Amino acid dipepetide frequency for Delftia phage RG-2014

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.601AlaAla: 15.601 ± 2.376
0.763AlaCys: 0.763 ± 0.22
6.783AlaAsp: 6.783 ± 0.668
7.122AlaGlu: 7.122 ± 0.676
3.222AlaPhe: 3.222 ± 0.393
8.267AlaGly: 8.267 ± 1.073
1.738AlaHis: 1.738 ± 0.354
4.875AlaIle: 4.875 ± 0.427
5.681AlaLys: 5.681 ± 0.703
10.132AlaLeu: 10.132 ± 1.388
3.561AlaMet: 3.561 ± 0.401
4.494AlaAsn: 4.494 ± 0.382
4.027AlaPro: 4.027 ± 0.52
6.105AlaGln: 6.105 ± 0.736
5.215AlaArg: 5.215 ± 0.465
5.087AlaSer: 5.087 ± 0.558
5.935AlaThr: 5.935 ± 0.553
7.122AlaVal: 7.122 ± 0.838
1.738AlaTrp: 1.738 ± 0.266
4.239AlaTyr: 4.239 ± 0.36
0.0AlaXaa: 0.0 ± 0.0
Cys
0.509CysAla: 0.509 ± 0.148
0.17CysCys: 0.17 ± 0.087
0.721CysAsp: 0.721 ± 0.222
0.509CysGlu: 0.509 ± 0.14
0.382CysPhe: 0.382 ± 0.118
0.805CysGly: 0.805 ± 0.212
0.636CysHis: 0.636 ± 0.258
0.551CysIle: 0.551 ± 0.183
0.509CysLys: 0.509 ± 0.188
0.763CysLeu: 0.763 ± 0.223
0.212CysMet: 0.212 ± 0.091
0.466CysAsn: 0.466 ± 0.159
0.339CysPro: 0.339 ± 0.143
0.424CysGln: 0.424 ± 0.136
0.297CysArg: 0.297 ± 0.128
0.636CysSer: 0.636 ± 0.159
0.466CysThr: 0.466 ± 0.156
0.509CysVal: 0.509 ± 0.173
0.339CysTrp: 0.339 ± 0.15
0.212CysTyr: 0.212 ± 0.093
0.0CysXaa: 0.0 ± 0.0
Asp
5.978AspAla: 5.978 ± 0.73
0.509AspCys: 0.509 ± 0.174
3.01AspAsp: 3.01 ± 0.365
3.18AspGlu: 3.18 ± 0.425
2.544AspPhe: 2.544 ± 0.272
4.748AspGly: 4.748 ± 0.488
1.017AspHis: 1.017 ± 0.21
2.586AspIle: 2.586 ± 0.379
3.01AspLys: 3.01 ± 0.293
5.85AspLeu: 5.85 ± 0.52
1.738AspMet: 1.738 ± 0.221
2.289AspAsn: 2.289 ± 0.325
3.9AspPro: 3.9 ± 0.421
3.095AspGln: 3.095 ± 0.399
3.18AspArg: 3.18 ± 0.336
2.84AspSer: 2.84 ± 0.365
3.349AspThr: 3.349 ± 0.297
3.222AspVal: 3.222 ± 0.426
0.975AspTrp: 0.975 ± 0.233
2.162AspTyr: 2.162 ± 0.322
0.0AspXaa: 0.0 ± 0.0
Glu
7.292GluAla: 7.292 ± 0.713
0.848GluCys: 0.848 ± 0.244
3.052GluAsp: 3.052 ± 0.303
4.112GluGlu: 4.112 ± 0.571
2.756GluPhe: 2.756 ± 0.35
3.858GluGly: 3.858 ± 0.572
1.187GluHis: 1.187 ± 0.249
3.773GluIle: 3.773 ± 0.378
3.604GluLys: 3.604 ± 0.424
5.384GluLeu: 5.384 ± 0.502
2.501GluMet: 2.501 ± 0.368
2.289GluAsn: 2.289 ± 0.364
1.95GluPro: 1.95 ± 0.355
3.646GluGln: 3.646 ± 0.391
2.925GluArg: 2.925 ± 0.386
2.332GluSer: 2.332 ± 0.353
3.052GluThr: 3.052 ± 0.352
3.349GluVal: 3.349 ± 0.455
0.805GluTrp: 0.805 ± 0.199
1.95GluTyr: 1.95 ± 0.38
0.0GluXaa: 0.0 ± 0.0
Phe
2.459PheAla: 2.459 ± 0.327
0.424PheCys: 0.424 ± 0.16
2.544PheAsp: 2.544 ± 0.292
1.653PheGlu: 1.653 ± 0.217
1.357PhePhe: 1.357 ± 0.231
2.756PheGly: 2.756 ± 0.306
0.89PheHis: 0.89 ± 0.21
1.441PheIle: 1.441 ± 0.279
2.077PheLys: 2.077 ± 0.209
2.671PheLeu: 2.671 ± 0.338
1.569PheMet: 1.569 ± 0.245
2.035PheAsn: 2.035 ± 0.394
1.314PhePro: 1.314 ± 0.215
1.526PheGln: 1.526 ± 0.271
2.077PheArg: 2.077 ± 0.247
2.12PheSer: 2.12 ± 0.303
2.544PheThr: 2.544 ± 0.332
2.501PheVal: 2.501 ± 0.302
0.594PheTrp: 0.594 ± 0.149
1.441PheTyr: 1.441 ± 0.252
0.0PheXaa: 0.0 ± 0.0
Gly
6.995GlyAla: 6.995 ± 0.656
0.509GlyCys: 0.509 ± 0.154
3.18GlyAsp: 3.18 ± 0.359
4.791GlyGlu: 4.791 ± 0.425
2.289GlyPhe: 2.289 ± 0.399
4.621GlyGly: 4.621 ± 0.471
1.272GlyHis: 1.272 ± 0.245
4.239GlyIle: 4.239 ± 0.336
5.172GlyLys: 5.172 ± 0.44
5.808GlyLeu: 5.808 ± 0.399
2.756GlyMet: 2.756 ± 0.377
3.18GlyAsn: 3.18 ± 0.472
2.586GlyPro: 2.586 ± 0.35
3.264GlyGln: 3.264 ± 0.355
3.604GlyArg: 3.604 ± 0.471
4.155GlySer: 4.155 ± 0.405
4.282GlyThr: 4.282 ± 0.445
4.579GlyVal: 4.579 ± 0.6
1.357GlyTrp: 1.357 ± 0.163
2.247GlyTyr: 2.247 ± 0.33
0.0GlyXaa: 0.0 ± 0.0
His
2.205HisAla: 2.205 ± 0.312
0.17HisCys: 0.17 ± 0.098
1.484HisAsp: 1.484 ± 0.306
1.187HisGlu: 1.187 ± 0.233
0.805HisPhe: 0.805 ± 0.152
1.06HisGly: 1.06 ± 0.264
0.509HisHis: 0.509 ± 0.202
0.933HisIle: 0.933 ± 0.223
0.975HisLys: 0.975 ± 0.194
2.162HisLeu: 2.162 ± 0.415
0.721HisMet: 0.721 ± 0.184
0.636HisAsn: 0.636 ± 0.153
1.229HisPro: 1.229 ± 0.281
0.509HisGln: 0.509 ± 0.126
1.272HisArg: 1.272 ± 0.301
0.763HisSer: 0.763 ± 0.176
0.805HisThr: 0.805 ± 0.23
1.314HisVal: 1.314 ± 0.241
0.466HisTrp: 0.466 ± 0.163
1.017HisTyr: 1.017 ± 0.213
0.0HisXaa: 0.0 ± 0.0
Ile
5.384IleAla: 5.384 ± 0.43
0.466IleCys: 0.466 ± 0.143
3.349IleAsp: 3.349 ± 0.404
2.671IleGlu: 2.671 ± 0.373
1.484IlePhe: 1.484 ± 0.212
3.01IleGly: 3.01 ± 0.345
1.06IleHis: 1.06 ± 0.253
1.95IleIle: 1.95 ± 0.295
2.501IleLys: 2.501 ± 0.363
3.9IleLeu: 3.9 ± 0.531
1.314IleMet: 1.314 ± 0.26
2.416IleAsn: 2.416 ± 0.296
2.756IlePro: 2.756 ± 0.383
2.247IleGln: 2.247 ± 0.328
3.392IleArg: 3.392 ± 0.445
2.798IleSer: 2.798 ± 0.371
3.052IleThr: 3.052 ± 0.408
2.628IleVal: 2.628 ± 0.312
0.594IleTrp: 0.594 ± 0.218
1.145IleTyr: 1.145 ± 0.265
0.0IleXaa: 0.0 ± 0.0
Lys
7.037LysAla: 7.037 ± 0.736
0.127LysCys: 0.127 ± 0.091
4.324LysAsp: 4.324 ± 0.348
3.264LysGlu: 3.264 ± 0.532
1.611LysPhe: 1.611 ± 0.315
4.027LysGly: 4.027 ± 0.479
1.187LysHis: 1.187 ± 0.209
1.908LysIle: 1.908 ± 0.285
2.883LysLys: 2.883 ± 0.346
5.045LysLeu: 5.045 ± 0.551
1.484LysMet: 1.484 ± 0.242
1.781LysAsn: 1.781 ± 0.298
3.01LysPro: 3.01 ± 0.393
2.459LysGln: 2.459 ± 0.296
2.925LysArg: 2.925 ± 0.36
2.628LysSer: 2.628 ± 0.277
3.646LysThr: 3.646 ± 0.326
3.307LysVal: 3.307 ± 0.397
0.509LysTrp: 0.509 ± 0.172
1.781LysTyr: 1.781 ± 0.247
0.0LysXaa: 0.0 ± 0.0
Leu
9.751LeuAla: 9.751 ± 1.134
0.805LeuCys: 0.805 ± 0.227
5.935LeuAsp: 5.935 ± 0.489
4.027LeuGlu: 4.027 ± 0.469
2.798LeuPhe: 2.798 ± 0.335
6.783LeuGly: 6.783 ± 0.463
2.586LeuHis: 2.586 ± 0.388
3.688LeuIle: 3.688 ± 0.442
4.494LeuLys: 4.494 ± 0.442
6.19LeuLeu: 6.19 ± 0.586
2.416LeuMet: 2.416 ± 0.291
3.688LeuAsn: 3.688 ± 0.371
4.663LeuPro: 4.663 ± 0.413
4.07LeuGln: 4.07 ± 0.411
4.875LeuArg: 4.875 ± 0.405
4.451LeuSer: 4.451 ± 0.447
5.13LeuThr: 5.13 ± 0.441
5.426LeuVal: 5.426 ± 0.531
0.975LeuTrp: 0.975 ± 0.248
1.993LeuTyr: 1.993 ± 0.296
0.0LeuXaa: 0.0 ± 0.0
Met
4.451MetAla: 4.451 ± 0.577
0.551MetCys: 0.551 ± 0.159
2.12MetAsp: 2.12 ± 0.329
2.035MetGlu: 2.035 ± 0.239
1.145MetPhe: 1.145 ± 0.233
2.205MetGly: 2.205 ± 0.34
0.763MetHis: 0.763 ± 0.171
1.102MetIle: 1.102 ± 0.232
1.484MetLys: 1.484 ± 0.251
2.798MetLeu: 2.798 ± 0.301
0.509MetMet: 0.509 ± 0.129
0.89MetAsn: 0.89 ± 0.194
1.653MetPro: 1.653 ± 0.299
1.526MetGln: 1.526 ± 0.21
1.865MetArg: 1.865 ± 0.213
3.137MetSer: 3.137 ± 0.339
1.993MetThr: 1.993 ± 0.29
1.993MetVal: 1.993 ± 0.202
0.424MetTrp: 0.424 ± 0.127
0.805MetTyr: 0.805 ± 0.198
0.0MetXaa: 0.0 ± 0.0
Asn
4.494AsnAla: 4.494 ± 0.518
0.339AsnCys: 0.339 ± 0.123
1.696AsnAsp: 1.696 ± 0.247
2.713AsnGlu: 2.713 ± 0.305
1.95AsnPhe: 1.95 ± 0.299
3.222AsnGly: 3.222 ± 0.498
0.89AsnHis: 0.89 ± 0.253
1.908AsnIle: 1.908 ± 0.259
1.823AsnLys: 1.823 ± 0.324
3.858AsnLeu: 3.858 ± 0.441
1.102AsnMet: 1.102 ± 0.145
1.526AsnAsn: 1.526 ± 0.273
3.18AsnPro: 3.18 ± 0.509
2.459AsnGln: 2.459 ± 0.268
2.162AsnArg: 2.162 ± 0.263
2.586AsnSer: 2.586 ± 0.287
1.696AsnThr: 1.696 ± 0.3
2.713AsnVal: 2.713 ± 0.255
0.678AsnTrp: 0.678 ± 0.152
1.399AsnTyr: 1.399 ± 0.338
0.0AsnXaa: 0.0 ± 0.0
Pro
5.638ProAla: 5.638 ± 0.51
0.297ProCys: 0.297 ± 0.121
2.332ProAsp: 2.332 ± 0.427
3.858ProGlu: 3.858 ± 0.418
1.865ProPhe: 1.865 ± 0.254
3.815ProGly: 3.815 ± 0.496
0.509ProHis: 0.509 ± 0.158
2.586ProIle: 2.586 ± 0.332
2.756ProLys: 2.756 ± 0.301
2.798ProLeu: 2.798 ± 0.376
1.484ProMet: 1.484 ± 0.19
2.459ProAsn: 2.459 ± 0.37
1.95ProPro: 1.95 ± 0.407
1.95ProGln: 1.95 ± 0.238
1.781ProArg: 1.781 ± 0.361
2.671ProSer: 2.671 ± 0.273
2.798ProThr: 2.798 ± 0.355
3.604ProVal: 3.604 ± 0.427
0.805ProTrp: 0.805 ± 0.199
1.569ProTyr: 1.569 ± 0.327
0.0ProXaa: 0.0 ± 0.0
Gln
6.614GlnAla: 6.614 ± 0.86
0.424GlnCys: 0.424 ± 0.145
1.653GlnAsp: 1.653 ± 0.183
2.968GlnGlu: 2.968 ± 0.338
1.993GlnPhe: 1.993 ± 0.252
3.264GlnGly: 3.264 ± 0.294
0.933GlnHis: 0.933 ± 0.157
2.205GlnIle: 2.205 ± 0.364
2.586GlnLys: 2.586 ± 0.399
4.663GlnLeu: 4.663 ± 0.375
2.162GlnMet: 2.162 ± 0.268
1.569GlnAsn: 1.569 ± 0.293
2.12GlnPro: 2.12 ± 0.286
3.095GlnGln: 3.095 ± 0.35
3.01GlnArg: 3.01 ± 0.365
1.908GlnSer: 1.908 ± 0.356
2.628GlnThr: 2.628 ± 0.435
3.349GlnVal: 3.349 ± 0.373
0.763GlnTrp: 0.763 ± 0.203
1.526GlnTyr: 1.526 ± 0.276
0.0GlnXaa: 0.0 ± 0.0
Arg
5.172ArgAla: 5.172 ± 0.48
0.805ArgCys: 0.805 ± 0.224
3.476ArgAsp: 3.476 ± 0.371
3.815ArgGlu: 3.815 ± 0.436
1.95ArgPhe: 1.95 ± 0.339
2.883ArgGly: 2.883 ± 0.463
1.017ArgHis: 1.017 ± 0.212
2.756ArgIle: 2.756 ± 0.368
3.646ArgLys: 3.646 ± 0.332
4.451ArgLeu: 4.451 ± 0.515
2.12ArgMet: 2.12 ± 0.275
2.459ArgAsn: 2.459 ± 0.258
2.289ArgPro: 2.289 ± 0.354
2.501ArgGln: 2.501 ± 0.326
2.501ArgArg: 2.501 ± 0.456
2.84ArgSer: 2.84 ± 0.308
2.713ArgThr: 2.713 ± 0.285
2.883ArgVal: 2.883 ± 0.325
1.357ArgTrp: 1.357 ± 0.254
1.569ArgTyr: 1.569 ± 0.315
0.0ArgXaa: 0.0 ± 0.0
Ser
5.384SerAla: 5.384 ± 0.454
0.212SerCys: 0.212 ± 0.098
3.137SerAsp: 3.137 ± 0.258
2.628SerGlu: 2.628 ± 0.245
1.738SerPhe: 1.738 ± 0.334
4.875SerGly: 4.875 ± 0.517
0.721SerHis: 0.721 ± 0.2
3.18SerIle: 3.18 ± 0.434
3.01SerLys: 3.01 ± 0.311
4.451SerLeu: 4.451 ± 0.432
1.569SerMet: 1.569 ± 0.231
2.205SerAsn: 2.205 ± 0.232
2.162SerPro: 2.162 ± 0.306
2.459SerGln: 2.459 ± 0.328
2.459SerArg: 2.459 ± 0.313
3.095SerSer: 3.095 ± 0.401
2.968SerThr: 2.968 ± 0.369
3.392SerVal: 3.392 ± 0.395
0.848SerTrp: 0.848 ± 0.176
1.441SerTyr: 1.441 ± 0.226
0.0SerXaa: 0.0 ± 0.0
Thr
5.469ThrAla: 5.469 ± 0.536
0.466ThrCys: 0.466 ± 0.145
3.18ThrAsp: 3.18 ± 0.408
3.604ThrGlu: 3.604 ± 0.442
2.12ThrPhe: 2.12 ± 0.281
4.027ThrGly: 4.027 ± 0.372
1.102ThrHis: 1.102 ± 0.195
3.349ThrIle: 3.349 ± 0.456
2.671ThrLys: 2.671 ± 0.434
4.367ThrLeu: 4.367 ± 0.368
2.077ThrMet: 2.077 ± 0.253
3.052ThrAsn: 3.052 ± 0.318
2.883ThrPro: 2.883 ± 0.282
2.459ThrGln: 2.459 ± 0.353
2.586ThrArg: 2.586 ± 0.283
2.416ThrSer: 2.416 ± 0.315
2.925ThrThr: 2.925 ± 0.424
3.731ThrVal: 3.731 ± 0.469
1.441ThrTrp: 1.441 ± 0.302
1.653ThrTyr: 1.653 ± 0.294
0.0ThrXaa: 0.0 ± 0.0
Val
7.249ValAla: 7.249 ± 1.046
0.636ValCys: 0.636 ± 0.18
3.731ValAsp: 3.731 ± 0.465
3.943ValGlu: 3.943 ± 0.53
1.738ValPhe: 1.738 ± 0.272
3.731ValGly: 3.731 ± 0.348
1.145ValHis: 1.145 ± 0.146
2.968ValIle: 2.968 ± 0.42
3.943ValLys: 3.943 ± 0.548
5.299ValLeu: 5.299 ± 0.468
2.628ValMet: 2.628 ± 0.317
2.671ValAsn: 2.671 ± 0.346
3.561ValPro: 3.561 ± 0.479
3.264ValGln: 3.264 ± 0.296
3.561ValArg: 3.561 ± 0.442
3.434ValSer: 3.434 ± 0.325
3.095ValThr: 3.095 ± 0.328
3.858ValVal: 3.858 ± 0.377
0.848ValTrp: 0.848 ± 0.198
1.611ValTyr: 1.611 ± 0.198
0.0ValXaa: 0.0 ± 0.0
Trp
1.102TrpAla: 1.102 ± 0.186
0.424TrpCys: 0.424 ± 0.134
1.399TrpAsp: 1.399 ± 0.253
0.933TrpGlu: 0.933 ± 0.276
0.975TrpPhe: 0.975 ± 0.196
0.933TrpGly: 0.933 ± 0.264
0.466TrpHis: 0.466 ± 0.129
0.848TrpIle: 0.848 ± 0.245
0.636TrpLys: 0.636 ± 0.124
1.738TrpLeu: 1.738 ± 0.278
0.594TrpMet: 0.594 ± 0.172
0.678TrpAsn: 0.678 ± 0.186
0.594TrpPro: 0.594 ± 0.222
0.594TrpGln: 0.594 ± 0.152
1.187TrpArg: 1.187 ± 0.267
0.678TrpSer: 0.678 ± 0.143
0.805TrpThr: 0.805 ± 0.197
1.017TrpVal: 1.017 ± 0.174
0.509TrpTrp: 0.509 ± 0.16
0.509TrpTyr: 0.509 ± 0.158
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.925TyrAla: 2.925 ± 0.398
0.509TyrCys: 0.509 ± 0.146
2.077TyrAsp: 2.077 ± 0.26
1.653TyrGlu: 1.653 ± 0.278
1.272TyrPhe: 1.272 ± 0.233
2.035TyrGly: 2.035 ± 0.373
0.594TyrHis: 0.594 ± 0.178
1.272TyrIle: 1.272 ± 0.283
1.484TyrLys: 1.484 ± 0.355
2.416TyrLeu: 2.416 ± 0.359
0.89TyrMet: 0.89 ± 0.174
1.611TyrAsn: 1.611 ± 0.366
1.357TyrPro: 1.357 ± 0.329
1.781TyrGln: 1.781 ± 0.228
2.332TyrArg: 2.332 ± 0.318
1.357TyrSer: 1.357 ± 0.242
1.696TyrThr: 1.696 ± 0.248
2.416TyrVal: 2.416 ± 0.305
0.594TyrTrp: 0.594 ± 0.153
0.763TyrTyr: 0.763 ± 0.131
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 88 proteins (23589 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski