Amino acid dipepetide frequency for Maribius salinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.149AlaAla: 18.149 ± 0.21	1.131AlaCys: 1.131 ± 0.039	7.802AlaAsp: 7.802 ± 0.12	8.12AlaGlu: 8.12 ± 0.132	4.296AlaPhe: 4.296 ± 0.073	11.405AlaGly: 11.405 ± 0.162	2.299AlaHis: 2.299 ± 0.054	5.83AlaIle: 5.83 ± 0.074	3.111AlaLys: 3.111 ± 0.067	14.123AlaLeu: 14.123 ± 0.165	3.941AlaMet: 3.941 ± 0.079	2.484AlaAsn: 2.484 ± 0.053	6.594AlaPro: 6.594 ± 0.11	4.398AlaGln: 4.398 ± 0.069	10.151AlaArg: 10.151 ± 0.147	5.353AlaSer: 5.353 ± 0.092	6.621AlaThr: 6.621 ± 0.141	8.735AlaVal: 8.735 ± 0.11	1.664AlaTrp: 1.664 ± 0.043	2.351AlaTyr: 2.351 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.08CysAla: 1.08 ± 0.036	0.102CysCys: 0.102 ± 0.009	0.641CysAsp: 0.641 ± 0.025	0.382CysGlu: 0.382 ± 0.02	0.299CysPhe: 0.299 ± 0.017	0.907CysGly: 0.907 ± 0.03	0.262CysHis: 0.262 ± 0.014	0.377CysIle: 0.377 ± 0.021	0.166CysLys: 0.166 ± 0.012	0.835CysLeu: 0.835 ± 0.027	0.155CysMet: 0.155 ± 0.011	0.201CysAsn: 0.201 ± 0.015	0.48CysPro: 0.48 ± 0.026	0.196CysGln: 0.196 ± 0.014	0.532CysArg: 0.532 ± 0.023	0.383CysSer: 0.383 ± 0.022	0.37CysThr: 0.37 ± 0.02	0.642CysVal: 0.642 ± 0.027	0.104CysTrp: 0.104 ± 0.01	0.18CysTyr: 0.18 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	9.097AspAla: 9.097 ± 0.132	0.527AspCys: 0.527 ± 0.022	4.607AspAsp: 4.607 ± 0.104	3.817AspGlu: 3.817 ± 0.07	2.373AspPhe: 2.373 ± 0.053	7.037AspGly: 7.037 ± 0.139	1.503AspHis: 1.503 ± 0.04	3.136AspIle: 3.136 ± 0.063	1.429AspLys: 1.429 ± 0.046	6.973AspLeu: 6.973 ± 0.093	1.83AspMet: 1.83 ± 0.045	1.253AspAsn: 1.253 ± 0.037	4.233AspPro: 4.233 ± 0.075	1.849AspGln: 1.849 ± 0.046	5.545AspArg: 5.545 ± 0.075	2.42AspSer: 2.42 ± 0.057	3.63AspThr: 3.63 ± 0.1	4.471AspVal: 4.471 ± 0.094	1.336AspTrp: 1.336 ± 0.038	1.616AspTyr: 1.616 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.537GluAla: 7.537 ± 0.124	0.321GluCys: 0.321 ± 0.019	3.853GluAsp: 3.853 ± 0.073	3.035GluGlu: 3.035 ± 0.085	1.533GluPhe: 1.533 ± 0.042	4.901GluGly: 4.901 ± 0.081	1.018GluHis: 1.018 ± 0.032	3.47GluIle: 3.47 ± 0.059	1.659GluLys: 1.659 ± 0.044	4.842GluLeu: 4.842 ± 0.091	1.743GluMet: 1.743 ± 0.044	1.594GluAsn: 1.594 ± 0.039	2.441GluPro: 2.441 ± 0.055	1.808GluGln: 1.808 ± 0.047	4.45GluArg: 4.45 ± 0.073	2.204GluSer: 2.204 ± 0.048	4.025GluThr: 4.025 ± 0.061	4.12GluVal: 4.12 ± 0.071	0.67GluTrp: 0.67 ± 0.025	1.008GluTyr: 1.008 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.502PheAla: 4.502 ± 0.068	0.383PheCys: 0.383 ± 0.021	3.078PheAsp: 3.078 ± 0.056	2.04PheGlu: 2.04 ± 0.043	1.417PhePhe: 1.417 ± 0.039	3.654PheGly: 3.654 ± 0.065	0.709PheHis: 0.709 ± 0.026	1.509PheIle: 1.509 ± 0.046	0.718PheLys: 0.718 ± 0.029	3.254PheLeu: 3.254 ± 0.069	0.813PheMet: 0.813 ± 0.032	0.938PheAsn: 0.938 ± 0.032	1.532PhePro: 1.532 ± 0.035	0.988PheGln: 0.988 ± 0.026	2.214PheArg: 2.214 ± 0.047	1.818PheSer: 1.818 ± 0.048	2.071PheThr: 2.071 ± 0.045	2.677PheVal: 2.677 ± 0.053	0.569PheTrp: 0.569 ± 0.023	0.865PheTyr: 0.865 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	11.109GlyAla: 11.109 ± 0.192	0.867GlyCys: 0.867 ± 0.03	5.917GlyAsp: 5.917 ± 0.133	4.697GlyGlu: 4.697 ± 0.072	3.615GlyPhe: 3.615 ± 0.059	8.479GlyGly: 8.479 ± 0.184	1.944GlyHis: 1.944 ± 0.044	4.469GlyIle: 4.469 ± 0.072	2.64GlyLys: 2.64 ± 0.064	9.552GlyLeu: 9.552 ± 0.109	2.573GlyMet: 2.573 ± 0.057	2.068GlyAsn: 2.068 ± 0.074	4.163GlyPro: 4.163 ± 0.066	3.317GlyGln: 3.317 ± 0.058	6.662GlyArg: 6.662 ± 0.094	4.278GlySer: 4.278 ± 0.093	5.267GlyThr: 5.267 ± 0.13	6.538GlyVal: 6.538 ± 0.104	1.603GlyTrp: 1.603 ± 0.042	2.181GlyTyr: 2.181 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.488HisAla: 2.488 ± 0.06	0.232HisCys: 0.232 ± 0.016	1.325HisAsp: 1.325 ± 0.041	1.017HisGlu: 1.017 ± 0.031	0.75HisPhe: 0.75 ± 0.028	1.976HisGly: 1.976 ± 0.044	0.56HisHis: 0.56 ± 0.033	0.813HisIle: 0.813 ± 0.025	0.435HisLys: 0.435 ± 0.021	1.998HisLeu: 1.998 ± 0.044	0.543HisMet: 0.543 ± 0.023	0.4HisAsn: 0.4 ± 0.019	1.305HisPro: 1.305 ± 0.034	0.482HisGln: 0.482 ± 0.021	1.389HisArg: 1.389 ± 0.039	0.772HisSer: 0.772 ± 0.031	0.756HisThr: 0.756 ± 0.027	1.617HisVal: 1.617 ± 0.042	0.336HisTrp: 0.336 ± 0.019	0.498HisTyr: 0.498 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.893IleAla: 6.893 ± 0.087	0.57IleCys: 0.57 ± 0.022	3.846IleAsp: 3.846 ± 0.074	3.243IleGlu: 3.243 ± 0.055	1.697IlePhe: 1.697 ± 0.043	4.531IleGly: 4.531 ± 0.086	0.862IleHis: 0.862 ± 0.029	1.863IleIle: 1.863 ± 0.047	1.052IleLys: 1.052 ± 0.035	4.625IleLeu: 4.625 ± 0.084	0.973IleMet: 0.973 ± 0.025	1.166IleAsn: 1.166 ± 0.035	2.208IlePro: 2.208 ± 0.056	1.052IleGln: 1.052 ± 0.033	2.956IleArg: 2.956 ± 0.062	2.495IleSer: 2.495 ± 0.05	2.652IleThr: 2.652 ± 0.053	3.739IleVal: 3.739 ± 0.074	0.659IleTrp: 0.659 ± 0.028	1.13IleTyr: 1.13 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.161LysAla: 3.161 ± 0.068	0.142LysCys: 0.142 ± 0.012	1.608LysAsp: 1.608 ± 0.055	1.134LysGlu: 1.134 ± 0.041	0.741LysPhe: 0.741 ± 0.025	2.216LysGly: 2.216 ± 0.056	0.491LysHis: 0.491 ± 0.026	1.353LysIle: 1.353 ± 0.038	1.032LysLys: 1.032 ± 0.049	2.502LysLeu: 2.502 ± 0.058	0.73LysMet: 0.73 ± 0.031	0.637LysAsn: 0.637 ± 0.029	1.493LysPro: 1.493 ± 0.045	0.713LysGln: 0.713 ± 0.028	1.958LysArg: 1.958 ± 0.062	1.459LysSer: 1.459 ± 0.048	1.614LysThr: 1.614 ± 0.044	1.914LysVal: 1.914 ± 0.043	0.298LysTrp: 0.298 ± 0.019	0.542LysTyr: 0.542 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	13.145LeuAla: 13.145 ± 0.163	0.856LeuCys: 0.856 ± 0.032	6.79LeuAsp: 6.79 ± 0.085	5.011LeuGlu: 5.011 ± 0.081	3.458LeuPhe: 3.458 ± 0.078	9.158LeuGly: 9.158 ± 0.117	1.823LeuHis: 1.823 ± 0.042	4.798LeuIle: 4.798 ± 0.083	2.758LeuLys: 2.758 ± 0.065	8.745LeuLeu: 8.745 ± 0.143	2.469LeuMet: 2.469 ± 0.05	2.464LeuAsn: 2.464 ± 0.045	5.575LeuPro: 5.575 ± 0.088	2.555LeuGln: 2.555 ± 0.055	7.24LeuArg: 7.24 ± 0.099	6.876LeuSer: 6.876 ± 0.081	5.79LeuThr: 5.79 ± 0.075	7.231LeuVal: 7.231 ± 0.103	1.352LeuTrp: 1.352 ± 0.039	1.842LeuTyr: 1.842 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.592MetAla: 3.592 ± 0.068	0.168MetCys: 0.168 ± 0.013	1.539MetAsp: 1.539 ± 0.037	1.32MetGlu: 1.32 ± 0.039	0.75MetPhe: 0.75 ± 0.03	2.345MetGly: 2.345 ± 0.053	0.434MetHis: 0.434 ± 0.018	1.374MetIle: 1.374 ± 0.039	0.93MetLys: 0.93 ± 0.032	2.468MetLeu: 2.468 ± 0.048	0.757MetMet: 0.757 ± 0.03	0.776MetAsn: 0.776 ± 0.035	1.442MetPro: 1.442 ± 0.04	0.891MetGln: 0.891 ± 0.031	1.899MetArg: 1.899 ± 0.051	1.689MetSer: 1.689 ± 0.041	2.032MetThr: 2.032 ± 0.044	1.835MetVal: 1.835 ± 0.041	0.237MetTrp: 0.237 ± 0.017	0.303MetTyr: 0.303 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.955AsnAla: 2.955 ± 0.06	0.22AsnCys: 0.22 ± 0.016	1.569AsnAsp: 1.569 ± 0.079	1.088AsnGlu: 1.088 ± 0.039	0.921AsnPhe: 0.921 ± 0.029	2.205AsnGly: 2.205 ± 0.061	0.454AsnHis: 0.454 ± 0.022	1.194AsnIle: 1.194 ± 0.034	0.515AsnLys: 0.515 ± 0.022	2.234AsnLeu: 2.234 ± 0.052	0.597AsnMet: 0.597 ± 0.025	0.557AsnAsn: 0.557 ± 0.029	1.659AsnPro: 1.659 ± 0.039	0.669AsnGln: 0.669 ± 0.029	1.646AsnArg: 1.646 ± 0.041	0.985AsnSer: 0.985 ± 0.031	1.175AsnThr: 1.175 ± 0.039	1.689AsnVal: 1.689 ± 0.057	0.352AsnTrp: 0.352 ± 0.02	0.584AsnTyr: 0.584 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.105ProAla: 6.105 ± 0.103	0.361ProCys: 0.361 ± 0.018	4.591ProAsp: 4.591 ± 0.076	4.103ProGlu: 4.103 ± 0.064	1.951ProPhe: 1.951 ± 0.048	5.19ProGly: 5.19 ± 0.091	1.116ProHis: 1.116 ± 0.033	2.126ProIle: 2.126 ± 0.044	1.418ProLys: 1.418 ± 0.041	4.767ProLeu: 4.767 ± 0.068	1.317ProMet: 1.317 ± 0.037	1.196ProAsn: 1.196 ± 0.034	2.556ProPro: 2.556 ± 0.062	1.648ProGln: 1.648 ± 0.041	3.145ProArg: 3.145 ± 0.065	2.457ProSer: 2.457 ± 0.05	2.385ProThr: 2.385 ± 0.046	4.31ProVal: 4.31 ± 0.072	0.711ProTrp: 0.711 ± 0.025	1.028ProTyr: 1.028 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.831GlnAla: 3.831 ± 0.066	0.187GlnCys: 0.187 ± 0.013	1.758GlnAsp: 1.758 ± 0.042	1.351GlnGlu: 1.351 ± 0.039	0.982GlnPhe: 0.982 ± 0.03	2.705GlnGly: 2.705 ± 0.055	0.498GlnHis: 0.498 ± 0.021	1.804GlnIle: 1.804 ± 0.045	0.884GlnLys: 0.884 ± 0.032	2.685GlnLeu: 2.685 ± 0.056	1.013GlnMet: 1.013 ± 0.03	0.734GlnAsn: 0.734 ± 0.027	1.643GlnPro: 1.643 ± 0.04	0.974GlnGln: 0.974 ± 0.043	2.189GlnArg: 2.189 ± 0.057	1.721GlnSer: 1.721 ± 0.053	1.685GlnThr: 1.685 ± 0.04	2.418GlnVal: 2.418 ± 0.052	0.387GlnTrp: 0.387 ± 0.022	0.504GlnTyr: 0.504 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.423ArgAla: 9.423 ± 0.149	0.453ArgCys: 0.453 ± 0.021	5.403ArgAsp: 5.403 ± 0.09	3.745ArgGlu: 3.745 ± 0.079	2.614ArgPhe: 2.614 ± 0.054	5.352ArgGly: 5.352 ± 0.081	1.598ArgHis: 1.598 ± 0.041	3.862ArgIle: 3.862 ± 0.065	1.928ArgLys: 1.928 ± 0.053	7.768ArgLeu: 7.768 ± 0.12	2.053ArgMet: 2.053 ± 0.055	1.671ArgAsn: 1.671 ± 0.047	3.74ArgPro: 3.74 ± 0.076	2.269ArgGln: 2.269 ± 0.049	5.527ArgArg: 5.527 ± 0.112	3.253ArgSer: 3.253 ± 0.053	3.144ArgThr: 3.144 ± 0.05	5.401ArgVal: 5.401 ± 0.074	0.991ArgTrp: 0.991 ± 0.035	1.41ArgTyr: 1.41 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.494SerAla: 5.494 ± 0.097	0.332SerCys: 0.332 ± 0.02	3.659SerAsp: 3.659 ± 0.066	2.798SerGlu: 2.798 ± 0.056	2.161SerPhe: 2.161 ± 0.046	5.242SerGly: 5.242 ± 0.118	0.989SerHis: 0.989 ± 0.029	2.234SerIle: 2.234 ± 0.049	1.213SerLys: 1.213 ± 0.041	4.863SerLeu: 4.863 ± 0.068	1.271SerMet: 1.271 ± 0.035	1.239SerAsn: 1.239 ± 0.038	2.431SerPro: 2.431 ± 0.049	1.447SerGln: 1.447 ± 0.033	3.336SerArg: 3.336 ± 0.058	2.375SerSer: 2.375 ± 0.053	2.374SerThr: 2.374 ± 0.055	3.775SerVal: 3.775 ± 0.087	0.677SerTrp: 0.677 ± 0.025	1.196SerTyr: 1.196 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.456ThrAla: 6.456 ± 0.117	0.449ThrCys: 0.449 ± 0.024	3.668ThrAsp: 3.668 ± 0.08	2.949ThrGlu: 2.949 ± 0.061	2.018ThrPhe: 2.018 ± 0.046	5.754ThrGly: 5.754 ± 0.116	1.076ThrHis: 1.076 ± 0.034	2.593ThrIle: 2.593 ± 0.061	1.193ThrLys: 1.193 ± 0.04	6.404ThrLeu: 6.404 ± 0.094	1.22ThrMet: 1.22 ± 0.036	1.172ThrAsn: 1.172 ± 0.038	3.548ThrPro: 3.548 ± 0.069	1.466ThrGln: 1.466 ± 0.039	3.649ThrArg: 3.649 ± 0.065	2.495ThrSer: 2.495 ± 0.065	2.877ThrThr: 2.877 ± 0.093	4.497ThrVal: 4.497 ± 0.078	0.685ThrTrp: 0.685 ± 0.025	1.154ThrTyr: 1.154 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.689ValAla: 9.689 ± 0.115	0.626ValCys: 0.626 ± 0.024	4.498ValAsp: 4.498 ± 0.092	4.563ValGlu: 4.563 ± 0.068	2.746ValPhe: 2.746 ± 0.055	5.734ValGly: 5.734 ± 0.098	1.271ValHis: 1.271 ± 0.033	3.88ValIle: 3.88 ± 0.065	1.864ValLys: 1.864 ± 0.047	7.475ValLeu: 7.475 ± 0.099	1.978ValMet: 1.978 ± 0.051	1.846ValAsn: 1.846 ± 0.046	3.767ValPro: 3.767 ± 0.064	1.993ValGln: 1.993 ± 0.043	4.403ValArg: 4.403 ± 0.072	4.22ValSer: 4.22 ± 0.089	4.972ValThr: 4.972 ± 0.078	5.807ValVal: 5.807 ± 0.089	0.97ValTrp: 0.97 ± 0.033	1.423ValTyr: 1.423 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.434TrpAla: 1.434 ± 0.04	0.147TrpCys: 0.147 ± 0.012	0.876TrpAsp: 0.876 ± 0.031	0.649TrpGlu: 0.649 ± 0.025	0.577TrpPhe: 0.577 ± 0.028	1.082TrpGly: 1.082 ± 0.04	0.317TrpHis: 0.317 ± 0.016	0.726TrpIle: 0.726 ± 0.025	0.349TrpLys: 0.349 ± 0.017	1.708TrpLeu: 1.708 ± 0.042	0.38TrpMet: 0.38 ± 0.02	0.362TrpAsn: 0.362 ± 0.016	0.684TrpPro: 0.684 ± 0.026	0.601TrpGln: 0.601 ± 0.025	1.206TrpArg: 1.206 ± 0.036	0.825TrpSer: 0.825 ± 0.027	0.826TrpThr: 0.826 ± 0.032	0.909TrpVal: 0.909 ± 0.031	0.249TrpTrp: 0.249 ± 0.014	0.244TrpTyr: 0.244 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.417TyrAla: 2.417 ± 0.047	0.222TyrCys: 0.222 ± 0.014	1.652TyrAsp: 1.652 ± 0.047	1.171TyrGlu: 1.171 ± 0.037	0.849TyrPhe: 0.849 ± 0.029	2.065TyrGly: 2.065 ± 0.055	0.465TyrHis: 0.465 ± 0.02	0.802TyrIle: 0.802 ± 0.027	0.445TyrLys: 0.445 ± 0.021	2.117TyrLeu: 2.117 ± 0.049	0.424TyrMet: 0.424 ± 0.02	0.508TyrAsn: 0.508 ± 0.021	0.987TyrPro: 0.987 ± 0.037	0.637TyrGln: 0.637 ± 0.024	1.509TyrArg: 1.509 ± 0.038	1.029TyrSer: 1.029 ± 0.026	1.054TyrThr: 1.054 ± 0.034	1.402TyrVal: 1.402 ± 0.036	0.302TyrTrp: 0.302 ± 0.02	0.518TyrTyr: 0.518 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3413 proteins (1074527 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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