Amino acid dipepetide frequency for Oita virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.902AlaAla: 1.902 ± 1.643
2.173AlaCys: 2.173 ± 0.324
2.173AlaAsp: 2.173 ± 1.041
3.26AlaGlu: 3.26 ± 1.176
2.173AlaPhe: 2.173 ± 0.535
2.445AlaGly: 2.445 ± 0.91
0.815AlaHis: 0.815 ± 0.358
5.162AlaIle: 5.162 ± 1.03
3.26AlaLys: 3.26 ± 1.092
4.89AlaLeu: 4.89 ± 1.423
0.272AlaMet: 0.272 ± 0.63
2.445AlaAsn: 2.445 ± 1.039
2.988AlaPro: 2.988 ± 3.039
0.543AlaGln: 0.543 ± 0.264
2.717AlaArg: 2.717 ± 0.976
2.717AlaSer: 2.717 ± 0.939
1.902AlaThr: 1.902 ± 0.246
1.902AlaVal: 1.902 ± 1.133
1.087AlaTrp: 1.087 ± 0.582
2.445AlaTyr: 2.445 ± 1.195
0.0AlaXaa: 0.0 ± 0.0
Cys
0.815CysAla: 0.815 ± 0.806
0.0CysCys: 0.0 ± 0.0
0.543CysAsp: 0.543 ± 0.32
1.902CysGlu: 1.902 ± 0.518
1.087CysPhe: 1.087 ± 0.358
1.63CysGly: 1.63 ± 0.59
1.358CysHis: 1.358 ± 0.938
1.902CysIle: 1.902 ± 0.495
1.087CysLys: 1.087 ± 0.635
3.26CysLeu: 3.26 ± 0.979
0.543CysMet: 0.543 ± 0.751
1.087CysAsn: 1.087 ± 0.633
0.815CysPro: 0.815 ± 0.866
0.0CysGln: 0.0 ± 0.0
0.543CysArg: 0.543 ± 0.317
1.358CysSer: 1.358 ± 0.355
1.087CysThr: 1.087 ± 1.301
0.815CysVal: 0.815 ± 0.475
0.815CysTrp: 0.815 ± 0.475
0.815CysTyr: 0.815 ± 0.389
0.0CysXaa: 0.0 ± 0.0
Asp
1.63AspAla: 1.63 ± 0.778
1.087AspCys: 1.087 ± 0.728
2.717AspAsp: 2.717 ± 0.829
3.803AspGlu: 3.803 ± 1.153
2.445AspPhe: 2.445 ± 0.731
3.803AspGly: 3.803 ± 0.584
1.63AspHis: 1.63 ± 0.59
3.803AspIle: 3.803 ± 0.958
2.173AspLys: 2.173 ± 0.379
5.705AspLeu: 5.705 ± 1.354
2.445AspMet: 2.445 ± 0.375
2.173AspAsn: 2.173 ± 0.996
3.532AspPro: 3.532 ± 1.099
2.988AspGln: 2.988 ± 1.119
2.988AspArg: 2.988 ± 0.701
4.075AspSer: 4.075 ± 1.763
3.532AspThr: 3.532 ± 1.197
2.988AspVal: 2.988 ± 1.742
1.358AspTrp: 1.358 ± 0.559
2.173AspTyr: 2.173 ± 0.861
0.0AspXaa: 0.0 ± 0.0
Glu
2.445GluAla: 2.445 ± 1.215
1.63GluCys: 1.63 ± 0.515
5.162GluAsp: 5.162 ± 2.775
10.595GluGlu: 10.595 ± 3.993
3.26GluPhe: 3.26 ± 0.765
3.803GluGly: 3.803 ± 0.995
1.63GluHis: 1.63 ± 0.407
7.335GluIle: 7.335 ± 0.891
5.433GluLys: 5.433 ± 1.919
6.248GluLeu: 6.248 ± 1.222
2.445GluMet: 2.445 ± 0.361
3.803GluAsn: 3.803 ± 1.072
2.717GluPro: 2.717 ± 0.582
2.445GluGln: 2.445 ± 0.702
3.26GluArg: 3.26 ± 1.322
4.618GluSer: 4.618 ± 0.708
2.717GluThr: 2.717 ± 0.706
4.618GluVal: 4.618 ± 1.051
1.087GluTrp: 1.087 ± 0.704
2.173GluTyr: 2.173 ± 0.786
0.0GluXaa: 0.0 ± 0.0
Phe
1.087PheAla: 1.087 ± 0.43
1.358PheCys: 1.358 ± 0.602
1.63PheAsp: 1.63 ± 0.95
2.445PheGlu: 2.445 ± 0.34
2.445PhePhe: 2.445 ± 2.133
2.988PheGly: 2.988 ± 0.735
1.087PheHis: 1.087 ± 0.529
1.902PheIle: 1.902 ± 0.733
3.532PheLys: 3.532 ± 2.78
4.618PheLeu: 4.618 ± 1.707
0.272PheMet: 0.272 ± 0.158
1.63PheAsn: 1.63 ± 0.793
2.173PhePro: 2.173 ± 1.267
1.358PheGln: 1.358 ± 0.792
3.26PheArg: 3.26 ± 1.272
2.717PheSer: 2.717 ± 0.939
2.173PheThr: 2.173 ± 0.669
1.902PheVal: 1.902 ± 0.704
0.815PheTrp: 0.815 ± 0.619
1.087PheTyr: 1.087 ± 0.772
0.0PheXaa: 0.0 ± 0.0
Gly
3.26GlyAla: 3.26 ± 1.103
0.543GlyCys: 0.543 ± 0.489
2.988GlyAsp: 2.988 ± 0.843
3.26GlyGlu: 3.26 ± 0.983
1.902GlyPhe: 1.902 ± 1.441
3.532GlyGly: 3.532 ± 1.756
1.087GlyHis: 1.087 ± 0.633
5.162GlyIle: 5.162 ± 1.398
3.26GlyLys: 3.26 ± 0.593
7.335GlyLeu: 7.335 ± 2.076
1.358GlyMet: 1.358 ± 0.9
2.717GlyAsn: 2.717 ± 0.685
2.445GlyPro: 2.445 ± 0.731
2.988GlyGln: 2.988 ± 1.094
3.803GlyArg: 3.803 ± 1.354
5.977GlySer: 5.977 ± 1.565
2.988GlyThr: 2.988 ± 0.94
3.26GlyVal: 3.26 ± 1.122
1.087GlyTrp: 1.087 ± 0.633
2.717GlyTyr: 2.717 ± 0.71
0.0GlyXaa: 0.0 ± 0.0
His
1.63HisAla: 1.63 ± 0.518
0.543HisCys: 0.543 ± 0.552
0.815HisAsp: 0.815 ± 0.42
3.26HisGlu: 3.26 ± 1.586
0.815HisPhe: 0.815 ± 0.295
0.272HisGly: 0.272 ± 0.406
0.815HisHis: 0.815 ± 0.566
1.358HisIle: 1.358 ± 0.559
2.717HisLys: 2.717 ± 0.82
2.173HisLeu: 2.173 ± 1.267
0.543HisMet: 0.543 ± 0.264
0.815HisAsn: 0.815 ± 0.512
2.988HisPro: 2.988 ± 0.794
0.815HisGln: 0.815 ± 0.35
1.087HisArg: 1.087 ± 0.633
1.63HisSer: 1.63 ± 0.793
0.543HisThr: 0.543 ± 0.552
0.543HisVal: 0.543 ± 0.811
0.543HisTrp: 0.543 ± 0.317
1.087HisTyr: 1.087 ± 0.393
0.0HisXaa: 0.0 ± 0.0
Ile
3.532IleAla: 3.532 ± 1.113
1.63IleCys: 1.63 ± 0.663
5.433IleAsp: 5.433 ± 1.274
5.433IleGlu: 5.433 ± 1.217
0.815IlePhe: 0.815 ± 0.619
3.532IleGly: 3.532 ± 1.12
1.63IleHis: 1.63 ± 0.793
3.803IleIle: 3.803 ± 1.135
6.792IleLys: 6.792 ± 2.037
5.162IleLeu: 5.162 ± 0.592
1.63IleMet: 1.63 ± 0.661
4.347IleAsn: 4.347 ± 1.395
3.803IlePro: 3.803 ± 1.071
4.075IleGln: 4.075 ± 1.184
5.433IleArg: 5.433 ± 1.336
5.977IleSer: 5.977 ± 1.853
2.445IleThr: 2.445 ± 1.319
2.717IleVal: 2.717 ± 0.515
1.358IleTrp: 1.358 ± 0.573
2.173IleTyr: 2.173 ± 0.379
0.0IleXaa: 0.0 ± 0.0
Lys
3.26LysAla: 3.26 ± 2.213
1.63LysCys: 1.63 ± 0.633
5.433LysAsp: 5.433 ± 2.932
7.063LysGlu: 7.063 ± 4.205
2.717LysPhe: 2.717 ± 1.377
5.162LysGly: 5.162 ± 1.289
1.63LysHis: 1.63 ± 0.785
5.977LysIle: 5.977 ± 1.707
6.248LysLys: 6.248 ± 2.062
5.162LysLeu: 5.162 ± 0.706
0.272LysMet: 0.272 ± 0.684
3.532LysAsn: 3.532 ± 1.017
1.902LysPro: 1.902 ± 0.624
0.815LysGln: 0.815 ± 0.358
4.618LysArg: 4.618 ± 1.687
3.532LysSer: 3.532 ± 0.844
3.803LysThr: 3.803 ± 0.682
5.977LysVal: 5.977 ± 1.281
1.902LysTrp: 1.902 ± 0.419
1.63LysTyr: 1.63 ± 0.59
0.0LysXaa: 0.0 ± 0.0
Leu
4.075LeuAla: 4.075 ± 1.071
2.445LeuCys: 2.445 ± 1.343
4.89LeuAsp: 4.89 ± 0.721
7.063LeuGlu: 7.063 ± 0.849
3.803LeuPhe: 3.803 ± 1.621
6.52LeuGly: 6.52 ± 1.931
2.717LeuHis: 2.717 ± 0.721
6.52LeuIle: 6.52 ± 2.886
7.335LeuLys: 7.335 ± 1.048
7.063LeuLeu: 7.063 ± 1.155
4.075LeuMet: 4.075 ± 1.453
5.162LeuAsn: 5.162 ± 1.119
2.988LeuPro: 2.988 ± 0.939
3.26LeuGln: 3.26 ± 1.077
6.792LeuArg: 6.792 ± 1.357
8.15LeuSer: 8.15 ± 1.025
4.347LeuThr: 4.347 ± 0.796
3.26LeuVal: 3.26 ± 0.834
1.087LeuTrp: 1.087 ± 0.478
3.803LeuTyr: 3.803 ± 0.483
0.0LeuXaa: 0.0 ± 0.0
Met
1.358MetAla: 1.358 ± 0.691
0.543MetCys: 0.543 ± 0.32
1.358MetAsp: 1.358 ± 0.522
1.087MetGlu: 1.087 ± 0.633
0.815MetPhe: 0.815 ± 0.358
2.173MetGly: 2.173 ± 0.513
0.272MetHis: 0.272 ± 0.158
1.358MetIle: 1.358 ± 0.538
1.087MetLys: 1.087 ± 0.532
1.087MetLeu: 1.087 ± 0.816
1.087MetMet: 1.087 ± 0.532
0.543MetAsn: 0.543 ± 0.32
0.0MetPro: 0.0 ± 0.0
1.087MetGln: 1.087 ± 0.358
2.173MetArg: 2.173 ± 0.535
1.902MetSer: 1.902 ± 0.811
2.173MetThr: 2.173 ± 0.924
1.087MetVal: 1.087 ± 0.529
0.0MetTrp: 0.0 ± 0.0
0.272MetTyr: 0.272 ± 0.63
0.0MetXaa: 0.0 ± 0.0
Asn
2.445AsnAla: 2.445 ± 0.447
1.087AsnCys: 1.087 ± 0.633
1.358AsnAsp: 1.358 ± 0.482
3.26AsnGlu: 3.26 ± 0.502
1.902AsnPhe: 1.902 ± 0.677
2.717AsnGly: 2.717 ± 1.063
1.358AsnHis: 1.358 ± 0.541
3.26AsnIle: 3.26 ± 0.855
2.988AsnLys: 2.988 ± 0.749
4.618AsnLeu: 4.618 ± 0.843
1.087AsnMet: 1.087 ± 0.393
2.173AsnAsn: 2.173 ± 1.267
4.075AsnPro: 4.075 ± 1.877
1.902AsnGln: 1.902 ± 0.515
1.902AsnArg: 1.902 ± 0.515
3.26AsnSer: 3.26 ± 0.502
1.087AsnThr: 1.087 ± 0.393
2.445AsnVal: 2.445 ± 0.34
0.543AsnTrp: 0.543 ± 0.317
2.445AsnTyr: 2.445 ± 1.139
0.0AsnXaa: 0.0 ± 0.0
Pro
1.902ProAla: 1.902 ± 1.798
0.272ProCys: 0.272 ± 0.158
3.803ProAsp: 3.803 ± 0.453
2.445ProGlu: 2.445 ± 0.666
1.358ProPhe: 1.358 ± 1.345
1.358ProGly: 1.358 ± 0.792
1.358ProHis: 1.358 ± 0.538
2.173ProIle: 2.173 ± 0.435
4.075ProLys: 4.075 ± 0.805
5.433ProLeu: 5.433 ± 1.103
0.272ProMet: 0.272 ± 0.321
1.902ProAsn: 1.902 ± 0.549
1.358ProPro: 1.358 ± 1.128
0.815ProGln: 0.815 ± 0.35
1.63ProArg: 1.63 ± 0.257
3.26ProSer: 3.26 ± 1.673
1.902ProThr: 1.902 ± 0.549
3.803ProVal: 3.803 ± 1.112
1.63ProTrp: 1.63 ± 0.697
1.63ProTyr: 1.63 ± 1.138
0.0ProXaa: 0.0 ± 0.0
Gln
1.63GlnAla: 1.63 ± 0.493
0.543GlnCys: 0.543 ± 0.348
1.902GlnAsp: 1.902 ± 0.585
2.445GlnGlu: 2.445 ± 0.954
0.815GlnPhe: 0.815 ± 0.295
3.532GlnGly: 3.532 ± 0.817
0.543GlnHis: 0.543 ± 0.264
1.63GlnIle: 1.63 ± 0.696
1.358GlnLys: 1.358 ± 0.361
3.26GlnLeu: 3.26 ± 0.805
0.272GlnMet: 0.272 ± 0.363
1.902GlnAsn: 1.902 ± 0.811
1.087GlnPro: 1.087 ± 0.439
0.543GlnGln: 0.543 ± 0.317
1.902GlnArg: 1.902 ± 0.608
3.803GlnSer: 3.803 ± 1.352
0.815GlnThr: 0.815 ± 0.42
1.63GlnVal: 1.63 ± 0.568
0.543GlnTrp: 0.543 ± 0.52
0.543GlnTyr: 0.543 ± 0.552
0.0GlnXaa: 0.0 ± 0.0
Arg
3.803ArgAla: 3.803 ± 0.698
1.358ArgCys: 1.358 ± 0.823
3.803ArgAsp: 3.803 ± 0.592
4.347ArgGlu: 4.347 ± 0.648
3.532ArgPhe: 3.532 ± 0.608
2.988ArgGly: 2.988 ± 1.094
1.902ArgHis: 1.902 ± 0.84
2.717ArgIle: 2.717 ± 0.857
4.89ArgLys: 4.89 ± 1.067
4.618ArgLeu: 4.618 ± 1.234
1.087ArgMet: 1.087 ± 0.343
2.717ArgAsn: 2.717 ± 0.795
1.087ArgPro: 1.087 ± 0.393
1.63ArgGln: 1.63 ± 0.434
3.26ArgArg: 3.26 ± 0.903
4.618ArgSer: 4.618 ± 0.996
3.26ArgThr: 3.26 ± 1.326
3.26ArgVal: 3.26 ± 1.353
0.815ArgTrp: 0.815 ± 0.566
1.63ArgTyr: 1.63 ± 0.639
0.0ArgXaa: 0.0 ± 0.0
Ser
4.618SerAla: 4.618 ± 1.249
1.902SerCys: 1.902 ± 0.532
7.063SerAsp: 7.063 ± 1.522
3.532SerGlu: 3.532 ± 0.719
3.26SerPhe: 3.26 ± 0.406
4.075SerGly: 4.075 ± 0.805
2.445SerHis: 2.445 ± 1.024
4.89SerIle: 4.89 ± 0.681
4.618SerLys: 4.618 ± 1.959
8.422SerLeu: 8.422 ± 3.582
0.815SerMet: 0.815 ± 0.522
1.358SerAsn: 1.358 ± 0.938
2.445SerPro: 2.445 ± 0.708
1.358SerGln: 1.358 ± 0.863
3.803SerArg: 3.803 ± 1.179
6.248SerSer: 6.248 ± 1.857
3.803SerThr: 3.803 ± 0.736
5.162SerVal: 5.162 ± 2.316
1.902SerTrp: 1.902 ± 0.771
2.445SerTyr: 2.445 ± 0.614
0.0SerXaa: 0.0 ± 0.0
Thr
3.803ThrAla: 3.803 ± 1.145
1.087ThrCys: 1.087 ± 0.439
1.902ThrAsp: 1.902 ± 0.246
5.977ThrGlu: 5.977 ± 2.32
1.902ThrPhe: 1.902 ± 0.771
3.26ThrGly: 3.26 ± 0.816
1.358ThrHis: 1.358 ± 1.16
2.173ThrIle: 2.173 ± 0.324
2.717ThrLys: 2.717 ± 0.646
4.618ThrLeu: 4.618 ± 1.051
0.543ThrMet: 0.543 ± 0.317
1.902ThrAsn: 1.902 ± 0.84
1.358ThrPro: 1.358 ± 0.654
1.63ThrGln: 1.63 ± 0.257
2.988ThrArg: 2.988 ± 1.396
3.532ThrSer: 3.532 ± 1.182
2.988ThrThr: 2.988 ± 0.825
3.26ThrVal: 3.26 ± 0.953
1.63ThrTrp: 1.63 ± 0.407
0.543ThrTyr: 0.543 ± 0.348
0.0ThrXaa: 0.0 ± 0.0
Val
1.63ValAla: 1.63 ± 0.821
1.087ValCys: 1.087 ± 0.358
1.358ValAsp: 1.358 ± 0.341
4.618ValGlu: 4.618 ± 1.284
2.717ValPhe: 2.717 ± 1.056
5.162ValGly: 5.162 ± 1.471
0.815ValHis: 0.815 ± 0.512
4.347ValIle: 4.347 ± 1.505
4.347ValLys: 4.347 ± 1.504
6.792ValLeu: 6.792 ± 0.98
0.815ValMet: 0.815 ± 0.358
1.902ValAsn: 1.902 ± 0.246
2.988ValPro: 2.988 ± 0.581
0.815ValGln: 0.815 ± 0.619
1.63ValArg: 1.63 ± 0.768
3.26ValSer: 3.26 ± 0.971
5.433ValThr: 5.433 ± 2.034
4.347ValVal: 4.347 ± 1.43
0.272ValTrp: 0.272 ± 0.158
1.63ValTyr: 1.63 ± 0.428
0.0ValXaa: 0.0 ± 0.0
Trp
0.543TrpAla: 0.543 ± 0.317
0.0TrpCys: 0.0 ± 0.0
1.087TrpAsp: 1.087 ± 0.697
1.087TrpGlu: 1.087 ± 0.337
1.087TrpPhe: 1.087 ± 0.772
1.087TrpGly: 1.087 ± 0.633
0.272TrpHis: 0.272 ± 0.158
2.717TrpIle: 2.717 ± 1.215
2.717TrpLys: 2.717 ± 0.418
0.272TrpLeu: 0.272 ± 0.158
0.543TrpMet: 0.543 ± 0.317
1.902TrpAsn: 1.902 ± 0.794
0.543TrpPro: 0.543 ± 0.317
0.815TrpGln: 0.815 ± 0.512
0.815TrpArg: 0.815 ± 0.389
1.358TrpSer: 1.358 ± 0.573
0.815TrpThr: 0.815 ± 0.35
1.358TrpVal: 1.358 ± 0.863
0.543TrpTrp: 0.543 ± 0.317
0.543TrpTyr: 0.543 ± 0.264
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.902TyrAla: 1.902 ± 0.643
0.543TyrCys: 0.543 ± 0.489
1.63TyrAsp: 1.63 ± 0.59
0.543TyrGlu: 0.543 ± 0.317
1.63TyrPhe: 1.63 ± 0.59
1.63TyrGly: 1.63 ± 0.671
0.272TyrHis: 0.272 ± 0.406
3.532TyrIle: 3.532 ± 0.287
1.902TyrLys: 1.902 ± 0.581
4.618TyrLeu: 4.618 ± 1.214
0.815TyrMet: 0.815 ± 0.42
1.902TyrAsn: 1.902 ± 0.643
1.087TyrPro: 1.087 ± 0.343
0.815TyrGln: 0.815 ± 0.35
2.717TyrArg: 2.717 ± 1.08
2.173TyrSer: 2.173 ± 0.535
1.358TyrThr: 1.358 ± 0.923
1.63TyrVal: 1.63 ± 0.639
1.087TyrTrp: 1.087 ± 0.529
1.358TyrTyr: 1.358 ± 0.677
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3682 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski