Amino acid dipepetide frequency for Helicobacter cinaedi CCUG 18818 = ATCC BAA-847

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.989AlaAla: 2.989 ± 0.1
0.991AlaCys: 0.991 ± 0.043
3.146AlaAsp: 3.146 ± 0.068
3.428AlaGlu: 3.428 ± 0.08
3.906AlaPhe: 3.906 ± 0.077
3.467AlaGly: 3.467 ± 0.085
1.528AlaHis: 1.528 ± 0.046
5.463AlaIle: 5.463 ± 0.108
6.603AlaLys: 6.603 ± 0.106
8.991AlaLeu: 8.991 ± 0.125
2.045AlaMet: 2.045 ± 0.059
3.743AlaAsn: 3.743 ± 0.082
2.04AlaPro: 2.04 ± 0.055
3.298AlaGln: 3.298 ± 0.065
2.691AlaArg: 2.691 ± 0.072
3.905AlaSer: 3.905 ± 0.079
3.372AlaThr: 3.372 ± 0.077
3.307AlaVal: 3.307 ± 0.088
0.537AlaTrp: 0.537 ± 0.032
3.033AlaTyr: 3.033 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.942CysAla: 0.942 ± 0.041
0.141CysCys: 0.141 ± 0.016
0.877CysAsp: 0.877 ± 0.036
1.085CysGlu: 1.085 ± 0.042
0.771CysPhe: 0.771 ± 0.033
1.191CysGly: 1.191 ± 0.045
0.33CysHis: 0.33 ± 0.025
0.945CysIle: 0.945 ± 0.034
0.854CysLys: 0.854 ± 0.034
1.061CysLeu: 1.061 ± 0.046
0.32CysMet: 0.32 ± 0.022
0.53CysAsn: 0.53 ± 0.03
0.386CysPro: 0.386 ± 0.026
0.382CysGln: 0.382 ± 0.027
0.309CysArg: 0.309 ± 0.022
0.681CysSer: 0.681 ± 0.028
0.386CysThr: 0.386 ± 0.027
1.292CysVal: 1.292 ± 0.046
0.086CysTrp: 0.086 ± 0.012
0.434CysTyr: 0.434 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
2.179AspAla: 2.179 ± 0.068
0.732AspCys: 0.732 ± 0.039
2.237AspAsp: 2.237 ± 0.067
4.226AspGlu: 4.226 ± 0.078
3.655AspPhe: 3.655 ± 0.08
2.614AspGly: 2.614 ± 0.076
0.419AspHis: 0.419 ± 0.025
4.747AspIle: 4.747 ± 0.094
4.625AspLys: 4.625 ± 0.099
4.391AspLeu: 4.391 ± 0.081
1.514AspMet: 1.514 ± 0.045
2.572AspAsn: 2.572 ± 0.074
0.953AspPro: 0.953 ± 0.044
0.503AspGln: 0.503 ± 0.025
1.832AspArg: 1.832 ± 0.056
6.125AspSer: 6.125 ± 0.103
2.767AspThr: 2.767 ± 0.071
2.808AspVal: 2.808 ± 0.063
0.377AspTrp: 0.377 ± 0.024
2.184AspTyr: 2.184 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
4.119GluAla: 4.119 ± 0.081
0.931GluCys: 0.931 ± 0.036
2.409GluAsp: 2.409 ± 0.064
3.456GluGlu: 3.456 ± 0.095
3.208GluPhe: 3.208 ± 0.07
2.832GluGly: 2.832 ± 0.071
1.142GluHis: 1.142 ± 0.043
6.232GluIle: 6.232 ± 0.094
4.97GluLys: 4.97 ± 0.096
6.606GluLeu: 6.606 ± 0.104
1.672GluMet: 1.672 ± 0.05
4.366GluAsn: 4.366 ± 0.084
1.413GluPro: 1.413 ± 0.049
2.752GluGln: 2.752 ± 0.078
2.708GluArg: 2.708 ± 0.067
7.083GluSer: 7.083 ± 0.137
1.992GluThr: 1.992 ± 0.059
3.99GluVal: 3.99 ± 0.087
0.636GluTrp: 0.636 ± 0.027
2.779GluTyr: 2.779 ± 0.073
0.0GluXaa: 0.0 ± 0.0
Phe
3.782PheAla: 3.782 ± 0.083
0.88PheCys: 0.88 ± 0.036
3.048PheAsp: 3.048 ± 0.074
3.163PheGlu: 3.163 ± 0.072
2.697PhePhe: 2.697 ± 0.077
3.737PheGly: 3.737 ± 0.081
0.929PheHis: 0.929 ± 0.034
3.979PheIle: 3.979 ± 0.094
3.199PheLys: 3.199 ± 0.07
5.017PheLeu: 5.017 ± 0.089
1.318PheMet: 1.318 ± 0.045
2.493PheAsn: 2.493 ± 0.061
1.237PhePro: 1.237 ± 0.043
1.123PheGln: 1.123 ± 0.04
1.454PheArg: 1.454 ± 0.044
4.232PheSer: 4.232 ± 0.084
2.126PheThr: 2.126 ± 0.055
3.552PheVal: 3.552 ± 0.087
0.481PheTrp: 0.481 ± 0.028
2.289PheTyr: 2.289 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
4.418GlyAla: 4.418 ± 0.1
0.715GlyCys: 0.715 ± 0.037
3.001GlyAsp: 3.001 ± 0.068
4.138GlyGlu: 4.138 ± 0.087
3.695GlyPhe: 3.695 ± 0.075
4.783GlyGly: 4.783 ± 0.135
1.022GlyHis: 1.022 ± 0.035
5.358GlyIle: 5.358 ± 0.11
4.343GlyLys: 4.343 ± 0.093
5.664GlyLeu: 5.664 ± 0.092
1.491GlyMet: 1.491 ± 0.053
2.711GlyAsn: 2.711 ± 0.057
0.592GlyPro: 0.592 ± 0.032
1.651GlyGln: 1.651 ± 0.061
2.25GlyArg: 2.25 ± 0.062
3.885GlySer: 3.885 ± 0.08
2.191GlyThr: 2.191 ± 0.071
4.783GlyVal: 4.783 ± 0.095
0.456GlyTrp: 0.456 ± 0.027
2.614GlyTyr: 2.614 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.068HisAla: 1.068 ± 0.044
0.34HisCys: 0.34 ± 0.023
0.623HisAsp: 0.623 ± 0.028
0.549HisGlu: 0.549 ± 0.03
1.517HisPhe: 1.517 ± 0.05
0.721HisGly: 0.721 ± 0.033
0.533HisHis: 0.533 ± 0.029
2.64HisIle: 2.64 ± 0.07
1.986HisLys: 1.986 ± 0.05
2.156HisLeu: 2.156 ± 0.06
0.28HisMet: 0.28 ± 0.021
1.582HisAsn: 1.582 ± 0.049
0.806HisPro: 0.806 ± 0.035
0.695HisGln: 0.695 ± 0.032
0.814HisArg: 0.814 ± 0.036
1.827HisSer: 1.827 ± 0.06
1.761HisThr: 1.761 ± 0.06
0.179HisVal: 0.179 ± 0.017
0.144HisTrp: 0.144 ± 0.013
1.051HisTyr: 1.051 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
6.762IleAla: 6.762 ± 0.103
1.093IleCys: 1.093 ± 0.037
4.529IleAsp: 4.529 ± 0.092
5.503IleGlu: 5.503 ± 0.092
3.94IlePhe: 3.94 ± 0.095
4.618IleGly: 4.618 ± 0.097
1.691IleHis: 1.691 ± 0.05
5.603IleIle: 5.603 ± 0.121
5.886IleLys: 5.886 ± 0.116
8.718IleLeu: 8.718 ± 0.135
1.663IleMet: 1.663 ± 0.056
3.884IleAsn: 3.884 ± 0.087
2.819IlePro: 2.819 ± 0.07
2.934IleGln: 2.934 ± 0.066
2.413IleArg: 2.413 ± 0.072
5.242IleSer: 5.242 ± 0.088
4.446IleThr: 4.446 ± 0.089
4.628IleVal: 4.628 ± 0.088
0.589IleTrp: 0.589 ± 0.032
3.063IleTyr: 3.063 ± 0.074
0.0IleXaa: 0.0 ± 0.0
Lys
6.278LysAla: 6.278 ± 0.107
0.626LysCys: 0.626 ± 0.032
5.414LysAsp: 5.414 ± 0.092
6.652LysGlu: 6.652 ± 0.137
2.23LysPhe: 2.23 ± 0.05
4.431LysGly: 4.431 ± 0.079
1.781LysHis: 1.781 ± 0.055
6.452LysIle: 6.452 ± 0.107
5.722LysLys: 5.722 ± 0.115
6.438LysLeu: 6.438 ± 0.106
1.835LysMet: 1.835 ± 0.051
4.998LysAsn: 4.998 ± 0.09
2.66LysPro: 2.66 ± 0.069
3.592LysGln: 3.592 ± 0.079
3.023LysArg: 3.023 ± 0.07
5.291LysSer: 5.291 ± 0.1
3.623LysThr: 3.623 ± 0.078
3.795LysVal: 3.795 ± 0.085
0.549LysTrp: 0.549 ± 0.031
2.401LysTyr: 2.401 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
7.089LeuAla: 7.089 ± 0.127
1.812LeuCys: 1.812 ± 0.063
6.023LeuAsp: 6.023 ± 0.1
7.797LeuGlu: 7.797 ± 0.113
4.73LeuPhe: 4.73 ± 0.104
6.661LeuGly: 6.661 ± 0.122
2.422LeuHis: 2.422 ± 0.061
6.219LeuIle: 6.219 ± 0.105
8.303LeuLys: 8.303 ± 0.127
9.922LeuLeu: 9.922 ± 0.161
2.126LeuMet: 2.126 ± 0.055
5.398LeuAsn: 5.398 ± 0.101
3.783LeuPro: 3.783 ± 0.087
4.942LeuGln: 4.942 ± 0.095
3.936LeuArg: 3.936 ± 0.075
8.521LeuSer: 8.521 ± 0.127
4.267LeuThr: 4.267 ± 0.075
4.892LeuVal: 4.892 ± 0.092
0.888LeuTrp: 0.888 ± 0.038
3.668LeuTyr: 3.668 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
1.696MetAla: 1.696 ± 0.054
0.339MetCys: 0.339 ± 0.022
1.077MetAsp: 1.077 ± 0.042
1.375MetGlu: 1.375 ± 0.052
0.925MetPhe: 0.925 ± 0.039
1.602MetGly: 1.602 ± 0.053
0.328MetHis: 0.328 ± 0.019
1.699MetIle: 1.699 ± 0.054
1.663MetLys: 1.663 ± 0.045
2.86MetLeu: 2.86 ± 0.067
0.533MetMet: 0.533 ± 0.028
1.015MetAsn: 1.015 ± 0.035
1.157MetPro: 1.157 ± 0.039
1.478MetGln: 1.478 ± 0.051
1.19MetArg: 1.19 ± 0.037
1.743MetSer: 1.743 ± 0.047
0.775MetThr: 0.775 ± 0.033
1.145MetVal: 1.145 ± 0.041
0.189MetTrp: 0.189 ± 0.017
0.641MetTyr: 0.641 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
5.417AsnAla: 5.417 ± 0.104
0.426AsnCys: 0.426 ± 0.026
2.802AsnAsp: 2.802 ± 0.062
3.573AsnGlu: 3.573 ± 0.08
2.301AsnPhe: 2.301 ± 0.066
3.336AsnGly: 3.336 ± 0.062
1.086AsnHis: 1.086 ± 0.041
4.397AsnIle: 4.397 ± 0.09
3.856AsnLys: 3.856 ± 0.088
5.909AsnLeu: 5.909 ± 0.1
1.067AsnMet: 1.067 ± 0.043
2.839AsnAsn: 2.839 ± 0.09
2.724AsnPro: 2.724 ± 0.07
1.802AsnGln: 1.802 ± 0.056
1.675AsnArg: 1.675 ± 0.043
2.706AsnSer: 2.706 ± 0.063
3.484AsnThr: 3.484 ± 0.091
2.916AsnVal: 2.916 ± 0.064
0.271AsnTrp: 0.271 ± 0.021
1.623AsnTyr: 1.623 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
1.462ProAla: 1.462 ± 0.048
0.428ProCys: 0.428 ± 0.029
1.12ProAsp: 1.12 ± 0.042
1.349ProGlu: 1.349 ± 0.048
1.839ProPhe: 1.839 ± 0.058
0.894ProGly: 0.894 ± 0.044
1.031ProHis: 1.031 ± 0.041
2.511ProIle: 2.511 ± 0.072
2.888ProLys: 2.888 ± 0.065
3.958ProLeu: 3.958 ± 0.08
0.709ProMet: 0.709 ± 0.03
2.003ProAsn: 2.003 ± 0.056
1.126ProPro: 1.126 ± 0.046
2.046ProGln: 2.046 ± 0.056
1.045ProArg: 1.045 ± 0.039
2.455ProSer: 2.455 ± 0.061
1.955ProThr: 1.955 ± 0.051
1.333ProVal: 1.333 ± 0.051
0.188ProTrp: 0.188 ± 0.019
1.579ProTyr: 1.579 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
2.841GlnAla: 2.841 ± 0.071
0.441GlnCys: 0.441 ± 0.028
2.665GlnAsp: 2.665 ± 0.072
3.422GlnGlu: 3.422 ± 0.084
1.114GlnPhe: 1.114 ± 0.043
2.699GlnGly: 2.699 ± 0.06
0.701GlnHis: 0.701 ± 0.034
3.249GlnIle: 3.249 ± 0.076
3.922GlnLys: 3.922 ± 0.079
2.165GlnLeu: 2.165 ± 0.063
0.978GlnMet: 0.978 ± 0.038
3.421GlnAsn: 3.421 ± 0.083
0.866GlnPro: 0.866 ± 0.035
1.326GlnGln: 1.326 ± 0.048
1.562GlnArg: 1.562 ± 0.051
3.502GlnSer: 3.502 ± 0.062
2.336GlnThr: 2.336 ± 0.058
1.906GlnVal: 1.906 ± 0.061
0.374GlnTrp: 0.374 ± 0.021
1.221GlnTyr: 1.221 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.493ArgAla: 2.493 ± 0.07
0.303ArgCys: 0.303 ± 0.019
2.185ArgAsp: 2.185 ± 0.058
3.036ArgGlu: 3.036 ± 0.08
2.398ArgPhe: 2.398 ± 0.06
2.12ArgGly: 2.12 ± 0.055
0.734ArgHis: 0.734 ± 0.034
3.492ArgIle: 3.492 ± 0.078
2.302ArgLys: 2.302 ± 0.063
3.964ArgLeu: 3.964 ± 0.074
0.823ArgMet: 0.823 ± 0.033
1.65ArgAsn: 1.65 ± 0.05
0.906ArgPro: 0.906 ± 0.038
1.314ArgGln: 1.314 ± 0.041
1.253ArgArg: 1.253 ± 0.047
1.852ArgSer: 1.852 ± 0.055
1.434ArgThr: 1.434 ± 0.049
2.452ArgVal: 2.452 ± 0.069
0.243ArgTrp: 0.243 ± 0.019
1.554ArgTyr: 1.554 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
4.683SerAla: 4.683 ± 0.093
0.775SerCys: 0.775 ± 0.036
2.847SerAsp: 2.847 ± 0.065
3.486SerGlu: 3.486 ± 0.076
4.193SerPhe: 4.193 ± 0.079
4.599SerGly: 4.599 ± 0.092
2.011SerHis: 2.011 ± 0.059
5.951SerIle: 5.951 ± 0.099
6.171SerLys: 6.171 ± 0.118
8.753SerLeu: 8.753 ± 0.148
1.727SerMet: 1.727 ± 0.049
3.68SerAsn: 3.68 ± 0.089
2.472SerPro: 2.472 ± 0.068
3.677SerGln: 3.677 ± 0.078
2.355SerArg: 2.355 ± 0.058
5.266SerSer: 5.266 ± 0.109
3.643SerThr: 3.643 ± 0.081
4.754SerVal: 4.754 ± 0.081
0.512SerTrp: 0.512 ± 0.027
2.807SerTyr: 2.807 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
2.511ThrAla: 2.511 ± 0.068
0.454ThrCys: 0.454 ± 0.025
1.938ThrAsp: 1.938 ± 0.054
2.026ThrGlu: 2.026 ± 0.056
2.142ThrPhe: 2.142 ± 0.061
2.086ThrGly: 2.086 ± 0.068
1.746ThrHis: 1.746 ± 0.055
3.464ThrIle: 3.464 ± 0.075
3.442ThrLys: 3.442 ± 0.075
6.532ThrLeu: 6.532 ± 0.114
1.039ThrMet: 1.039 ± 0.035
2.56ThrAsn: 2.56 ± 0.07
2.801ThrPro: 2.801 ± 0.074
3.937ThrGln: 3.937 ± 0.086
1.799ThrArg: 1.799 ± 0.05
3.255ThrSer: 3.255 ± 0.075
2.54ThrThr: 2.54 ± 0.074
0.496ThrVal: 0.496 ± 0.03
0.275ThrTrp: 0.275 ± 0.024
1.86ThrTyr: 1.86 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
4.283ValAla: 4.283 ± 0.09
0.991ValCys: 0.991 ± 0.038
2.878ValAsp: 2.878 ± 0.072
3.724ValGlu: 3.724 ± 0.077
2.998ValPhe: 2.998 ± 0.071
4.283ValGly: 4.283 ± 0.103
0.672ValHis: 0.672 ± 0.038
4.238ValIle: 4.238 ± 0.087
3.662ValLys: 3.662 ± 0.074
5.797ValLeu: 5.797 ± 0.109
1.382ValMet: 1.382 ± 0.051
2.286ValAsn: 2.286 ± 0.058
1.592ValPro: 1.592 ± 0.057
1.446ValGln: 1.446 ± 0.047
2.286ValArg: 2.286 ± 0.065
4.186ValSer: 4.186 ± 0.083
1.568ValThr: 1.568 ± 0.051
3.816ValVal: 3.816 ± 0.087
0.544ValTrp: 0.544 ± 0.034
1.91ValTyr: 1.91 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.522TrpAla: 0.522 ± 0.032
0.105TrpCys: 0.105 ± 0.013
0.414TrpAsp: 0.414 ± 0.024
0.567TrpGlu: 0.567 ± 0.027
0.358TrpPhe: 0.358 ± 0.024
0.617TrpGly: 0.617 ± 0.035
0.254TrpHis: 0.254 ± 0.023
0.66TrpIle: 0.66 ± 0.032
0.394TrpLys: 0.394 ± 0.025
0.951TrpLeu: 0.951 ± 0.039
0.107TrpMet: 0.107 ± 0.012
0.394TrpAsn: 0.394 ± 0.023
0.056TrpPro: 0.056 ± 0.009
0.479TrpGln: 0.479 ± 0.027
0.411TrpArg: 0.411 ± 0.025
0.423TrpSer: 0.423 ± 0.027
0.176TrpThr: 0.176 ± 0.019
0.465TrpVal: 0.465 ± 0.027
0.117TrpTrp: 0.117 ± 0.015
0.271TrpTyr: 0.271 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.95TyrAla: 2.95 ± 0.066
0.476TyrCys: 0.476 ± 0.024
2.227TyrAsp: 2.227 ± 0.063
2.74TyrGlu: 2.74 ± 0.074
2.122TyrPhe: 2.122 ± 0.058
2.469TyrGly: 2.469 ± 0.069
0.908TyrHis: 0.908 ± 0.041
2.727TyrIle: 2.727 ± 0.065
3.002TyrLys: 3.002 ± 0.081
3.545TyrLeu: 3.545 ± 0.076
0.802TyrMet: 0.802 ± 0.039
2.089TyrAsn: 2.089 ± 0.064
1.528TyrPro: 1.528 ± 0.05
1.333TyrGln: 1.333 ± 0.049
1.5TyrArg: 1.5 ± 0.054
2.181TyrSer: 2.181 ± 0.062
2.06TyrThr: 2.06 ± 0.052
2.033TyrVal: 2.033 ± 0.058
0.286TyrTrp: 0.286 ± 0.018
1.474TyrTyr: 1.474 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2315 proteins (675867 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski