Amino acid dipepetide frequency for Sanguibacter gelidistatuariae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.875AlaAla: 20.875 ± 0.216	0.821AlaCys: 0.821 ± 0.03	8.247AlaAsp: 8.247 ± 0.107	7.302AlaGlu: 7.302 ± 0.093	3.629AlaPhe: 3.629 ± 0.073	13.177AlaGly: 13.177 ± 0.134	2.719AlaHis: 2.719 ± 0.064	5.396AlaIle: 5.396 ± 0.071	2.545AlaLys: 2.545 ± 0.063	14.215AlaLeu: 14.215 ± 0.146	2.577AlaMet: 2.577 ± 0.052	2.274AlaAsn: 2.274 ± 0.046	7.32AlaPro: 7.32 ± 0.113	4.652AlaGln: 4.652 ± 0.07	9.332AlaArg: 9.332 ± 0.112	7.609AlaSer: 7.609 ± 0.092	8.613AlaThr: 8.613 ± 0.105	11.833AlaVal: 11.833 ± 0.122	1.874AlaTrp: 1.874 ± 0.037	2.275AlaTyr: 2.275 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.809CysAla: 0.809 ± 0.03	0.056CysCys: 0.056 ± 0.008	0.329CysAsp: 0.329 ± 0.018	0.34CysGlu: 0.34 ± 0.018	0.169CysPhe: 0.169 ± 0.014	0.64CysGly: 0.64 ± 0.023	0.131CysHis: 0.131 ± 0.01	0.207CysIle: 0.207 ± 0.014	0.085CysLys: 0.085 ± 0.009	0.534CysLeu: 0.534 ± 0.022	0.097CysMet: 0.097 ± 0.009	0.097CysAsn: 0.097 ± 0.009	0.367CysPro: 0.367 ± 0.019	0.154CysGln: 0.154 ± 0.011	0.326CysArg: 0.326 ± 0.017	0.41CysSer: 0.41 ± 0.02	0.389CysThr: 0.389 ± 0.019	0.519CysVal: 0.519 ± 0.023	0.059CysTrp: 0.059 ± 0.007	0.115CysTyr: 0.115 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.581AspAla: 8.581 ± 0.098	0.304AspCys: 0.304 ± 0.018	4.106AspAsp: 4.106 ± 0.066	3.591AspGlu: 3.591 ± 0.061	1.603AspPhe: 1.603 ± 0.043	6.155AspGly: 6.155 ± 0.086	1.342AspHis: 1.342 ± 0.04	2.147AspIle: 2.147 ± 0.045	1.046AspLys: 1.046 ± 0.035	6.955AspLeu: 6.955 ± 0.083	0.897AspMet: 0.897 ± 0.029	0.972AspAsn: 0.972 ± 0.033	4.271AspPro: 4.271 ± 0.061	1.67AspGln: 1.67 ± 0.039	4.024AspArg: 4.024 ± 0.066	2.859AspSer: 2.859 ± 0.051	2.886AspThr: 2.886 ± 0.06	5.933AspVal: 5.933 ± 0.075	0.88AspTrp: 0.88 ± 0.029	1.183AspTyr: 1.183 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.67GluAla: 6.67 ± 0.085	0.263GluCys: 0.263 ± 0.017	2.621GluAsp: 2.621 ± 0.05	2.562GluGlu: 2.562 ± 0.055	1.359GluPhe: 1.359 ± 0.038	3.749GluGly: 3.749 ± 0.058	1.473GluHis: 1.473 ± 0.037	2.771GluIle: 2.771 ± 0.058	1.189GluLys: 1.189 ± 0.038	6.038GluLeu: 6.038 ± 0.076	0.974GluMet: 0.974 ± 0.031	1.101GluAsn: 1.101 ± 0.032	2.833GluPro: 2.833 ± 0.064	1.96GluGln: 1.96 ± 0.047	4.215GluArg: 4.215 ± 0.076	2.682GluSer: 2.682 ± 0.052	2.791GluThr: 2.791 ± 0.053	4.757GluVal: 4.757 ± 0.063	0.682GluTrp: 0.682 ± 0.022	0.998GluTyr: 0.998 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.944PheAla: 3.944 ± 0.055	0.203PheCys: 0.203 ± 0.012	2.103PheAsp: 2.103 ± 0.042	1.479PheGlu: 1.479 ± 0.039	0.981PhePhe: 0.981 ± 0.034	2.947PheGly: 2.947 ± 0.062	0.53PheHis: 0.53 ± 0.023	1.062PheIle: 1.062 ± 0.034	0.479PheLys: 0.479 ± 0.021	2.7PheLeu: 2.7 ± 0.055	0.458PheMet: 0.458 ± 0.02	0.654PheAsn: 0.654 ± 0.028	1.323PhePro: 1.323 ± 0.039	0.686PheGln: 0.686 ± 0.024	1.512PheArg: 1.512 ± 0.037	1.812PheSer: 1.812 ± 0.042	2.128PheThr: 2.128 ± 0.045	2.671PheVal: 2.671 ± 0.054	0.47PheTrp: 0.47 ± 0.019	0.606PheTyr: 0.606 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	11.592GlyAla: 11.592 ± 0.12	0.606GlyCys: 0.606 ± 0.027	5.031GlyAsp: 5.031 ± 0.067	4.641GlyGlu: 4.641 ± 0.067	2.819GlyPhe: 2.819 ± 0.052	7.59GlyGly: 7.59 ± 0.105	1.939GlyHis: 1.939 ± 0.044	3.982GlyIle: 3.982 ± 0.059	2.149GlyLys: 2.149 ± 0.05	9.198GlyLeu: 9.198 ± 0.1	2.04GlyMet: 2.04 ± 0.042	1.571GlyAsn: 1.571 ± 0.04	4.434GlyPro: 4.434 ± 0.068	2.846GlyGln: 2.846 ± 0.061	6.077GlyArg: 6.077 ± 0.091	5.68GlySer: 5.68 ± 0.07	6.162GlyThr: 6.162 ± 0.096	7.935GlyVal: 7.935 ± 0.086	1.71GlyTrp: 1.71 ± 0.033	2.235GlyTyr: 2.235 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.475HisAla: 2.475 ± 0.051	0.129HisCys: 0.129 ± 0.011	1.299HisAsp: 1.299 ± 0.036	1.106HisGlu: 1.106 ± 0.03	0.536HisPhe: 0.536 ± 0.02	1.96HisGly: 1.96 ± 0.046	0.572HisHis: 0.572 ± 0.023	0.648HisIle: 0.648 ± 0.024	0.311HisLys: 0.311 ± 0.016	2.29HisLeu: 2.29 ± 0.049	0.299HisMet: 0.299 ± 0.016	0.391HisAsn: 0.391 ± 0.018	1.495HisPro: 1.495 ± 0.041	0.542HisGln: 0.542 ± 0.024	1.534HisArg: 1.534 ± 0.04	1.057HisSer: 1.057 ± 0.027	1.148HisThr: 1.148 ± 0.03	1.845HisVal: 1.845 ± 0.042	0.286HisTrp: 0.286 ± 0.016	0.39HisTyr: 0.39 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.962IleAla: 5.962 ± 0.088	0.289IleCys: 0.289 ± 0.016	3.166IleAsp: 3.166 ± 0.054	2.542IleGlu: 2.542 ± 0.052	1.132IlePhe: 1.132 ± 0.04	4.068IleGly: 4.068 ± 0.066	0.704IleHis: 0.704 ± 0.025	1.728IleIle: 1.728 ± 0.052	0.846IleLys: 0.846 ± 0.026	3.484IleLeu: 3.484 ± 0.057	0.672IleMet: 0.672 ± 0.024	1.01IleAsn: 1.01 ± 0.033	2.17IlePro: 2.17 ± 0.047	0.893IleGln: 0.893 ± 0.026	2.293IleArg: 2.293 ± 0.049	2.315IleSer: 2.315 ± 0.045	2.961IleThr: 2.961 ± 0.059	3.903IleVal: 3.903 ± 0.07	0.439IleTrp: 0.439 ± 0.019	0.718IleTyr: 0.718 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.426LysAla: 2.426 ± 0.055	0.07LysCys: 0.07 ± 0.007	1.153LysAsp: 1.153 ± 0.04	0.905LysGlu: 0.905 ± 0.035	0.539LysPhe: 0.539 ± 0.023	1.45LysGly: 1.45 ± 0.038	0.425LysHis: 0.425 ± 0.019	1.019LysIle: 1.019 ± 0.037	0.64LysLys: 0.64 ± 0.03	1.684LysLeu: 1.684 ± 0.046	0.414LysMet: 0.414 ± 0.017	0.563LysAsn: 0.563 ± 0.024	1.048LysPro: 1.048 ± 0.035	0.555LysGln: 0.555 ± 0.021	1.194LysArg: 1.194 ± 0.034	1.116LysSer: 1.116 ± 0.037	1.268LysThr: 1.268 ± 0.037	1.849LysVal: 1.849 ± 0.044	0.22LysTrp: 0.22 ± 0.015	0.455LysTyr: 0.455 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.536LeuAla: 15.536 ± 0.145	0.625LeuCys: 0.625 ± 0.024	6.854LeuAsp: 6.854 ± 0.091	4.8LeuGlu: 4.8 ± 0.063	2.643LeuPhe: 2.643 ± 0.054	9.15LeuGly: 9.15 ± 0.089	1.836LeuHis: 1.836 ± 0.045	3.682LeuIle: 3.682 ± 0.061	1.674LeuLys: 1.674 ± 0.051	10.199LeuLeu: 10.199 ± 0.114	1.64LeuMet: 1.64 ± 0.043	1.765LeuAsn: 1.765 ± 0.041	5.578LeuPro: 5.578 ± 0.075	2.195LeuGln: 2.195 ± 0.046	7.295LeuArg: 7.295 ± 0.083	5.879LeuSer: 5.879 ± 0.063	7.392LeuThr: 7.392 ± 0.082	10.115LeuVal: 10.115 ± 0.119	1.204LeuTrp: 1.204 ± 0.034	1.524LeuTyr: 1.524 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.323MetAla: 2.323 ± 0.044	0.116MetCys: 0.116 ± 0.01	0.924MetAsp: 0.924 ± 0.028	0.622MetGlu: 0.622 ± 0.023	0.559MetPhe: 0.559 ± 0.024	1.299MetGly: 1.299 ± 0.036	0.378MetHis: 0.378 ± 0.019	0.898MetIle: 0.898 ± 0.031	0.374MetLys: 0.374 ± 0.017	1.822MetLeu: 1.822 ± 0.041	0.316MetMet: 0.316 ± 0.017	0.473MetAsn: 0.473 ± 0.019	1.073MetPro: 1.073 ± 0.032	0.442MetGln: 0.442 ± 0.02	1.288MetArg: 1.288 ± 0.035	1.579MetSer: 1.579 ± 0.034	1.862MetThr: 1.862 ± 0.036	1.584MetVal: 1.584 ± 0.04	0.22MetTrp: 0.22 ± 0.015	0.288MetTyr: 0.288 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.243AsnAla: 2.243 ± 0.046	0.098AsnCys: 0.098 ± 0.009	1.113AsnAsp: 1.113 ± 0.033	0.885AsnGlu: 0.885 ± 0.029	0.644AsnPhe: 0.644 ± 0.022	1.767AsnGly: 1.767 ± 0.048	0.41AsnHis: 0.41 ± 0.019	0.796AsnIle: 0.796 ± 0.026	0.423AsnLys: 0.423 ± 0.02	1.994AsnLeu: 1.994 ± 0.04	0.327AsnMet: 0.327 ± 0.018	0.468AsnAsn: 0.468 ± 0.021	1.426AsnPro: 1.426 ± 0.04	0.582AsnGln: 0.582 ± 0.023	1.199AsnArg: 1.199 ± 0.035	1.015AsnSer: 1.015 ± 0.029	1.138AsnThr: 1.138 ± 0.035	1.576AsnVal: 1.576 ± 0.036	0.252AsnTrp: 0.252 ± 0.015	0.438AsnTyr: 0.438 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	8.122ProAla: 8.122 ± 0.107	0.224ProCys: 0.224 ± 0.016	4.066ProAsp: 4.066 ± 0.067	3.508ProGlu: 3.508 ± 0.058	1.55ProPhe: 1.55 ± 0.04	5.725ProGly: 5.725 ± 0.083	1.112ProHis: 1.112 ± 0.03	1.855ProIle: 1.855 ± 0.041	0.873ProLys: 0.873 ± 0.03	4.777ProLeu: 4.777 ± 0.076	0.933ProMet: 0.933 ± 0.031	0.89ProAsn: 0.89 ± 0.026	2.553ProPro: 2.553 ± 0.058	1.578ProGln: 1.578 ± 0.042	3.355ProArg: 3.355 ± 0.056	3.555ProSer: 3.555 ± 0.061	3.96ProThr: 3.96 ± 0.072	5.41ProVal: 5.41 ± 0.086	0.827ProTrp: 0.827 ± 0.029	1.007ProTyr: 1.007 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.774GlnAla: 3.774 ± 0.073	0.165GlnCys: 0.165 ± 0.013	1.367GlnAsp: 1.367 ± 0.035	1.267GlnGlu: 1.267 ± 0.036	0.833GlnPhe: 0.833 ± 0.028	2.21GlnGly: 2.21 ± 0.043	0.569GlnHis: 0.569 ± 0.02	1.504GlnIle: 1.504 ± 0.035	0.504GlnLys: 0.504 ± 0.021	2.852GlnLeu: 2.852 ± 0.052	0.638GlnMet: 0.638 ± 0.021	0.594GlnAsn: 0.594 ± 0.024	1.638GlnPro: 1.638 ± 0.053	1.009GlnGln: 1.009 ± 0.037	2.143GlnArg: 2.143 ± 0.05	1.527GlnSer: 1.527 ± 0.041	1.666GlnThr: 1.666 ± 0.04	3.056GlnVal: 3.056 ± 0.051	0.45GlnTrp: 0.45 ± 0.022	0.576GlnTyr: 0.576 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.675ArgAla: 8.675 ± 0.101	0.344ArgCys: 0.344 ± 0.018	3.721ArgAsp: 3.721 ± 0.063	3.835ArgGlu: 3.835 ± 0.072	1.994ArgPhe: 1.994 ± 0.047	5.337ArgGly: 5.337 ± 0.078	1.341ArgHis: 1.341 ± 0.032	2.993ArgIle: 2.993 ± 0.054	1.338ArgLys: 1.338 ± 0.04	6.897ArgLeu: 6.897 ± 0.09	1.551ArgMet: 1.551 ± 0.042	1.203ArgAsn: 1.203 ± 0.032	3.769ArgPro: 3.769 ± 0.065	1.932ArgGln: 1.932 ± 0.036	6.119ArgArg: 6.119 ± 0.1	4.476ArgSer: 4.476 ± 0.072	4.566ArgThr: 4.566 ± 0.071	5.542ArgVal: 5.542 ± 0.073	1.223ArgTrp: 1.223 ± 0.035	1.374ArgTyr: 1.374 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	7.881SerAla: 7.881 ± 0.083	0.349SerCys: 0.349 ± 0.017	3.379SerAsp: 3.379 ± 0.062	2.699SerGlu: 2.699 ± 0.053	1.813SerPhe: 1.813 ± 0.044	6.199SerGly: 6.199 ± 0.072	1.096SerHis: 1.096 ± 0.033	2.446SerIle: 2.446 ± 0.048	1.085SerLys: 1.085 ± 0.03	5.542SerLeu: 5.542 ± 0.073	1.324SerMet: 1.324 ± 0.032	1.014SerAsn: 1.014 ± 0.03	3.453SerPro: 3.453 ± 0.055	1.65SerGln: 1.65 ± 0.032	3.752SerArg: 3.752 ± 0.06	3.88SerSer: 3.88 ± 0.069	4.098SerThr: 4.098 ± 0.071	5.063SerVal: 5.063 ± 0.073	1.015SerTrp: 1.015 ± 0.033	1.209SerTyr: 1.209 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	8.566ThrAla: 8.566 ± 0.088	0.341ThrCys: 0.341 ± 0.02	3.967ThrAsp: 3.967 ± 0.067	3.104ThrGlu: 3.104 ± 0.054	2.137ThrPhe: 2.137 ± 0.042	6.523ThrGly: 6.523 ± 0.083	1.245ThrHis: 1.245 ± 0.03	2.959ThrIle: 2.959 ± 0.05	1.248ThrLys: 1.248 ± 0.034	6.413ThrLeu: 6.413 ± 0.08	1.122ThrMet: 1.122 ± 0.033	1.249ThrAsn: 1.249 ± 0.032	4.244ThrPro: 4.244 ± 0.07	1.785ThrGln: 1.785 ± 0.039	3.911ThrArg: 3.911 ± 0.06	4.21ThrSer: 4.21 ± 0.075	4.978ThrThr: 4.978 ± 0.099	6.457ThrVal: 6.457 ± 0.092	1.08ThrTrp: 1.08 ± 0.036	1.307ThrTyr: 1.307 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	12.768ValAla: 12.768 ± 0.113	0.606ValCys: 0.606 ± 0.022	5.801ValAsp: 5.801 ± 0.073	4.845ValGlu: 4.845 ± 0.068	2.593ValPhe: 2.593 ± 0.046	7.49ValGly: 7.49 ± 0.085	1.849ValHis: 1.849 ± 0.038	3.93ValIle: 3.93 ± 0.063	1.531ValLys: 1.531 ± 0.042	10.199ValLeu: 10.199 ± 0.104	1.603ValMet: 1.603 ± 0.04	1.694ValAsn: 1.694 ± 0.035	5.131ValPro: 5.131 ± 0.069	2.116ValGln: 2.116 ± 0.044	6.189ValArg: 6.189 ± 0.086	5.203ValSer: 5.203 ± 0.068	6.58ValThr: 6.58 ± 0.089	10.539ValVal: 10.539 ± 0.132	1.231ValTrp: 1.231 ± 0.031	1.542ValTyr: 1.542 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.672TrpAla: 1.672 ± 0.037	0.11TrpCys: 0.11 ± 0.01	0.891TrpAsp: 0.891 ± 0.028	0.672TrpGlu: 0.672 ± 0.025	0.539TrpPhe: 0.539 ± 0.021	1.023TrpGly: 1.023 ± 0.029	0.349TrpHis: 0.349 ± 0.019	0.638TrpIle: 0.638 ± 0.023	0.288TrpLys: 0.288 ± 0.016	1.641TrpLeu: 1.641 ± 0.041	0.308TrpMet: 0.308 ± 0.017	0.388TrpAsn: 0.388 ± 0.018	0.731TrpPro: 0.731 ± 0.027	0.518TrpGln: 0.518 ± 0.021	1.111TrpArg: 1.111 ± 0.037	0.984TrpSer: 0.984 ± 0.031	1.049TrpThr: 1.049 ± 0.03	1.175TrpVal: 1.175 ± 0.035	0.346TrpTrp: 0.346 ± 0.017	0.298TrpTyr: 0.298 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.39TyrAla: 2.39 ± 0.047	0.112TyrCys: 0.112 ± 0.009	1.265TyrAsp: 1.265 ± 0.034	0.985TyrGlu: 0.985 ± 0.03	0.677TyrPhe: 0.677 ± 0.026	1.779TyrGly: 1.779 ± 0.044	0.296TyrHis: 0.296 ± 0.017	0.636TyrIle: 0.636 ± 0.022	0.363TyrLys: 0.363 ± 0.018	2.151TyrLeu: 2.151 ± 0.047	0.25TyrMet: 0.25 ± 0.014	0.421TyrAsn: 0.421 ± 0.018	1.021TyrPro: 1.021 ± 0.027	0.578TyrGln: 0.578 ± 0.025	1.364TyrArg: 1.364 ± 0.038	1.104TyrSer: 1.104 ± 0.035	1.208TyrThr: 1.208 ± 0.04	1.674TyrVal: 1.674 ± 0.04	0.265TyrTrp: 0.265 ± 0.015	0.435TyrTyr: 0.435 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3525 proteins (1210563 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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