Amino acid dipepetide frequency for Aeromicrobium choanae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.229AlaAla: 18.229 ± 0.184
0.919AlaCys: 0.919 ± 0.031
8.177AlaAsp: 8.177 ± 0.087
8.075AlaGlu: 8.075 ± 0.111
3.821AlaPhe: 3.821 ± 0.069
11.814AlaGly: 11.814 ± 0.114
2.434AlaHis: 2.434 ± 0.053
5.295AlaIle: 5.295 ± 0.083
2.96AlaLys: 2.96 ± 0.073
13.123AlaLeu: 13.123 ± 0.146
2.936AlaMet: 2.936 ± 0.056
2.092AlaAsn: 2.092 ± 0.047
5.883AlaPro: 5.883 ± 0.095
3.657AlaGln: 3.657 ± 0.062
8.878AlaArg: 8.878 ± 0.11
6.565AlaSer: 6.565 ± 0.082
7.694AlaThr: 7.694 ± 0.106
11.315AlaVal: 11.315 ± 0.11
2.05AlaTrp: 2.05 ± 0.053
2.325AlaTyr: 2.325 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.742CysAla: 0.742 ± 0.026
0.055CysCys: 0.055 ± 0.007
0.424CysAsp: 0.424 ± 0.027
0.348CysGlu: 0.348 ± 0.019
0.209CysPhe: 0.209 ± 0.014
0.77CysGly: 0.77 ± 0.029
0.165CysHis: 0.165 ± 0.013
0.195CysIle: 0.195 ± 0.013
0.096CysLys: 0.096 ± 0.009
0.59CysLeu: 0.59 ± 0.024
0.089CysMet: 0.089 ± 0.011
0.109CysAsn: 0.109 ± 0.011
0.357CysPro: 0.357 ± 0.018
0.147CysGln: 0.147 ± 0.012
0.491CysArg: 0.491 ± 0.021
0.392CysSer: 0.392 ± 0.02
0.382CysThr: 0.382 ± 0.022
0.536CysVal: 0.536 ± 0.024
0.078CysTrp: 0.078 ± 0.008
0.119CysTyr: 0.119 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.887AspAla: 7.887 ± 0.09
0.288AspCys: 0.288 ± 0.016
4.636AspAsp: 4.636 ± 0.078
4.889AspGlu: 4.889 ± 0.075
1.822AspPhe: 1.822 ± 0.041
5.966AspGly: 5.966 ± 0.095
1.582AspHis: 1.582 ± 0.045
2.182AspIle: 2.182 ± 0.046
1.033AspLys: 1.033 ± 0.033
7.581AspLeu: 7.581 ± 0.088
0.857AspMet: 0.857 ± 0.027
0.848AspAsn: 0.848 ± 0.028
4.593AspPro: 4.593 ± 0.078
1.789AspGln: 1.789 ± 0.041
5.062AspArg: 5.062 ± 0.073
2.719AspSer: 2.719 ± 0.053
2.999AspThr: 2.999 ± 0.057
6.205AspVal: 6.205 ± 0.087
0.994AspTrp: 0.994 ± 0.029
1.159AspTyr: 1.159 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.367GluAla: 7.367 ± 0.096
0.323GluCys: 0.323 ± 0.019
3.323GluAsp: 3.323 ± 0.053
3.081GluGlu: 3.081 ± 0.067
1.826GluPhe: 1.826 ± 0.038
4.571GluGly: 4.571 ± 0.063
1.528GluHis: 1.528 ± 0.042
2.726GluIle: 2.726 ± 0.055
1.334GluLys: 1.334 ± 0.037
6.433GluLeu: 6.433 ± 0.095
1.001GluMet: 1.001 ± 0.035
1.122GluAsn: 1.122 ± 0.034
3.592GluPro: 3.592 ± 0.099
2.285GluGln: 2.285 ± 0.049
5.471GluArg: 5.471 ± 0.076
3.204GluSer: 3.204 ± 0.057
3.001GluThr: 3.001 ± 0.053
5.431GluVal: 5.431 ± 0.078
0.754GluTrp: 0.754 ± 0.027
1.088GluTyr: 1.088 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.041PheAla: 4.041 ± 0.061
0.243PheCys: 0.243 ± 0.016
2.447PheAsp: 2.447 ± 0.049
1.789PheGlu: 1.789 ± 0.042
0.928PhePhe: 0.928 ± 0.036
3.348PheGly: 3.348 ± 0.059
0.594PheHis: 0.594 ± 0.024
0.961PheIle: 0.961 ± 0.035
0.525PheLys: 0.525 ± 0.021
2.677PheLeu: 2.677 ± 0.057
0.506PheMet: 0.506 ± 0.022
0.614PheAsn: 0.614 ± 0.023
1.276PhePro: 1.276 ± 0.036
0.646PheGln: 0.646 ± 0.024
1.742PheArg: 1.742 ± 0.039
1.646PheSer: 1.646 ± 0.049
2.088PheThr: 2.088 ± 0.05
2.932PheVal: 2.932 ± 0.056
0.449PheTrp: 0.449 ± 0.023
0.616PheTyr: 0.616 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
10.244GlyAla: 10.244 ± 0.117
0.644GlyCys: 0.644 ± 0.027
5.531GlyAsp: 5.531 ± 0.086
4.924GlyGlu: 4.924 ± 0.071
3.143GlyPhe: 3.143 ± 0.057
7.686GlyGly: 7.686 ± 0.105
2.091GlyHis: 2.091 ± 0.05
4.052GlyIle: 4.052 ± 0.073
2.247GlyLys: 2.247 ± 0.043
9.203GlyLeu: 9.203 ± 0.102
1.787GlyMet: 1.787 ± 0.043
1.579GlyAsn: 1.579 ± 0.044
4.239GlyPro: 4.239 ± 0.067
2.468GlyGln: 2.468 ± 0.049
6.895GlyArg: 6.895 ± 0.082
5.512GlySer: 5.512 ± 0.074
5.848GlyThr: 5.848 ± 0.094
7.919GlyVal: 7.919 ± 0.086
1.648GlyTrp: 1.648 ± 0.042
2.069GlyTyr: 2.069 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.518HisAla: 2.518 ± 0.055
0.139HisCys: 0.139 ± 0.012
1.516HisAsp: 1.516 ± 0.044
1.296HisGlu: 1.296 ± 0.037
0.567HisPhe: 0.567 ± 0.022
2.166HisGly: 2.166 ± 0.054
0.724HisHis: 0.724 ± 0.029
0.538HisIle: 0.538 ± 0.023
0.281HisLys: 0.281 ± 0.018
2.387HisLeu: 2.387 ± 0.056
0.31HisMet: 0.31 ± 0.016
0.332HisAsn: 0.332 ± 0.017
1.49HisPro: 1.49 ± 0.042
0.595HisGln: 0.595 ± 0.023
1.823HisArg: 1.823 ± 0.047
0.846HisSer: 0.846 ± 0.031
1.048HisThr: 1.048 ± 0.033
2.076HisVal: 2.076 ± 0.049
0.298HisTrp: 0.298 ± 0.016
0.42HisTyr: 0.42 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.164IleAla: 6.164 ± 0.084
0.273IleCys: 0.273 ± 0.016
3.221IleAsp: 3.221 ± 0.059
2.813IleGlu: 2.813 ± 0.05
0.933IlePhe: 0.933 ± 0.028
4.315IleGly: 4.315 ± 0.083
0.692IleHis: 0.692 ± 0.027
1.369IleIle: 1.369 ± 0.039
0.827IleLys: 0.827 ± 0.03
3.051IleLeu: 3.051 ± 0.062
0.546IleMet: 0.546 ± 0.024
0.85IleAsn: 0.85 ± 0.03
1.854IlePro: 1.854 ± 0.05
0.812IleGln: 0.812 ± 0.028
2.344IleArg: 2.344 ± 0.045
2.122IleSer: 2.122 ± 0.046
2.57IleThr: 2.57 ± 0.048
4.119IleVal: 4.119 ± 0.068
0.407IleTrp: 0.407 ± 0.021
0.668IleTyr: 0.668 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
2.827LysAla: 2.827 ± 0.058
0.112LysCys: 0.112 ± 0.009
1.225LysAsp: 1.225 ± 0.037
1.047LysGlu: 1.047 ± 0.028
0.526LysPhe: 0.526 ± 0.023
1.736LysGly: 1.736 ± 0.051
0.431LysHis: 0.431 ± 0.018
0.964LysIle: 0.964 ± 0.03
0.896LysLys: 0.896 ± 0.044
1.829LysLeu: 1.829 ± 0.047
0.399LysMet: 0.399 ± 0.02
0.52LysAsn: 0.52 ± 0.023
1.233LysPro: 1.233 ± 0.034
0.708LysGln: 0.708 ± 0.028
1.532LysArg: 1.532 ± 0.04
1.297LysSer: 1.297 ± 0.04
1.177LysThr: 1.177 ± 0.038
2.166LysVal: 2.166 ± 0.051
0.226LysTrp: 0.226 ± 0.014
0.485LysTyr: 0.485 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
14.323LeuAla: 14.323 ± 0.144
0.574LeuCys: 0.574 ± 0.025
7.173LeuAsp: 7.173 ± 0.099
5.615LeuGlu: 5.615 ± 0.082
2.589LeuPhe: 2.589 ± 0.057
9.308LeuGly: 9.308 ± 0.102
1.921LeuHis: 1.921 ± 0.049
3.418LeuIle: 3.418 ± 0.066
1.937LeuLys: 1.937 ± 0.044
10.0LeuLeu: 10.0 ± 0.123
1.839LeuMet: 1.839 ± 0.038
1.728LeuAsn: 1.728 ± 0.038
5.493LeuPro: 5.493 ± 0.07
2.367LeuGln: 2.367 ± 0.046
7.508LeuArg: 7.508 ± 0.098
5.457LeuSer: 5.457 ± 0.078
6.428LeuThr: 6.428 ± 0.079
10.411LeuVal: 10.411 ± 0.113
1.202LeuTrp: 1.202 ± 0.037
1.457LeuTyr: 1.457 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
2.388MetAla: 2.388 ± 0.042
0.115MetCys: 0.115 ± 0.01
0.958MetAsp: 0.958 ± 0.03
0.753MetGlu: 0.753 ± 0.028
0.516MetPhe: 0.516 ± 0.024
1.435MetGly: 1.435 ± 0.041
0.355MetHis: 0.355 ± 0.018
0.743MetIle: 0.743 ± 0.026
0.484MetLys: 0.484 ± 0.021
1.887MetLeu: 1.887 ± 0.045
0.36MetMet: 0.36 ± 0.02
0.51MetAsn: 0.51 ± 0.019
1.013MetPro: 1.013 ± 0.028
0.454MetGln: 0.454 ± 0.022
1.485MetArg: 1.485 ± 0.034
1.542MetSer: 1.542 ± 0.034
1.875MetThr: 1.875 ± 0.045
1.501MetVal: 1.501 ± 0.036
0.213MetTrp: 0.213 ± 0.014
0.304MetTyr: 0.304 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.27AsnAla: 2.27 ± 0.044
0.13AsnCys: 0.13 ± 0.011
1.173AsnAsp: 1.173 ± 0.036
0.952AsnGlu: 0.952 ± 0.03
0.528AsnPhe: 0.528 ± 0.022
1.708AsnGly: 1.708 ± 0.048
0.394AsnHis: 0.394 ± 0.02
0.694AsnIle: 0.694 ± 0.025
0.344AsnLys: 0.344 ± 0.02
1.909AsnLeu: 1.909 ± 0.045
0.277AsnMet: 0.277 ± 0.015
0.416AsnAsn: 0.416 ± 0.022
1.383AsnPro: 1.383 ± 0.041
0.521AsnGln: 0.521 ± 0.023
1.266AsnArg: 1.266 ± 0.04
0.878AsnSer: 0.878 ± 0.032
1.069AsnThr: 1.069 ± 0.034
1.621AsnVal: 1.621 ± 0.038
0.278AsnTrp: 0.278 ± 0.016
0.395AsnTyr: 0.395 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
6.719ProAla: 6.719 ± 0.09
0.247ProCys: 0.247 ± 0.016
4.166ProAsp: 4.166 ± 0.07
4.048ProGlu: 4.048 ± 0.065
1.671ProPhe: 1.671 ± 0.047
5.18ProGly: 5.18 ± 0.076
1.161ProHis: 1.161 ± 0.035
1.954ProIle: 1.954 ± 0.05
1.219ProLys: 1.219 ± 0.035
4.543ProLeu: 4.543 ± 0.076
0.982ProMet: 0.982 ± 0.032
0.913ProAsn: 0.913 ± 0.028
2.369ProPro: 2.369 ± 0.061
1.472ProGln: 1.472 ± 0.038
3.482ProArg: 3.482 ± 0.062
2.964ProSer: 2.964 ± 0.056
3.663ProThr: 3.663 ± 0.095
4.981ProVal: 4.981 ± 0.074
0.94ProTrp: 0.94 ± 0.03
1.001ProTyr: 1.001 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.301GlnAla: 3.301 ± 0.055
0.148GlnCys: 0.148 ± 0.013
1.389GlnAsp: 1.389 ± 0.036
1.355GlnGlu: 1.355 ± 0.041
0.794GlnPhe: 0.794 ± 0.027
2.05GlnGly: 2.05 ± 0.048
0.657GlnHis: 0.657 ± 0.025
1.234GlnIle: 1.234 ± 0.035
0.611GlnLys: 0.611 ± 0.025
2.829GlnLeu: 2.829 ± 0.054
0.562GlnMet: 0.562 ± 0.022
0.555GlnAsn: 0.555 ± 0.023
1.433GlnPro: 1.433 ± 0.044
1.146GlnGln: 1.146 ± 0.033
2.477GlnArg: 2.477 ± 0.054
1.361GlnSer: 1.361 ± 0.036
1.394GlnThr: 1.394 ± 0.032
2.728GlnVal: 2.728 ± 0.055
0.49GlnTrp: 0.49 ± 0.022
0.596GlnTyr: 0.596 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
8.569ArgAla: 8.569 ± 0.104
0.422ArgCys: 0.422 ± 0.021
4.565ArgAsp: 4.565 ± 0.077
4.697ArgGlu: 4.697 ± 0.077
2.424ArgPhe: 2.424 ± 0.047
5.344ArgGly: 5.344 ± 0.077
1.78ArgHis: 1.78 ± 0.041
3.456ArgIle: 3.456 ± 0.058
1.493ArgLys: 1.493 ± 0.037
7.881ArgLeu: 7.881 ± 0.099
1.711ArgMet: 1.711 ± 0.041
1.314ArgAsn: 1.314 ± 0.039
4.001ArgPro: 4.001 ± 0.069
2.124ArgGln: 2.124 ± 0.053
6.858ArgArg: 6.858 ± 0.094
4.181ArgSer: 4.181 ± 0.072
4.556ArgThr: 4.556 ± 0.064
6.293ArgVal: 6.293 ± 0.084
1.407ArgTrp: 1.407 ± 0.038
1.488ArgTyr: 1.488 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.527SerAla: 6.527 ± 0.085
0.349SerCys: 0.349 ± 0.02
3.111SerAsp: 3.111 ± 0.059
2.737SerGlu: 2.737 ± 0.053
1.865SerPhe: 1.865 ± 0.051
5.825SerGly: 5.825 ± 0.082
1.088SerHis: 1.088 ± 0.033
2.242SerIle: 2.242 ± 0.047
1.119SerLys: 1.119 ± 0.038
5.375SerLeu: 5.375 ± 0.064
1.324SerMet: 1.324 ± 0.034
1.001SerAsn: 1.001 ± 0.031
2.967SerPro: 2.967 ± 0.054
1.386SerGln: 1.386 ± 0.035
3.843SerArg: 3.843 ± 0.055
3.275SerSer: 3.275 ± 0.064
3.618SerThr: 3.618 ± 0.07
4.861SerVal: 4.861 ± 0.075
0.887SerTrp: 0.887 ± 0.032
1.108SerTyr: 1.108 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
7.555ThrAla: 7.555 ± 0.096
0.414ThrCys: 0.414 ± 0.023
3.586ThrAsp: 3.586 ± 0.059
3.419ThrGlu: 3.419 ± 0.078
1.988ThrPhe: 1.988 ± 0.044
5.885ThrGly: 5.885 ± 0.086
1.17ThrHis: 1.17 ± 0.03
2.924ThrIle: 2.924 ± 0.065
1.349ThrLys: 1.349 ± 0.042
5.743ThrLeu: 5.743 ± 0.076
1.142ThrMet: 1.142 ± 0.033
1.153ThrAsn: 1.153 ± 0.04
3.675ThrPro: 3.675 ± 0.068
1.457ThrGln: 1.457 ± 0.04
3.921ThrArg: 3.921 ± 0.059
3.657ThrSer: 3.657 ± 0.072
4.437ThrThr: 4.437 ± 0.116
6.224ThrVal: 6.224 ± 0.103
1.084ThrTrp: 1.084 ± 0.032
1.403ThrTyr: 1.403 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
12.557ValAla: 12.557 ± 0.118
0.638ValCys: 0.638 ± 0.027
6.191ValAsp: 6.191 ± 0.083
5.796ValGlu: 5.796 ± 0.074
2.667ValPhe: 2.667 ± 0.057
7.639ValGly: 7.639 ± 0.083
1.944ValHis: 1.944 ± 0.044
3.816ValIle: 3.816 ± 0.064
1.858ValLys: 1.858 ± 0.048
9.885ValLeu: 9.885 ± 0.1
1.735ValMet: 1.735 ± 0.047
1.796ValAsn: 1.796 ± 0.045
5.109ValPro: 5.109 ± 0.066
2.094ValGln: 2.094 ± 0.044
6.657ValArg: 6.657 ± 0.086
4.948ValSer: 4.948 ± 0.072
6.29ValThr: 6.29 ± 0.113
10.201ValVal: 10.201 ± 0.122
1.166ValTrp: 1.166 ± 0.036
1.458ValTyr: 1.458 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.628TrpAla: 1.628 ± 0.047
0.138TrpCys: 0.138 ± 0.012
0.896TrpAsp: 0.896 ± 0.032
0.691TrpGlu: 0.691 ± 0.026
0.588TrpPhe: 0.588 ± 0.024
1.104TrpGly: 1.104 ± 0.036
0.346TrpHis: 0.346 ± 0.019
0.687TrpIle: 0.687 ± 0.03
0.344TrpLys: 0.344 ± 0.019
1.814TrpLeu: 1.814 ± 0.043
0.305TrpMet: 0.305 ± 0.018
0.377TrpAsn: 0.377 ± 0.021
0.785TrpPro: 0.785 ± 0.029
0.498TrpGln: 0.498 ± 0.023
1.253TrpArg: 1.253 ± 0.04
1.007TrpSer: 1.007 ± 0.03
0.98TrpThr: 0.98 ± 0.032
1.15TrpVal: 1.15 ± 0.033
0.403TrpTrp: 0.403 ± 0.022
0.292TrpTyr: 0.292 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.39TyrAla: 2.39 ± 0.052
0.124TyrCys: 0.124 ± 0.01
1.384TyrAsp: 1.384 ± 0.037
1.135TyrGlu: 1.135 ± 0.033
0.661TyrPhe: 0.661 ± 0.026
1.877TyrGly: 1.877 ± 0.044
0.314TyrHis: 0.314 ± 0.017
0.499TyrIle: 0.499 ± 0.024
0.377TyrLys: 0.377 ± 0.021
2.01TyrLeu: 2.01 ± 0.048
0.223TyrMet: 0.223 ± 0.014
0.375TyrAsn: 0.375 ± 0.019
0.926TyrPro: 0.926 ± 0.033
0.484TyrGln: 0.484 ± 0.023
1.576TyrArg: 1.576 ± 0.04
0.938TyrSer: 0.938 ± 0.03
1.07TyrThr: 1.07 ± 0.037
1.777TyrVal: 1.777 ± 0.041
0.31TyrTrp: 0.31 ± 0.017
0.39TyrTyr: 0.39 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3277 proteins (1069643 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski