Amino acid dipepetide frequency for Flavobacterium aurantiibacter

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.008AlaAla: 7.008 ± 0.131	0.681AlaCys: 0.681 ± 0.031	4.187AlaAsp: 4.187 ± 0.085	4.833AlaGlu: 4.833 ± 0.082	3.893AlaPhe: 3.893 ± 0.069	4.904AlaGly: 4.904 ± 0.109	1.184AlaHis: 1.184 ± 0.037	5.222AlaIle: 5.222 ± 0.075	5.079AlaLys: 5.079 ± 0.102	7.17AlaLeu: 7.17 ± 0.1	1.405AlaMet: 1.405 ± 0.044	4.088AlaAsn: 4.088 ± 0.08	2.455AlaPro: 2.455 ± 0.072	3.098AlaGln: 3.098 ± 0.059	2.479AlaArg: 2.479 ± 0.054	4.37AlaSer: 4.37 ± 0.092	4.694AlaThr: 4.694 ± 0.116	5.653AlaVal: 5.653 ± 0.094	0.628AlaTrp: 0.628 ± 0.03	2.548AlaTyr: 2.548 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.625CysAla: 0.625 ± 0.028	0.128CysCys: 0.128 ± 0.011	0.434CysAsp: 0.434 ± 0.029	0.499CysGlu: 0.499 ± 0.023	0.491CysPhe: 0.491 ± 0.025	0.726CysGly: 0.726 ± 0.033	0.177CysHis: 0.177 ± 0.014	0.587CysIle: 0.587 ± 0.029	0.49CysLys: 0.49 ± 0.027	0.738CysLeu: 0.738 ± 0.031	0.137CysMet: 0.137 ± 0.012	0.443CysAsn: 0.443 ± 0.024	0.376CysPro: 0.376 ± 0.023	0.273CysGln: 0.273 ± 0.017	0.302CysArg: 0.302 ± 0.019	0.662CysSer: 0.662 ± 0.031	0.526CysThr: 0.526 ± 0.027	0.506CysVal: 0.506 ± 0.023	0.062CysTrp: 0.062 ± 0.009	0.323CysTyr: 0.323 ± 0.017	0.001CysXaa: 0.001 ± 0.001
Asp	3.908AspAla: 3.908 ± 0.066	0.42AspCys: 0.42 ± 0.026	2.496AspAsp: 2.496 ± 0.056	3.346AspGlu: 3.346 ± 0.071	3.766AspPhe: 3.766 ± 0.078	3.481AspGly: 3.481 ± 0.074	0.719AspHis: 0.719 ± 0.031	3.671AspIle: 3.671 ± 0.062	3.419AspLys: 3.419 ± 0.081	5.35AspLeu: 5.35 ± 0.081	0.916AspMet: 0.916 ± 0.034	2.636AspAsn: 2.636 ± 0.067	1.638AspPro: 1.638 ± 0.045	1.591AspGln: 1.591 ± 0.041	2.023AspArg: 2.023 ± 0.052	3.126AspSer: 3.126 ± 0.061	2.698AspThr: 2.698 ± 0.067	3.56AspVal: 3.56 ± 0.079	0.639AspTrp: 0.639 ± 0.026	2.568AspTyr: 2.568 ± 0.057	0.001AspXaa: 0.001 ± 0.001
Glu	4.533GluAla: 4.533 ± 0.083	0.318GluCys: 0.318 ± 0.019	2.519GluAsp: 2.519 ± 0.066	3.853GluGlu: 3.853 ± 0.083	2.867GluPhe: 2.867 ± 0.054	2.944GluGly: 2.944 ± 0.063	1.069GluHis: 1.069 ± 0.034	5.386GluIle: 5.386 ± 0.084	5.078GluLys: 5.078 ± 0.105	6.109GluLeu: 6.109 ± 0.099	1.375GluMet: 1.375 ± 0.042	4.318GluAsn: 4.318 ± 0.082	1.7GluPro: 1.7 ± 0.046	2.671GluGln: 2.671 ± 0.06	2.862GluArg: 2.862 ± 0.078	3.426GluSer: 3.426 ± 0.067	3.74GluThr: 3.74 ± 0.065	4.277GluVal: 4.277 ± 0.069	0.513GluTrp: 0.513 ± 0.023	2.056GluTyr: 2.056 ± 0.053	0.001GluXaa: 0.001 ± 0.001
Phe	3.872PheAla: 3.872 ± 0.062	0.569PheCys: 0.569 ± 0.024	3.506PheAsp: 3.506 ± 0.064	3.846PheGlu: 3.846 ± 0.069	2.998PhePhe: 2.998 ± 0.078	3.82PheGly: 3.82 ± 0.074	0.838PheHis: 0.838 ± 0.032	3.551PheIle: 3.551 ± 0.073	3.423PheLys: 3.423 ± 0.071	5.132PheLeu: 5.132 ± 0.086	1.052PheMet: 1.052 ± 0.037	3.147PheAsn: 3.147 ± 0.071	1.899PhePro: 1.899 ± 0.046	1.92PheGln: 1.92 ± 0.046	2.025PheArg: 2.025 ± 0.042	4.302PheSer: 4.302 ± 0.087	3.463PheThr: 3.463 ± 0.078	3.516PheVal: 3.516 ± 0.064	0.583PheTrp: 0.583 ± 0.028	2.257PheTyr: 2.257 ± 0.061	0.0PheXaa: 0.0 ± 0.0
Gly	4.394GlyAla: 4.394 ± 0.094	0.641GlyCys: 0.641 ± 0.032	2.972GlyAsp: 2.972 ± 0.067	3.061GlyGlu: 3.061 ± 0.07	3.836GlyPhe: 3.836 ± 0.066	4.334GlyGly: 4.334 ± 0.097	0.992GlyHis: 0.992 ± 0.032	5.089GlyIle: 5.089 ± 0.081	4.738GlyLys: 4.738 ± 0.078	5.488GlyLeu: 5.488 ± 0.081	1.385GlyMet: 1.385 ± 0.04	3.661GlyAsn: 3.661 ± 0.087	1.396GlyPro: 1.396 ± 0.048	1.935GlyGln: 1.935 ± 0.047	2.246GlyArg: 2.246 ± 0.054	4.308GlySer: 4.308 ± 0.082	4.525GlyThr: 4.525 ± 0.136	4.261GlyVal: 4.261 ± 0.072	0.673GlyTrp: 0.673 ± 0.029	2.515GlyTyr: 2.515 ± 0.06	0.001GlyXaa: 0.001 ± 0.001
His	1.074HisAla: 1.074 ± 0.036	0.178HisCys: 0.178 ± 0.013	0.763HisAsp: 0.763 ± 0.03	0.985HisGlu: 0.985 ± 0.034	1.238HisPhe: 1.238 ± 0.038	1.052HisGly: 1.052 ± 0.033	0.425HisHis: 0.425 ± 0.023	1.244HisIle: 1.244 ± 0.035	1.057HisLys: 1.057 ± 0.035	1.704HisLeu: 1.704 ± 0.047	0.26HisMet: 0.26 ± 0.016	0.829HisAsn: 0.829 ± 0.031	0.798HisPro: 0.798 ± 0.032	0.706HisGln: 0.706 ± 0.029	0.73HisArg: 0.73 ± 0.032	0.966HisSer: 0.966 ± 0.033	0.847HisThr: 0.847 ± 0.026	0.933HisVal: 0.933 ± 0.032	0.157HisTrp: 0.157 ± 0.013	0.736HisTyr: 0.736 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.906IleAla: 5.906 ± 0.086	0.718IleCys: 0.718 ± 0.029	4.666IleAsp: 4.666 ± 0.075	4.772IleGlu: 4.772 ± 0.084	3.438IlePhe: 3.438 ± 0.073	4.581IleGly: 4.581 ± 0.077	1.211IleHis: 1.211 ± 0.039	4.631IleIle: 4.631 ± 0.078	4.621IleLys: 4.621 ± 0.085	6.381IleLeu: 6.381 ± 0.092	1.07IleMet: 1.07 ± 0.036	3.862IleAsn: 3.862 ± 0.077	3.129IlePro: 3.129 ± 0.059	2.613IleGln: 2.613 ± 0.051	2.851IleArg: 2.851 ± 0.053	5.297IleSer: 5.297 ± 0.085	4.376IleThr: 4.376 ± 0.092	4.677IleVal: 4.677 ± 0.078	0.604IleTrp: 0.604 ± 0.024	2.6IleTyr: 2.6 ± 0.053	0.003IleXaa: 0.003 ± 0.002
Lys	4.852LysAla: 4.852 ± 0.095	0.39LysCys: 0.39 ± 0.024	3.314LysAsp: 3.314 ± 0.075	4.349LysGlu: 4.349 ± 0.095	3.064LysPhe: 3.064 ± 0.071	3.468LysGly: 3.468 ± 0.066	1.254LysHis: 1.254 ± 0.043	5.539LysIle: 5.539 ± 0.106	5.617LysLys: 5.617 ± 0.115	6.469LysLeu: 6.469 ± 0.102	1.826LysMet: 1.826 ± 0.049	4.282LysAsn: 4.282 ± 0.086	2.571LysPro: 2.571 ± 0.057	2.861LysGln: 2.861 ± 0.066	2.994LysArg: 2.994 ± 0.071	4.73LysSer: 4.73 ± 0.087	4.243LysThr: 4.243 ± 0.072	4.19LysVal: 4.19 ± 0.073	0.754LysTrp: 0.754 ± 0.029	2.767LysTyr: 2.767 ± 0.061	0.004LysXaa: 0.004 ± 0.002
Leu	7.214LeuAla: 7.214 ± 0.095	0.749LeuCys: 0.749 ± 0.03	4.617LeuAsp: 4.617 ± 0.07	5.947LeuGlu: 5.947 ± 0.105	5.278LeuPhe: 5.278 ± 0.098	5.658LeuGly: 5.658 ± 0.082	1.669LeuHis: 1.669 ± 0.044	6.322LeuIle: 6.322 ± 0.093	6.913LeuLys: 6.913 ± 0.121	9.549LeuLeu: 9.549 ± 0.137	1.863LeuMet: 1.863 ± 0.051	5.256LeuAsn: 5.256 ± 0.088	3.792LeuPro: 3.792 ± 0.077	4.01LeuGln: 4.01 ± 0.074	3.992LeuArg: 3.992 ± 0.068	6.572LeuSer: 6.572 ± 0.092	5.553LeuThr: 5.553 ± 0.091	5.815LeuVal: 5.815 ± 0.077	0.782LeuTrp: 0.782 ± 0.03	3.127LeuTyr: 3.127 ± 0.062	0.003LeuXaa: 0.003 ± 0.002
Met	1.392MetAla: 1.392 ± 0.044	0.14MetCys: 0.14 ± 0.013	0.804MetAsp: 0.804 ± 0.033	1.09MetGlu: 1.09 ± 0.039	0.796MetPhe: 0.796 ± 0.03	1.179MetGly: 1.179 ± 0.041	0.379MetHis: 0.379 ± 0.021	1.314MetIle: 1.314 ± 0.038	1.859MetLys: 1.859 ± 0.047	1.87MetLeu: 1.87 ± 0.042	0.432MetMet: 0.432 ± 0.023	1.142MetAsn: 1.142 ± 0.035	0.837MetPro: 0.837 ± 0.03	0.848MetGln: 0.848 ± 0.032	0.967MetArg: 0.967 ± 0.035	1.337MetSer: 1.337 ± 0.039	1.031MetThr: 1.031 ± 0.036	0.996MetVal: 0.996 ± 0.03	0.143MetTrp: 0.143 ± 0.013	0.658MetTyr: 0.658 ± 0.028	0.001MetXaa: 0.001 ± 0.001
Asn	4.139AsnAla: 4.139 ± 0.083	0.518AsnCys: 0.518 ± 0.029	2.995AsnAsp: 2.995 ± 0.068	3.366AsnGlu: 3.366 ± 0.071	3.27AsnPhe: 3.27 ± 0.068	4.185AsnGly: 4.185 ± 0.099	0.939AsnHis: 0.939 ± 0.035	3.794AsnIle: 3.794 ± 0.077	3.474AsnLys: 3.474 ± 0.075	5.339AsnLeu: 5.339 ± 0.089	1.086AsnMet: 1.086 ± 0.031	3.295AsnAsn: 3.295 ± 0.089	2.919AsnPro: 2.919 ± 0.071	2.413AsnGln: 2.413 ± 0.055	2.445AsnArg: 2.445 ± 0.047	3.747AsnSer: 3.747 ± 0.087	3.342AsnThr: 3.342 ± 0.082	3.502AsnVal: 3.502 ± 0.073	0.689AsnTrp: 0.689 ± 0.031	2.582AsnTyr: 2.582 ± 0.069	0.001AsnXaa: 0.001 ± 0.001
Pro	2.707ProAla: 2.707 ± 0.083	0.246ProCys: 0.246 ± 0.016	2.096ProAsp: 2.096 ± 0.06	2.831ProGlu: 2.831 ± 0.063	2.046ProPhe: 2.046 ± 0.051	2.025ProGly: 2.025 ± 0.051	0.581ProHis: 0.581 ± 0.029	2.653ProIle: 2.653 ± 0.053	2.461ProLys: 2.461 ± 0.054	3.122ProLeu: 3.122 ± 0.062	0.632ProMet: 0.632 ± 0.028	2.41ProAsn: 2.41 ± 0.05	0.929ProPro: 0.929 ± 0.039	1.323ProGln: 1.323 ± 0.038	1.05ProArg: 1.05 ± 0.03	2.158ProSer: 2.158 ± 0.056	2.425ProThr: 2.425 ± 0.064	2.443ProVal: 2.443 ± 0.057	0.291ProTrp: 0.291 ± 0.022	1.343ProTyr: 1.343 ± 0.04	0.001ProXaa: 0.001 ± 0.001
Gln	2.743GlnAla: 2.743 ± 0.058	0.212GlnCys: 0.212 ± 0.017	1.52GlnAsp: 1.52 ± 0.046	2.143GlnGlu: 2.143 ± 0.054	2.094GlnPhe: 2.094 ± 0.047	1.85GlnGly: 1.85 ± 0.049	0.678GlnHis: 0.678 ± 0.029	2.977GlnIle: 2.977 ± 0.061	2.945GlnLys: 2.945 ± 0.064	4.136GlnLeu: 4.136 ± 0.071	0.796GlnMet: 0.796 ± 0.029	2.453GlnAsn: 2.453 ± 0.056	1.282GlnPro: 1.282 ± 0.042	1.974GlnGln: 1.974 ± 0.06	1.695GlnArg: 1.695 ± 0.042	2.172GlnSer: 2.172 ± 0.05	2.451GlnThr: 2.451 ± 0.064	2.41GlnVal: 2.41 ± 0.056	0.347GlnTrp: 0.347 ± 0.021	1.37GlnTyr: 1.37 ± 0.041	0.001GlnXaa: 0.001 ± 0.001
Arg	2.644ArgAla: 2.644 ± 0.051	0.304ArgCys: 0.304 ± 0.02	1.887ArgAsp: 1.887 ± 0.046	2.504ArgGlu: 2.504 ± 0.065	2.482ArgPhe: 2.482 ± 0.058	2.059ArgGly: 2.059 ± 0.05	0.63ArgHis: 0.63 ± 0.028	3.365ArgIle: 3.365 ± 0.056	3.195ArgLys: 3.195 ± 0.06	3.76ArgLeu: 3.76 ± 0.064	1.024ArgMet: 1.024 ± 0.036	2.42ArgAsn: 2.42 ± 0.064	1.155ArgPro: 1.155 ± 0.036	1.359ArgGln: 1.359 ± 0.044	1.591ArgArg: 1.591 ± 0.053	2.171ArgSer: 2.171 ± 0.052	2.12ArgThr: 2.12 ± 0.052	2.49ArgVal: 2.49 ± 0.063	0.42ArgTrp: 0.42 ± 0.019	1.748ArgTyr: 1.748 ± 0.049	0.001ArgXaa: 0.001 ± 0.001
Ser	4.84SerAla: 4.84 ± 0.097	0.696SerCys: 0.696 ± 0.031	3.562SerAsp: 3.562 ± 0.064	4.129SerGlu: 4.129 ± 0.07	4.041SerPhe: 4.041 ± 0.076	5.026SerGly: 5.026 ± 0.118	0.945SerHis: 0.945 ± 0.027	4.691SerIle: 4.691 ± 0.084	4.424SerLys: 4.424 ± 0.073	5.774SerLeu: 5.774 ± 0.077	1.176SerMet: 1.176 ± 0.036	3.661SerAsn: 3.661 ± 0.076	2.021SerPro: 2.021 ± 0.064	2.246SerGln: 2.246 ± 0.053	2.332SerArg: 2.332 ± 0.053	4.357SerSer: 4.357 ± 0.1	3.895SerThr: 3.895 ± 0.089	4.328SerVal: 4.328 ± 0.068	0.685SerTrp: 0.685 ± 0.028	2.61SerTyr: 2.61 ± 0.063	0.005SerXaa: 0.005 ± 0.002
Thr	5.302ThrAla: 5.302 ± 0.125	0.454ThrCys: 0.454 ± 0.023	3.522ThrAsp: 3.522 ± 0.068	3.496ThrGlu: 3.496 ± 0.065	3.46ThrPhe: 3.46 ± 0.076	4.176ThrGly: 4.176 ± 0.111	0.997ThrHis: 0.997 ± 0.033	4.384ThrIle: 4.384 ± 0.105	3.354ThrLys: 3.354 ± 0.07	5.496ThrLeu: 5.496 ± 0.099	0.813ThrMet: 0.813 ± 0.03	3.427ThrAsn: 3.427 ± 0.084	2.798ThrPro: 2.798 ± 0.093	2.089ThrGln: 2.089 ± 0.056	1.813ThrArg: 1.813 ± 0.047	3.686ThrSer: 3.686 ± 0.095	4.158ThrThr: 4.158 ± 0.134	4.453ThrVal: 4.453 ± 0.117	0.579ThrTrp: 0.579 ± 0.026	2.463ThrTyr: 2.463 ± 0.048	0.003ThrXaa: 0.003 ± 0.002
Val	5.259ValAla: 5.259 ± 0.1	0.653ValCys: 0.653 ± 0.031	3.474ValAsp: 3.474 ± 0.06	3.79ValGlu: 3.79 ± 0.069	3.575ValPhe: 3.575 ± 0.06	4.002ValGly: 4.002 ± 0.072	1.049ValHis: 1.049 ± 0.039	4.571ValIle: 4.571 ± 0.079	4.176ValLys: 4.176 ± 0.075	6.4ValLeu: 6.4 ± 0.08	1.089ValMet: 1.089 ± 0.041	3.686ValAsn: 3.686 ± 0.079	2.435ValPro: 2.435 ± 0.055	2.174ValGln: 2.174 ± 0.053	2.619ValArg: 2.619 ± 0.052	4.8ValSer: 4.8 ± 0.087	4.069ValThr: 4.069 ± 0.103	4.969ValVal: 4.969 ± 0.089	0.613ValTrp: 0.613 ± 0.025	2.348ValTyr: 2.348 ± 0.051	0.005ValXaa: 0.005 ± 0.002
Trp	0.602TrpAla: 0.602 ± 0.03	0.093TrpCys: 0.093 ± 0.011	0.484TrpAsp: 0.484 ± 0.02	0.564TrpGlu: 0.564 ± 0.025	0.598TrpPhe: 0.598 ± 0.024	0.526TrpGly: 0.526 ± 0.026	0.206TrpHis: 0.206 ± 0.015	0.677TrpIle: 0.677 ± 0.029	0.738TrpLys: 0.738 ± 0.03	0.942TrpLeu: 0.942 ± 0.034	0.256TrpMet: 0.256 ± 0.018	0.691TrpAsn: 0.691 ± 0.025	0.253TrpPro: 0.253 ± 0.017	0.49TrpGln: 0.49 ± 0.022	0.42TrpArg: 0.42 ± 0.021	0.647TrpSer: 0.647 ± 0.033	0.527TrpThr: 0.527 ± 0.025	0.546TrpVal: 0.546 ± 0.029	0.149TrpTrp: 0.149 ± 0.012	0.383TrpTyr: 0.383 ± 0.021	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.565TyrAla: 2.565 ± 0.058	0.397TyrCys: 0.397 ± 0.022	2.152TyrAsp: 2.152 ± 0.054	2.208TyrGlu: 2.208 ± 0.051	2.486TyrPhe: 2.486 ± 0.061	2.453TyrGly: 2.453 ± 0.057	0.739TyrHis: 0.739 ± 0.029	2.333TyrIle: 2.333 ± 0.05	2.476TyrLys: 2.476 ± 0.066	3.748TyrLeu: 3.748 ± 0.062	0.621TyrMet: 0.621 ± 0.027	2.332TyrAsn: 2.332 ± 0.066	1.387TyrPro: 1.387 ± 0.042	1.656TyrGln: 1.656 ± 0.042	1.892TyrArg: 1.892 ± 0.05	2.609TyrSer: 2.609 ± 0.064	2.238TyrThr: 2.238 ± 0.06	2.231TyrVal: 2.231 ± 0.048	0.482TyrTrp: 0.482 ± 0.022	1.671TyrTyr: 1.671 ± 0.054	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.004XaaGlu: 0.004 ± 0.002	0.003XaaPhe: 0.003 ± 0.002	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.004XaaIle: 0.004 ± 0.002	0.002XaaLys: 0.002 ± 0.002	0.004XaaLeu: 0.004 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.003XaaAsn: 0.003 ± 0.002	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.002	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2902 proteins (924509 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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