Amino acid dipepetide frequency for Xanthomonas phage phiLf2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.103AlaAla: 17.103 ± 3.761
2.012AlaCys: 2.012 ± 0.642
4.527AlaAsp: 4.527 ± 1.168
7.042AlaGlu: 7.042 ± 2.326
2.012AlaPhe: 2.012 ± 0.863
13.581AlaGly: 13.581 ± 2.872
1.509AlaHis: 1.509 ± 0.756
3.521AlaIle: 3.521 ± 0.964
7.545AlaLys: 7.545 ± 1.184
9.054AlaLeu: 9.054 ± 2.207
5.533AlaMet: 5.533 ± 1.429
2.515AlaAsn: 2.515 ± 1.324
7.545AlaPro: 7.545 ± 1.932
3.018AlaGln: 3.018 ± 1.22
9.054AlaArg: 9.054 ± 2.518
5.533AlaSer: 5.533 ± 1.474
5.533AlaThr: 5.533 ± 1.13
10.06AlaVal: 10.06 ± 1.463
3.018AlaTrp: 3.018 ± 0.991
2.012AlaTyr: 2.012 ± 1.385
0.0AlaXaa: 0.0 ± 0.0
Cys
5.03CysAla: 5.03 ± 1.635
0.503CysCys: 0.503 ± 0.647
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
2.012CysGly: 2.012 ± 0.976
0.0CysHis: 0.0 ± 0.0
0.503CysIle: 0.503 ± 0.367
0.503CysLys: 0.503 ± 0.699
1.006CysLeu: 1.006 ± 0.67
0.503CysMet: 0.503 ± 0.699
0.503CysAsn: 0.503 ± 0.464
2.012CysPro: 2.012 ± 1.446
0.503CysGln: 0.503 ± 0.433
0.503CysArg: 0.503 ± 0.413
1.006CysSer: 1.006 ± 0.768
2.515CysThr: 2.515 ± 0.525
2.012CysVal: 2.012 ± 0.916
0.0CysTrp: 0.0 ± 0.0
0.503CysTyr: 0.503 ± 0.464
0.0CysXaa: 0.0 ± 0.0
Asp
6.036AspAla: 6.036 ± 1.495
0.0AspCys: 0.0 ± 0.0
4.024AspAsp: 4.024 ± 1.124
3.018AspGlu: 3.018 ± 1.569
2.012AspPhe: 2.012 ± 1.402
15.091AspGly: 15.091 ± 9.38
1.006AspHis: 1.006 ± 0.866
2.012AspIle: 2.012 ± 0.856
1.006AspLys: 1.006 ± 0.826
6.036AspLeu: 6.036 ± 1.227
0.0AspMet: 0.0 ± 0.0
1.509AspAsn: 1.509 ± 0.564
3.521AspPro: 3.521 ± 0.962
1.509AspGln: 1.509 ± 0.758
5.533AspArg: 5.533 ± 1.638
1.509AspSer: 1.509 ± 0.759
3.521AspThr: 3.521 ± 0.787
3.521AspVal: 3.521 ± 0.99
1.006AspTrp: 1.006 ± 0.508
1.006AspTyr: 1.006 ± 0.611
0.0AspXaa: 0.0 ± 0.0
Glu
5.03GluAla: 5.03 ± 1.723
0.503GluCys: 0.503 ± 0.413
0.503GluAsp: 0.503 ± 0.647
2.012GluGlu: 2.012 ± 0.869
3.521GluPhe: 3.521 ± 1.244
5.03GluGly: 5.03 ± 1.043
0.0GluHis: 0.0 ± 0.0
0.503GluIle: 0.503 ± 0.413
5.03GluLys: 5.03 ± 1.407
4.527GluLeu: 4.527 ± 0.981
0.0GluMet: 0.0 ± 0.0
1.509GluAsn: 1.509 ± 0.759
0.0GluPro: 0.0 ± 0.0
2.012GluGln: 2.012 ± 0.865
1.509GluArg: 1.509 ± 0.942
2.515GluSer: 2.515 ± 0.744
0.0GluThr: 0.0 ± 0.0
2.012GluVal: 2.012 ± 0.957
1.509GluTrp: 1.509 ± 0.941
1.509GluTyr: 1.509 ± 1.461
0.0GluXaa: 0.0 ± 0.0
Phe
4.024PheAla: 4.024 ± 1.249
0.0PheCys: 0.0 ± 0.0
1.006PheAsp: 1.006 ± 0.489
0.503PheGlu: 0.503 ± 0.367
2.515PhePhe: 2.515 ± 0.77
1.006PheGly: 1.006 ± 0.714
2.012PheHis: 2.012 ± 0.696
1.509PheIle: 1.509 ± 0.641
2.012PheLys: 2.012 ± 0.994
1.509PheLeu: 1.509 ± 0.881
1.509PheMet: 1.509 ± 0.827
2.012PheAsn: 2.012 ± 0.857
2.012PhePro: 2.012 ± 1.02
1.509PheGln: 1.509 ± 0.613
1.509PheArg: 1.509 ± 0.746
3.521PheSer: 3.521 ± 1.345
1.006PheThr: 1.006 ± 0.787
2.012PheVal: 2.012 ± 1.24
0.503PheTrp: 0.503 ± 0.367
1.509PheTyr: 1.509 ± 0.665
0.0PheXaa: 0.0 ± 0.0
Gly
9.054GlyAla: 9.054 ± 1.61
2.012GlyCys: 2.012 ± 0.976
15.091GlyAsp: 15.091 ± 9.531
3.521GlyGlu: 3.521 ± 1.223
3.018GlyPhe: 3.018 ± 1.396
21.127GlyGly: 21.127 ± 10.06
1.509GlyHis: 1.509 ± 0.746
3.521GlyIle: 3.521 ± 1.038
5.533GlyLys: 5.533 ± 2.059
5.533GlyLeu: 5.533 ± 1.764
2.515GlyMet: 2.515 ± 1.127
2.012GlyAsn: 2.012 ± 1.118
5.03GlyPro: 5.03 ± 1.22
3.018GlyGln: 3.018 ± 1.157
7.545GlyArg: 7.545 ± 1.955
4.024GlySer: 4.024 ± 1.267
3.521GlyThr: 3.521 ± 1.145
7.042GlyVal: 7.042 ± 1.505
2.012GlyTrp: 2.012 ± 1.015
4.527GlyTyr: 4.527 ± 0.964
0.0GlyXaa: 0.0 ± 0.0
His
1.509HisAla: 1.509 ± 0.898
1.509HisCys: 1.509 ± 0.566
0.0HisAsp: 0.0 ± 0.0
1.006HisGlu: 1.006 ± 0.496
0.0HisPhe: 0.0 ± 0.0
2.012HisGly: 2.012 ± 1.274
0.0HisHis: 0.0 ± 0.0
1.509HisIle: 1.509 ± 0.759
0.0HisLys: 0.0 ± 0.0
1.509HisLeu: 1.509 ± 0.613
0.0HisMet: 0.0 ± 0.0
0.503HisAsn: 0.503 ± 0.464
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
1.509HisArg: 1.509 ± 1.088
0.503HisSer: 0.503 ± 0.367
1.006HisThr: 1.006 ± 0.496
2.012HisVal: 2.012 ± 0.808
0.0HisTrp: 0.0 ± 0.0
0.503HisTyr: 0.503 ± 0.367
0.0HisXaa: 0.0 ± 0.0
Ile
6.036IleAla: 6.036 ± 1.899
0.0IleCys: 0.0 ± 0.0
2.515IleAsp: 2.515 ± 0.856
3.018IleGlu: 3.018 ± 1.227
1.006IlePhe: 1.006 ± 0.735
4.024IleGly: 4.024 ± 1.712
1.006IleHis: 1.006 ± 0.557
2.012IleIle: 2.012 ± 0.988
1.006IleLys: 1.006 ± 0.806
4.024IleLeu: 4.024 ± 1.699
2.012IleMet: 2.012 ± 0.992
2.515IleAsn: 2.515 ± 0.84
1.509IlePro: 1.509 ± 0.758
0.503IleGln: 0.503 ± 0.367
1.006IleArg: 1.006 ± 0.735
1.006IleSer: 1.006 ± 0.571
2.012IleThr: 2.012 ± 0.707
2.012IleVal: 2.012 ± 0.621
0.503IleTrp: 0.503 ± 0.536
1.509IleTyr: 1.509 ± 0.613
0.0IleXaa: 0.0 ± 0.0
Lys
5.03LysAla: 5.03 ± 1.579
1.509LysCys: 1.509 ± 0.716
4.024LysAsp: 4.024 ± 1.913
0.503LysGlu: 0.503 ± 0.413
1.509LysPhe: 1.509 ± 0.736
5.533LysGly: 5.533 ± 1.601
2.012LysHis: 2.012 ± 0.847
1.509LysIle: 1.509 ± 0.918
4.527LysLys: 4.527 ± 1.295
2.012LysLeu: 2.012 ± 1.018
1.006LysMet: 1.006 ± 0.625
1.509LysAsn: 1.509 ± 1.102
2.012LysPro: 2.012 ± 1.083
1.509LysGln: 1.509 ± 1.051
4.024LysArg: 4.024 ± 1.735
2.515LysSer: 2.515 ± 0.711
3.018LysThr: 3.018 ± 1.274
2.012LysVal: 2.012 ± 1.047
1.509LysTrp: 1.509 ± 0.834
1.006LysTyr: 1.006 ± 0.489
0.0LysXaa: 0.0 ± 0.0
Leu
7.545LeuAla: 7.545 ± 1.759
1.509LeuCys: 1.509 ± 0.883
6.539LeuAsp: 6.539 ± 2.08
3.521LeuGlu: 3.521 ± 2.27
2.515LeuPhe: 2.515 ± 0.832
5.533LeuGly: 5.533 ± 1.071
1.006LeuHis: 1.006 ± 0.489
2.515LeuIle: 2.515 ± 1.082
1.509LeuLys: 1.509 ± 0.759
4.527LeuLeu: 4.527 ± 1.489
0.503LeuMet: 0.503 ± 0.551
1.509LeuAsn: 1.509 ± 0.827
2.515LeuPro: 2.515 ± 0.93
3.521LeuGln: 3.521 ± 1.352
8.551LeuArg: 8.551 ± 1.511
5.533LeuSer: 5.533 ± 1.581
7.042LeuThr: 7.042 ± 1.85
5.533LeuVal: 5.533 ± 2.037
1.509LeuTrp: 1.509 ± 1.068
2.515LeuTyr: 2.515 ± 0.802
0.0LeuXaa: 0.0 ± 0.0
Met
4.024MetAla: 4.024 ± 1.538
0.0MetCys: 0.0 ± 0.0
1.509MetAsp: 1.509 ± 0.762
0.503MetGlu: 0.503 ± 0.413
0.503MetPhe: 0.503 ± 0.647
0.503MetGly: 0.503 ± 0.732
0.0MetHis: 0.0 ± 0.0
1.006MetIle: 1.006 ± 0.923
1.509MetLys: 1.509 ± 0.71
2.012MetLeu: 2.012 ± 0.829
1.509MetMet: 1.509 ± 0.626
0.0MetAsn: 0.0 ± 0.0
1.006MetPro: 1.006 ± 0.843
0.503MetGln: 0.503 ± 0.536
1.509MetArg: 1.509 ± 1.161
2.012MetSer: 2.012 ± 0.736
3.018MetThr: 3.018 ± 1.3
3.521MetVal: 3.521 ± 1.36
1.006MetTrp: 1.006 ± 0.701
1.006MetTyr: 1.006 ± 0.866
0.0MetXaa: 0.0 ± 0.0
Asn
1.509AsnAla: 1.509 ± 0.694
0.0AsnCys: 0.0 ± 0.0
1.509AsnAsp: 1.509 ± 0.912
1.006AsnGlu: 1.006 ± 0.735
2.012AsnPhe: 2.012 ± 0.743
2.012AsnGly: 2.012 ± 1.076
0.503AsnHis: 0.503 ± 0.367
0.0AsnIle: 0.0 ± 0.0
2.012AsnLys: 2.012 ± 0.923
1.509AsnLeu: 1.509 ± 0.926
1.006AsnMet: 1.006 ± 0.496
1.006AsnAsn: 1.006 ± 0.496
1.509AsnPro: 1.509 ± 1.013
1.006AsnGln: 1.006 ± 0.826
2.515AsnArg: 2.515 ± 1.255
0.503AsnSer: 0.503 ± 0.413
2.515AsnThr: 2.515 ± 1.022
1.006AsnVal: 1.006 ± 0.735
0.0AsnTrp: 0.0 ± 0.0
0.503AsnTyr: 0.503 ± 0.731
0.0AsnXaa: 0.0 ± 0.0
Pro
9.557ProAla: 9.557 ± 2.079
1.006ProCys: 1.006 ± 1.102
3.521ProAsp: 3.521 ± 1.387
2.515ProGlu: 2.515 ± 0.525
0.0ProPhe: 0.0 ± 0.0
4.527ProGly: 4.527 ± 1.959
0.503ProHis: 0.503 ± 0.433
1.509ProIle: 1.509 ± 0.758
2.515ProLys: 2.515 ± 0.76
4.527ProLeu: 4.527 ± 1.554
2.515ProMet: 2.515 ± 1.098
0.0ProAsn: 0.0 ± 0.0
4.527ProPro: 4.527 ± 1.193
0.0ProGln: 0.0 ± 0.0
1.509ProArg: 1.509 ± 0.884
5.533ProSer: 5.533 ± 1.186
1.509ProThr: 1.509 ± 1.393
3.018ProVal: 3.018 ± 0.907
2.012ProTrp: 2.012 ± 0.651
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
2.515GlnAla: 2.515 ± 1.45
1.006GlnCys: 1.006 ± 0.768
1.006GlnAsp: 1.006 ± 0.735
2.515GlnGlu: 2.515 ± 1.234
1.006GlnPhe: 1.006 ± 0.508
4.024GlnGly: 4.024 ± 0.754
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
1.006GlnLys: 1.006 ± 0.774
3.018GlnLeu: 3.018 ± 1.088
0.503GlnMet: 0.503 ± 0.367
0.503GlnAsn: 0.503 ± 0.367
1.006GlnPro: 1.006 ± 0.774
0.503GlnGln: 0.503 ± 0.367
2.515GlnArg: 2.515 ± 0.525
2.012GlnSer: 2.012 ± 1.222
2.012GlnThr: 2.012 ± 0.977
2.012GlnVal: 2.012 ± 0.581
3.018GlnTrp: 3.018 ± 0.94
0.503GlnTyr: 0.503 ± 0.413
0.0GlnXaa: 0.0 ± 0.0
Arg
10.563ArgAla: 10.563 ± 2.724
0.503ArgCys: 0.503 ± 0.413
2.515ArgAsp: 2.515 ± 0.902
3.018ArgGlu: 3.018 ± 1.086
0.503ArgPhe: 0.503 ± 0.367
3.521ArgGly: 3.521 ± 1.376
1.006ArgHis: 1.006 ± 0.826
4.024ArgIle: 4.024 ± 0.987
4.527ArgLys: 4.527 ± 1.641
6.539ArgLeu: 6.539 ± 1.318
2.012ArgMet: 2.012 ± 0.748
1.509ArgAsn: 1.509 ± 0.746
2.012ArgPro: 2.012 ± 0.707
3.521ArgGln: 3.521 ± 1.172
6.036ArgArg: 6.036 ± 1.558
3.018ArgSer: 3.018 ± 1.478
1.006ArgThr: 1.006 ± 0.672
7.042ArgVal: 7.042 ± 1.588
1.509ArgTrp: 1.509 ± 1.409
2.515ArgTyr: 2.515 ± 0.626
0.0ArgXaa: 0.0 ± 0.0
Ser
7.042SerAla: 7.042 ± 0.899
2.012SerCys: 2.012 ± 0.863
5.03SerAsp: 5.03 ± 0.838
1.509SerGlu: 1.509 ± 0.801
3.018SerPhe: 3.018 ± 1.126
7.042SerGly: 7.042 ± 1.55
1.006SerHis: 1.006 ± 0.508
2.012SerIle: 2.012 ± 0.689
2.515SerLys: 2.515 ± 0.874
3.018SerLeu: 3.018 ± 0.778
0.0SerMet: 0.0 ± 0.0
1.509SerAsn: 1.509 ± 0.827
2.012SerPro: 2.012 ± 0.879
2.012SerGln: 2.012 ± 1.022
1.006SerArg: 1.006 ± 0.557
5.03SerSer: 5.03 ± 1.143
4.527SerThr: 4.527 ± 0.926
5.03SerVal: 5.03 ± 0.989
0.0SerTrp: 0.0 ± 0.0
1.509SerTyr: 1.509 ± 0.68
0.0SerXaa: 0.0 ± 0.0
Thr
6.036ThrAla: 6.036 ± 1.637
3.521ThrCys: 3.521 ± 1.518
2.012ThrAsp: 2.012 ± 0.863
0.503ThrGlu: 0.503 ± 0.367
1.509ThrPhe: 1.509 ± 0.966
4.527ThrGly: 4.527 ± 2.092
0.0ThrHis: 0.0 ± 0.0
2.012ThrIle: 2.012 ± 0.795
2.515ThrLys: 2.515 ± 0.997
4.527ThrLeu: 4.527 ± 1.553
1.006ThrMet: 1.006 ± 0.729
0.0ThrAsn: 0.0 ± 0.0
6.539ThrPro: 6.539 ± 2.166
3.521ThrGln: 3.521 ± 1.793
1.509ThrArg: 1.509 ± 0.855
2.515ThrSer: 2.515 ± 0.744
2.515ThrThr: 2.515 ± 1.033
4.527ThrVal: 4.527 ± 1.759
1.509ThrTrp: 1.509 ± 1.239
2.515ThrTyr: 2.515 ± 0.905
0.0ThrXaa: 0.0 ± 0.0
Val
10.06ValAla: 10.06 ± 2.539
0.503ValCys: 0.503 ± 0.464
5.533ValAsp: 5.533 ± 1.258
1.006ValGlu: 1.006 ± 0.51
3.018ValPhe: 3.018 ± 1.29
7.545ValGly: 7.545 ± 1.485
1.509ValHis: 1.509 ± 0.758
6.036ValIle: 6.036 ± 1.546
2.012ValLys: 2.012 ± 1.138
5.533ValLeu: 5.533 ± 1.583
3.018ValMet: 3.018 ± 1.462
2.012ValAsn: 2.012 ± 0.808
2.515ValPro: 2.515 ± 0.942
1.509ValGln: 1.509 ± 0.758
6.539ValArg: 6.539 ± 1.484
3.018ValSer: 3.018 ± 0.918
4.024ValThr: 4.024 ± 1.333
5.03ValVal: 5.03 ± 1.27
2.012ValTrp: 2.012 ± 0.877
1.006ValTyr: 1.006 ± 0.489
0.0ValXaa: 0.0 ± 0.0
Trp
2.515TrpAla: 2.515 ± 0.749
1.509TrpCys: 1.509 ± 1.321
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
2.012TrpPhe: 2.012 ± 1.252
0.503TrpGly: 0.503 ± 0.732
0.503TrpHis: 0.503 ± 0.433
2.515TrpIle: 2.515 ± 1.068
0.503TrpLys: 0.503 ± 0.413
2.515TrpLeu: 2.515 ± 1.135
1.006TrpMet: 1.006 ± 0.595
0.503TrpAsn: 0.503 ± 0.464
1.006TrpPro: 1.006 ± 0.489
0.503TrpGln: 0.503 ± 0.536
2.515TrpArg: 2.515 ± 1.305
2.515TrpSer: 2.515 ± 1.085
0.503TrpThr: 0.503 ± 0.367
1.509TrpVal: 1.509 ± 0.485
0.503TrpTrp: 0.503 ± 0.464
1.006TrpTyr: 1.006 ± 0.611
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.509TyrAla: 1.509 ± 0.68
0.0TyrCys: 0.0 ± 0.0
2.012TyrAsp: 2.012 ± 1.088
2.515TyrGlu: 2.515 ± 0.849
1.509TyrPhe: 1.509 ± 1.102
2.012TyrGly: 2.012 ± 0.847
0.0TyrHis: 0.0 ± 0.0
1.006TyrIle: 1.006 ± 0.557
0.503TyrLys: 0.503 ± 0.464
2.515TyrLeu: 2.515 ± 1.02
0.0TyrMet: 0.0 ± 0.0
0.503TyrAsn: 0.503 ± 0.367
2.515TyrPro: 2.515 ± 0.915
0.503TyrGln: 0.503 ± 0.731
0.503TyrArg: 0.503 ± 0.367
3.018TyrSer: 3.018 ± 0.917
3.018TyrThr: 3.018 ± 1.276
2.515TyrVal: 2.515 ± 0.921
1.006TyrTrp: 1.006 ± 0.737
0.503TyrTyr: 0.503 ± 0.464
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (1989 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski