Amino acid dipepetide frequency for Geoalkalibacter subterraneus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.181AlaAla: 10.181 ± 0.128	1.283AlaCys: 1.283 ± 0.064	5.231AlaAsp: 5.231 ± 0.076	6.523AlaGlu: 6.523 ± 0.094	3.542AlaPhe: 3.542 ± 0.069	7.786AlaGly: 7.786 ± 0.106	1.893AlaHis: 1.893 ± 0.05	4.675AlaIle: 4.675 ± 0.079	3.047AlaLys: 3.047 ± 0.069	10.598AlaLeu: 10.598 ± 0.144	2.41AlaMet: 2.41 ± 0.059	2.194AlaAsn: 2.194 ± 0.053	3.673AlaPro: 3.673 ± 0.068	3.701AlaGln: 3.701 ± 0.063	6.961AlaArg: 6.961 ± 0.097	4.402AlaSer: 4.402 ± 0.075	4.05AlaThr: 4.05 ± 0.065	6.972AlaVal: 6.972 ± 0.088	0.948AlaTrp: 0.948 ± 0.034	2.145AlaTyr: 2.145 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.149CysAla: 1.149 ± 0.057	0.196CysCys: 0.196 ± 0.015	0.721CysAsp: 0.721 ± 0.028	0.746CysGlu: 0.746 ± 0.029	0.477CysPhe: 0.477 ± 0.023	1.238CysGly: 1.238 ± 0.039	0.897CysHis: 0.897 ± 0.146	0.561CysIle: 0.561 ± 0.026	0.363CysLys: 0.363 ± 0.022	1.211CysLeu: 1.211 ± 0.041	0.217CysMet: 0.217 ± 0.014	0.381CysAsn: 0.381 ± 0.021	0.786CysPro: 0.786 ± 0.035	0.359CysGln: 0.359 ± 0.019	1.04CysArg: 1.04 ± 0.038	0.723CysSer: 0.723 ± 0.04	0.58CysThr: 0.58 ± 0.028	0.742CysVal: 0.742 ± 0.031	0.13CysTrp: 0.13 ± 0.011	0.295CysTyr: 0.295 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	5.044AspAla: 5.044 ± 0.082	0.853AspCys: 0.853 ± 0.063	3.041AspAsp: 3.041 ± 0.066	4.23AspGlu: 4.23 ± 0.078	2.778AspPhe: 2.778 ± 0.055	4.442AspGly: 4.442 ± 0.104	1.314AspHis: 1.314 ± 0.039	3.351AspIle: 3.351 ± 0.063	2.258AspLys: 2.258 ± 0.057	7.033AspLeu: 7.033 ± 0.087	1.263AspMet: 1.263 ± 0.039	1.755AspAsn: 1.755 ± 0.05	3.194AspPro: 3.194 ± 0.069	2.191AspGln: 2.191 ± 0.05	3.896AspArg: 3.896 ± 0.068	2.984AspSer: 2.984 ± 0.069	2.303AspThr: 2.303 ± 0.052	3.608AspVal: 3.608 ± 0.068	0.772AspTrp: 0.772 ± 0.029	1.834AspTyr: 1.834 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.477GluAla: 6.477 ± 0.1	0.614GluCys: 0.614 ± 0.03	3.862GluAsp: 3.862 ± 0.061	5.585GluGlu: 5.585 ± 0.1	2.321GluPhe: 2.321 ± 0.055	5.09GluGly: 5.09 ± 0.092	1.428GluHis: 1.428 ± 0.041	4.726GluIle: 4.726 ± 0.08	4.706GluLys: 4.706 ± 0.085	6.702GluLeu: 6.702 ± 0.095	2.019GluMet: 2.019 ± 0.047	2.606GluAsn: 2.606 ± 0.054	2.55GluPro: 2.55 ± 0.064	3.328GluGln: 3.328 ± 0.072	4.926GluArg: 4.926 ± 0.083	3.411GluSer: 3.411 ± 0.061	3.56GluThr: 3.56 ± 0.059	5.195GluVal: 5.195 ± 0.083	0.612GluTrp: 0.612 ± 0.029	1.554GluTyr: 1.554 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.462PheAla: 3.462 ± 0.061	0.635PheCys: 0.635 ± 0.027	2.759PheAsp: 2.759 ± 0.055	2.562PheGlu: 2.562 ± 0.051	2.073PhePhe: 2.073 ± 0.051	3.314PheGly: 3.314 ± 0.068	0.899PheHis: 0.899 ± 0.029	2.142PheIle: 2.142 ± 0.053	1.565PheLys: 1.565 ± 0.044	4.31PheLeu: 4.31 ± 0.078	0.917PheMet: 0.917 ± 0.035	1.461PheAsn: 1.461 ± 0.038	1.769PhePro: 1.769 ± 0.048	1.2PheGln: 1.2 ± 0.038	2.403PheArg: 2.403 ± 0.062	2.986PheSer: 2.986 ± 0.066	2.017PheThr: 2.017 ± 0.048	2.644PheVal: 2.644 ± 0.053	0.494PheTrp: 0.494 ± 0.026	1.172PheTyr: 1.172 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.589GlyAla: 6.589 ± 0.095	1.176GlyCys: 1.176 ± 0.042	4.338GlyAsp: 4.338 ± 0.07	5.575GlyGlu: 5.575 ± 0.085	3.342GlyPhe: 3.342 ± 0.059	6.216GlyGly: 6.216 ± 0.109	1.783GlyHis: 1.783 ± 0.043	4.665GlyIle: 4.665 ± 0.075	3.876GlyLys: 3.876 ± 0.068	7.806GlyLeu: 7.806 ± 0.108	2.237GlyMet: 2.237 ± 0.051	2.38GlyAsn: 2.38 ± 0.063	2.504GlyPro: 2.504 ± 0.056	2.735GlyGln: 2.735 ± 0.054	5.631GlyArg: 5.631 ± 0.082	4.321GlySer: 4.321 ± 0.085	3.992GlyThr: 3.992 ± 0.075	5.757GlyVal: 5.757 ± 0.079	0.958GlyTrp: 0.958 ± 0.033	2.355GlyTyr: 2.355 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.812HisAla: 1.812 ± 0.062	0.368HisCys: 0.368 ± 0.021	1.327HisAsp: 1.327 ± 0.044	1.278HisGlu: 1.278 ± 0.037	1.054HisPhe: 1.054 ± 0.032	1.903HisGly: 1.903 ± 0.052	0.686HisHis: 0.686 ± 0.056	1.169HisIle: 1.169 ± 0.037	0.822HisLys: 0.822 ± 0.028	2.525HisLeu: 2.525 ± 0.057	0.395HisMet: 0.395 ± 0.023	0.734HisAsn: 0.734 ± 0.033	1.524HisPro: 1.524 ± 0.044	0.97HisGln: 0.97 ± 0.04	1.615HisArg: 1.615 ± 0.044	1.195HisSer: 1.195 ± 0.043	1.039HisThr: 1.039 ± 0.048	1.258HisVal: 1.258 ± 0.035	0.26HisTrp: 0.26 ± 0.018	0.706HisTyr: 0.706 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.223IleAla: 5.223 ± 0.084	0.707IleCys: 0.707 ± 0.03	3.93IleAsp: 3.93 ± 0.067	4.503IleGlu: 4.503 ± 0.081	2.318IlePhe: 2.318 ± 0.054	4.366IleGly: 4.366 ± 0.074	1.277IleHis: 1.277 ± 0.042	2.845IleIle: 2.845 ± 0.063	2.298IleLys: 2.298 ± 0.055	5.492IleLeu: 5.492 ± 0.096	1.136IleMet: 1.136 ± 0.038	1.938IleAsn: 1.938 ± 0.046	2.736IlePro: 2.736 ± 0.054	1.549IleGln: 1.549 ± 0.043	3.448IleArg: 3.448 ± 0.068	3.284IleSer: 3.284 ± 0.06	2.748IleThr: 2.748 ± 0.056	3.659IleVal: 3.659 ± 0.069	0.46IleTrp: 0.46 ± 0.022	1.435IleTyr: 1.435 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.972LysAla: 3.972 ± 0.078	0.343LysCys: 0.343 ± 0.022	2.384LysAsp: 2.384 ± 0.062	3.172LysGlu: 3.172 ± 0.074	1.319LysPhe: 1.319 ± 0.043	3.26LysGly: 3.26 ± 0.066	0.766LysHis: 0.766 ± 0.033	2.878LysIle: 2.878 ± 0.061	2.985LysLys: 2.985 ± 0.081	3.688LysLeu: 3.688 ± 0.075	1.155LysMet: 1.155 ± 0.041	1.669LysAsn: 1.669 ± 0.043	1.882LysPro: 1.882 ± 0.048	1.604LysGln: 1.604 ± 0.044	2.702LysArg: 2.702 ± 0.058	2.357LysSer: 2.357 ± 0.053	2.396LysThr: 2.396 ± 0.06	3.205LysVal: 3.205 ± 0.062	0.378LysTrp: 0.378 ± 0.021	1.064LysTyr: 1.064 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	10.459LeuAla: 10.459 ± 0.13	1.321LeuCys: 1.321 ± 0.044	6.338LeuAsp: 6.338 ± 0.086	7.635LeuGlu: 7.635 ± 0.118	4.235LeuPhe: 4.235 ± 0.079	7.666LeuGly: 7.666 ± 0.114	2.324LeuHis: 2.324 ± 0.056	5.219LeuIle: 5.219 ± 0.093	4.695LeuLys: 4.695 ± 0.08	10.904LeuLeu: 10.904 ± 0.174	2.293LeuMet: 2.293 ± 0.053	3.11LeuAsn: 3.11 ± 0.058	5.295LeuPro: 5.295 ± 0.074	3.641LeuGln: 3.641 ± 0.072	7.468LeuArg: 7.468 ± 0.117	6.63LeuSer: 6.63 ± 0.106	5.398LeuThr: 5.398 ± 0.08	7.447LeuVal: 7.447 ± 0.099	1.066LeuTrp: 1.066 ± 0.036	2.446LeuTyr: 2.446 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.562MetAla: 2.562 ± 0.064	0.195MetCys: 0.195 ± 0.014	1.235MetAsp: 1.235 ± 0.037	1.653MetGlu: 1.653 ± 0.045	0.727MetPhe: 0.727 ± 0.033	1.761MetGly: 1.761 ± 0.043	0.444MetHis: 0.444 ± 0.025	1.355MetIle: 1.355 ± 0.041	1.423MetLys: 1.423 ± 0.039	2.29MetLeu: 2.29 ± 0.054	0.561MetMet: 0.561 ± 0.028	0.842MetAsn: 0.842 ± 0.027	1.199MetPro: 1.199 ± 0.036	0.857MetGln: 0.857 ± 0.033	1.479MetArg: 1.479 ± 0.041	1.429MetSer: 1.429 ± 0.04	1.469MetThr: 1.469 ± 0.04	1.932MetVal: 1.932 ± 0.039	0.152MetTrp: 0.152 ± 0.013	0.355MetTyr: 0.355 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.646AsnAla: 2.646 ± 0.054	0.478AsnCys: 0.478 ± 0.034	1.586AsnAsp: 1.586 ± 0.042	1.682AsnGlu: 1.682 ± 0.046	1.246AsnPhe: 1.246 ± 0.041	2.274AsnGly: 2.274 ± 0.062	0.686AsnHis: 0.686 ± 0.03	1.918AsnIle: 1.918 ± 0.046	1.156AsnLys: 1.156 ± 0.041	3.658AsnLeu: 3.658 ± 0.069	0.717AsnMet: 0.717 ± 0.028	1.015AsnAsn: 1.015 ± 0.04	2.117AsnPro: 2.117 ± 0.046	1.131AsnGln: 1.131 ± 0.035	2.171AsnArg: 2.171 ± 0.055	1.464AsnSer: 1.464 ± 0.05	1.408AsnThr: 1.408 ± 0.043	2.038AsnVal: 2.038 ± 0.051	0.39AsnTrp: 0.39 ± 0.025	0.939AsnTyr: 0.939 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.116ProAla: 4.116 ± 0.081	0.476ProCys: 0.476 ± 0.023	3.162ProAsp: 3.162 ± 0.063	4.114ProGlu: 4.114 ± 0.076	1.975ProPhe: 1.975 ± 0.049	3.859ProGly: 3.859 ± 0.072	1.097ProHis: 1.097 ± 0.041	1.871ProIle: 1.871 ± 0.047	1.494ProLys: 1.494 ± 0.043	4.656ProLeu: 4.656 ± 0.071	1.006ProMet: 1.006 ± 0.031	1.132ProAsn: 1.132 ± 0.038	2.129ProPro: 2.129 ± 0.052	1.994ProGln: 1.994 ± 0.045	2.896ProArg: 2.896 ± 0.06	2.471ProSer: 2.471 ± 0.052	2.024ProThr: 2.024 ± 0.046	3.798ProVal: 3.798 ± 0.064	0.601ProTrp: 0.601 ± 0.027	1.183ProTyr: 1.183 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.92GlnAla: 3.92 ± 0.072	0.418GlnCys: 0.418 ± 0.024	1.821GlnAsp: 1.821 ± 0.042	2.648GlnGlu: 2.648 ± 0.056	1.238GlnPhe: 1.238 ± 0.039	3.079GlnGly: 3.079 ± 0.062	0.691GlnHis: 0.691 ± 0.03	2.238GlnIle: 2.238 ± 0.05	1.902GlnLys: 1.902 ± 0.05	3.307GlnLeu: 3.307 ± 0.059	0.952GlnMet: 0.952 ± 0.037	1.116GlnAsn: 1.116 ± 0.036	1.463GlnPro: 1.463 ± 0.04	1.853GlnGln: 1.853 ± 0.056	2.79GlnArg: 2.79 ± 0.058	1.945GlnSer: 1.945 ± 0.046	1.792GlnThr: 1.792 ± 0.047	2.972GlnVal: 2.972 ± 0.058	0.488GlnTrp: 0.488 ± 0.022	0.846GlnTyr: 0.846 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	5.316ArgAla: 5.316 ± 0.089	0.844ArgCys: 0.844 ± 0.033	4.068ArgAsp: 4.068 ± 0.08	5.637ArgGlu: 5.637 ± 0.106	2.98ArgPhe: 2.98 ± 0.058	4.447ArgGly: 4.447 ± 0.072	1.65ArgHis: 1.65 ± 0.041	4.668ArgIle: 4.668 ± 0.081	3.172ArgLys: 3.172 ± 0.067	7.796ArgLeu: 7.796 ± 0.09	1.848ArgMet: 1.848 ± 0.049	2.236ArgAsn: 2.236 ± 0.052	2.811ArgPro: 2.811 ± 0.058	2.939ArgGln: 2.939 ± 0.058	5.464ArgArg: 5.464 ± 0.093	3.504ArgSer: 3.504 ± 0.063	3.083ArgThr: 3.083 ± 0.056	4.687ArgVal: 4.687 ± 0.081	0.766ArgTrp: 0.766 ± 0.027	2.121ArgTyr: 2.121 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.027SerAla: 5.027 ± 0.083	0.807SerCys: 0.807 ± 0.06	3.158SerAsp: 3.158 ± 0.065	3.457SerGlu: 3.457 ± 0.063	2.5SerPhe: 2.5 ± 0.057	5.041SerGly: 5.041 ± 0.095	1.268SerHis: 1.268 ± 0.04	2.727SerIle: 2.727 ± 0.06	1.877SerLys: 1.877 ± 0.049	6.067SerLeu: 6.067 ± 0.092	1.347SerMet: 1.347 ± 0.04	1.597SerAsn: 1.597 ± 0.046	2.763SerPro: 2.763 ± 0.063	1.886SerGln: 1.886 ± 0.052	3.995SerArg: 3.995 ± 0.075	3.34SerSer: 3.34 ± 0.078	2.55SerThr: 2.55 ± 0.062	3.531SerVal: 3.531 ± 0.064	0.711SerTrp: 0.711 ± 0.031	1.471SerTyr: 1.471 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.541ThrAla: 4.541 ± 0.071	0.63ThrCys: 0.63 ± 0.039	2.629ThrAsp: 2.629 ± 0.057	2.822ThrGlu: 2.822 ± 0.054	1.948ThrPhe: 1.948 ± 0.047	4.449ThrGly: 4.449 ± 0.079	1.086ThrHis: 1.086 ± 0.03	2.661ThrIle: 2.661 ± 0.059	1.381ThrLys: 1.381 ± 0.043	5.97ThrLeu: 5.97 ± 0.081	0.993ThrMet: 0.993 ± 0.034	1.292ThrAsn: 1.292 ± 0.039	2.763ThrPro: 2.763 ± 0.068	1.541ThrGln: 1.541 ± 0.039	3.057ThrArg: 3.057 ± 0.056	2.539ThrSer: 2.539 ± 0.064	2.54ThrThr: 2.54 ± 0.068	3.71ThrVal: 3.71 ± 0.071	0.495ThrTrp: 0.495 ± 0.022	1.264ThrTyr: 1.264 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	6.826ValAla: 6.826 ± 0.101	0.94ValCys: 0.94 ± 0.034	4.39ValAsp: 4.39 ± 0.064	5.258ValGlu: 5.258 ± 0.089	2.984ValPhe: 2.984 ± 0.059	5.092ValGly: 5.092 ± 0.082	1.468ValHis: 1.468 ± 0.044	3.974ValIle: 3.974 ± 0.067	2.84ValLys: 2.84 ± 0.061	7.342ValLeu: 7.342 ± 0.106	1.733ValMet: 1.733 ± 0.044	2.142ValAsn: 2.142 ± 0.054	3.117ValPro: 3.117 ± 0.058	2.227ValGln: 2.227 ± 0.053	4.974ValArg: 4.974 ± 0.079	4.134ValSer: 4.134 ± 0.07	3.712ValThr: 3.712 ± 0.067	5.854ValVal: 5.854 ± 0.087	0.649ValTrp: 0.649 ± 0.027	1.665ValTyr: 1.665 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.8TrpAla: 0.8 ± 0.032	0.147TrpCys: 0.147 ± 0.012	0.597TrpAsp: 0.597 ± 0.027	0.701TrpGlu: 0.701 ± 0.03	0.458TrpPhe: 0.458 ± 0.022	0.836TrpGly: 0.836 ± 0.036	0.278TrpHis: 0.278 ± 0.015	0.551TrpIle: 0.551 ± 0.023	0.453TrpLys: 0.453 ± 0.024	1.19TrpLeu: 1.19 ± 0.04	0.252TrpMet: 0.252 ± 0.018	0.356TrpAsn: 0.356 ± 0.023	0.438TrpPro: 0.438 ± 0.025	0.607TrpGln: 0.607 ± 0.024	0.879TrpArg: 0.879 ± 0.032	0.626TrpSer: 0.626 ± 0.028	0.495TrpThr: 0.495 ± 0.026	0.698TrpVal: 0.698 ± 0.028	0.154TrpTrp: 0.154 ± 0.014	0.287TrpTyr: 0.287 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.097TyrAla: 2.097 ± 0.054	0.382TyrCys: 0.382 ± 0.021	1.565TyrAsp: 1.565 ± 0.046	1.491TyrGlu: 1.491 ± 0.038	1.265TyrPhe: 1.265 ± 0.039	2.116TyrGly: 2.116 ± 0.05	0.703TyrHis: 0.703 ± 0.028	1.157TyrIle: 1.157 ± 0.033	0.867TyrLys: 0.867 ± 0.032	3.048TyrLeu: 3.048 ± 0.062	0.47TyrMet: 0.47 ± 0.022	0.764TyrAsn: 0.764 ± 0.028	1.342TyrPro: 1.342 ± 0.039	1.166TyrGln: 1.166 ± 0.04	2.241TyrArg: 2.241 ± 0.051	1.373TyrSer: 1.373 ± 0.043	1.156TyrThr: 1.156 ± 0.041	1.613TyrVal: 1.613 ± 0.04	0.319TyrTrp: 0.319 ± 0.022	0.876TyrTyr: 0.876 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2987 proteins (924840 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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