Amino acid dipepetide frequency for Blattella germanica (German cockroach) (Blatta germanica)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.847AlaAla: 4.847 ± 0.039	1.102AlaCys: 1.102 ± 0.017	2.708AlaAsp: 2.708 ± 0.018	3.597AlaGlu: 3.597 ± 0.027	2.264AlaPhe: 2.264 ± 0.02	3.362AlaGly: 3.362 ± 0.028	1.318AlaHis: 1.318 ± 0.013	3.166AlaIle: 3.166 ± 0.023	3.158AlaLys: 3.158 ± 0.02	5.34AlaLeu: 5.34 ± 0.034	1.443AlaMet: 1.443 ± 0.013	2.345AlaAsn: 2.345 ± 0.017	2.744AlaPro: 2.744 ± 0.029	2.105AlaGln: 2.105 ± 0.018	2.903AlaArg: 2.903 ± 0.021	4.641AlaSer: 4.641 ± 0.025	3.536AlaThr: 3.536 ± 0.025	4.218AlaVal: 4.218 ± 0.026	0.596AlaTrp: 0.596 ± 0.008	1.602AlaTyr: 1.602 ± 0.016	0.001AlaXaa: 0.001 ± 0.0
Cys	1.07CysAla: 1.07 ± 0.014	0.567CysCys: 0.567 ± 0.01	1.155CysAsp: 1.155 ± 0.016	1.309CysGlu: 1.309 ± 0.018	0.909CysPhe: 0.909 ± 0.01	1.459CysGly: 1.459 ± 0.025	0.598CysHis: 0.598 ± 0.009	1.231CysIle: 1.231 ± 0.015	1.272CysLys: 1.272 ± 0.014	2.024CysLeu: 2.024 ± 0.02	0.561CysMet: 0.561 ± 0.013	1.134CysAsn: 1.134 ± 0.014	1.097CysPro: 1.097 ± 0.025	0.807CysGln: 0.807 ± 0.014	1.202CysArg: 1.202 ± 0.023	1.85CysSer: 1.85 ± 0.022	1.142CysThr: 1.142 ± 0.015	1.365CysVal: 1.365 ± 0.018	0.255CysTrp: 0.255 ± 0.006	0.656CysTyr: 0.656 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	2.619AspAla: 2.619 ± 0.019	1.046AspCys: 1.046 ± 0.016	3.602AspAsp: 3.602 ± 0.038	3.887AspGlu: 3.887 ± 0.026	2.164AspPhe: 2.164 ± 0.018	2.947AspGly: 2.947 ± 0.023	1.147AspHis: 1.147 ± 0.013	3.404AspIle: 3.404 ± 0.022	2.927AspLys: 2.927 ± 0.021	4.624AspLeu: 4.624 ± 0.026	1.252AspMet: 1.252 ± 0.011	2.415AspAsn: 2.415 ± 0.022	2.291AspPro: 2.291 ± 0.025	1.54AspGln: 1.54 ± 0.014	2.492AspArg: 2.492 ± 0.025	4.204AspSer: 4.204 ± 0.027	2.643AspThr: 2.643 ± 0.017	3.507AspVal: 3.507 ± 0.024	0.627AspTrp: 0.627 ± 0.01	1.597AspTyr: 1.597 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	3.669GluAla: 3.669 ± 0.026	1.278GluCys: 1.278 ± 0.022	4.183GluAsp: 4.183 ± 0.027	6.774GluGlu: 6.774 ± 0.062	2.219GluPhe: 2.219 ± 0.017	3.315GluGly: 3.315 ± 0.024	1.503GluHis: 1.503 ± 0.015	3.869GluIle: 3.869 ± 0.029	4.86GluLys: 4.86 ± 0.039	5.634GluLeu: 5.634 ± 0.038	1.692GluMet: 1.692 ± 0.015	3.743GluAsn: 3.743 ± 0.026	2.384GluPro: 2.384 ± 0.024	2.56GluGln: 2.56 ± 0.025	3.628GluArg: 3.628 ± 0.03	4.542GluSer: 4.542 ± 0.033	3.848GluThr: 3.848 ± 0.027	4.099GluVal: 4.099 ± 0.025	0.68GluTrp: 0.68 ± 0.01	1.853GluTyr: 1.853 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	2.031PheAla: 2.031 ± 0.016	0.994PheCys: 0.994 ± 0.012	1.836PheAsp: 1.836 ± 0.016	2.19PheGlu: 2.19 ± 0.017	1.837PhePhe: 1.837 ± 0.019	2.383PheGly: 2.383 ± 0.026	1.194PheHis: 1.194 ± 0.012	2.438PheIle: 2.438 ± 0.022	2.21PheLys: 2.21 ± 0.02	4.175PheLeu: 4.175 ± 0.033	0.945PheMet: 0.945 ± 0.012	1.918PheAsn: 1.918 ± 0.017	1.934PhePro: 1.934 ± 0.017	1.707PheGln: 1.707 ± 0.016	2.06PheArg: 2.06 ± 0.019	3.452PheSer: 3.452 ± 0.027	2.305PheThr: 2.305 ± 0.019	2.581PheVal: 2.581 ± 0.021	0.493PheTrp: 0.493 ± 0.008	1.424PheTyr: 1.424 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	3.242GlyAla: 3.242 ± 0.027	1.11GlyCys: 1.11 ± 0.016	2.88GlyAsp: 2.88 ± 0.026	3.269GlyGlu: 3.269 ± 0.028	2.271GlyPhe: 2.271 ± 0.021	4.627GlyGly: 4.627 ± 0.075	1.636GlyHis: 1.636 ± 0.017	3.245GlyIle: 3.245 ± 0.023	3.528GlyLys: 3.528 ± 0.024	4.583GlyLeu: 4.583 ± 0.032	1.294GlyMet: 1.294 ± 0.015	2.855GlyAsn: 2.855 ± 0.022	2.387GlyPro: 2.387 ± 0.039	1.906GlyGln: 1.906 ± 0.017	3.245GlyArg: 3.245 ± 0.026	4.892GlySer: 4.892 ± 0.047	3.175GlyThr: 3.175 ± 0.023	3.444GlyVal: 3.444 ± 0.028	0.653GlyTrp: 0.653 ± 0.011	1.893GlyTyr: 1.893 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.298HisAla: 1.298 ± 0.015	0.654HisCys: 0.654 ± 0.01	1.096HisAsp: 1.096 ± 0.012	1.377HisGlu: 1.377 ± 0.015	1.206HisPhe: 1.206 ± 0.013	1.472HisGly: 1.472 ± 0.016	1.222HisHis: 1.222 ± 0.022	1.619HisIle: 1.619 ± 0.016	1.524HisLys: 1.524 ± 0.015	2.742HisLeu: 2.742 ± 0.018	0.753HisMet: 0.753 ± 0.011	1.263HisAsn: 1.263 ± 0.013	1.39HisPro: 1.39 ± 0.015	1.194HisGln: 1.194 ± 0.016	1.542HisArg: 1.542 ± 0.014	2.217HisSer: 2.217 ± 0.019	1.521HisThr: 1.521 ± 0.02	1.666HisVal: 1.666 ± 0.017	0.339HisTrp: 0.339 ± 0.007	0.911HisTyr: 0.911 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.215IleAla: 3.215 ± 0.026	1.425IleCys: 1.425 ± 0.018	2.684IleAsp: 2.684 ± 0.021	3.36IleGlu: 3.36 ± 0.021	2.566IlePhe: 2.566 ± 0.02	2.809IleGly: 2.809 ± 0.021	1.632IleHis: 1.632 ± 0.016	3.544IleIle: 3.544 ± 0.029	3.488IleLys: 3.488 ± 0.026	5.604IleLeu: 5.604 ± 0.036	1.356IleMet: 1.356 ± 0.014	2.835IleAsn: 2.835 ± 0.02	3.041IlePro: 3.041 ± 0.022	2.33IleGln: 2.33 ± 0.017	2.894IleArg: 2.894 ± 0.02	4.64IleSer: 4.64 ± 0.027	3.305IleThr: 3.305 ± 0.02	3.6IleVal: 3.6 ± 0.026	0.65IleTrp: 0.65 ± 0.009	1.839IleTyr: 1.839 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.175LysAla: 3.175 ± 0.023	1.375LysCys: 1.375 ± 0.018	3.231LysAsp: 3.231 ± 0.025	4.793LysGlu: 4.793 ± 0.038	2.345LysPhe: 2.345 ± 0.019	2.848LysGly: 2.848 ± 0.023	1.645LysHis: 1.645 ± 0.017	3.747LysIle: 3.747 ± 0.024	5.492LysLys: 5.492 ± 0.045	5.863LysLeu: 5.863 ± 0.032	1.695LysMet: 1.695 ± 0.016	3.218LysAsn: 3.218 ± 0.025	2.842LysPro: 2.842 ± 0.035	2.612LysGln: 2.612 ± 0.017	3.76LysArg: 3.76 ± 0.025	4.778LysSer: 4.778 ± 0.035	3.636LysThr: 3.636 ± 0.026	3.712LysVal: 3.712 ± 0.023	0.775LysTrp: 0.775 ± 0.012	2.105LysTyr: 2.105 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	5.369LeuAla: 5.369 ± 0.031	1.966LeuCys: 1.966 ± 0.018	4.485LeuAsp: 4.485 ± 0.026	6.036LeuGlu: 6.036 ± 0.038	3.717LeuPhe: 3.717 ± 0.03	4.618LeuGly: 4.618 ± 0.031	2.721LeuHis: 2.721 ± 0.019	4.656LeuIle: 4.656 ± 0.03	6.193LeuLys: 6.193 ± 0.036	9.421LeuLeu: 9.421 ± 0.058	2.186LeuMet: 2.186 ± 0.018	4.346LeuAsn: 4.346 ± 0.03	4.732LeuPro: 4.732 ± 0.029	4.782LeuGln: 4.782 ± 0.034	5.258LeuArg: 5.258 ± 0.029	7.236LeuSer: 7.236 ± 0.036	5.02LeuThr: 5.02 ± 0.026	5.471LeuVal: 5.471 ± 0.031	1.068LeuTrp: 1.068 ± 0.012	2.849LeuTyr: 2.849 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	1.641MetAla: 1.641 ± 0.014	0.512MetCys: 0.512 ± 0.008	1.319MetAsp: 1.319 ± 0.014	1.753MetGlu: 1.753 ± 0.016	1.04MetPhe: 1.04 ± 0.012	1.293MetGly: 1.293 ± 0.014	0.554MetHis: 0.554 ± 0.01	1.156MetIle: 1.156 ± 0.013	1.82MetLys: 1.82 ± 0.018	2.167MetLeu: 2.167 ± 0.018	0.71MetMet: 0.71 ± 0.013	1.175MetAsn: 1.175 ± 0.013	1.091MetPro: 1.091 ± 0.012	0.981MetGln: 0.981 ± 0.012	1.211MetArg: 1.211 ± 0.012	1.886MetSer: 1.886 ± 0.016	1.299MetThr: 1.299 ± 0.012	1.43MetVal: 1.43 ± 0.014	0.3MetTrp: 0.3 ± 0.005	0.853MetTyr: 0.853 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.584AsnAla: 2.584 ± 0.023	1.071AsnCys: 1.071 ± 0.015	2.241AsnAsp: 2.241 ± 0.017	3.066AsnGlu: 3.066 ± 0.025	2.059AsnPhe: 2.059 ± 0.019	2.805AsnGly: 2.805 ± 0.022	1.19AsnHis: 1.19 ± 0.014	3.448AsnIle: 3.448 ± 0.026	3.353AsnLys: 3.353 ± 0.025	4.425AsnLeu: 4.425 ± 0.029	1.282AsnMet: 1.282 ± 0.012	3.089AsnAsn: 3.089 ± 0.03	2.261AsnPro: 2.261 ± 0.025	1.726AsnGln: 1.726 ± 0.017	2.408AsnArg: 2.408 ± 0.02	4.158AsnSer: 4.158 ± 0.03	2.769AsnThr: 2.769 ± 0.022	3.306AsnVal: 3.306 ± 0.024	0.59AsnTrp: 0.59 ± 0.009	1.631AsnTyr: 1.631 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	2.892ProAla: 2.892 ± 0.026	0.871ProCys: 0.871 ± 0.027	2.492ProAsp: 2.492 ± 0.02	3.325ProGlu: 3.325 ± 0.03	1.828ProPhe: 1.828 ± 0.017	3.009ProGly: 3.009 ± 0.045	1.334ProHis: 1.334 ± 0.015	2.484ProIle: 2.484 ± 0.021	2.695ProLys: 2.695 ± 0.024	4.188ProLeu: 4.188 ± 0.028	0.958ProMet: 0.958 ± 0.013	2.17ProAsn: 2.17 ± 0.02	4.325ProPro: 4.325 ± 0.07	2.201ProGln: 2.201 ± 0.024	2.594ProArg: 2.594 ± 0.029	4.477ProSer: 4.477 ± 0.047	3.059ProThr: 3.059 ± 0.033	3.448ProVal: 3.448 ± 0.035	0.499ProTrp: 0.499 ± 0.008	1.568ProTyr: 1.568 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	2.172GlnAla: 2.172 ± 0.019	0.892GlnCys: 0.892 ± 0.015	1.955GlnAsp: 1.955 ± 0.015	2.955GlnGlu: 2.955 ± 0.023	1.48GlnPhe: 1.48 ± 0.015	1.952GlnGly: 1.952 ± 0.021	1.297GlnHis: 1.297 ± 0.015	2.168GlnIle: 2.168 ± 0.016	2.556GlnLys: 2.556 ± 0.021	3.892GlnLeu: 3.892 ± 0.023	1.034GlnMet: 1.034 ± 0.013	2.188GlnAsn: 2.188 ± 0.018	1.972GlnPro: 1.972 ± 0.021	2.953GlnGln: 2.953 ± 0.046	2.489GlnArg: 2.489 ± 0.02	2.917GlnSer: 2.917 ± 0.023	2.211GlnThr: 2.211 ± 0.022	2.321GlnVal: 2.321 ± 0.018	0.494GlnTrp: 0.494 ± 0.009	1.249GlnTyr: 1.249 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	2.797ArgAla: 2.797 ± 0.022	1.119ArgCys: 1.119 ± 0.023	2.683ArgAsp: 2.683 ± 0.024	3.416ArgGlu: 3.416 ± 0.024	2.023ArgPhe: 2.023 ± 0.017	2.955ArgGly: 2.955 ± 0.028	1.654ArgHis: 1.654 ± 0.017	2.967ArgIle: 2.967 ± 0.018	4.09ArgLys: 4.09 ± 0.027	4.881ArgLeu: 4.881 ± 0.03	1.368ArgMet: 1.368 ± 0.013	2.897ArgAsn: 2.897 ± 0.022	2.696ArgPro: 2.696 ± 0.029	2.227ArgGln: 2.227 ± 0.017	4.374ArgArg: 4.374 ± 0.042	4.189ArgSer: 4.189 ± 0.036	2.969ArgThr: 2.969 ± 0.02	3.043ArgVal: 3.043 ± 0.024	0.799ArgTrp: 0.799 ± 0.012	1.662ArgTyr: 1.662 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	4.592SerAla: 4.592 ± 0.032	1.721SerCys: 1.721 ± 0.021	4.339SerAsp: 4.339 ± 0.029	5.14SerGlu: 5.14 ± 0.038	3.159SerPhe: 3.159 ± 0.022	5.078SerGly: 5.078 ± 0.043	2.089SerHis: 2.089 ± 0.019	4.315SerIle: 4.315 ± 0.024	4.647SerLys: 4.647 ± 0.034	7.3SerLeu: 7.3 ± 0.036	1.725SerMet: 1.725 ± 0.016	3.954SerAsn: 3.954 ± 0.028	4.574SerPro: 4.574 ± 0.046	3.15SerGln: 3.15 ± 0.024	4.22SerArg: 4.22 ± 0.035	9.322SerSer: 9.322 ± 0.095	5.31SerThr: 5.31 ± 0.042	5.221SerVal: 5.221 ± 0.027	0.901SerTrp: 0.901 ± 0.01	2.382SerTyr: 2.382 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	3.603ThrAla: 3.603 ± 0.021	1.289ThrCys: 1.289 ± 0.017	2.752ThrAsp: 2.752 ± 0.023	3.684ThrGlu: 3.684 ± 0.031	2.307ThrPhe: 2.307 ± 0.019	3.376ThrGly: 3.376 ± 0.023	1.395ThrHis: 1.395 ± 0.016	3.19ThrIle: 3.19 ± 0.021	3.248ThrLys: 3.248 ± 0.023	5.101ThrLeu: 5.101 ± 0.026	1.322ThrMet: 1.322 ± 0.014	2.674ThrAsn: 2.674 ± 0.022	3.323ThrPro: 3.323 ± 0.03	2.111ThrGln: 2.111 ± 0.021	2.813ThrArg: 2.813 ± 0.022	5.362ThrSer: 5.362 ± 0.038	4.162ThrThr: 4.162 ± 0.056	4.031ThrVal: 4.031 ± 0.027	0.744ThrTrp: 0.744 ± 0.011	1.739ThrTyr: 1.739 ± 0.017	0.001ThrXaa: 0.001 ± 0.0
Val	3.983ValAla: 3.983 ± 0.029	1.642ValCys: 1.642 ± 0.024	3.175ValAsp: 3.175 ± 0.021	3.947ValGlu: 3.947 ± 0.026	2.629ValPhe: 2.629 ± 0.024	3.268ValGly: 3.268 ± 0.023	1.692ValHis: 1.692 ± 0.015	3.527ValIle: 3.527 ± 0.023	3.832ValLys: 3.832 ± 0.023	5.97ValLeu: 5.97 ± 0.034	1.528ValMet: 1.528 ± 0.016	2.987ValAsn: 2.987 ± 0.021	3.463ValPro: 3.463 ± 0.033	2.589ValGln: 2.589 ± 0.019	3.234ValArg: 3.234 ± 0.02	5.089ValSer: 5.089 ± 0.032	3.924ValThr: 3.924 ± 0.024	4.411ValVal: 4.411 ± 0.029	0.75ValTrp: 0.75 ± 0.011	1.911ValTyr: 1.911 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	0.616TrpAla: 0.616 ± 0.011	0.264TrpCys: 0.264 ± 0.006	0.583TrpAsp: 0.583 ± 0.009	0.695TrpGlu: 0.695 ± 0.009	0.528TrpPhe: 0.528 ± 0.009	0.64TrpGly: 0.64 ± 0.01	0.292TrpHis: 0.292 ± 0.006	0.69TrpIle: 0.69 ± 0.01	0.892TrpLys: 0.892 ± 0.011	1.184TrpLeu: 1.184 ± 0.014	0.314TrpMet: 0.314 ± 0.007	0.651TrpAsn: 0.651 ± 0.01	0.459TrpPro: 0.459 ± 0.008	0.46TrpGln: 0.46 ± 0.008	0.784TrpArg: 0.784 ± 0.011	0.839TrpSer: 0.839 ± 0.011	0.679TrpThr: 0.679 ± 0.01	0.644TrpVal: 0.644 ± 0.012	0.186TrpTrp: 0.186 ± 0.005	0.396TrpTyr: 0.396 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.576TyrAla: 1.576 ± 0.019	0.765TyrCys: 0.765 ± 0.01	1.535TyrAsp: 1.535 ± 0.014	1.761TyrGlu: 1.761 ± 0.017	1.554TyrPhe: 1.554 ± 0.018	1.921TyrGly: 1.921 ± 0.022	0.892TyrHis: 0.892 ± 0.011	1.955TyrIle: 1.955 ± 0.02	1.86TyrLys: 1.86 ± 0.021	3.013TyrLeu: 3.013 ± 0.024	0.774TyrMet: 0.774 ± 0.01	1.608TyrAsn: 1.608 ± 0.015	1.41TyrPro: 1.41 ± 0.02	1.206TyrGln: 1.206 ± 0.014	1.699TyrArg: 1.699 ± 0.016	2.449TyrSer: 2.449 ± 0.015	1.711TyrThr: 1.711 ± 0.016	2.033TyrVal: 2.033 ± 0.022	0.397TyrTrp: 0.397 ± 0.008	1.249TyrTyr: 1.249 ± 0.015	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.11XaaXaa: 0.11 ± 0.022

Statistics based on 29020 proteins (8958027 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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