Amino acid dipepetide frequency for Zooshikella ganghwensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.799AlaAla: 6.799 ± 0.079
1.018AlaCys: 1.018 ± 0.029
4.282AlaAsp: 4.282 ± 0.053
5.37AlaGlu: 5.37 ± 0.06
3.236AlaPhe: 3.236 ± 0.05
5.232AlaGly: 5.232 ± 0.069
1.712AlaHis: 1.712 ± 0.032
5.682AlaIle: 5.682 ± 0.06
4.748AlaLys: 4.748 ± 0.056
8.922AlaLeu: 8.922 ± 0.086
2.043AlaMet: 2.043 ± 0.039
3.438AlaAsn: 3.438 ± 0.057
2.52AlaPro: 2.52 ± 0.043
3.625AlaGln: 3.625 ± 0.056
3.338AlaArg: 3.338 ± 0.053
5.008AlaSer: 5.008 ± 0.059
4.254AlaThr: 4.254 ± 0.053
5.169AlaVal: 5.169 ± 0.066
1.003AlaTrp: 1.003 ± 0.028
2.565AlaTyr: 2.565 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.76CysAla: 0.76 ± 0.024
0.23CysCys: 0.23 ± 0.013
0.554CysAsp: 0.554 ± 0.019
0.568CysGlu: 0.568 ± 0.02
0.569CysPhe: 0.569 ± 0.021
0.91CysGly: 0.91 ± 0.024
0.389CysHis: 0.389 ± 0.016
0.781CysIle: 0.781 ± 0.022
0.545CysLys: 0.545 ± 0.02
1.281CysLeu: 1.281 ± 0.033
0.21CysMet: 0.21 ± 0.011
0.455CysAsn: 0.455 ± 0.019
0.54CysPro: 0.54 ± 0.019
0.639CysGln: 0.639 ± 0.019
0.557CysArg: 0.557 ± 0.019
0.805CysSer: 0.805 ± 0.024
0.528CysThr: 0.528 ± 0.02
0.699CysVal: 0.699 ± 0.022
0.227CysTrp: 0.227 ± 0.013
0.415CysTyr: 0.415 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.893AspAla: 3.893 ± 0.076
0.566AspCys: 0.566 ± 0.019
2.956AspAsp: 2.956 ± 0.07
3.471AspGlu: 3.471 ± 0.05
2.327AspPhe: 2.327 ± 0.034
3.45AspGly: 3.45 ± 0.082
1.213AspHis: 1.213 ± 0.03
3.848AspIle: 3.848 ± 0.06
3.074AspLys: 3.074 ± 0.054
4.898AspLeu: 4.898 ± 0.053
1.049AspMet: 1.049 ± 0.026
2.406AspAsn: 2.406 ± 0.051
2.161AspPro: 2.161 ± 0.039
2.657AspGln: 2.657 ± 0.044
2.256AspArg: 2.256 ± 0.037
3.082AspSer: 3.082 ± 0.041
2.752AspThr: 2.752 ± 0.053
3.286AspVal: 3.286 ± 0.047
0.844AspTrp: 0.844 ± 0.024
2.162AspTyr: 2.162 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
4.992GluAla: 4.992 ± 0.063
0.532GluCys: 0.532 ± 0.019
2.657GluAsp: 2.657 ± 0.043
3.462GluGlu: 3.462 ± 0.06
2.07GluPhe: 2.07 ± 0.038
3.456GluGly: 3.456 ± 0.057
1.538GluHis: 1.538 ± 0.033
3.654GluIle: 3.654 ± 0.05
3.839GluLys: 3.839 ± 0.058
6.117GluLeu: 6.117 ± 0.065
1.258GluMet: 1.258 ± 0.029
2.518GluAsn: 2.518 ± 0.042
2.099GluPro: 2.099 ± 0.04
3.993GluGln: 3.993 ± 0.065
3.025GluArg: 3.025 ± 0.05
3.406GluSer: 3.406 ± 0.045
3.019GluThr: 3.019 ± 0.048
4.001GluVal: 4.001 ± 0.052
0.788GluTrp: 0.788 ± 0.022
1.899GluTyr: 1.899 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.01PheAla: 3.01 ± 0.048
0.568PheCys: 0.568 ± 0.02
2.473PheAsp: 2.473 ± 0.034
2.211PheGlu: 2.211 ± 0.041
1.88PhePhe: 1.88 ± 0.044
2.65PheGly: 2.65 ± 0.046
0.869PheHis: 0.869 ± 0.026
3.03PheIle: 3.03 ± 0.059
2.136PheLys: 2.136 ± 0.039
3.604PheLeu: 3.604 ± 0.055
0.9PheMet: 0.9 ± 0.024
2.243PheAsn: 2.243 ± 0.035
1.467PhePro: 1.467 ± 0.035
1.504PheGln: 1.504 ± 0.03
1.594PheArg: 1.594 ± 0.037
3.361PheSer: 3.361 ± 0.042
2.372PheThr: 2.372 ± 0.04
2.29PheVal: 2.29 ± 0.039
0.588PheTrp: 0.588 ± 0.017
1.567PheTyr: 1.567 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
4.35GlyAla: 4.35 ± 0.069
0.915GlyCys: 0.915 ± 0.025
3.453GlyAsp: 3.453 ± 0.09
3.75GlyGlu: 3.75 ± 0.052
2.954GlyPhe: 2.954 ± 0.047
4.189GlyGly: 4.189 ± 0.081
1.592GlyHis: 1.592 ± 0.033
4.562GlyIle: 4.562 ± 0.057
3.945GlyLys: 3.945 ± 0.053
6.585GlyLeu: 6.585 ± 0.078
1.569GlyMet: 1.569 ± 0.033
2.734GlyAsn: 2.734 ± 0.066
1.744GlyPro: 1.744 ± 0.038
2.906GlyGln: 2.906 ± 0.063
2.885GlyArg: 2.885 ± 0.051
3.741GlySer: 3.741 ± 0.058
3.034GlyThr: 3.034 ± 0.057
4.479GlyVal: 4.479 ± 0.053
1.037GlyTrp: 1.037 ± 0.026
2.652GlyTyr: 2.652 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.603HisAla: 1.603 ± 0.028
0.421HisCys: 0.421 ± 0.017
1.164HisAsp: 1.164 ± 0.025
1.394HisGlu: 1.394 ± 0.031
1.154HisPhe: 1.154 ± 0.03
1.517HisGly: 1.517 ± 0.032
0.896HisHis: 0.896 ± 0.026
1.641HisIle: 1.641 ± 0.034
1.227HisLys: 1.227 ± 0.026
2.573HisLeu: 2.573 ± 0.045
0.517HisMet: 0.517 ± 0.017
1.034HisAsn: 1.034 ± 0.021
1.221HisPro: 1.221 ± 0.029
1.533HisGln: 1.533 ± 0.033
1.158HisArg: 1.158 ± 0.024
1.542HisSer: 1.542 ± 0.029
1.3HisThr: 1.3 ± 0.027
1.397HisVal: 1.397 ± 0.03
0.483HisTrp: 0.483 ± 0.02
1.255HisTyr: 1.255 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.86IleAla: 5.86 ± 0.065
0.758IleCys: 0.758 ± 0.021
4.032IleAsp: 4.032 ± 0.048
4.151IleGlu: 4.151 ± 0.055
2.285IlePhe: 2.285 ± 0.047
4.018IleGly: 4.018 ± 0.055
1.573IleHis: 1.573 ± 0.033
4.297IleIle: 4.297 ± 0.062
4.155IleLys: 4.155 ± 0.052
5.357IleLeu: 5.357 ± 0.074
1.24IleMet: 1.24 ± 0.03
3.754IleAsn: 3.754 ± 0.057
3.088IlePro: 3.088 ± 0.053
2.598IleGln: 2.598 ± 0.047
3.005IleArg: 3.005 ± 0.044
4.678IleSer: 4.678 ± 0.057
4.19IleThr: 4.19 ± 0.055
3.859IleVal: 3.859 ± 0.051
0.733IleTrp: 0.733 ± 0.022
1.939IleTyr: 1.939 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.894LysAla: 4.894 ± 0.065
0.465LysCys: 0.465 ± 0.016
2.769LysAsp: 2.769 ± 0.048
3.238LysGlu: 3.238 ± 0.041
1.46LysPhe: 1.46 ± 0.032
3.459LysGly: 3.459 ± 0.057
1.562LysHis: 1.562 ± 0.032
3.296LysIle: 3.296 ± 0.055
3.806LysLys: 3.806 ± 0.066
5.811LysLeu: 5.811 ± 0.061
1.178LysMet: 1.178 ± 0.029
2.629LysAsn: 2.629 ± 0.045
2.818LysPro: 2.818 ± 0.052
3.656LysGln: 3.656 ± 0.044
3.102LysArg: 3.102 ± 0.048
3.382LysSer: 3.382 ± 0.05
3.3LysThr: 3.3 ± 0.047
3.844LysVal: 3.844 ± 0.055
0.594LysTrp: 0.594 ± 0.019
1.85LysTyr: 1.85 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
9.532LeuAla: 9.532 ± 0.09
1.222LeuCys: 1.222 ± 0.031
5.136LeuAsp: 5.136 ± 0.065
5.546LeuGlu: 5.546 ± 0.069
4.325LeuPhe: 4.325 ± 0.065
6.334LeuGly: 6.334 ± 0.067
2.238LeuHis: 2.238 ± 0.039
6.597LeuIle: 6.597 ± 0.083
6.126LeuLys: 6.126 ± 0.064
11.304LeuLeu: 11.304 ± 0.143
2.267LeuMet: 2.267 ± 0.039
4.803LeuAsn: 4.803 ± 0.069
5.044LeuPro: 5.044 ± 0.069
5.021LeuGln: 5.021 ± 0.085
4.47LeuArg: 4.47 ± 0.055
7.91LeuSer: 7.91 ± 0.078
6.371LeuThr: 6.371 ± 0.067
6.624LeuVal: 6.624 ± 0.071
1.2LeuTrp: 1.2 ± 0.027
2.981LeuTyr: 2.981 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
1.993MetAla: 1.993 ± 0.036
0.201MetCys: 0.201 ± 0.01
1.088MetAsp: 1.088 ± 0.029
1.058MetGlu: 1.058 ± 0.027
0.677MetPhe: 0.677 ± 0.023
1.42MetGly: 1.42 ± 0.032
0.458MetHis: 0.458 ± 0.018
1.273MetIle: 1.273 ± 0.029
1.239MetLys: 1.239 ± 0.03
2.379MetLeu: 2.379 ± 0.046
0.527MetMet: 0.527 ± 0.019
0.952MetAsn: 0.952 ± 0.026
1.125MetPro: 1.125 ± 0.029
1.042MetGln: 1.042 ± 0.026
1.042MetArg: 1.042 ± 0.028
1.616MetSer: 1.616 ± 0.034
1.276MetThr: 1.276 ± 0.029
1.442MetVal: 1.442 ± 0.033
0.198MetTrp: 0.198 ± 0.011
0.504MetTyr: 0.504 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.34AsnAla: 3.34 ± 0.055
0.464AsnCys: 0.464 ± 0.021
2.422AsnAsp: 2.422 ± 0.066
2.588AsnGlu: 2.588 ± 0.043
1.54AsnPhe: 1.54 ± 0.035
2.72AsnGly: 2.72 ± 0.054
1.179AsnHis: 1.179 ± 0.027
3.047AsnIle: 3.047 ± 0.045
2.845AsnLys: 2.845 ± 0.052
3.935AsnLeu: 3.935 ± 0.059
0.933AsnMet: 0.933 ± 0.024
2.486AsnAsn: 2.486 ± 0.056
2.253AsnPro: 2.253 ± 0.044
2.529AsnGln: 2.529 ± 0.046
2.01AsnArg: 2.01 ± 0.038
2.712AsnSer: 2.712 ± 0.044
2.823AsnThr: 2.823 ± 0.05
2.565AsnVal: 2.565 ± 0.04
0.638AsnTrp: 0.638 ± 0.018
1.726AsnTyr: 1.726 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
3.187ProAla: 3.187 ± 0.058
0.407ProCys: 0.407 ± 0.015
2.546ProAsp: 2.546 ± 0.047
3.274ProGlu: 3.274 ± 0.051
1.76ProPhe: 1.76 ± 0.03
2.625ProGly: 2.625 ± 0.048
0.998ProHis: 0.998 ± 0.028
2.629ProIle: 2.629 ± 0.041
2.267ProLys: 2.267 ± 0.034
4.319ProLeu: 4.319 ± 0.065
0.914ProMet: 0.914 ± 0.023
1.791ProAsn: 1.791 ± 0.038
1.707ProPro: 1.707 ± 0.056
1.806ProGln: 1.806 ± 0.04
1.551ProArg: 1.551 ± 0.033
2.721ProSer: 2.721 ± 0.044
2.205ProThr: 2.205 ± 0.043
3.096ProVal: 3.096 ± 0.048
0.648ProTrp: 0.648 ± 0.021
1.419ProTyr: 1.419 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.649GlnAla: 4.649 ± 0.066
0.552GlnCys: 0.552 ± 0.019
2.016GlnAsp: 2.016 ± 0.038
2.605GlnGlu: 2.605 ± 0.045
1.853GlnPhe: 1.853 ± 0.033
3.286GlnGly: 3.286 ± 0.049
1.755GlnHis: 1.755 ± 0.037
2.492GlnIle: 2.492 ± 0.041
2.487GlnLys: 2.487 ± 0.04
6.604GlnLeu: 6.604 ± 0.083
0.943GlnMet: 0.943 ± 0.023
1.635GlnAsn: 1.635 ± 0.037
2.296GlnPro: 2.296 ± 0.048
4.824GlnGln: 4.824 ± 0.076
2.994GlnArg: 2.994 ± 0.051
3.074GlnSer: 3.074 ± 0.05
2.572GlnThr: 2.572 ± 0.055
3.389GlnVal: 3.389 ± 0.048
0.944GlnTrp: 0.944 ± 0.025
1.712GlnTyr: 1.712 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.137ArgAla: 3.137 ± 0.044
0.571ArgCys: 0.571 ± 0.02
2.196ArgAsp: 2.196 ± 0.038
2.694ArgGlu: 2.694 ± 0.045
2.202ArgPhe: 2.202 ± 0.039
2.461ArgGly: 2.461 ± 0.047
1.258ArgHis: 1.258 ± 0.026
3.053ArgIle: 3.053 ± 0.047
2.569ArgLys: 2.569 ± 0.043
5.394ArgLeu: 5.394 ± 0.06
1.035ArgMet: 1.035 ± 0.025
1.833ArgAsn: 1.833 ± 0.032
1.675ArgPro: 1.675 ± 0.031
2.645ArgGln: 2.645 ± 0.044
2.475ArgArg: 2.475 ± 0.049
2.605ArgSer: 2.605 ± 0.041
2.109ArgThr: 2.109 ± 0.038
3.07ArgVal: 3.07 ± 0.048
0.837ArgTrp: 0.837 ± 0.025
2.083ArgTyr: 2.083 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
4.853SerAla: 4.853 ± 0.07
0.756SerCys: 0.756 ± 0.022
3.257SerAsp: 3.257 ± 0.051
3.596SerGlu: 3.596 ± 0.055
2.897SerPhe: 2.897 ± 0.045
4.568SerGly: 4.568 ± 0.058
1.684SerHis: 1.684 ± 0.033
4.421SerIle: 4.421 ± 0.052
3.404SerLys: 3.404 ± 0.055
7.289SerLeu: 7.289 ± 0.08
1.445SerMet: 1.445 ± 0.032
2.727SerAsn: 2.727 ± 0.048
2.776SerPro: 2.776 ± 0.041
3.186SerGln: 3.186 ± 0.051
2.872SerArg: 2.872 ± 0.041
4.773SerSer: 4.773 ± 0.071
3.705SerThr: 3.705 ± 0.056
4.234SerVal: 4.234 ± 0.051
0.961SerTrp: 0.961 ± 0.027
2.219SerTyr: 2.219 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
4.529ThrAla: 4.529 ± 0.068
0.592ThrCys: 0.592 ± 0.02
2.924ThrAsp: 2.924 ± 0.055
3.121ThrGlu: 3.121 ± 0.05
2.165ThrPhe: 2.165 ± 0.041
3.858ThrGly: 3.858 ± 0.058
1.467ThrHis: 1.467 ± 0.03
3.715ThrIle: 3.715 ± 0.059
2.611ThrLys: 2.611 ± 0.045
6.521ThrLeu: 6.521 ± 0.078
1.028ThrMet: 1.028 ± 0.025
2.177ThrAsn: 2.177 ± 0.041
2.85ThrPro: 2.85 ± 0.044
2.715ThrGln: 2.715 ± 0.052
2.246ThrArg: 2.246 ± 0.038
3.502ThrSer: 3.502 ± 0.053
3.536ThrThr: 3.536 ± 0.067
3.782ThrVal: 3.782 ± 0.051
0.62ThrTrp: 0.62 ± 0.02
1.819ThrTyr: 1.819 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
5.373ValAla: 5.373 ± 0.061
0.782ValCys: 0.782 ± 0.026
3.841ValAsp: 3.841 ± 0.063
3.816ValGlu: 3.816 ± 0.055
2.734ValPhe: 2.734 ± 0.041
3.999ValGly: 3.999 ± 0.06
1.27ValHis: 1.27 ± 0.029
4.793ValIle: 4.793 ± 0.049
3.836ValLys: 3.836 ± 0.056
6.401ValLeu: 6.401 ± 0.068
1.567ValMet: 1.567 ± 0.034
3.157ValAsn: 3.157 ± 0.047
2.371ValPro: 2.371 ± 0.043
2.221ValGln: 2.221 ± 0.038
2.673ValArg: 2.673 ± 0.045
4.512ValSer: 4.512 ± 0.056
3.942ValThr: 3.942 ± 0.059
4.838ValVal: 4.838 ± 0.069
0.739ValTrp: 0.739 ± 0.024
1.97ValTyr: 1.97 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.835TrpAla: 0.835 ± 0.023
0.159TrpCys: 0.159 ± 0.009
0.595TrpAsp: 0.595 ± 0.022
0.717TrpGlu: 0.717 ± 0.026
0.6TrpPhe: 0.6 ± 0.02
0.772TrpGly: 0.772 ± 0.022
0.409TrpHis: 0.409 ± 0.016
0.716TrpIle: 0.716 ± 0.022
0.571TrpLys: 0.571 ± 0.019
2.023TrpLeu: 2.023 ± 0.045
0.297TrpMet: 0.297 ± 0.015
0.483TrpAsn: 0.483 ± 0.017
0.557TrpPro: 0.557 ± 0.021
1.232TrpGln: 1.232 ± 0.034
0.789TrpArg: 0.789 ± 0.022
0.887TrpSer: 0.887 ± 0.025
0.564TrpThr: 0.564 ± 0.021
1.011TrpVal: 1.011 ± 0.028
0.211TrpTrp: 0.211 ± 0.013
0.491TrpTyr: 0.491 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.377TyrAla: 2.377 ± 0.037
0.483TyrCys: 0.483 ± 0.02
1.989TyrAsp: 1.989 ± 0.075
1.695TyrGlu: 1.695 ± 0.033
1.624TyrPhe: 1.624 ± 0.035
2.151TyrGly: 2.151 ± 0.037
0.972TyrHis: 0.972 ± 0.025
2.04TyrIle: 2.04 ± 0.039
1.683TyrLys: 1.683 ± 0.033
3.734TyrLeu: 3.734 ± 0.059
0.592TyrMet: 0.592 ± 0.019
1.498TyrAsn: 1.498 ± 0.04
1.56TyrPro: 1.56 ± 0.032
2.353TyrGln: 2.353 ± 0.042
1.86TyrArg: 1.86 ± 0.031
2.304TyrSer: 2.304 ± 0.039
1.928TyrThr: 1.928 ± 0.041
1.762TyrVal: 1.762 ± 0.037
0.625TyrTrp: 0.625 ± 0.021
1.429TyrTyr: 1.429 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5263 proteins (1647448 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski