Amino acid dipepetide frequency for Black medic leaf roll virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.776AlaAla: 0.776 ± 0.949
0.776AlaCys: 0.776 ± 0.949
2.329AlaAsp: 2.329 ± 1.169
0.776AlaGlu: 0.776 ± 0.755
2.329AlaPhe: 2.329 ± 1.246
1.553AlaGly: 1.553 ± 0.855
0.776AlaHis: 0.776 ± 0.616
2.329AlaIle: 2.329 ± 1.174
3.106AlaLys: 3.106 ± 1.623
1.553AlaLeu: 1.553 ± 0.855
1.553AlaMet: 1.553 ± 1.174
1.553AlaAsn: 1.553 ± 0.855
1.553AlaPro: 1.553 ± 1.673
2.329AlaGln: 2.329 ± 1.837
2.329AlaArg: 2.329 ± 1.357
3.106AlaSer: 3.106 ± 1.762
2.329AlaThr: 2.329 ± 1.069
1.553AlaVal: 1.553 ± 1.484
1.553AlaTrp: 1.553 ± 1.027
0.776AlaTyr: 0.776 ± 0.837
0.0AlaXaa: 0.0 ± 0.0
Cys
0.776CysAla: 0.776 ± 0.949
1.553CysCys: 1.553 ± 0.892
3.106CysAsp: 3.106 ± 2.262
0.0CysGlu: 0.0 ± 0.0
0.776CysPhe: 0.776 ± 0.616
0.776CysGly: 0.776 ± 0.797
0.0CysHis: 0.0 ± 0.0
2.329CysIle: 2.329 ± 2.053
3.106CysLys: 3.106 ± 1.794
2.329CysLeu: 2.329 ± 1.282
0.0CysMet: 0.0 ± 0.0
1.553CysAsn: 1.553 ± 0.944
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.553CysArg: 1.553 ± 1.012
1.553CysSer: 1.553 ± 1.019
3.106CysThr: 3.106 ± 1.168
0.0CysVal: 0.0 ± 0.0
0.776CysTrp: 0.776 ± 0.616
1.553CysTyr: 1.553 ± 1.108
0.0CysXaa: 0.0 ± 0.0
Asp
2.329AspAla: 2.329 ± 1.403
1.553AspCys: 1.553 ± 0.944
6.211AspAsp: 6.211 ± 2.038
6.988AspGlu: 6.988 ± 2.8
1.553AspPhe: 1.553 ± 0.892
3.882AspGly: 3.882 ± 1.965
0.776AspHis: 0.776 ± 0.616
1.553AspIle: 1.553 ± 0.846
4.658AspLys: 4.658 ± 1.162
4.658AspLeu: 4.658 ± 1.686
5.435AspMet: 5.435 ± 1.691
1.553AspAsn: 1.553 ± 1.108
0.776AspPro: 0.776 ± 0.797
0.0AspGln: 0.0 ± 0.0
2.329AspArg: 2.329 ± 0.982
6.211AspSer: 6.211 ± 1.756
1.553AspThr: 1.553 ± 0.892
6.988AspVal: 6.988 ± 2.444
0.0AspTrp: 0.0 ± 0.0
3.106AspTyr: 3.106 ± 1.586
0.0AspXaa: 0.0 ± 0.0
Glu
2.329GluAla: 2.329 ± 0.908
0.0GluCys: 0.0 ± 0.0
16.304GluAsp: 16.304 ± 5.247
7.764GluGlu: 7.764 ± 2.993
2.329GluPhe: 2.329 ± 1.246
5.435GluGly: 5.435 ± 1.75
1.553GluHis: 1.553 ± 1.036
2.329GluIle: 2.329 ± 1.298
3.106GluLys: 3.106 ± 1.551
5.435GluLeu: 5.435 ± 1.814
0.776GluMet: 0.776 ± 0.616
0.776GluAsn: 0.776 ± 0.755
0.0GluPro: 0.0 ± 0.0
4.658GluGln: 4.658 ± 1.65
6.211GluArg: 6.211 ± 2.043
3.882GluSer: 3.882 ± 1.57
0.776GluThr: 0.776 ± 0.949
5.435GluVal: 5.435 ± 2.445
0.776GluTrp: 0.776 ± 0.755
3.106GluTyr: 3.106 ± 1.898
0.0GluXaa: 0.0 ± 0.0
Phe
1.553PheAla: 1.553 ± 1.232
0.776PheCys: 0.776 ± 0.837
2.329PheAsp: 2.329 ± 1.046
1.553PheGlu: 1.553 ± 1.232
0.0PhePhe: 0.0 ± 0.0
0.776PheGly: 0.776 ± 0.696
0.0PheHis: 0.0 ± 0.0
2.329PheIle: 2.329 ± 1.234
0.776PheLys: 0.776 ± 0.696
3.882PheLeu: 3.882 ± 2.162
0.0PheMet: 0.0 ± 0.0
2.329PheAsn: 2.329 ± 1.556
1.553PhePro: 1.553 ± 0.892
1.553PheGln: 1.553 ± 0.974
0.776PheArg: 0.776 ± 0.616
4.658PheSer: 4.658 ± 1.613
2.329PheThr: 2.329 ± 1.293
4.658PheVal: 4.658 ± 1.666
0.776PheTrp: 0.776 ± 0.837
3.106PheTyr: 3.106 ± 0.966
0.0PheXaa: 0.0 ± 0.0
Gly
1.553GlyAla: 1.553 ± 0.855
0.776GlyCys: 0.776 ± 0.696
3.106GlyAsp: 3.106 ± 1.305
6.211GlyGlu: 6.211 ± 2.295
3.106GlyPhe: 3.106 ± 2.147
4.658GlyGly: 4.658 ± 2.338
0.0GlyHis: 0.0 ± 0.0
3.882GlyIle: 3.882 ± 1.246
6.211GlyLys: 6.211 ± 2.347
3.106GlyLeu: 3.106 ± 1.273
2.329GlyMet: 2.329 ± 1.246
2.329GlyAsn: 2.329 ± 1.064
3.106GlyPro: 3.106 ± 1.411
1.553GlyGln: 1.553 ± 1.047
3.106GlyArg: 3.106 ± 1.623
3.882GlySer: 3.882 ± 1.387
1.553GlyThr: 1.553 ± 0.855
6.988GlyVal: 6.988 ± 1.911
0.0GlyTrp: 0.0 ± 0.0
3.882GlyTyr: 3.882 ± 1.54
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.776HisCys: 0.776 ± 0.797
0.0HisAsp: 0.0 ± 0.0
0.776HisGlu: 0.776 ± 0.616
1.553HisPhe: 1.553 ± 1.232
1.553HisGly: 1.553 ± 1.119
0.0HisHis: 0.0 ± 0.0
1.553HisIle: 1.553 ± 0.991
0.776HisLys: 0.776 ± 0.696
1.553HisLeu: 1.553 ± 0.791
0.776HisMet: 0.776 ± 0.797
0.776HisAsn: 0.776 ± 0.755
0.776HisPro: 0.776 ± 0.696
0.776HisGln: 0.776 ± 0.616
0.776HisArg: 0.776 ± 0.742
1.553HisSer: 1.553 ± 1.104
0.776HisThr: 0.776 ± 0.755
3.106HisVal: 3.106 ± 1.532
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.106IleAla: 3.106 ± 1.401
4.658IleCys: 4.658 ± 2.034
0.776IleAsp: 0.776 ± 0.696
7.764IleGlu: 7.764 ± 2.591
0.0IlePhe: 0.0 ± 0.0
2.329IleGly: 2.329 ± 1.724
0.0IleHis: 0.0 ± 0.0
6.988IleIle: 6.988 ± 2.053
4.658IleLys: 4.658 ± 1.294
2.329IleLeu: 2.329 ± 1.428
3.882IleMet: 3.882 ± 2.142
2.329IleAsn: 2.329 ± 1.516
3.882IlePro: 3.882 ± 1.077
3.882IleGln: 3.882 ± 1.496
3.106IleArg: 3.106 ± 1.9
2.329IleSer: 2.329 ± 1.475
5.435IleThr: 5.435 ± 2.456
6.211IleVal: 6.211 ± 2.211
2.329IleTrp: 2.329 ± 1.263
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
3.106LysAla: 3.106 ± 0.995
0.776LysCys: 0.776 ± 0.797
2.329LysAsp: 2.329 ± 1.127
4.658LysGlu: 4.658 ± 2.119
2.329LysPhe: 2.329 ± 1.155
0.776LysGly: 0.776 ± 0.742
0.776LysHis: 0.776 ± 0.616
6.211LysIle: 6.211 ± 1.937
6.211LysLys: 6.211 ± 2.59
5.435LysLeu: 5.435 ± 1.391
1.553LysMet: 1.553 ± 1.74
1.553LysAsn: 1.553 ± 0.974
1.553LysPro: 1.553 ± 0.855
1.553LysGln: 1.553 ± 0.791
7.764LysArg: 7.764 ± 2.88
4.658LysSer: 4.658 ± 1.971
7.764LysThr: 7.764 ± 1.807
5.435LysVal: 5.435 ± 1.589
1.553LysTrp: 1.553 ± 0.991
3.882LysTyr: 3.882 ± 1.724
0.0LysXaa: 0.0 ± 0.0
Leu
2.329LeuAla: 2.329 ± 1.879
0.776LeuCys: 0.776 ± 0.797
5.435LeuAsp: 5.435 ± 2.691
3.106LeuGlu: 3.106 ± 1.06
4.658LeuPhe: 4.658 ± 0.927
3.882LeuGly: 3.882 ± 1.38
2.329LeuHis: 2.329 ± 1.235
3.882LeuIle: 3.882 ± 1.884
9.317LeuLys: 9.317 ± 2.258
9.317LeuLeu: 9.317 ± 3.041
1.553LeuMet: 1.553 ± 1.063
8.54LeuAsn: 8.54 ± 3.044
1.553LeuPro: 1.553 ± 1.595
4.658LeuGln: 4.658 ± 1.231
6.988LeuArg: 6.988 ± 1.988
6.211LeuSer: 6.211 ± 2.4
1.553LeuThr: 1.553 ± 0.855
8.54LeuVal: 8.54 ± 1.658
0.0LeuTrp: 0.0 ± 0.0
3.882LeuTyr: 3.882 ± 1.271
0.0LeuXaa: 0.0 ± 0.0
Met
1.553MetAla: 1.553 ± 0.892
0.0MetCys: 0.0 ± 0.0
0.776MetAsp: 0.776 ± 0.616
3.106MetGlu: 3.106 ± 1.745
3.106MetPhe: 3.106 ± 1.486
2.329MetGly: 2.329 ± 1.428
0.0MetHis: 0.0 ± 0.0
0.776MetIle: 0.776 ± 0.797
6.988MetLys: 6.988 ± 2.73
5.435MetLeu: 5.435 ± 2.209
0.0MetMet: 0.0 ± 0.0
1.553MetAsn: 1.553 ± 0.974
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
1.553MetArg: 1.553 ± 1.036
0.0MetSer: 0.0 ± 0.0
0.0MetThr: 0.0 ± 0.0
3.882MetVal: 3.882 ± 1.666
0.0MetTrp: 0.0 ± 0.0
1.553MetTyr: 1.553 ± 1.484
0.0MetXaa: 0.0 ± 0.0
Asn
0.0AsnAla: 0.0 ± 0.0
0.0AsnCys: 0.0 ± 0.0
0.776AsnAsp: 0.776 ± 0.755
1.553AsnGlu: 1.553 ± 1.047
1.553AsnPhe: 1.553 ± 0.855
3.882AsnGly: 3.882 ± 1.647
1.553AsnHis: 1.553 ± 1.392
2.329AsnIle: 2.329 ± 2.088
3.882AsnLys: 3.882 ± 1.715
2.329AsnLeu: 2.329 ± 0.97
1.553AsnMet: 1.553 ± 1.063
3.106AsnAsn: 3.106 ± 2.011
2.329AsnPro: 2.329 ± 1.744
0.0AsnGln: 0.0 ± 0.0
0.776AsnArg: 0.776 ± 0.755
0.776AsnSer: 0.776 ± 0.949
3.882AsnThr: 3.882 ± 1.045
1.553AsnVal: 1.553 ± 1.019
1.553AsnTrp: 1.553 ± 1.484
4.658AsnTyr: 4.658 ± 1.507
0.0AsnXaa: 0.0 ± 0.0
Pro
2.329ProAla: 2.329 ± 1.209
0.0ProCys: 0.0 ± 0.0
1.553ProAsp: 1.553 ± 1.03
2.329ProGlu: 2.329 ± 1.849
1.553ProPhe: 1.553 ± 1.745
2.329ProGly: 2.329 ± 1.009
0.0ProHis: 0.0 ± 0.0
3.106ProIle: 3.106 ± 1.505
0.776ProLys: 0.776 ± 0.837
3.106ProLeu: 3.106 ± 1.564
0.776ProMet: 0.776 ± 0.742
0.776ProAsn: 0.776 ± 0.742
0.776ProPro: 0.776 ± 0.742
0.776ProGln: 0.776 ± 0.616
1.553ProArg: 1.553 ± 1.232
3.882ProSer: 3.882 ± 1.554
0.776ProThr: 0.776 ± 0.742
1.553ProVal: 1.553 ± 1.019
1.553ProTrp: 1.553 ± 1.232
0.776ProTyr: 0.776 ± 0.949
0.0ProXaa: 0.0 ± 0.0
Gln
0.776GlnAla: 0.776 ± 0.949
0.0GlnCys: 0.0 ± 0.0
1.553GlnAsp: 1.553 ± 1.104
2.329GlnGlu: 2.329 ± 1.357
0.776GlnPhe: 0.776 ± 0.837
4.658GlnGly: 4.658 ± 2.457
1.553GlnHis: 1.553 ± 1.036
1.553GlnIle: 1.553 ± 1.51
2.329GlnLys: 2.329 ± 0.943
6.211GlnLeu: 6.211 ± 1.603
0.776GlnMet: 0.776 ± 0.837
0.0GlnAsn: 0.0 ± 0.0
0.0GlnPro: 0.0 ± 0.0
0.776GlnGln: 0.776 ± 0.755
0.776GlnArg: 0.776 ± 0.616
1.553GlnSer: 1.553 ± 1.232
0.776GlnThr: 0.776 ± 0.742
3.882GlnVal: 3.882 ± 1.334
0.0GlnTrp: 0.0 ± 0.0
0.776GlnTyr: 0.776 ± 0.755
0.0GlnXaa: 0.0 ± 0.0
Arg
0.776ArgAla: 0.776 ± 0.742
3.106ArgCys: 3.106 ± 1.733
2.329ArgAsp: 2.329 ± 0.935
5.435ArgGlu: 5.435 ± 1.898
1.553ArgPhe: 1.553 ± 0.974
3.106ArgGly: 3.106 ± 1.314
0.776ArgHis: 0.776 ± 0.837
3.882ArgIle: 3.882 ± 1.217
1.553ArgLys: 1.553 ± 0.846
6.988ArgLeu: 6.988 ± 2.367
1.553ArgMet: 1.553 ± 1.063
1.553ArgAsn: 1.553 ± 1.127
2.329ArgPro: 2.329 ± 1.169
0.776ArgGln: 0.776 ± 0.616
10.093ArgArg: 10.093 ± 2.892
6.211ArgSer: 6.211 ± 2.362
3.882ArgThr: 3.882 ± 1.895
3.106ArgVal: 3.106 ± 1.117
2.329ArgTrp: 2.329 ± 1.396
3.106ArgTyr: 3.106 ± 1.706
0.0ArgXaa: 0.0 ± 0.0
Ser
4.658SerAla: 4.658 ± 2.963
3.106SerCys: 3.106 ± 1.694
2.329SerAsp: 2.329 ± 0.957
5.435SerGlu: 5.435 ± 3.387
3.106SerPhe: 3.106 ± 1.514
5.435SerGly: 5.435 ± 1.469
0.776SerHis: 0.776 ± 0.696
6.211SerIle: 6.211 ± 2.083
1.553SerLys: 1.553 ± 1.019
4.658SerLeu: 4.658 ± 1.534
2.329SerMet: 2.329 ± 1.097
3.882SerAsn: 3.882 ± 2.179
2.329SerPro: 2.329 ± 0.97
2.329SerGln: 2.329 ± 1.127
5.435SerArg: 5.435 ± 1.411
7.764SerSer: 7.764 ± 3.452
0.776SerThr: 0.776 ± 0.616
5.435SerVal: 5.435 ± 1.692
0.0SerTrp: 0.0 ± 0.0
7.764SerTyr: 7.764 ± 2.808
0.0SerXaa: 0.0 ± 0.0
Thr
1.553ThrAla: 1.553 ± 1.027
2.329ThrCys: 2.329 ± 1.071
1.553ThrAsp: 1.553 ± 0.791
3.106ThrGlu: 3.106 ± 1.702
0.776ThrPhe: 0.776 ± 0.755
3.882ThrGly: 3.882 ± 1.79
1.553ThrHis: 1.553 ± 0.942
1.553ThrIle: 1.553 ± 1.027
0.776ThrLys: 0.776 ± 0.742
3.882ThrLeu: 3.882 ± 1.345
1.553ThrMet: 1.553 ± 1.035
0.776ThrAsn: 0.776 ± 0.742
3.882ThrPro: 3.882 ± 1.476
2.329ThrGln: 2.329 ± 1.058
2.329ThrArg: 2.329 ± 1.174
4.658ThrSer: 4.658 ± 1.508
3.106ThrThr: 3.106 ± 1.009
2.329ThrVal: 2.329 ± 1.196
0.776ThrTrp: 0.776 ± 0.616
2.329ThrTyr: 2.329 ± 1.524
0.0ThrXaa: 0.0 ± 0.0
Val
0.776ValAla: 0.776 ± 0.949
3.106ValCys: 3.106 ± 2.891
3.882ValAsp: 3.882 ± 1.808
3.882ValGlu: 3.882 ± 1.355
3.106ValPhe: 3.106 ± 1.389
3.106ValGly: 3.106 ± 1.67
2.329ValHis: 2.329 ± 1.104
5.435ValIle: 5.435 ± 2.294
9.317ValLys: 9.317 ± 2.523
10.87ValLeu: 10.87 ± 1.477
4.658ValMet: 4.658 ± 1.433
2.329ValAsn: 2.329 ± 0.976
0.776ValPro: 0.776 ± 0.797
0.0ValGln: 0.0 ± 0.0
6.211ValArg: 6.211 ± 2.576
9.317ValSer: 9.317 ± 2.963
2.329ValThr: 2.329 ± 1.127
6.211ValVal: 6.211 ± 2.912
0.0ValTrp: 0.0 ± 0.0
5.435ValTyr: 5.435 ± 2.189
0.0ValXaa: 0.0 ± 0.0
Trp
1.553TrpAla: 1.553 ± 1.03
0.776TrpCys: 0.776 ± 0.616
2.329TrpAsp: 2.329 ± 1.16
1.553TrpGlu: 1.553 ± 1.232
0.776TrpPhe: 0.776 ± 0.755
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.776TrpIle: 0.776 ± 0.696
0.776TrpLys: 0.776 ± 0.797
0.776TrpLeu: 0.776 ± 0.949
0.776TrpMet: 0.776 ± 0.616
0.0TrpAsn: 0.0 ± 0.0
0.776TrpPro: 0.776 ± 0.742
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.776TrpSer: 0.776 ± 0.873
0.0TrpThr: 0.0 ± 0.0
2.329TrpVal: 2.329 ± 1.138
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.106TyrAla: 3.106 ± 1.884
0.0TyrCys: 0.0 ± 0.0
3.106TyrAsp: 3.106 ± 1.714
4.658TyrGlu: 4.658 ± 2.51
0.776TyrPhe: 0.776 ± 0.797
6.988TyrGly: 6.988 ± 1.815
3.106TyrHis: 3.106 ± 1.308
6.988TyrIle: 6.988 ± 1.417
0.776TyrLys: 0.776 ± 0.837
4.658TyrLeu: 4.658 ± 2.169
0.0TyrMet: 0.0 ± 0.0
0.776TyrAsn: 0.776 ± 0.742
2.329TyrPro: 2.329 ± 1.209
3.106TyrGln: 3.106 ± 1.421
0.776TyrArg: 0.776 ± 0.837
2.329TyrSer: 2.329 ± 1.297
2.329TyrThr: 2.329 ± 1.293
3.882TyrVal: 3.882 ± 1.504
0.0TyrTrp: 0.0 ± 0.0
2.329TyrTyr: 2.329 ± 1.274
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (1289 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski