Amino acid dipepetide frequency for Halomonas xianhensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.441AlaAla: 11.441 ± 0.139	1.243AlaCys: 1.243 ± 0.035	5.656AlaAsp: 5.656 ± 0.078	7.16AlaGlu: 7.16 ± 0.092	3.857AlaPhe: 3.857 ± 0.054	8.882AlaGly: 8.882 ± 0.099	2.341AlaHis: 2.341 ± 0.042	5.519AlaIle: 5.519 ± 0.072	2.916AlaLys: 2.916 ± 0.049	13.549AlaLeu: 13.549 ± 0.138	3.424AlaMet: 3.424 ± 0.052	2.724AlaAsn: 2.724 ± 0.05	4.672AlaPro: 4.672 ± 0.066	4.347AlaGln: 4.347 ± 0.069	8.028AlaArg: 8.028 ± 0.102	6.424AlaSer: 6.424 ± 0.078	5.261AlaThr: 5.261 ± 0.068	7.296AlaVal: 7.296 ± 0.069	1.953AlaTrp: 1.953 ± 0.045	2.541AlaTyr: 2.541 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.883CysAla: 0.883 ± 0.028	0.152CysCys: 0.152 ± 0.011	0.579CysAsp: 0.579 ± 0.019	0.564CysGlu: 0.564 ± 0.02	0.335CysPhe: 0.335 ± 0.015	0.899CysGly: 0.899 ± 0.029	0.351CysHis: 0.351 ± 0.019	0.434CysIle: 0.434 ± 0.019	0.18CysLys: 0.18 ± 0.011	1.093CysLeu: 1.093 ± 0.029	0.191CysMet: 0.191 ± 0.012	0.262CysAsn: 0.262 ± 0.014	0.553CysPro: 0.553 ± 0.023	0.387CysGln: 0.387 ± 0.018	0.812CysArg: 0.812 ± 0.027	0.5CysSer: 0.5 ± 0.02	0.396CysThr: 0.396 ± 0.02	0.632CysVal: 0.632 ± 0.023	0.135CysTrp: 0.135 ± 0.01	0.252CysTyr: 0.252 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.465AspAla: 6.465 ± 0.093	0.492AspCys: 0.492 ± 0.02	3.712AspAsp: 3.712 ± 0.064	4.205AspGlu: 4.205 ± 0.053	2.095AspPhe: 2.095 ± 0.042	4.485AspGly: 4.485 ± 0.082	1.345AspHis: 1.345 ± 0.036	3.194AspIle: 3.194 ± 0.049	1.742AspLys: 1.742 ± 0.041	5.413AspLeu: 5.413 ± 0.072	1.432AspMet: 1.432 ± 0.037	1.73AspAsn: 1.73 ± 0.041	2.94AspPro: 2.94 ± 0.051	2.004AspGln: 2.004 ± 0.041	3.721AspArg: 3.721 ± 0.052	2.947AspSer: 2.947 ± 0.053	3.219AspThr: 3.219 ± 0.054	4.12AspVal: 4.12 ± 0.058	1.075AspTrp: 1.075 ± 0.03	1.81AspTyr: 1.81 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.807GluAla: 7.807 ± 0.093	0.51GluCys: 0.51 ± 0.021	3.135GluAsp: 3.135 ± 0.05	3.832GluGlu: 3.832 ± 0.067	1.777GluPhe: 1.777 ± 0.041	4.74GluGly: 4.74 ± 0.065	1.772GluHis: 1.772 ± 0.041	3.031GluIle: 3.031 ± 0.053	1.916GluLys: 1.916 ± 0.039	6.603GluLeu: 6.603 ± 0.081	1.436GluMet: 1.436 ± 0.034	1.58GluAsn: 1.58 ± 0.039	2.814GluPro: 2.814 ± 0.057	3.195GluGln: 3.195 ± 0.059	6.018GluArg: 6.018 ± 0.079	3.348GluSer: 3.348 ± 0.057	3.587GluThr: 3.587 ± 0.054	4.336GluVal: 4.336 ± 0.059	0.844GluTrp: 0.844 ± 0.026	1.309GluTyr: 1.309 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.672PheAla: 3.672 ± 0.055	0.376PheCys: 0.376 ± 0.016	2.424PheAsp: 2.424 ± 0.046	2.138PheGlu: 2.138 ± 0.043	1.383PhePhe: 1.383 ± 0.041	3.085PheGly: 3.085 ± 0.052	0.816PheHis: 0.816 ± 0.024	1.711PheIle: 1.711 ± 0.041	0.933PheLys: 0.933 ± 0.028	3.385PheLeu: 3.385 ± 0.064	0.887PheMet: 0.887 ± 0.025	1.055PheAsn: 1.055 ± 0.029	1.451PhePro: 1.451 ± 0.032	1.098PheGln: 1.098 ± 0.027	1.974PheArg: 1.974 ± 0.039	2.26PheSer: 2.26 ± 0.039	1.984PheThr: 1.984 ± 0.044	2.506PheVal: 2.506 ± 0.053	0.531PheTrp: 0.531 ± 0.024	0.977PheTyr: 0.977 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	7.1GlyAla: 7.1 ± 0.084	0.925GlyCys: 0.925 ± 0.027	4.476GlyAsp: 4.476 ± 0.054	5.481GlyGlu: 5.481 ± 0.076	3.184GlyPhe: 3.184 ± 0.046	6.334GlyGly: 6.334 ± 0.094	2.102GlyHis: 2.102 ± 0.037	4.588GlyIle: 4.588 ± 0.069	2.843GlyLys: 2.843 ± 0.052	9.273GlyLeu: 9.273 ± 0.105	2.494GlyMet: 2.494 ± 0.047	2.372GlyAsn: 2.372 ± 0.053	2.749GlyPro: 2.749 ± 0.052	3.392GlyGln: 3.392 ± 0.053	5.271GlyArg: 5.271 ± 0.069	4.288GlySer: 4.288 ± 0.06	3.917GlyThr: 3.917 ± 0.053	6.057GlyVal: 6.057 ± 0.069	1.418GlyTrp: 1.418 ± 0.037	2.504GlyTyr: 2.504 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.63HisAla: 2.63 ± 0.049	0.334HisCys: 0.334 ± 0.016	1.602HisAsp: 1.602 ± 0.037	1.506HisGlu: 1.506 ± 0.033	0.997HisPhe: 0.997 ± 0.03	2.273HisGly: 2.273 ± 0.044	0.778HisHis: 0.778 ± 0.028	0.983HisIle: 0.983 ± 0.027	0.55HisLys: 0.55 ± 0.02	2.62HisLeu: 2.62 ± 0.046	0.533HisMet: 0.533 ± 0.019	0.596HisAsn: 0.596 ± 0.024	1.496HisPro: 1.496 ± 0.036	0.91HisGln: 0.91 ± 0.027	1.811HisArg: 1.811 ± 0.04	1.145HisSer: 1.145 ± 0.033	1.041HisThr: 1.041 ± 0.027	1.709HisVal: 1.709 ± 0.041	0.447HisTrp: 0.447 ± 0.018	0.796HisTyr: 0.796 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.836IleAla: 5.836 ± 0.088	0.425IleCys: 0.425 ± 0.023	3.762IleAsp: 3.762 ± 0.05	3.627IleGlu: 3.627 ± 0.053	1.481IlePhe: 1.481 ± 0.043	4.459IleGly: 4.459 ± 0.063	1.063IleHis: 1.063 ± 0.028	2.065IleIle: 2.065 ± 0.047	1.331IleLys: 1.331 ± 0.03	4.234IleLeu: 4.234 ± 0.062	0.931IleMet: 0.931 ± 0.03	1.533IleAsn: 1.533 ± 0.04	2.3IlePro: 2.3 ± 0.048	1.537IleGln: 1.537 ± 0.036	2.981IleArg: 2.981 ± 0.049	2.56IleSer: 2.56 ± 0.046	2.52IleThr: 2.52 ± 0.046	3.752IleVal: 3.752 ± 0.064	0.482IleTrp: 0.482 ± 0.016	1.134IleTyr: 1.134 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.247LysAla: 3.247 ± 0.057	0.155LysCys: 0.155 ± 0.01	1.387LysAsp: 1.387 ± 0.033	1.597LysGlu: 1.597 ± 0.041	0.63LysPhe: 0.63 ± 0.023	2.196LysGly: 2.196 ± 0.042	0.697LysHis: 0.697 ± 0.027	1.177LysIle: 1.177 ± 0.035	0.983LysLys: 0.983 ± 0.039	2.907LysLeu: 2.907 ± 0.053	0.612LysMet: 0.612 ± 0.022	0.674LysAsn: 0.674 ± 0.028	1.544LysPro: 1.544 ± 0.037	1.216LysGln: 1.216 ± 0.034	2.409LysArg: 2.409 ± 0.052	1.456LysSer: 1.456 ± 0.038	1.446LysThr: 1.446 ± 0.033	2.111LysVal: 2.111 ± 0.048	0.276LysTrp: 0.276 ± 0.015	0.584LysTyr: 0.584 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.501LeuAla: 14.501 ± 0.132	1.096LeuCys: 1.096 ± 0.034	7.196LeuAsp: 7.196 ± 0.101	7.193LeuGlu: 7.193 ± 0.091	3.899LeuPhe: 3.899 ± 0.075	9.426LeuGly: 9.426 ± 0.106	2.415LeuHis: 2.415 ± 0.046	5.492LeuIle: 5.492 ± 0.075	3.323LeuLys: 3.323 ± 0.066	12.013LeuLeu: 12.013 ± 0.152	2.738LeuMet: 2.738 ± 0.054	2.97LeuAsn: 2.97 ± 0.045	6.194LeuPro: 6.194 ± 0.081	3.521LeuGln: 3.521 ± 0.057	6.997LeuArg: 6.997 ± 0.082	6.804LeuSer: 6.804 ± 0.083	5.844LeuThr: 5.844 ± 0.064	7.919LeuVal: 7.919 ± 0.089	1.504LeuTrp: 1.504 ± 0.039	2.405LeuTyr: 2.405 ± 0.043	0.001LeuXaa: 0.001 ± 0.001
Met	3.182MetAla: 3.182 ± 0.05	0.153MetCys: 0.153 ± 0.011	1.18MetAsp: 1.18 ± 0.031	1.146MetGlu: 1.146 ± 0.032	0.687MetPhe: 0.687 ± 0.025	1.832MetGly: 1.832 ± 0.038	0.59MetHis: 0.59 ± 0.019	1.265MetIle: 1.265 ± 0.033	0.838MetLys: 0.838 ± 0.025	2.877MetLeu: 2.877 ± 0.048	0.652MetMet: 0.652 ± 0.025	0.804MetAsn: 0.804 ± 0.025	1.591MetPro: 1.591 ± 0.039	1.088MetGln: 1.088 ± 0.031	1.681MetArg: 1.681 ± 0.034	1.717MetSer: 1.717 ± 0.037	1.754MetThr: 1.754 ± 0.039	1.643MetVal: 1.643 ± 0.037	0.21MetTrp: 0.21 ± 0.011	0.38MetTyr: 0.38 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.069AsnAla: 3.069 ± 0.055	0.239AsnCys: 0.239 ± 0.014	1.66AsnAsp: 1.66 ± 0.036	1.597AsnGlu: 1.597 ± 0.035	0.877AsnPhe: 0.877 ± 0.029	2.222AsnGly: 2.222 ± 0.052	0.621AsnHis: 0.621 ± 0.023	1.271AsnIle: 1.271 ± 0.034	0.616AsnLys: 0.616 ± 0.021	2.788AsnLeu: 2.788 ± 0.047	0.593AsnMet: 0.593 ± 0.022	0.732AsnAsn: 0.732 ± 0.022	1.688AsnPro: 1.688 ± 0.038	1.055AsnGln: 1.055 ± 0.028	1.914AsnArg: 1.914 ± 0.045	1.195AsnSer: 1.195 ± 0.037	1.314AsnThr: 1.314 ± 0.031	1.96AsnVal: 1.96 ± 0.036	0.379AsnTrp: 0.379 ± 0.018	0.738AsnTyr: 0.738 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.132ProAla: 5.132 ± 0.071	0.364ProCys: 0.364 ± 0.018	3.398ProAsp: 3.398 ± 0.056	3.865ProGlu: 3.865 ± 0.055	1.766ProPhe: 1.766 ± 0.044	4.33ProGly: 4.33 ± 0.057	1.153ProHis: 1.153 ± 0.032	2.015ProIle: 2.015 ± 0.04	1.164ProLys: 1.164 ± 0.032	5.456ProLeu: 5.456 ± 0.07	1.184ProMet: 1.184 ± 0.03	1.213ProAsn: 1.213 ± 0.032	2.18ProPro: 2.18 ± 0.052	1.921ProGln: 1.921 ± 0.042	3.035ProArg: 3.035 ± 0.051	2.776ProSer: 2.776 ± 0.045	2.261ProThr: 2.261 ± 0.043	3.925ProVal: 3.925 ± 0.057	0.823ProTrp: 0.823 ± 0.024	1.2ProTyr: 1.2 ± 0.032	0.001ProXaa: 0.001 ± 0.001
Gln	5.855GlnAla: 5.855 ± 0.082	0.315GlnCys: 0.315 ± 0.015	1.867GlnAsp: 1.867 ± 0.033	2.183GlnGlu: 2.183 ± 0.042	1.077GlnPhe: 1.077 ± 0.029	3.505GlnGly: 3.505 ± 0.061	0.987GlnHis: 0.987 ± 0.03	1.52GlnIle: 1.52 ± 0.041	0.883GlnLys: 0.883 ± 0.029	4.225GlnLeu: 4.225 ± 0.062	0.869GlnMet: 0.869 ± 0.025	0.817GlnAsn: 0.817 ± 0.025	2.088GlnPro: 2.088 ± 0.042	2.14GlnGln: 2.14 ± 0.054	3.807GlnArg: 3.807 ± 0.063	1.91GlnSer: 1.91 ± 0.038	1.76GlnThr: 1.76 ± 0.035	3.029GlnVal: 3.029 ± 0.055	0.667GlnTrp: 0.667 ± 0.024	0.807GlnTyr: 0.807 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.374ArgAla: 6.374 ± 0.081	0.625ArgCys: 0.625 ± 0.023	4.235ArgAsp: 4.235 ± 0.064	5.113ArgGlu: 5.113 ± 0.07	2.889ArgPhe: 2.889 ± 0.044	4.497ArgGly: 4.497 ± 0.058	2.401ArgHis: 2.401 ± 0.048	3.564ArgIle: 3.564 ± 0.048	1.911ArgLys: 1.911 ± 0.046	9.76ArgLeu: 9.76 ± 0.125	1.754ArgMet: 1.754 ± 0.038	1.844ArgAsn: 1.844 ± 0.032	3.125ArgPro: 3.125 ± 0.052	3.818ArgGln: 3.818 ± 0.061	5.755ArgArg: 5.755 ± 0.096	3.413ArgSer: 3.413 ± 0.05	2.95ArgThr: 2.95 ± 0.041	4.675ArgVal: 4.675 ± 0.063	1.165ArgTrp: 1.165 ± 0.034	2.339ArgTyr: 2.339 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.312SerAla: 5.312 ± 0.069	0.5SerCys: 0.5 ± 0.02	3.062SerAsp: 3.062 ± 0.052	3.251SerGlu: 3.251 ± 0.049	1.854SerPhe: 1.854 ± 0.044	5.026SerGly: 5.026 ± 0.063	1.378SerHis: 1.378 ± 0.032	2.453SerIle: 2.453 ± 0.042	1.261SerLys: 1.261 ± 0.032	6.905SerLeu: 6.905 ± 0.079	1.525SerMet: 1.525 ± 0.034	1.376SerAsn: 1.376 ± 0.037	2.877SerPro: 2.877 ± 0.051	2.409SerGln: 2.409 ± 0.044	4.324SerArg: 4.324 ± 0.064	3.155SerSer: 3.155 ± 0.063	2.512SerThr: 2.512 ± 0.049	3.871SerVal: 3.871 ± 0.058	0.787SerTrp: 0.787 ± 0.028	1.321SerTyr: 1.321 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.036ThrAla: 5.036 ± 0.074	0.518ThrCys: 0.518 ± 0.023	2.53ThrAsp: 2.53 ± 0.041	2.475ThrGlu: 2.475 ± 0.047	1.85ThrPhe: 1.85 ± 0.037	4.262ThrGly: 4.262 ± 0.057	1.277ThrHis: 1.277 ± 0.033	2.122ThrIle: 2.122 ± 0.045	0.968ThrLys: 0.968 ± 0.03	7.278ThrLeu: 7.278 ± 0.087	1.124ThrMet: 1.124 ± 0.029	1.184ThrAsn: 1.184 ± 0.028	3.406ThrPro: 3.406 ± 0.052	1.976ThrGln: 1.976 ± 0.044	3.554ThrArg: 3.554 ± 0.051	2.762ThrSer: 2.762 ± 0.055	2.598ThrThr: 2.598 ± 0.053	3.606ThrVal: 3.606 ± 0.059	0.735ThrTrp: 0.735 ± 0.03	1.215ThrTyr: 1.215 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.932ValAla: 7.932 ± 0.075	0.692ValCys: 0.692 ± 0.025	4.234ValAsp: 4.234 ± 0.07	4.694ValGlu: 4.694 ± 0.061	2.481ValPhe: 2.481 ± 0.048	5.301ValGly: 5.301 ± 0.067	1.55ValHis: 1.55 ± 0.039	4.036ValIle: 4.036 ± 0.066	1.96ValLys: 1.96 ± 0.044	7.593ValLeu: 7.593 ± 0.092	2.006ValMet: 2.006 ± 0.042	2.045ValAsn: 2.045 ± 0.042	3.449ValPro: 3.449 ± 0.05	2.177ValGln: 2.177 ± 0.04	4.522ValArg: 4.522 ± 0.059	4.381ValSer: 4.381 ± 0.062	4.177ValThr: 4.177 ± 0.057	5.606ValVal: 5.606 ± 0.07	0.917ValTrp: 0.917 ± 0.028	1.573ValTyr: 1.573 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.231TrpAla: 1.231 ± 0.031	0.19TrpCys: 0.19 ± 0.012	0.616TrpAsp: 0.616 ± 0.021	0.672TrpGlu: 0.672 ± 0.022	0.546TrpPhe: 0.546 ± 0.023	0.938TrpGly: 0.938 ± 0.025	0.461TrpHis: 0.461 ± 0.018	0.627TrpIle: 0.627 ± 0.022	0.415TrpLys: 0.415 ± 0.018	2.534TrpLeu: 2.534 ± 0.062	0.398TrpMet: 0.398 ± 0.019	0.385TrpAsn: 0.385 ± 0.017	0.723TrpPro: 0.723 ± 0.023	1.002TrpGln: 1.002 ± 0.029	1.271TrpArg: 1.271 ± 0.038	0.778TrpSer: 0.778 ± 0.027	0.659TrpThr: 0.659 ± 0.024	0.966TrpVal: 0.966 ± 0.03	0.3TrpTrp: 0.3 ± 0.017	0.358TrpTyr: 0.358 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.528TyrAla: 2.528 ± 0.045	0.285TyrCys: 0.285 ± 0.014	1.435TyrAsp: 1.435 ± 0.034	1.29TyrGlu: 1.29 ± 0.031	0.984TyrPhe: 0.984 ± 0.027	2.074TyrGly: 2.074 ± 0.042	0.662TyrHis: 0.662 ± 0.022	0.944TyrIle: 0.944 ± 0.028	0.57TyrLys: 0.57 ± 0.022	2.95TyrLeu: 2.95 ± 0.052	0.484TyrMet: 0.484 ± 0.02	0.633TyrAsn: 0.633 ± 0.023	1.321TyrPro: 1.321 ± 0.032	1.116TyrGln: 1.116 ± 0.025	2.323TyrArg: 2.323 ± 0.042	1.34TyrSer: 1.34 ± 0.036	1.275TyrThr: 1.275 ± 0.037	1.609TyrVal: 1.609 ± 0.038	0.422TyrTrp: 0.422 ± 0.019	0.73TyrTyr: 0.73 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.008XaaXaa: 0.008 ± 0.007

Statistics based on 4043 proteins (1302872 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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