Amino acid dipepetide frequency for Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.209AlaAla: 6.209 ± 0.089	0.926AlaCys: 0.926 ± 0.022	3.275AlaAsp: 3.275 ± 0.039	4.281AlaGlu: 4.281 ± 0.047	2.806AlaPhe: 2.806 ± 0.041	4.209AlaGly: 4.209 ± 0.053	1.513AlaHis: 1.513 ± 0.027	3.644AlaIle: 3.644 ± 0.042	4.39AlaLys: 4.39 ± 0.053	7.019AlaLeu: 7.019 ± 0.069	1.5AlaMet: 1.5 ± 0.025	2.936AlaAsn: 2.936 ± 0.034	3.504AlaPro: 3.504 ± 0.053	3.095AlaGln: 3.095 ± 0.051	3.608AlaArg: 3.608 ± 0.045	6.597AlaSer: 6.597 ± 0.067	4.034AlaThr: 4.034 ± 0.057	4.299AlaVal: 4.299 ± 0.039	0.654AlaTrp: 0.654 ± 0.017	1.889AlaTyr: 1.889 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	0.821CysAla: 0.821 ± 0.018	0.306CysCys: 0.306 ± 0.012	0.734CysAsp: 0.734 ± 0.019	0.71CysGlu: 0.71 ± 0.018	0.712CysPhe: 0.712 ± 0.021	0.97CysGly: 0.97 ± 0.024	0.334CysHis: 0.334 ± 0.013	0.84CysIle: 0.84 ± 0.018	0.72CysLys: 0.72 ± 0.019	1.357CysLeu: 1.357 ± 0.026	0.278CysMet: 0.278 ± 0.012	0.534CysAsn: 0.534 ± 0.013	0.544CysPro: 0.544 ± 0.016	0.467CysGln: 0.467 ± 0.014	0.616CysArg: 0.616 ± 0.017	1.172CysSer: 1.172 ± 0.025	0.638CysThr: 0.638 ± 0.015	0.985CysVal: 0.985 ± 0.02	0.176CysTrp: 0.176 ± 0.008	0.489CysTyr: 0.489 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.959AspAla: 3.959 ± 0.049	0.68AspCys: 0.68 ± 0.017	3.796AspAsp: 3.796 ± 0.061	4.779AspGlu: 4.779 ± 0.057	2.751AspPhe: 2.751 ± 0.037	3.116AspGly: 3.116 ± 0.049	1.104AspHis: 1.104 ± 0.025	3.243AspIle: 3.243 ± 0.046	3.043AspLys: 3.043 ± 0.037	5.612AspLeu: 5.612 ± 0.048	1.074AspMet: 1.074 ± 0.027	2.288AspAsn: 2.288 ± 0.035	2.557AspPro: 2.557 ± 0.034	1.956AspGln: 1.956 ± 0.032	2.354AspArg: 2.354 ± 0.03	4.628AspSer: 4.628 ± 0.057	2.677AspThr: 2.677 ± 0.035	3.706AspVal: 3.706 ± 0.048	0.635AspTrp: 0.635 ± 0.016	1.951AspTyr: 1.951 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	4.559GluAla: 4.559 ± 0.051	0.705GluCys: 0.705 ± 0.016	4.334GluAsp: 4.334 ± 0.055	5.855GluGlu: 5.855 ± 0.091	2.783GluPhe: 2.783 ± 0.035	3.285GluGly: 3.285 ± 0.042	1.464GluHis: 1.464 ± 0.025	3.704GluIle: 3.704 ± 0.042	4.733GluLys: 4.733 ± 0.06	6.935GluLeu: 6.935 ± 0.069	1.386GluMet: 1.386 ± 0.023	3.514GluAsn: 3.514 ± 0.04	2.474GluPro: 2.474 ± 0.033	2.907GluGln: 2.907 ± 0.041	3.467GluArg: 3.467 ± 0.046	5.227GluSer: 5.227 ± 0.059	3.687GluThr: 3.687 ± 0.084	3.87GluVal: 3.87 ± 0.047	0.702GluTrp: 0.702 ± 0.017	2.033GluTyr: 2.033 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	2.829PheAla: 2.829 ± 0.042	0.615PheCys: 0.615 ± 0.016	2.665PheAsp: 2.665 ± 0.033	2.971PheGlu: 2.971 ± 0.04	2.023PhePhe: 2.023 ± 0.04	2.779PheGly: 2.779 ± 0.058	0.996PheHis: 0.996 ± 0.022	2.321PheIle: 2.321 ± 0.033	2.776PheLys: 2.776 ± 0.039	4.2PheLeu: 4.2 ± 0.057	0.918PheMet: 0.918 ± 0.02	2.033PheAsn: 2.033 ± 0.032	1.798PhePro: 1.798 ± 0.028	1.925PheGln: 1.925 ± 0.024	1.903PheArg: 1.903 ± 0.031	3.78PheSer: 3.78 ± 0.044	2.377PheThr: 2.377 ± 0.039	2.893PheVal: 2.893 ± 0.037	0.53PheTrp: 0.53 ± 0.016	1.489PheTyr: 1.489 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	4.207GlyAla: 4.207 ± 0.058	0.839GlyCys: 0.839 ± 0.019	3.036GlyAsp: 3.036 ± 0.04	3.337GlyGlu: 3.337 ± 0.043	2.677GlyPhe: 2.677 ± 0.042	3.888GlyGly: 3.888 ± 0.073	1.289GlyHis: 1.289 ± 0.027	3.178GlyIle: 3.178 ± 0.044	3.609GlyLys: 3.609 ± 0.045	5.223GlyLeu: 5.223 ± 0.053	1.063GlyMet: 1.063 ± 0.023	2.578GlyAsn: 2.578 ± 0.037	2.127GlyPro: 2.127 ± 0.034	2.011GlyGln: 2.011 ± 0.035	2.683GlyArg: 2.683 ± 0.041	5.625GlySer: 5.625 ± 0.065	3.178GlyThr: 3.178 ± 0.052	3.718GlyVal: 3.718 ± 0.041	0.679GlyTrp: 0.679 ± 0.022	1.819GlyTyr: 1.819 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	1.413HisAla: 1.413 ± 0.022	0.323HisCys: 0.323 ± 0.013	1.158HisAsp: 1.158 ± 0.023	1.423HisGlu: 1.423 ± 0.026	1.014HisPhe: 1.014 ± 0.022	1.283HisGly: 1.283 ± 0.025	0.609HisHis: 0.609 ± 0.019	1.215HisIle: 1.215 ± 0.021	1.242HisLys: 1.242 ± 0.022	2.163HisLeu: 2.163 ± 0.031	0.468HisMet: 0.468 ± 0.014	0.999HisAsn: 0.999 ± 0.018	1.128HisPro: 1.128 ± 0.023	0.944HisGln: 0.944 ± 0.023	1.155HisArg: 1.155 ± 0.022	1.93HisSer: 1.93 ± 0.033	1.094HisThr: 1.094 ± 0.019	1.339HisVal: 1.339 ± 0.024	0.249HisTrp: 0.249 ± 0.01	0.776HisTyr: 0.776 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	3.538IleAla: 3.538 ± 0.04	0.789IleCys: 0.789 ± 0.019	3.224IleAsp: 3.224 ± 0.04	3.493IleGlu: 3.493 ± 0.041	2.353IlePhe: 2.353 ± 0.035	2.868IleGly: 2.868 ± 0.039	1.12IleHis: 1.12 ± 0.023	2.892IleIle: 2.892 ± 0.041	3.454IleLys: 3.454 ± 0.038	5.152IleLeu: 5.152 ± 0.053	1.149IleMet: 1.149 ± 0.021	2.49IleAsn: 2.49 ± 0.036	2.704IlePro: 2.704 ± 0.036	2.038IleGln: 2.038 ± 0.032	2.453IleArg: 2.453 ± 0.031	4.746IleSer: 4.746 ± 0.054	2.845IleThr: 2.845 ± 0.036	3.384IleVal: 3.384 ± 0.041	0.602IleTrp: 0.602 ± 0.015	1.684IleTyr: 1.684 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.164LysAla: 4.164 ± 0.05	0.784LysCys: 0.784 ± 0.02	3.516LysAsp: 3.516 ± 0.046	4.33LysGlu: 4.33 ± 0.057	2.814LysPhe: 2.814 ± 0.034	2.959LysGly: 2.959 ± 0.044	1.49LysHis: 1.49 ± 0.025	3.58LysIle: 3.58 ± 0.042	5.219LysLys: 5.219 ± 0.082	6.689LysLeu: 6.689 ± 0.066	1.286LysMet: 1.286 ± 0.025	3.259LysAsn: 3.259 ± 0.039	3.008LysPro: 3.008 ± 0.041	2.592LysGln: 2.592 ± 0.036	3.884LysArg: 3.884 ± 0.051	5.118LysSer: 5.118 ± 0.055	3.577LysThr: 3.577 ± 0.044	3.845LysVal: 3.845 ± 0.039	0.756LysTrp: 0.756 ± 0.02	2.018LysTyr: 2.018 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	6.716LeuAla: 6.716 ± 0.059	1.435LeuCys: 1.435 ± 0.025	5.505LeuAsp: 5.505 ± 0.059	6.753LeuGlu: 6.753 ± 0.075	4.056LeuPhe: 4.056 ± 0.058	5.22LeuGly: 5.22 ± 0.053	2.125LeuHis: 2.125 ± 0.03	4.832LeuIle: 4.832 ± 0.054	6.894LeuLys: 6.894 ± 0.065	9.64LeuLeu: 9.64 ± 0.096	1.991LeuMet: 1.991 ± 0.028	4.599LeuAsn: 4.599 ± 0.042	4.734LeuPro: 4.734 ± 0.048	4.62LeuGln: 4.62 ± 0.051	5.415LeuArg: 5.415 ± 0.045	8.444LeuSer: 8.444 ± 0.078	5.052LeuThr: 5.052 ± 0.052	5.929LeuVal: 5.929 ± 0.059	0.993LeuTrp: 0.993 ± 0.021	2.948LeuTyr: 2.948 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	1.547MetAla: 1.547 ± 0.027	0.3MetCys: 0.3 ± 0.011	1.19MetAsp: 1.19 ± 0.022	1.153MetGlu: 1.153 ± 0.021	0.848MetPhe: 0.848 ± 0.018	1.247MetGly: 1.247 ± 0.022	0.394MetHis: 0.394 ± 0.014	1.089MetIle: 1.089 ± 0.022	1.274MetLys: 1.274 ± 0.022	1.908MetLeu: 1.908 ± 0.028	0.474MetMet: 0.474 ± 0.015	1.013MetAsn: 1.013 ± 0.022	0.917MetPro: 0.917 ± 0.023	0.725MetGln: 0.725 ± 0.019	1.03MetArg: 1.03 ± 0.021	2.055MetSer: 2.055 ± 0.028	1.029MetThr: 1.029 ± 0.021	1.231MetVal: 1.231 ± 0.024	0.204MetTrp: 0.204 ± 0.009	0.526MetTyr: 0.526 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.205AsnAla: 3.205 ± 0.034	0.624AsnCys: 0.624 ± 0.015	2.603AsnAsp: 2.603 ± 0.038	3.134AsnGlu: 3.134 ± 0.037	2.119AsnPhe: 2.119 ± 0.032	2.786AsnGly: 2.786 ± 0.035	0.914AsnHis: 0.914 ± 0.02	2.534AsnIle: 2.534 ± 0.034	2.938AsnLys: 2.938 ± 0.042	4.303AsnLeu: 4.303 ± 0.044	0.989AsnMet: 0.989 ± 0.021	2.377AsnAsn: 2.377 ± 0.051	2.198AsnPro: 2.198 ± 0.033	1.641AsnGln: 1.641 ± 0.028	2.036AsnArg: 2.036 ± 0.028	4.255AsnSer: 4.255 ± 0.052	2.464AsnThr: 2.464 ± 0.032	2.928AsnVal: 2.928 ± 0.037	0.546AsnTrp: 0.546 ± 0.015	1.603AsnTyr: 1.603 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	3.558ProAla: 3.558 ± 0.067	0.421ProCys: 0.421 ± 0.015	2.339ProAsp: 2.339 ± 0.036	3.44ProGlu: 3.44 ± 0.043	1.92ProPhe: 1.92 ± 0.03	2.511ProGly: 2.511 ± 0.039	1.096ProHis: 1.096 ± 0.024	2.182ProIle: 2.182 ± 0.034	2.696ProLys: 2.696 ± 0.038	4.33ProLeu: 4.33 ± 0.044	0.797ProMet: 0.797 ± 0.017	1.983ProAsn: 1.983 ± 0.034	2.685ProPro: 2.685 ± 0.063	2.355ProGln: 2.355 ± 0.039	2.28ProArg: 2.28 ± 0.033	4.548ProSer: 4.548 ± 0.056	2.663ProThr: 2.663 ± 0.05	3.021ProVal: 3.021 ± 0.037	0.48ProTrp: 0.48 ± 0.017	1.271ProTyr: 1.271 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	2.753GlnAla: 2.753 ± 0.05	0.474GlnCys: 0.474 ± 0.014	2.326GlnAsp: 2.326 ± 0.035	3.078GlnGlu: 3.078 ± 0.047	1.742GlnPhe: 1.742 ± 0.026	2.121GlnGly: 2.121 ± 0.031	0.99GlnHis: 0.99 ± 0.023	2.195GlnIle: 2.195 ± 0.032	2.773GlnLys: 2.773 ± 0.039	4.317GlnLeu: 4.317 ± 0.049	0.836GlnMet: 0.836 ± 0.02	1.997GlnAsn: 1.997 ± 0.023	1.933GlnPro: 1.933 ± 0.038	3.027GlnGln: 3.027 ± 0.115	2.342GlnArg: 2.342 ± 0.039	3.192GlnSer: 3.192 ± 0.04	2.093GlnThr: 2.093 ± 0.032	2.452GlnVal: 2.452 ± 0.028	0.452GlnTrp: 0.452 ± 0.013	1.245GlnTyr: 1.245 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	3.495ArgAla: 3.495 ± 0.037	0.704ArgCys: 0.704 ± 0.017	2.847ArgAsp: 2.847 ± 0.039	3.482ArgGlu: 3.482 ± 0.052	2.223ArgPhe: 2.223 ± 0.036	2.747ArgGly: 2.747 ± 0.038	1.135ArgHis: 1.135 ± 0.022	2.745ArgIle: 2.745 ± 0.033	3.733ArgLys: 3.733 ± 0.047	4.872ArgLeu: 4.872 ± 0.048	1.022ArgMet: 1.022 ± 0.024	2.38ArgAsn: 2.38 ± 0.03	2.161ArgPro: 2.161 ± 0.033	2.101ArgGln: 2.101 ± 0.037	3.46ArgArg: 3.46 ± 0.041	4.309ArgSer: 4.309 ± 0.042	2.564ArgThr: 2.564 ± 0.031	2.943ArgVal: 2.943 ± 0.04	0.565ArgTrp: 0.565 ± 0.015	1.579ArgTyr: 1.579 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.355SerAla: 6.355 ± 0.069	1.079SerCys: 1.079 ± 0.022	4.66SerAsp: 4.66 ± 0.055	5.54SerGlu: 5.54 ± 0.062	3.796SerPhe: 3.796 ± 0.042	5.423SerGly: 5.423 ± 0.063	1.882SerHis: 1.882 ± 0.031	4.477SerIle: 4.477 ± 0.054	5.709SerLys: 5.709 ± 0.059	8.482SerLeu: 8.482 ± 0.075	1.763SerMet: 1.763 ± 0.028	4.102SerAsn: 4.102 ± 0.047	4.159SerPro: 4.159 ± 0.054	3.812SerGln: 3.812 ± 0.043	4.562SerArg: 4.562 ± 0.053	10.445SerSer: 10.445 ± 0.184	5.303SerThr: 5.303 ± 0.095	5.191SerVal: 5.191 ± 0.052	0.883SerTrp: 0.883 ± 0.023	2.413SerTyr: 2.413 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	3.886ThrAla: 3.886 ± 0.041	0.747ThrCys: 0.747 ± 0.02	2.599ThrAsp: 2.599 ± 0.038	3.229ThrGlu: 3.229 ± 0.066	2.365ThrPhe: 2.365 ± 0.053	3.408ThrGly: 3.408 ± 0.075	1.161ThrHis: 1.161 ± 0.021	2.926ThrIle: 2.926 ± 0.043	3.336ThrLys: 3.336 ± 0.044	5.247ThrLeu: 5.247 ± 0.049	1.025ThrMet: 1.025 ± 0.021	2.384ThrAsn: 2.384 ± 0.03	3.1ThrPro: 3.1 ± 0.062	2.087ThrGln: 2.087 ± 0.031	2.603ThrArg: 2.603 ± 0.034	5.127ThrSer: 5.127 ± 0.093	3.427ThrThr: 3.427 ± 0.116	3.474ThrVal: 3.474 ± 0.05	0.588ThrTrp: 0.588 ± 0.016	1.507ThrTyr: 1.507 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	4.506ValAla: 4.506 ± 0.047	0.891ValCys: 0.891 ± 0.02	3.595ValAsp: 3.595 ± 0.041	4.067ValGlu: 4.067 ± 0.047	2.821ValPhe: 2.821 ± 0.038	3.48ValGly: 3.48 ± 0.046	1.324ValHis: 1.324 ± 0.025	3.222ValIle: 3.222 ± 0.041	3.767ValLys: 3.767 ± 0.047	6.315ValLeu: 6.315 ± 0.056	1.237ValMet: 1.237 ± 0.021	2.645ValAsn: 2.645 ± 0.037	3.262ValPro: 3.262 ± 0.04	2.278ValGln: 2.278 ± 0.028	3.012ValArg: 3.012 ± 0.039	5.483ValSer: 5.483 ± 0.053	3.328ValThr: 3.328 ± 0.044	4.319ValVal: 4.319 ± 0.044	0.675ValTrp: 0.675 ± 0.018	1.916ValTyr: 1.916 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.666TrpAla: 0.666 ± 0.019	0.275TrpCys: 0.275 ± 0.011	0.708TrpAsp: 0.708 ± 0.016	0.63TrpGlu: 0.63 ± 0.017	0.526TrpPhe: 0.526 ± 0.017	0.608TrpGly: 0.608 ± 0.019	0.242TrpHis: 0.242 ± 0.01	0.59TrpIle: 0.59 ± 0.015	0.772TrpLys: 0.772 ± 0.017	1.033TrpLeu: 1.033 ± 0.022	0.236TrpMet: 0.236 ± 0.009	0.58TrpAsn: 0.58 ± 0.015	0.354TrpPro: 0.354 ± 0.012	0.419TrpGln: 0.419 ± 0.013	0.646TrpArg: 0.646 ± 0.016	0.9TrpSer: 0.9 ± 0.02	0.594TrpThr: 0.594 ± 0.027	0.602TrpVal: 0.602 ± 0.016	0.172TrpTrp: 0.172 ± 0.009	0.36TrpTyr: 0.36 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.999TyrAla: 1.999 ± 0.029	0.487TyrCys: 0.487 ± 0.015	1.796TyrAsp: 1.796 ± 0.031	1.94TyrGlu: 1.94 ± 0.034	1.474TyrPhe: 1.474 ± 0.029	1.855TyrGly: 1.855 ± 0.037	0.742TyrHis: 0.742 ± 0.018	1.567TyrIle: 1.567 ± 0.027	1.809TyrLys: 1.809 ± 0.029	3.104TyrLeu: 3.104 ± 0.04	0.665TyrMet: 0.665 ± 0.016	1.507TyrAsn: 1.507 ± 0.024	1.231TyrPro: 1.231 ± 0.023	1.336TyrGln: 1.336 ± 0.024	1.559TyrArg: 1.559 ± 0.025	2.458TyrSer: 2.458 ± 0.034	1.603TyrThr: 1.603 ± 0.038	2.013TyrVal: 2.013 ± 0.041	0.37TyrTrp: 0.37 ± 0.014	1.235TyrTyr: 1.235 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5093 proteins (2500247 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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