Amino acid dipepetide frequency for Caviid betaherpesvirus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.501AlaAla: 7.501 ± 0.526
1.896AlaCys: 1.896 ± 0.201
5.12AlaAsp: 5.12 ± 0.447
4.193AlaGlu: 4.193 ± 0.341
3.266AlaPhe: 3.266 ± 0.279
4.382AlaGly: 4.382 ± 0.32
1.686AlaHis: 1.686 ± 0.166
3.687AlaIle: 3.687 ± 0.446
2.297AlaLys: 2.297 ± 0.182
6.005AlaLeu: 6.005 ± 0.405
2.212AlaMet: 2.212 ± 0.212
2.191AlaAsn: 2.191 ± 0.228
3.645AlaPro: 3.645 ± 0.396
1.77AlaGln: 1.77 ± 0.251
5.394AlaArg: 5.394 ± 0.344
6.215AlaSer: 6.215 ± 0.464
4.972AlaThr: 4.972 ± 0.392
6.574AlaVal: 6.574 ± 0.46
0.843AlaTrp: 0.843 ± 0.129
2.149AlaTyr: 2.149 ± 0.217
0.0AlaXaa: 0.0 ± 0.0
Cys
1.896CysAla: 1.896 ± 0.225
0.759CysCys: 0.759 ± 0.127
1.959CysAsp: 1.959 ± 0.214
1.37CysGlu: 1.37 ± 0.166
1.053CysPhe: 1.053 ± 0.151
1.938CysGly: 1.938 ± 0.242
0.569CysHis: 0.569 ± 0.112
1.117CysIle: 1.117 ± 0.167
0.653CysLys: 0.653 ± 0.122
1.981CysLeu: 1.981 ± 0.208
0.632CysMet: 0.632 ± 0.117
0.611CysAsn: 0.611 ± 0.109
1.053CysPro: 1.053 ± 0.149
0.737CysGln: 0.737 ± 0.124
2.002CysArg: 2.002 ± 0.241
1.496CysSer: 1.496 ± 0.19
1.117CysThr: 1.117 ± 0.14
2.402CysVal: 2.402 ± 0.236
0.147CysTrp: 0.147 ± 0.059
0.99CysTyr: 0.99 ± 0.167
0.0CysXaa: 0.0 ± 0.0
Asp
6.342AspAla: 6.342 ± 0.467
1.053AspCys: 1.053 ± 0.137
6.237AspAsp: 6.237 ± 0.488
4.888AspGlu: 4.888 ± 0.417
2.318AspPhe: 2.318 ± 0.22
6.468AspGly: 6.468 ± 0.56
1.264AspHis: 1.264 ± 0.191
2.781AspIle: 2.781 ± 0.314
1.875AspLys: 1.875 ± 0.305
5.162AspLeu: 5.162 ± 0.407
1.875AspMet: 1.875 ± 0.163
2.023AspAsn: 2.023 ± 0.203
3.181AspPro: 3.181 ± 0.328
1.433AspGln: 1.433 ± 0.216
5.246AspArg: 5.246 ± 0.359
4.024AspSer: 4.024 ± 0.35
3.898AspThr: 3.898 ± 0.325
5.857AspVal: 5.857 ± 0.4
0.442AspTrp: 0.442 ± 0.098
1.791AspTyr: 1.791 ± 0.171
0.0AspXaa: 0.0 ± 0.0
Glu
3.708GluAla: 3.708 ± 0.296
1.475GluCys: 1.475 ± 0.188
4.003GluAsp: 4.003 ± 0.408
3.498GluGlu: 3.498 ± 0.327
2.065GluPhe: 2.065 ± 0.263
2.549GluGly: 2.549 ± 0.225
1.601GluHis: 1.601 ± 0.153
2.276GluIle: 2.276 ± 0.25
1.77GluLys: 1.77 ± 0.188
5.036GluLeu: 5.036 ± 0.484
0.948GluMet: 0.948 ± 0.109
2.339GluAsn: 2.339 ± 0.245
2.887GluPro: 2.887 ± 0.278
1.791GluGln: 1.791 ± 0.223
4.635GluArg: 4.635 ± 0.364
4.256GluSer: 4.256 ± 0.268
4.34GluThr: 4.34 ± 0.373
2.528GluVal: 2.528 ± 0.267
0.442GluTrp: 0.442 ± 0.097
1.791GluTyr: 1.791 ± 0.228
0.0GluXaa: 0.0 ± 0.0
Phe
2.444PheAla: 2.444 ± 0.239
1.243PheCys: 1.243 ± 0.174
2.908PheAsp: 2.908 ± 0.237
1.833PheGlu: 1.833 ± 0.15
2.044PhePhe: 2.044 ± 0.242
2.402PheGly: 2.402 ± 0.259
1.032PheHis: 1.032 ± 0.151
2.086PheIle: 2.086 ± 0.25
1.306PheLys: 1.306 ± 0.158
3.898PheLeu: 3.898 ± 0.278
1.096PheMet: 1.096 ± 0.157
1.264PheAsn: 1.264 ± 0.177
2.065PhePro: 2.065 ± 0.228
1.138PheGln: 1.138 ± 0.17
2.823PheArg: 2.823 ± 0.236
3.097PheSer: 3.097 ± 0.28
1.854PheThr: 1.854 ± 0.249
3.603PheVal: 3.603 ± 0.282
0.274PheTrp: 0.274 ± 0.063
1.433PheTyr: 1.433 ± 0.215
0.0PheXaa: 0.0 ± 0.0
Gly
4.404GlyAla: 4.404 ± 0.333
1.517GlyCys: 1.517 ± 0.224
4.614GlyAsp: 4.614 ± 0.408
3.266GlyGlu: 3.266 ± 0.276
2.065GlyPhe: 2.065 ± 0.188
5.352GlyGly: 5.352 ± 0.557
1.138GlyHis: 1.138 ± 0.153
2.486GlyIle: 2.486 ± 0.231
2.423GlyLys: 2.423 ± 0.213
5.204GlyLeu: 5.204 ± 0.364
1.327GlyMet: 1.327 ± 0.165
2.023GlyAsn: 2.023 ± 0.24
2.865GlyPro: 2.865 ± 0.284
1.538GlyGln: 1.538 ± 0.199
5.183GlyArg: 5.183 ± 0.458
5.794GlySer: 5.794 ± 0.449
4.066GlyThr: 4.066 ± 0.297
4.34GlyVal: 4.34 ± 0.276
0.653GlyTrp: 0.653 ± 0.111
2.023GlyTyr: 2.023 ± 0.257
0.0GlyXaa: 0.0 ± 0.0
His
1.622HisAla: 1.622 ± 0.178
0.4HisCys: 0.4 ± 0.096
1.728HisAsp: 1.728 ± 0.181
1.412HisGlu: 1.412 ± 0.21
0.885HisPhe: 0.885 ± 0.133
1.896HisGly: 1.896 ± 0.221
0.99HisHis: 0.99 ± 0.168
1.032HisIle: 1.032 ± 0.142
0.737HisLys: 0.737 ± 0.135
2.233HisLeu: 2.233 ± 0.197
0.78HisMet: 0.78 ± 0.141
0.948HisAsn: 0.948 ± 0.158
1.517HisPro: 1.517 ± 0.135
0.506HisGln: 0.506 ± 0.105
2.381HisArg: 2.381 ± 0.263
1.201HisSer: 1.201 ± 0.179
1.011HisThr: 1.011 ± 0.139
2.36HisVal: 2.36 ± 0.197
0.19HisTrp: 0.19 ± 0.072
0.927HisTyr: 0.927 ± 0.14
0.0HisXaa: 0.0 ± 0.0
Ile
3.224IleAla: 3.224 ± 0.249
1.306IleCys: 1.306 ± 0.167
2.844IleAsp: 2.844 ± 0.307
2.002IleGlu: 2.002 ± 0.248
1.538IlePhe: 1.538 ± 0.181
2.402IleGly: 2.402 ± 0.23
1.011IleHis: 1.011 ± 0.146
2.339IleIle: 2.339 ± 0.283
1.58IleLys: 1.58 ± 0.21
3.94IleLeu: 3.94 ± 0.359
1.475IleMet: 1.475 ± 0.181
1.981IleAsn: 1.981 ± 0.237
2.549IlePro: 2.549 ± 0.187
1.348IleGln: 1.348 ± 0.274
4.003IleArg: 4.003 ± 0.334
3.519IleSer: 3.519 ± 0.347
3.013IleThr: 3.013 ± 0.311
3.982IleVal: 3.982 ± 0.353
0.527IleTrp: 0.527 ± 0.092
1.749IleTyr: 1.749 ± 0.224
0.0IleXaa: 0.0 ± 0.0
Lys
2.002LysAla: 2.002 ± 0.234
0.801LysCys: 0.801 ± 0.138
2.233LysAsp: 2.233 ± 0.267
1.707LysGlu: 1.707 ± 0.241
1.201LysPhe: 1.201 ± 0.186
1.264LysGly: 1.264 ± 0.178
1.243LysHis: 1.243 ± 0.143
2.634LysIle: 2.634 ± 0.223
1.686LysLys: 1.686 ± 0.24
3.434LysLeu: 3.434 ± 0.402
0.843LysMet: 0.843 ± 0.132
1.664LysAsn: 1.664 ± 0.227
1.749LysPro: 1.749 ± 0.186
1.454LysGln: 1.454 ± 0.198
3.455LysArg: 3.455 ± 0.322
2.613LysSer: 2.613 ± 0.241
2.381LysThr: 2.381 ± 0.262
1.538LysVal: 1.538 ± 0.182
0.211LysTrp: 0.211 ± 0.071
0.885LysTyr: 0.885 ± 0.134
0.0LysXaa: 0.0 ± 0.0
Leu
6.342LeuAla: 6.342 ± 0.364
3.055LeuCys: 3.055 ± 0.304
5.162LeuAsp: 5.162 ± 0.386
4.446LeuGlu: 4.446 ± 0.437
4.13LeuPhe: 4.13 ± 0.273
4.382LeuGly: 4.382 ± 0.32
2.086LeuHis: 2.086 ± 0.224
4.382LeuIle: 4.382 ± 0.385
3.54LeuLys: 3.54 ± 0.396
8.617LeuLeu: 8.617 ± 0.487
1.917LeuMet: 1.917 ± 0.22
3.476LeuAsn: 3.476 ± 0.318
4.488LeuPro: 4.488 ± 0.297
2.36LeuGln: 2.36 ± 0.275
7.648LeuArg: 7.648 ± 0.467
7.859LeuSer: 7.859 ± 0.391
5.225LeuThr: 5.225 ± 0.38
5.562LeuVal: 5.562 ± 0.357
0.695LeuTrp: 0.695 ± 0.143
3.498LeuTyr: 3.498 ± 0.282
0.0LeuXaa: 0.0 ± 0.0
Met
1.896MetAla: 1.896 ± 0.198
0.485MetCys: 0.485 ± 0.107
1.412MetAsp: 1.412 ± 0.195
1.348MetGlu: 1.348 ± 0.192
1.18MetPhe: 1.18 ± 0.179
1.264MetGly: 1.264 ± 0.175
0.59MetHis: 0.59 ± 0.127
1.138MetIle: 1.138 ± 0.16
1.053MetLys: 1.053 ± 0.16
2.592MetLeu: 2.592 ± 0.239
0.695MetMet: 0.695 ± 0.13
0.99MetAsn: 0.99 ± 0.178
0.927MetPro: 0.927 ± 0.127
0.632MetGln: 0.632 ± 0.101
1.812MetArg: 1.812 ± 0.209
1.959MetSer: 1.959 ± 0.215
1.475MetThr: 1.475 ± 0.195
1.391MetVal: 1.391 ± 0.151
0.232MetTrp: 0.232 ± 0.071
0.969MetTyr: 0.969 ± 0.127
0.0MetXaa: 0.0 ± 0.0
Asn
2.802AsnAla: 2.802 ± 0.259
0.632AsnCys: 0.632 ± 0.109
2.276AsnAsp: 2.276 ± 0.22
1.728AsnGlu: 1.728 ± 0.249
1.011AsnPhe: 1.011 ± 0.123
2.423AsnGly: 2.423 ± 0.207
0.801AsnHis: 0.801 ± 0.118
1.875AsnIle: 1.875 ± 0.223
1.348AsnLys: 1.348 ± 0.165
2.718AsnLeu: 2.718 ± 0.244
0.843AsnMet: 0.843 ± 0.13
1.222AsnAsn: 1.222 ± 0.176
1.664AsnPro: 1.664 ± 0.198
0.653AsnGln: 0.653 ± 0.128
2.697AsnArg: 2.697 ± 0.258
2.36AsnSer: 2.36 ± 0.226
2.128AsnThr: 2.128 ± 0.271
4.024AsnVal: 4.024 ± 0.351
0.379AsnTrp: 0.379 ± 0.104
0.969AsnTyr: 0.969 ± 0.127
0.0AsnXaa: 0.0 ± 0.0
Pro
3.413ProAla: 3.413 ± 0.457
0.885ProCys: 0.885 ± 0.14
3.434ProAsp: 3.434 ± 0.315
2.823ProGlu: 2.823 ± 0.263
2.044ProPhe: 2.044 ± 0.239
3.771ProGly: 3.771 ± 0.38
1.306ProHis: 1.306 ± 0.158
2.17ProIle: 2.17 ± 0.193
1.938ProLys: 1.938 ± 0.265
4.024ProLeu: 4.024 ± 0.319
0.737ProMet: 0.737 ± 0.155
1.412ProAsn: 1.412 ± 0.186
3.729ProPro: 3.729 ± 0.396
1.391ProGln: 1.391 ± 0.21
3.687ProArg: 3.687 ± 0.325
5.057ProSer: 5.057 ± 0.414
2.781ProThr: 2.781 ± 0.227
4.045ProVal: 4.045 ± 0.274
0.506ProTrp: 0.506 ± 0.104
1.875ProTyr: 1.875 ± 0.23
0.0ProXaa: 0.0 ± 0.0
Gln
1.664GlnAla: 1.664 ± 0.196
0.674GlnCys: 0.674 ± 0.127
1.686GlnAsp: 1.686 ± 0.203
1.538GlnGlu: 1.538 ± 0.21
1.306GlnPhe: 1.306 ± 0.165
0.948GlnGly: 0.948 ± 0.142
0.927GlnHis: 0.927 ± 0.142
1.517GlnIle: 1.517 ± 0.179
1.201GlnLys: 1.201 ± 0.185
2.718GlnLeu: 2.718 ± 0.252
0.716GlnMet: 0.716 ± 0.118
1.391GlnAsn: 1.391 ± 0.186
1.348GlnPro: 1.348 ± 0.267
1.18GlnGln: 1.18 ± 0.244
2.191GlnArg: 2.191 ± 0.261
1.791GlnSer: 1.791 ± 0.202
1.812GlnThr: 1.812 ± 0.28
1.496GlnVal: 1.496 ± 0.216
0.169GlnTrp: 0.169 ± 0.057
0.969GlnTyr: 0.969 ± 0.131
0.0GlnXaa: 0.0 ± 0.0
Arg
5.52ArgAla: 5.52 ± 0.402
2.086ArgCys: 2.086 ± 0.246
6.026ArgAsp: 6.026 ± 0.392
4.656ArgGlu: 4.656 ± 0.333
3.266ArgPhe: 3.266 ± 0.248
4.509ArgGly: 4.509 ± 0.435
2.57ArgHis: 2.57 ± 0.224
3.181ArgIle: 3.181 ± 0.313
2.844ArgLys: 2.844 ± 0.265
8.112ArgLeu: 8.112 ± 0.425
1.791ArgMet: 1.791 ± 0.197
3.16ArgAsn: 3.16 ± 0.323
3.708ArgPro: 3.708 ± 0.283
2.17ArgGln: 2.17 ± 0.224
8.491ArgArg: 8.491 ± 0.744
6.215ArgSer: 6.215 ± 0.483
4.13ArgThr: 4.13 ± 0.309
5.331ArgVal: 5.331 ± 0.369
0.948ArgTrp: 0.948 ± 0.128
3.266ArgTyr: 3.266 ± 0.278
0.0ArgXaa: 0.0 ± 0.0
Ser
6.426SerAla: 6.426 ± 0.44
1.538SerCys: 1.538 ± 0.2
6.005SerAsp: 6.005 ± 0.469
4.72SerGlu: 4.72 ± 0.36
2.95SerPhe: 2.95 ± 0.279
5.752SerGly: 5.752 ± 0.451
2.002SerHis: 2.002 ± 0.208
2.865SerIle: 2.865 ± 0.217
2.634SerLys: 2.634 ± 0.28
6.616SerLeu: 6.616 ± 0.353
1.896SerMet: 1.896 ± 0.184
1.938SerAsn: 1.938 ± 0.21
4.298SerPro: 4.298 ± 0.359
2.044SerGln: 2.044 ± 0.229
6.574SerArg: 6.574 ± 0.473
8.091SerSer: 8.091 ± 0.67
4.762SerThr: 4.762 ± 0.347
6.553SerVal: 6.553 ± 0.425
0.906SerTrp: 0.906 ± 0.158
2.191SerTyr: 2.191 ± 0.218
0.0SerXaa: 0.0 ± 0.0
Thr
5.626ThrAla: 5.626 ± 0.399
1.622ThrCys: 1.622 ± 0.18
3.645ThrAsp: 3.645 ± 0.308
3.308ThrGlu: 3.308 ± 0.329
2.781ThrPhe: 2.781 ± 0.212
3.455ThrGly: 3.455 ± 0.247
1.032ThrHis: 1.032 ± 0.11
2.887ThrIle: 2.887 ± 0.236
2.023ThrLys: 2.023 ± 0.273
5.331ThrLeu: 5.331 ± 0.469
1.306ThrMet: 1.306 ± 0.191
1.707ThrAsn: 1.707 ± 0.238
3.371ThrPro: 3.371 ± 0.26
1.58ThrGln: 1.58 ± 0.223
4.087ThrArg: 4.087 ± 0.335
4.93ThrSer: 4.93 ± 0.42
4.488ThrThr: 4.488 ± 0.431
4.993ThrVal: 4.993 ± 0.299
0.611ThrTrp: 0.611 ± 0.104
1.875ThrTyr: 1.875 ± 0.183
0.0ThrXaa: 0.0 ± 0.0
Val
5.836ValAla: 5.836 ± 0.345
2.023ValCys: 2.023 ± 0.221
3.94ValAsp: 3.94 ± 0.3
3.329ValGlu: 3.329 ± 0.249
2.908ValPhe: 2.908 ± 0.34
4.298ValGly: 4.298 ± 0.294
1.77ValHis: 1.77 ± 0.213
3.624ValIle: 3.624 ± 0.292
2.549ValLys: 2.549 ± 0.231
7.227ValLeu: 7.227 ± 0.395
1.896ValMet: 1.896 ± 0.227
2.57ValAsn: 2.57 ± 0.266
3.961ValPro: 3.961 ± 0.35
2.402ValGln: 2.402 ± 0.188
6.258ValArg: 6.258 ± 0.403
7.501ValSer: 7.501 ± 0.519
4.93ValThr: 4.93 ± 0.338
6.173ValVal: 6.173 ± 0.43
0.864ValTrp: 0.864 ± 0.158
2.592ValTyr: 2.592 ± 0.219
0.0ValXaa: 0.0 ± 0.0
Trp
0.674TrpAla: 0.674 ± 0.121
0.211TrpCys: 0.211 ± 0.059
0.337TrpAsp: 0.337 ± 0.085
0.464TrpGlu: 0.464 ± 0.072
0.59TrpPhe: 0.59 ± 0.117
0.464TrpGly: 0.464 ± 0.099
0.232TrpHis: 0.232 ± 0.08
0.632TrpIle: 0.632 ± 0.13
0.485TrpLys: 0.485 ± 0.099
0.843TrpLeu: 0.843 ± 0.132
0.295TrpMet: 0.295 ± 0.075
0.337TrpAsn: 0.337 ± 0.087
0.59TrpPro: 0.59 ± 0.122
0.232TrpGln: 0.232 ± 0.054
0.506TrpArg: 0.506 ± 0.104
0.737TrpSer: 0.737 ± 0.149
0.59TrpThr: 0.59 ± 0.096
0.59TrpVal: 0.59 ± 0.112
0.169TrpTrp: 0.169 ± 0.053
0.527TrpTyr: 0.527 ± 0.098
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.655TyrAla: 2.655 ± 0.236
0.822TyrCys: 0.822 ± 0.161
2.592TyrAsp: 2.592 ± 0.224
1.433TyrGlu: 1.433 ± 0.123
1.243TyrPhe: 1.243 ± 0.137
2.36TyrGly: 2.36 ± 0.287
0.906TyrHis: 0.906 ± 0.145
1.622TyrIle: 1.622 ± 0.166
1.053TyrLys: 1.053 ± 0.153
3.181TyrLeu: 3.181 ± 0.285
0.737TyrMet: 0.737 ± 0.123
1.306TyrAsn: 1.306 ± 0.193
1.433TyrPro: 1.433 ± 0.205
0.885TyrGln: 0.885 ± 0.129
2.908TyrArg: 2.908 ± 0.295
2.044TyrSer: 2.044 ± 0.223
1.686TyrThr: 1.686 ± 0.222
3.308TyrVal: 3.308 ± 0.259
0.295TyrTrp: 0.295 ± 0.087
1.454TyrTyr: 1.454 ± 0.195
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 100 proteins (47463 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski