 0.048	3.095ProGlu: 3.095 ± 0.064	2.008ProPhe: 2.008 ± 0.052	2.735ProGly: 2.735 ± 0.055	1.025ProHis: 1.025 ± 0.038	2.691ProIle: 2.691 ± 0.048	2.365ProLys: 2.365 ± 0.054	4.589ProLeu: 4.589 ± 0.081	0.928ProMet: 0.928 ± 0.032	1.918ProAsn: 1.918 ± 0.045	1.53ProPro: 1.53 ± 0.046	1.898ProGln: 1.898 ± 0.047	1.503ProArg: 1.503 ± 0.044	2.852ProSer: 2.852 ± 0.056	1.876ProThr: 1.876 ± 0.051	2.895ProVal: 2.895 ± 0.061	0.524ProTrp: 0.524 ± 0.025	1.444ProTyr: 1.444 ± 0.041	0.001ProXaa: 0.001 ± 0.001
Gln	4.409GlnAla: 4.409 ± 0.082	0.481GlnCys: 0.481 ± 0.023	2.045GlnAsp: 2.045 ± 0.053	3.08GlnGlu: 3.08 ± 0.07	2.315GlnPhe: 2.315 ± 0.051	2.783GlnGly: 2.783 ± 0.063	1.261GlnHis: 1.261 ± 0.039	3.159GlnIle: 3.159 ± 0.063	2.798GlnLys: 2.798 ± 0.066	5.663GlnLeu: 5.663 ± 0.099	1.083GlnMet: 1.083 ± 0.031	2.213GlnAsn: 2.213 ± 0.054	1.751GlnPro: 1.751 ± 0.048	3.224GlnGln: 3.224 ± 0.088	2.326GlnArg: 2.326 ± 0.054	2.922GlnSer: 2.922 ± 0.055	2.375GlnThr: 2.375 ± 0.052	2.787GlnVal: 2.787 ± 0.061	0.624GlnTrp: 0.624 ± 0.029	1.517GlnTyr: 1.517 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	3.39ArgAla: 3.39 ± 0.067	0.495ArgCys: 0.495 ± 0.027	2.176ArgAsp: 2.176 ± 0.05	3.23ArgGlu: 3.23 ± 0.065	2.299ArgPhe: 2.299 ± 0.057	2.477ArgGly: 2.477 ± 0.061	1.252ArgHis: 1.252 ± 0.041	3.235ArgIle: 3.235 ± 0.059	2.651ArgLys: 2.651 ± 0.056	5.485ArgLeu: 5.485 ± 0.089	1.118ArgMet: 1.118 ± 0.033	1.941ArgAsn: 1.941 ± 0.046	1.564ArgPro: 1.564 ± 0.042	2.412ArgGln: 2.412 ± 0.055	2.307ArgArg: 2.307 ± 0.058	2.517ArgSer: 2.517 ± 0.054	1.902ArgThr: 1.902 ± 0.046	2.792ArgVal: 2.792 ± 0.059	0.591ArgTrp: 0.591 ± 0.023	1.777ArgTyr: 1.777 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.738SerAla: 4.738 ± 0.081	0.893SerCys: 0.893 ± 0.033	2.738SerAsp: 2.738 ± 0.055	3.624SerGlu: 3.624 ± 0.064	3.254SerPhe: 3.254 ± 0.062	4.243SerGly: 4.243 ± 0.075	1.777SerHis: 1.777 ± 0.039	4.538SerIle: 4.538 ± 0.082	3.747SerLys: 3.747 ± 0.073	8.321SerLeu: 8.321 ± 0.1	1.733SerMet: 1.733 ± 0.048	3.119SerAsn: 3.119 ± 0.054	2.937SerPro: 2.937 ± 0.065	3.187SerGln: 3.187 ± 0.062	3.038SerArg: 3.038 ± 0.048	4.825SerSer: 4.825 ± 0.081	3.093SerThr: 3.093 ± 0.06	3.505SerVal: 3.505 ± 0.064	0.905SerTrp: 0.905 ± 0.035	2.328SerTyr: 2.328 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.157ThrAla: 4.157 ± 0.074	0.523ThrCys: 0.523 ± 0.027	2.087ThrAsp: 2.087 ± 0.041	2.573ThrGlu: 2.573 ± 0.063	1.919ThrPhe: 1.919 ± 0.046	3.479ThrGly: 3.479 ± 0.076	1.206ThrHis: 1.206 ± 0.039	3.337ThrIle: 3.337 ± 0.059	2.281ThrLys: 2.281 ± 0.051	5.457ThrLeu: 5.457 ± 0.084	0.997ThrMet: 0.997 ± 0.031	1.762ThrAsn: 1.762 ± 0.052	2.396ThrPro: 2.396 ± 0.054	2.067ThrGln: 2.067 ± 0.055	2.055ThrArg: 2.055 ± 0.048	2.939ThrSer: 2.939 ± 0.056	2.639ThrThr: 2.639 ± 0.064	3.218ThrVal: 3.218 ± 0.064	0.528ThrTrp: 0.528 ± 0.027	1.434ThrTyr: 1.434 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	4.867ValAla: 4.867 ± 0.077	0.674ValCys: 0.674 ± 0.026	3.066ValAsp: 3.066 ± 0.055	3.427ValGlu: 3.427 ± 0.065	2.685ValPhe: 2.685 ± 0.057	3.482ValGly: 3.482 ± 0.072	1.287ValHis: 1.287 ± 0.041	4.38ValIle: 4.38 ± 0.075	3.38ValLys: 3.38 ± 0.068	6.628ValLeu: 6.628 ± 0.096	1.501ValMet: 1.501 ± 0.042	2.85ValAsn: 2.85 ± 0.059	2.258ValPro: 2.258 ± 0.053	2.172ValGln: 2.172 ± 0.053	2.464ValArg: 2.464 ± 0.054	4.033ValSer: 4.033 ± 0.07	2.756ValThr: 2.756 ± 0.064	3.933ValVal: 3.933 ± 0.081	0.628ValTrp: 0.628 ± 0.026	1.766ValTyr: 1.766 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.738TrpAla: 0.738 ± 0.03	0.114TrpCys: 0.114 ± 0.01	0.514TrpAsp: 0.514 ± 0.023	0.553TrpGlu: 0.553 ± 0.026	0.618TrpPhe: 0.618 ± 0.025	0.71TrpGly: 0.71 ± 0.029	0.37TrpHis: 0.37 ± 0.021	0.793TrpIle: 0.793 ± 0.03	0.521TrpLys: 0.521 ± 0.029	1.813TrpLeu: 1.813 ± 0.054	0.307TrpMet: 0.307 ± 0.02	0.494TrpAsn: 0.494 ± 0.024	0.508TrpPro: 0.508 ± 0.028	0.907TrpGln: 0.907 ± 0.03	0.591TrpArg: 0.591 ± 0.026	0.651TrpSer: 0.651 ± 0.025	0.452TrpThr: 0.452 ± 0.023	0.684TrpVal: 0.684 ± 0.028	0.173TrpTrp: 0.173 ± 0.014	0.389TrpTyr: 0.389 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.432TyrAla: 2.432 ± 0.052	0.563TyrCys: 0.563 ± 0.023	1.448TyrAsp: 1.448 ± 0.041	1.803TyrGlu: 1.803 ± 0.047	1.848TyrPhe: 1.848 ± 0.049	2.144TyrGly: 2.144 ± 0.044	0.957TyrHis: 0.957 ± 0.03	1.784TyrIle: 1.784 ± 0.051	1.567TyrLys: 1.567 ± 0.042	4.154TyrLeu: 4.154 ± 0.078	0.6TyrMet: 0.6 ± 0.025	1.268TyrAsn: 1.268 ± 0.042	1.537TyrPro: 1.537 ± 0.043	2.052TyrGln: 2.052 ± 0.045	1.794TyrArg: 1.794 ± 0.049	2.289TyrSer: 2.289 ± 0.052	1.304TyrThr: 1.304 ± 0.037	1.758TyrVal: 1.758 ± 0.039	0.514TyrTrp: 0.514 ± 0.024	1.372TyrTyr: 1.372 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.015XaaXaa: 0.015 ± 0.007

Statistics based on 2787 proteins (923784 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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