Amino acid dipepetide frequency for Dishui Lake virophage 6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.101AlaAla: 8.101 ± 1.949
0.881AlaCys: 0.881 ± 0.353
3.698AlaAsp: 3.698 ± 0.897
5.107AlaGlu: 5.107 ± 1.319
2.994AlaPhe: 2.994 ± 0.632
7.221AlaGly: 7.221 ± 3.214
0.352AlaHis: 0.352 ± 0.227
4.755AlaIle: 4.755 ± 1.344
2.994AlaLys: 2.994 ± 0.821
6.164AlaLeu: 6.164 ± 1.444
1.409AlaMet: 1.409 ± 0.621
5.46AlaAsn: 5.46 ± 1.85
2.29AlaPro: 2.29 ± 0.626
4.051AlaGln: 4.051 ± 1.146
4.051AlaArg: 4.051 ± 1.077
6.516AlaSer: 6.516 ± 0.969
5.107AlaThr: 5.107 ± 1.055
6.869AlaVal: 6.869 ± 2.231
0.176AlaTrp: 0.176 ± 0.157
1.057AlaTyr: 1.057 ± 0.338
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.352CysCys: 0.352 ± 0.208
0.352CysAsp: 0.352 ± 0.201
0.881CysGlu: 0.881 ± 0.509
0.352CysPhe: 0.352 ± 0.224
0.528CysGly: 0.528 ± 0.209
0.176CysHis: 0.176 ± 0.182
0.881CysIle: 0.881 ± 0.387
0.528CysLys: 0.528 ± 0.314
1.057CysLeu: 1.057 ± 0.633
0.0CysMet: 0.0 ± 0.0
0.352CysAsn: 0.352 ± 0.315
0.176CysPro: 0.176 ± 0.157
0.0CysGln: 0.0 ± 0.0
0.352CysArg: 0.352 ± 0.21
0.352CysSer: 0.352 ± 0.205
0.0CysThr: 0.0 ± 0.0
0.704CysVal: 0.704 ± 0.233
1.057CysTrp: 1.057 ± 0.622
0.352CysTyr: 0.352 ± 0.266
0.0CysXaa: 0.0 ± 0.0
Asp
2.113AspAla: 2.113 ± 0.409
0.352AspCys: 0.352 ± 0.227
4.579AspAsp: 4.579 ± 0.658
5.284AspGlu: 5.284 ± 1.056
3.17AspPhe: 3.17 ± 0.97
2.818AspGly: 2.818 ± 0.539
0.352AspHis: 0.352 ± 0.205
5.46AspIle: 5.46 ± 0.836
3.346AspLys: 3.346 ± 0.708
4.755AspLeu: 4.755 ± 0.883
1.937AspMet: 1.937 ± 0.28
2.466AspAsn: 2.466 ± 0.599
2.113AspPro: 2.113 ± 0.577
1.233AspGln: 1.233 ± 0.421
1.937AspArg: 1.937 ± 0.671
2.818AspSer: 2.818 ± 0.835
2.818AspThr: 2.818 ± 0.482
4.227AspVal: 4.227 ± 0.766
0.528AspTrp: 0.528 ± 0.406
2.642AspTyr: 2.642 ± 0.488
0.0AspXaa: 0.0 ± 0.0
Glu
3.698GluAla: 3.698 ± 0.811
0.352GluCys: 0.352 ± 0.195
5.107GluAsp: 5.107 ± 1.256
7.397GluGlu: 7.397 ± 1.904
2.113GluPhe: 2.113 ± 0.878
4.227GluGly: 4.227 ± 0.684
0.881GluHis: 0.881 ± 0.349
4.227GluIle: 4.227 ± 0.864
4.579GluLys: 4.579 ± 1.344
6.516GluLeu: 6.516 ± 1.531
1.761GluMet: 1.761 ± 0.436
2.642GluAsn: 2.642 ± 0.692
2.642GluPro: 2.642 ± 1.019
1.761GluGln: 1.761 ± 0.391
4.403GluArg: 4.403 ± 1.032
2.818GluSer: 2.818 ± 0.768
2.994GluThr: 2.994 ± 0.716
3.875GluVal: 3.875 ± 1.02
0.176GluTrp: 0.176 ± 0.157
2.818GluTyr: 2.818 ± 0.757
0.0GluXaa: 0.0 ± 0.0
Phe
2.642PheAla: 2.642 ± 0.408
0.176PheCys: 0.176 ± 0.168
2.466PheAsp: 2.466 ± 0.446
1.409PheGlu: 1.409 ± 0.53
1.233PhePhe: 1.233 ± 0.347
1.233PheGly: 1.233 ± 0.436
0.528PheHis: 0.528 ± 0.231
2.642PheIle: 2.642 ± 0.645
2.642PheLys: 2.642 ± 1.074
2.994PheLeu: 2.994 ± 0.748
0.176PheMet: 0.176 ± 0.134
4.051PheAsn: 4.051 ± 0.746
2.466PhePro: 2.466 ± 0.598
2.642PheGln: 2.642 ± 0.758
1.585PheArg: 1.585 ± 0.469
2.818PheSer: 2.818 ± 1.045
2.466PheThr: 2.466 ± 0.604
1.937PheVal: 1.937 ± 0.565
0.352PheTrp: 0.352 ± 0.201
1.057PheTyr: 1.057 ± 0.253
0.0PheXaa: 0.0 ± 0.0
Gly
8.454GlyAla: 8.454 ± 3.381
0.528GlyCys: 0.528 ± 0.271
3.346GlyAsp: 3.346 ± 0.793
4.051GlyGlu: 4.051 ± 0.813
3.346GlyPhe: 3.346 ± 0.596
5.812GlyGly: 5.812 ± 1.308
0.704GlyHis: 0.704 ± 0.28
4.227GlyIle: 4.227 ± 0.986
4.579GlyLys: 4.579 ± 0.838
5.107GlyLeu: 5.107 ± 0.893
1.057GlyMet: 1.057 ± 0.333
5.284GlyAsn: 5.284 ± 1.504
0.176GlyPro: 0.176 ± 0.134
3.875GlyGln: 3.875 ± 1.413
4.227GlyArg: 4.227 ± 0.893
5.46GlySer: 5.46 ± 1.406
2.818GlyThr: 2.818 ± 1.156
5.636GlyVal: 5.636 ± 1.575
0.881GlyTrp: 0.881 ± 0.436
1.409GlyTyr: 1.409 ± 0.294
0.0GlyXaa: 0.0 ± 0.0
His
0.528HisAla: 0.528 ± 0.333
0.176HisCys: 0.176 ± 0.15
0.528HisAsp: 0.528 ± 0.338
0.352HisGlu: 0.352 ± 0.239
0.528HisPhe: 0.528 ± 0.366
0.352HisGly: 0.352 ± 0.239
0.176HisHis: 0.176 ± 0.173
1.233HisIle: 1.233 ± 0.459
0.176HisLys: 0.176 ± 0.15
0.704HisLeu: 0.704 ± 0.497
0.176HisMet: 0.176 ± 0.154
1.057HisAsn: 1.057 ± 0.453
0.528HisPro: 0.528 ± 0.26
0.352HisGln: 0.352 ± 0.195
1.233HisArg: 1.233 ± 0.532
2.113HisSer: 2.113 ± 0.564
0.528HisThr: 0.528 ± 0.26
0.0HisVal: 0.0 ± 0.0
0.176HisTrp: 0.176 ± 0.15
0.176HisTyr: 0.176 ± 0.169
0.0HisXaa: 0.0 ± 0.0
Ile
3.875IleAla: 3.875 ± 0.865
0.881IleCys: 0.881 ± 0.371
4.051IleAsp: 4.051 ± 0.83
4.755IleGlu: 4.755 ± 0.873
2.113IlePhe: 2.113 ± 0.597
4.579IleGly: 4.579 ± 1.942
0.881IleHis: 0.881 ± 0.462
3.346IleIle: 3.346 ± 1.073
4.755IleLys: 4.755 ± 0.861
4.227IleLeu: 4.227 ± 0.851
1.233IleMet: 1.233 ± 0.308
5.107IleAsn: 5.107 ± 1.017
2.818IlePro: 2.818 ± 0.535
2.642IleGln: 2.642 ± 0.76
4.051IleArg: 4.051 ± 1.168
4.227IleSer: 4.227 ± 1.08
3.522IleThr: 3.522 ± 0.639
3.522IleVal: 3.522 ± 0.68
0.528IleTrp: 0.528 ± 0.311
2.994IleTyr: 2.994 ± 0.918
0.0IleXaa: 0.0 ± 0.0
Lys
4.227LysAla: 4.227 ± 1.211
0.881LysCys: 0.881 ± 0.787
4.931LysAsp: 4.931 ± 1.07
4.755LysGlu: 4.755 ± 1.679
1.585LysPhe: 1.585 ± 0.518
5.107LysGly: 5.107 ± 0.803
0.704LysHis: 0.704 ± 0.452
4.227LysIle: 4.227 ± 1.004
5.46LysLys: 5.46 ± 1.827
4.051LysLeu: 4.051 ± 0.826
1.937LysMet: 1.937 ± 0.579
3.522LysAsn: 3.522 ± 1.105
2.642LysPro: 2.642 ± 0.678
2.642LysGln: 2.642 ± 0.757
3.522LysArg: 3.522 ± 0.766
1.937LysSer: 1.937 ± 0.706
2.642LysThr: 2.642 ± 0.939
2.29LysVal: 2.29 ± 0.529
0.704LysTrp: 0.704 ± 0.374
2.818LysTyr: 2.818 ± 0.694
0.0LysXaa: 0.0 ± 0.0
Leu
5.636LeuAla: 5.636 ± 0.981
0.176LeuCys: 0.176 ± 0.157
3.698LeuAsp: 3.698 ± 0.873
4.227LeuGlu: 4.227 ± 1.149
2.818LeuPhe: 2.818 ± 1.135
6.34LeuGly: 6.34 ± 0.913
0.881LeuHis: 0.881 ± 0.339
3.698LeuIle: 3.698 ± 0.781
7.397LeuLys: 7.397 ± 1.571
7.221LeuLeu: 7.221 ± 0.857
1.585LeuMet: 1.585 ± 0.458
7.221LeuAsn: 7.221 ± 1.055
5.107LeuPro: 5.107 ± 1.071
3.522LeuGln: 3.522 ± 0.788
4.931LeuArg: 4.931 ± 0.991
5.636LeuSer: 5.636 ± 0.694
5.812LeuThr: 5.812 ± 1.068
3.698LeuVal: 3.698 ± 0.712
1.057LeuTrp: 1.057 ± 0.367
3.17LeuTyr: 3.17 ± 0.966
0.0LeuXaa: 0.0 ± 0.0
Met
0.881MetAla: 0.881 ± 0.436
0.528MetCys: 0.528 ± 0.237
1.409MetAsp: 1.409 ± 0.423
0.704MetGlu: 0.704 ± 0.328
0.528MetPhe: 0.528 ± 0.337
1.057MetGly: 1.057 ± 0.427
0.0MetHis: 0.0 ± 0.0
0.704MetIle: 0.704 ± 0.459
1.057MetLys: 1.057 ± 0.44
1.585MetLeu: 1.585 ± 0.398
1.233MetMet: 1.233 ± 0.425
2.29MetAsn: 2.29 ± 0.788
2.113MetPro: 2.113 ± 0.439
0.0MetGln: 0.0 ± 0.0
1.233MetArg: 1.233 ± 0.395
1.761MetSer: 1.761 ± 0.583
1.409MetThr: 1.409 ± 0.27
1.409MetVal: 1.409 ± 0.406
0.176MetTrp: 0.176 ± 0.134
0.528MetTyr: 0.528 ± 0.298
0.0MetXaa: 0.0 ± 0.0
Asn
7.221AsnAla: 7.221 ± 2.675
0.528AsnCys: 0.528 ± 0.212
3.698AsnAsp: 3.698 ± 0.514
2.466AsnGlu: 2.466 ± 0.527
2.466AsnPhe: 2.466 ± 0.54
4.755AsnGly: 4.755 ± 1.127
1.233AsnHis: 1.233 ± 0.312
4.227AsnIle: 4.227 ± 0.779
2.818AsnLys: 2.818 ± 0.479
5.812AsnLeu: 5.812 ± 0.756
1.233AsnMet: 1.233 ± 0.444
4.227AsnAsn: 4.227 ± 1.242
4.051AsnPro: 4.051 ± 0.982
3.875AsnGln: 3.875 ± 1.398
2.994AsnArg: 2.994 ± 0.663
3.875AsnSer: 3.875 ± 0.969
3.522AsnThr: 3.522 ± 0.828
3.346AsnVal: 3.346 ± 0.628
0.704AsnTrp: 0.704 ± 0.355
1.937AsnTyr: 1.937 ± 0.405
0.0AsnXaa: 0.0 ± 0.0
Pro
4.227ProAla: 4.227 ± 0.868
0.176ProCys: 0.176 ± 0.157
1.937ProAsp: 1.937 ± 0.516
1.761ProGlu: 1.761 ± 0.35
1.937ProPhe: 1.937 ± 0.608
0.0ProGly: 0.0 ± 0.0
0.704ProHis: 0.704 ± 0.276
3.17ProIle: 3.17 ± 0.836
4.051ProLys: 4.051 ± 1.237
5.107ProLeu: 5.107 ± 1.007
0.704ProMet: 0.704 ± 0.337
2.466ProAsn: 2.466 ± 0.842
4.755ProPro: 4.755 ± 2.064
5.107ProGln: 5.107 ± 2.081
3.17ProArg: 3.17 ± 0.742
2.994ProSer: 2.994 ± 0.948
3.17ProThr: 3.17 ± 1.11
2.29ProVal: 2.29 ± 0.894
0.0ProTrp: 0.0 ± 0.0
3.17ProTyr: 3.17 ± 0.881
0.0ProXaa: 0.0 ± 0.0
Gln
2.466GlnAla: 2.466 ± 0.659
0.176GlnCys: 0.176 ± 0.168
2.113GlnAsp: 2.113 ± 0.632
2.113GlnGlu: 2.113 ± 0.755
1.937GlnPhe: 1.937 ± 0.635
4.403GlnGly: 4.403 ± 3.043
0.0GlnHis: 0.0 ± 0.0
3.17GlnIle: 3.17 ± 0.673
2.642GlnLys: 2.642 ± 0.75
4.051GlnLeu: 4.051 ± 0.667
1.057GlnMet: 1.057 ± 0.533
2.29GlnAsn: 2.29 ± 0.68
4.403GlnPro: 4.403 ± 2.557
3.698GlnGln: 3.698 ± 1.401
4.051GlnArg: 4.051 ± 1.331
2.466GlnSer: 2.466 ± 0.842
3.17GlnThr: 3.17 ± 1.233
2.994GlnVal: 2.994 ± 0.63
0.0GlnTrp: 0.0 ± 0.0
1.057GlnTyr: 1.057 ± 0.288
0.0GlnXaa: 0.0 ± 0.0
Arg
2.642ArgAla: 2.642 ± 0.94
0.352ArgCys: 0.352 ± 0.18
2.994ArgAsp: 2.994 ± 0.655
5.636ArgGlu: 5.636 ± 1.227
2.642ArgPhe: 2.642 ± 0.489
5.988ArgGly: 5.988 ± 1.207
1.233ArgHis: 1.233 ± 0.411
4.051ArgIle: 4.051 ± 0.693
2.466ArgLys: 2.466 ± 0.384
5.46ArgLeu: 5.46 ± 0.809
2.29ArgMet: 2.29 ± 0.654
3.346ArgAsn: 3.346 ± 1.061
3.346ArgPro: 3.346 ± 0.861
2.29ArgGln: 2.29 ± 1.009
5.284ArgArg: 5.284 ± 1.259
2.113ArgSer: 2.113 ± 0.612
2.29ArgThr: 2.29 ± 0.6
2.29ArgVal: 2.29 ± 0.664
0.704ArgTrp: 0.704 ± 0.37
1.761ArgTyr: 1.761 ± 0.704
0.0ArgXaa: 0.0 ± 0.0
Ser
7.573SerAla: 7.573 ± 1.318
0.176SerCys: 0.176 ± 0.182
2.818SerAsp: 2.818 ± 0.556
3.17SerGlu: 3.17 ± 0.466
2.29SerPhe: 2.29 ± 0.785
6.164SerGly: 6.164 ± 1.287
0.881SerHis: 0.881 ± 0.356
5.46SerIle: 5.46 ± 1.046
2.113SerLys: 2.113 ± 0.736
5.812SerLeu: 5.812 ± 1.116
1.057SerMet: 1.057 ± 0.331
2.642SerAsn: 2.642 ± 0.57
2.113SerPro: 2.113 ± 0.444
2.29SerGln: 2.29 ± 0.647
2.113SerArg: 2.113 ± 0.735
5.812SerSer: 5.812 ± 1.252
3.346SerThr: 3.346 ± 0.659
5.636SerVal: 5.636 ± 2.303
0.704SerTrp: 0.704 ± 0.331
1.585SerTyr: 1.585 ± 0.399
0.0SerXaa: 0.0 ± 0.0
Thr
4.051ThrAla: 4.051 ± 0.95
0.176ThrCys: 0.176 ± 0.15
3.346ThrAsp: 3.346 ± 0.723
3.346ThrGlu: 3.346 ± 0.868
1.233ThrPhe: 1.233 ± 0.419
3.698ThrGly: 3.698 ± 0.757
0.352ThrHis: 0.352 ± 0.187
2.642ThrIle: 2.642 ± 0.613
3.17ThrLys: 3.17 ± 0.801
3.875ThrLeu: 3.875 ± 0.801
0.704ThrMet: 0.704 ± 0.261
3.17ThrAsn: 3.17 ± 1.098
3.875ThrPro: 3.875 ± 1.055
4.755ThrGln: 4.755 ± 2.499
2.466ThrArg: 2.466 ± 0.796
2.466ThrSer: 2.466 ± 0.44
4.051ThrThr: 4.051 ± 2.463
2.818ThrVal: 2.818 ± 0.819
0.352ThrTrp: 0.352 ± 0.205
1.761ThrTyr: 1.761 ± 0.65
0.0ThrXaa: 0.0 ± 0.0
Val
8.278ValAla: 8.278 ± 3.216
0.881ValCys: 0.881 ± 0.252
1.585ValAsp: 1.585 ± 0.562
3.698ValGlu: 3.698 ± 0.581
2.818ValPhe: 2.818 ± 0.579
4.755ValGly: 4.755 ± 1.662
0.352ValHis: 0.352 ± 0.215
3.875ValIle: 3.875 ± 0.696
2.29ValLys: 2.29 ± 0.632
6.164ValLeu: 6.164 ± 0.744
0.528ValMet: 0.528 ± 0.322
3.346ValAsn: 3.346 ± 1.13
3.875ValPro: 3.875 ± 0.848
2.29ValGln: 2.29 ± 0.638
5.284ValArg: 5.284 ± 0.874
4.403ValSer: 4.403 ± 0.861
0.352ValThr: 0.352 ± 0.251
4.755ValVal: 4.755 ± 0.823
0.176ValTrp: 0.176 ± 0.15
1.409ValTyr: 1.409 ± 0.31
0.0ValXaa: 0.0 ± 0.0
Trp
0.176TrpAla: 0.176 ± 0.157
0.528TrpCys: 0.528 ± 0.258
0.176TrpAsp: 0.176 ± 0.178
1.937TrpGlu: 1.937 ± 0.764
0.176TrpPhe: 0.176 ± 0.15
0.704TrpGly: 0.704 ± 0.336
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.881TrpLys: 0.881 ± 0.436
0.704TrpLeu: 0.704 ± 0.371
0.0TrpMet: 0.0 ± 0.0
1.057TrpAsn: 1.057 ± 0.563
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.704TrpArg: 0.704 ± 0.247
0.352TrpSer: 0.352 ± 0.205
0.176TrpThr: 0.176 ± 0.15
1.057TrpVal: 1.057 ± 0.449
0.176TrpTrp: 0.176 ± 0.178
0.176TrpTyr: 0.176 ± 0.157
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.466TyrAla: 2.466 ± 0.771
0.176TyrCys: 0.176 ± 0.167
2.113TyrAsp: 2.113 ± 0.527
2.113TyrGlu: 2.113 ± 0.434
1.233TyrPhe: 1.233 ± 0.423
1.233TyrGly: 1.233 ± 0.256
0.704TyrHis: 0.704 ± 0.342
2.113TyrIle: 2.113 ± 0.477
2.642TyrLys: 2.642 ± 0.707
2.466TyrLeu: 2.466 ± 0.808
0.352TyrMet: 0.352 ± 0.237
2.994TyrAsn: 2.994 ± 0.586
1.409TyrPro: 1.409 ± 0.646
1.233TyrGln: 1.233 ± 0.38
1.585TyrArg: 1.585 ± 0.352
2.818TyrSer: 2.818 ± 0.594
2.113TyrThr: 2.113 ± 0.548
1.761TyrVal: 1.761 ± 0.663
0.352TyrTrp: 0.352 ± 0.181
2.29TyrTyr: 2.29 ± 0.693
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (5679 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski