Amino acid dipepetide frequency for Hubei tombus-like virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.652AlaAla: 3.652 ± 0.934
0.73AlaCys: 0.73 ± 0.901
2.191AlaAsp: 2.191 ± 0.768
2.922AlaGlu: 2.922 ± 1.002
2.191AlaPhe: 2.191 ± 1.168
5.113AlaGly: 5.113 ± 1.327
1.461AlaHis: 1.461 ± 0.779
2.191AlaIle: 2.191 ± 1.168
2.191AlaLys: 2.191 ± 0.768
6.574AlaLeu: 6.574 ± 2.303
2.191AlaMet: 2.191 ± 1.168
3.652AlaAsn: 3.652 ± 1.052
5.844AlaPro: 5.844 ± 1.747
1.461AlaGln: 1.461 ± 0.938
4.383AlaArg: 4.383 ± 1.564
5.844AlaSer: 5.844 ± 2.2
6.574AlaThr: 6.574 ± 2.48
6.574AlaVal: 6.574 ± 2.618
0.73AlaTrp: 0.73 ± 0.964
2.922AlaTyr: 2.922 ± 1.002
0.0AlaXaa: 0.0 ± 0.0
Cys
0.73CysAla: 0.73 ± 0.389
0.73CysCys: 0.73 ± 1.12
2.191CysAsp: 2.191 ± 0.927
0.73CysGlu: 0.73 ± 0.389
0.73CysPhe: 0.73 ± 1.12
2.922CysGly: 2.922 ± 1.558
0.0CysHis: 0.0 ± 0.0
1.461CysIle: 1.461 ± 0.779
0.73CysLys: 0.73 ± 0.389
1.461CysLeu: 1.461 ± 0.757
1.461CysMet: 1.461 ± 0.779
0.0CysAsn: 0.0 ± 0.0
1.461CysPro: 1.461 ± 0.938
1.461CysGln: 1.461 ± 0.938
0.0CysArg: 0.0 ± 0.0
1.461CysSer: 1.461 ± 0.779
0.73CysThr: 0.73 ± 0.389
2.922CysVal: 2.922 ± 1.558
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.922AspAla: 2.922 ± 1.002
2.191AspCys: 2.191 ± 1.168
2.922AspAsp: 2.922 ± 1.514
2.922AspGlu: 2.922 ± 1.558
1.461AspPhe: 1.461 ± 0.779
5.844AspGly: 5.844 ± 1.89
0.73AspHis: 0.73 ± 0.389
2.922AspIle: 2.922 ± 0.935
4.383AspLys: 4.383 ± 1.241
2.922AspLeu: 2.922 ± 1.558
0.73AspMet: 0.73 ± 0.389
2.191AspAsn: 2.191 ± 1.811
5.113AspPro: 5.113 ± 1.021
0.73AspGln: 0.73 ± 0.389
2.191AspArg: 2.191 ± 1.265
3.652AspSer: 3.652 ± 1.294
2.922AspThr: 2.922 ± 1.514
2.922AspVal: 2.922 ± 0.935
0.0AspTrp: 0.0 ± 0.0
0.73AspTyr: 0.73 ± 0.389
0.73AspXaa: 0.73 ± 0.389
Glu
2.922GluAla: 2.922 ± 1.558
0.73GluCys: 0.73 ± 1.12
0.73GluAsp: 0.73 ± 0.389
2.922GluGlu: 2.922 ± 1.021
2.191GluPhe: 2.191 ± 1.168
1.461GluGly: 1.461 ± 1.803
2.191GluHis: 2.191 ± 1.168
0.73GluIle: 0.73 ± 0.389
2.191GluLys: 2.191 ± 1.168
3.652GluLeu: 3.652 ± 0.587
2.922GluMet: 2.922 ± 1.558
0.73GluAsn: 0.73 ± 0.389
4.383GluPro: 4.383 ± 0.937
3.652GluGln: 3.652 ± 1.256
5.844GluArg: 5.844 ± 3.116
1.461GluSer: 1.461 ± 0.938
2.191GluThr: 2.191 ± 1.618
4.383GluVal: 4.383 ± 2.337
2.191GluTrp: 2.191 ± 1.168
2.191GluTyr: 2.191 ± 0.768
0.0GluXaa: 0.0 ± 0.0
Phe
1.461PheAla: 1.461 ± 0.779
0.73PheCys: 0.73 ± 0.389
3.652PheAsp: 3.652 ± 0.587
2.191PheGlu: 2.191 ± 0.798
0.0PhePhe: 0.0 ± 0.0
4.383PheGly: 4.383 ± 1.596
1.461PheHis: 1.461 ± 2.24
0.0PheIle: 0.0 ± 0.0
0.0PheLys: 0.0 ± 0.0
1.461PheLeu: 1.461 ± 0.779
0.0PheMet: 0.0 ± 0.0
3.652PheAsn: 3.652 ± 1.21
1.461PhePro: 1.461 ± 0.779
2.191PheGln: 2.191 ± 2.046
1.461PheArg: 1.461 ± 0.938
3.652PheSer: 3.652 ± 1.796
2.191PheThr: 2.191 ± 0.798
1.461PheVal: 1.461 ± 0.779
1.461PheTrp: 1.461 ± 0.779
2.922PheTyr: 2.922 ± 1.021
0.0PheXaa: 0.0 ± 0.0
Gly
5.113GlyAla: 5.113 ± 3.142
2.191GlyCys: 2.191 ± 1.168
5.113GlyAsp: 5.113 ± 1.115
2.191GlyGlu: 2.191 ± 0.798
2.922GlyPhe: 2.922 ± 1.021
10.226GlyGly: 10.226 ± 3.101
0.73GlyHis: 0.73 ± 0.964
5.113GlyIle: 5.113 ± 2.039
6.574GlyLys: 6.574 ± 0.634
4.383GlyLeu: 4.383 ± 2.337
3.652GlyMet: 3.652 ± 1.294
3.652GlyAsn: 3.652 ± 1.391
4.383GlyPro: 4.383 ± 2.376
2.191GlyGln: 2.191 ± 1.709
5.113GlyArg: 5.113 ± 2.726
3.652GlySer: 3.652 ± 1.052
5.844GlyThr: 5.844 ± 1.021
2.191GlyVal: 2.191 ± 0.768
0.73GlyTrp: 0.73 ± 0.901
2.191GlyTyr: 2.191 ± 1.618
0.0GlyXaa: 0.0 ± 0.0
His
0.73HisAla: 0.73 ± 0.389
0.73HisCys: 0.73 ± 0.389
0.73HisAsp: 0.73 ± 0.389
1.461HisGlu: 1.461 ± 0.779
0.73HisPhe: 0.73 ± 1.12
2.191HisGly: 2.191 ± 1.222
1.461HisHis: 1.461 ± 2.24
0.0HisIle: 0.0 ± 0.0
1.461HisLys: 1.461 ± 0.779
0.0HisLeu: 0.0 ± 0.0
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.73HisPro: 0.73 ± 0.389
0.73HisGln: 0.73 ± 0.901
1.461HisArg: 1.461 ± 0.938
1.461HisSer: 1.461 ± 2.24
0.73HisThr: 0.73 ± 0.389
1.461HisVal: 1.461 ± 0.779
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.113IleAla: 5.113 ± 1.021
0.73IleCys: 0.73 ± 0.389
1.461IleAsp: 1.461 ± 0.779
0.73IleGlu: 0.73 ± 0.389
2.191IlePhe: 2.191 ± 1.168
1.461IleGly: 1.461 ± 0.757
0.0IleHis: 0.0 ± 0.0
1.461IleIle: 1.461 ± 0.779
1.461IleLys: 1.461 ± 0.779
3.652IleLeu: 3.652 ± 1.052
0.0IleMet: 0.0 ± 0.0
0.73IleAsn: 0.73 ± 0.389
4.383IlePro: 4.383 ± 1.241
0.0IleGln: 0.0 ± 0.0
1.461IleArg: 1.461 ± 0.779
2.922IleSer: 2.922 ± 1.027
0.73IleThr: 0.73 ± 0.389
2.191IleVal: 2.191 ± 0.768
0.0IleTrp: 0.0 ± 0.0
1.461IleTyr: 1.461 ± 0.779
0.0IleXaa: 0.0 ± 0.0
Lys
4.383LysAla: 4.383 ± 1.555
0.73LysCys: 0.73 ± 0.389
2.922LysAsp: 2.922 ± 1.558
3.652LysGlu: 3.652 ± 1.21
0.73LysPhe: 0.73 ± 0.901
4.383LysGly: 4.383 ± 1.535
0.73LysHis: 0.73 ± 0.389
0.0LysIle: 0.0 ± 0.0
3.652LysLys: 3.652 ± 1.947
1.461LysLeu: 1.461 ± 0.757
0.73LysMet: 0.73 ± 0.901
4.383LysAsn: 4.383 ± 2.338
4.383LysPro: 4.383 ± 1.627
0.0LysGln: 0.0 ± 0.0
4.383LysArg: 4.383 ± 2.337
2.922LysSer: 2.922 ± 1.732
4.383LysThr: 4.383 ± 1.535
5.844LysVal: 5.844 ± 1.871
1.461LysTrp: 1.461 ± 0.757
1.461LysTyr: 1.461 ± 0.779
0.0LysXaa: 0.0 ± 0.0
Leu
4.383LeuAla: 4.383 ± 1.008
0.0LeuCys: 0.0 ± 0.0
5.113LeuAsp: 5.113 ± 1.885
5.113LeuGlu: 5.113 ± 2.726
1.461LeuPhe: 1.461 ± 0.779
5.113LeuGly: 5.113 ± 1.021
0.73LeuHis: 0.73 ± 1.12
0.73LeuIle: 0.73 ± 0.389
5.113LeuLys: 5.113 ± 1.115
7.305LeuLeu: 7.305 ± 1.503
1.461LeuMet: 1.461 ± 0.727
2.191LeuAsn: 2.191 ± 0.768
5.113LeuPro: 5.113 ± 2.143
2.922LeuGln: 2.922 ± 0.671
3.652LeuArg: 3.652 ± 1.256
6.574LeuSer: 6.574 ± 3.031
3.652LeuThr: 3.652 ± 1.497
5.113LeuVal: 5.113 ± 1.021
1.461LeuTrp: 1.461 ± 0.938
2.191LeuTyr: 2.191 ± 2.704
0.0LeuXaa: 0.0 ± 0.0
Met
4.383MetAla: 4.383 ± 1.535
0.73MetCys: 0.73 ± 0.389
0.73MetAsp: 0.73 ± 0.901
1.461MetGlu: 1.461 ± 0.779
0.0MetPhe: 0.0 ± 0.0
1.461MetGly: 1.461 ± 0.779
0.73MetHis: 0.73 ± 0.389
0.0MetIle: 0.0 ± 0.0
1.461MetLys: 1.461 ± 0.779
0.73MetLeu: 0.73 ± 0.389
0.0MetMet: 0.0 ± 0.0
2.191MetAsn: 2.191 ± 1.618
0.73MetPro: 0.73 ± 1.12
2.191MetGln: 2.191 ± 1.168
1.461MetArg: 1.461 ± 0.779
2.191MetSer: 2.191 ± 0.927
0.73MetThr: 0.73 ± 0.901
2.191MetVal: 2.191 ± 1.168
0.73MetTrp: 0.73 ± 1.12
0.73MetTyr: 0.73 ± 1.12
0.0MetXaa: 0.0 ± 0.0
Asn
5.844AsnAla: 5.844 ± 1.021
0.73AsnCys: 0.73 ± 0.389
2.922AsnAsp: 2.922 ± 1.732
0.73AsnGlu: 0.73 ± 0.389
2.922AsnPhe: 2.922 ± 0.671
3.652AsnGly: 3.652 ± 0.587
0.0AsnHis: 0.0 ± 0.0
4.383AsnIle: 4.383 ± 1.535
2.922AsnLys: 2.922 ± 1.558
2.922AsnLeu: 2.922 ± 1.732
0.73AsnMet: 0.73 ± 0.389
3.652AsnAsn: 3.652 ± 2.497
0.73AsnPro: 0.73 ± 0.389
1.461AsnGln: 1.461 ± 1.564
2.191AsnArg: 2.191 ± 1.265
4.383AsnSer: 4.383 ± 1.199
2.191AsnThr: 2.191 ± 1.222
2.191AsnVal: 2.191 ± 0.927
0.73AsnTrp: 0.73 ± 0.389
1.461AsnTyr: 1.461 ± 1.803
0.0AsnXaa: 0.0 ± 0.0
Pro
3.652ProAla: 3.652 ± 1.456
0.0ProCys: 0.0 ± 0.0
2.922ProAsp: 2.922 ± 1.514
5.113ProGlu: 5.113 ± 1.674
2.191ProPhe: 2.191 ± 0.798
3.652ProGly: 3.652 ± 1.391
0.73ProHis: 0.73 ± 0.901
1.461ProIle: 1.461 ± 0.779
0.73ProLys: 0.73 ± 0.389
3.652ProLeu: 3.652 ± 1.21
0.73ProMet: 0.73 ± 0.389
1.461ProAsn: 1.461 ± 0.757
2.922ProPro: 2.922 ± 1.876
2.191ProGln: 2.191 ± 1.265
8.766ProArg: 8.766 ± 3.334
5.844ProSer: 5.844 ± 2.858
5.113ProThr: 5.113 ± 1.392
9.496ProVal: 9.496 ± 3.255
1.461ProTrp: 1.461 ± 0.779
4.383ProTyr: 4.383 ± 1.008
0.0ProXaa: 0.0 ± 0.0
Gln
1.461GlnAla: 1.461 ± 1.564
0.0GlnCys: 0.0 ± 0.0
1.461GlnAsp: 1.461 ± 2.24
0.73GlnGlu: 0.73 ± 0.389
1.461GlnPhe: 1.461 ± 0.779
2.191GlnGly: 2.191 ± 1.709
0.73GlnHis: 0.73 ± 0.389
0.73GlnIle: 0.73 ± 0.389
1.461GlnLys: 1.461 ± 0.779
2.922GlnLeu: 2.922 ± 1.015
1.461GlnMet: 1.461 ± 1.206
2.922GlnAsn: 2.922 ± 1.654
2.922GlnPro: 2.922 ± 1.932
0.0GlnGln: 0.0 ± 0.0
4.383GlnArg: 4.383 ± 2.668
2.922GlnSer: 2.922 ± 1.558
2.191GlnThr: 2.191 ± 2.046
2.191GlnVal: 2.191 ± 0.798
1.461GlnTrp: 1.461 ± 1.803
0.73GlnTyr: 0.73 ± 0.389
0.0GlnXaa: 0.0 ± 0.0
Arg
4.383ArgAla: 4.383 ± 1.564
2.922ArgCys: 2.922 ± 1.558
6.574ArgAsp: 6.574 ± 1.719
4.383ArgGlu: 4.383 ± 1.555
3.652ArgPhe: 3.652 ± 1.256
4.383ArgGly: 4.383 ± 1.555
0.0ArgHis: 0.0 ± 0.0
2.191ArgIle: 2.191 ± 2.029
6.574ArgLys: 6.574 ± 1.844
5.113ArgLeu: 5.113 ± 1.116
0.73ArgMet: 0.73 ± 1.12
3.652ArgAsn: 3.652 ± 1.256
2.191ArgPro: 2.191 ± 0.9
2.191ArgGln: 2.191 ± 1.265
6.574ArgArg: 6.574 ± 2.559
3.652ArgSer: 3.652 ± 2.008
6.574ArgThr: 6.574 ± 1.699
4.383ArgVal: 4.383 ± 0.69
1.461ArgTrp: 1.461 ± 0.779
2.922ArgTyr: 2.922 ± 1.558
0.0ArgXaa: 0.0 ± 0.0
Ser
5.113SerAla: 5.113 ± 1.427
2.922SerCys: 2.922 ± 1.027
1.461SerAsp: 1.461 ± 0.757
0.73SerGlu: 0.73 ± 0.389
4.383SerPhe: 4.383 ± 1.199
7.305SerGly: 7.305 ± 4.92
0.0SerHis: 0.0 ± 0.0
0.73SerIle: 0.73 ± 0.964
3.652SerLys: 3.652 ± 1.21
6.574SerLeu: 6.574 ± 1.458
0.0SerMet: 0.0 ± 0.761
2.922SerAsn: 2.922 ± 1.027
7.305SerPro: 7.305 ± 3.637
3.652SerGln: 3.652 ± 2.109
8.035SerArg: 8.035 ± 2.515
5.113SerSer: 5.113 ± 2.467
7.305SerThr: 7.305 ± 4.79
2.922SerVal: 2.922 ± 1.027
2.191SerTrp: 2.191 ± 1.168
2.191SerTyr: 2.191 ± 0.927
0.0SerXaa: 0.0 ± 0.0
Thr
3.652ThrAla: 3.652 ± 2.027
0.73ThrCys: 0.73 ± 1.12
1.461ThrAsp: 1.461 ± 0.779
4.383ThrGlu: 4.383 ± 1.008
2.191ThrPhe: 2.191 ± 1.265
2.922ThrGly: 2.922 ± 1.002
2.191ThrHis: 2.191 ± 2.029
3.652ThrIle: 3.652 ± 1.21
3.652ThrLys: 3.652 ± 0.587
4.383ThrLeu: 4.383 ± 2.835
3.652ThrMet: 3.652 ± 1.256
2.922ThrAsn: 2.922 ± 1.732
6.574ThrPro: 6.574 ± 2.743
2.191ThrGln: 2.191 ± 2.046
4.383ThrArg: 4.383 ± 1.008
4.383ThrSer: 4.383 ± 3.084
5.113ThrThr: 5.113 ± 2.133
4.383ThrVal: 4.383 ± 0.736
0.73ThrTrp: 0.73 ± 0.901
2.922ThrTyr: 2.922 ± 1.654
0.0ThrXaa: 0.0 ± 0.0
Val
6.574ValAla: 6.574 ± 2.114
1.461ValCys: 1.461 ± 0.757
3.652ValAsp: 3.652 ± 1.21
4.383ValGlu: 4.383 ± 2.337
2.922ValPhe: 2.922 ± 1.002
5.844ValGly: 5.844 ± 1.359
1.461ValHis: 1.461 ± 0.779
2.191ValIle: 2.191 ± 0.768
2.191ValLys: 2.191 ± 1.168
4.383ValLeu: 4.383 ± 2.337
0.73ValMet: 0.73 ± 0.389
3.652ValAsn: 3.652 ± 1.506
3.652ValPro: 3.652 ± 1.796
1.461ValGln: 1.461 ± 0.757
6.574ValArg: 6.574 ± 2.303
8.035ValSer: 8.035 ± 1.907
3.652ValThr: 3.652 ± 1.696
8.766ValVal: 8.766 ± 1.163
1.461ValTrp: 1.461 ± 1.927
3.652ValTyr: 3.652 ± 0.587
0.0ValXaa: 0.0 ± 0.0
Trp
0.73TrpAla: 0.73 ± 0.389
0.0TrpCys: 0.0 ± 0.0
1.461TrpAsp: 1.461 ± 0.779
0.73TrpGlu: 0.73 ± 0.389
0.73TrpPhe: 0.73 ± 0.389
1.461TrpGly: 1.461 ± 0.779
0.0TrpHis: 0.0 ± 0.0
1.461TrpIle: 1.461 ± 0.757
0.0TrpLys: 0.0 ± 0.0
3.652TrpLeu: 3.652 ± 0.587
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.73TrpPro: 0.73 ± 1.12
1.461TrpGln: 1.461 ± 0.757
1.461TrpArg: 1.461 ± 0.779
2.191TrpSer: 2.191 ± 1.222
1.461TrpThr: 1.461 ± 0.757
0.73TrpVal: 0.73 ± 0.389
1.461TrpTrp: 1.461 ± 0.779
1.461TrpTyr: 1.461 ± 0.779
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.191TyrAla: 2.191 ± 1.168
2.191TyrCys: 2.191 ± 0.768
1.461TyrAsp: 1.461 ± 0.779
2.191TyrGlu: 2.191 ± 0.927
0.73TyrPhe: 0.73 ± 1.12
1.461TyrGly: 1.461 ± 1.803
0.73TyrHis: 0.73 ± 0.901
0.73TyrIle: 0.73 ± 0.389
2.191TyrLys: 2.191 ± 1.168
2.191TyrLeu: 2.191 ± 1.168
2.922TyrMet: 2.922 ± 1.654
2.191TyrAsn: 2.191 ± 1.168
1.461TyrPro: 1.461 ± 1.803
2.191TyrGln: 2.191 ± 1.618
0.73TyrArg: 0.73 ± 0.389
2.922TyrSer: 2.922 ± 1.027
2.191TyrThr: 2.191 ± 0.927
4.383TyrVal: 4.383 ± 1.526
1.461TyrTrp: 1.461 ± 0.779
1.461TyrTyr: 1.461 ± 0.757
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.73XaaGly: 0.73 ± 0.389
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1370 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski