Amino acid dipepetide frequency for Saccharopolyspora coralli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.313AlaAla: 17.313 ± 0.143
1.067AlaCys: 1.067 ± 0.029
7.965AlaAsp: 7.965 ± 0.076
8.91AlaGlu: 8.91 ± 0.095
3.345AlaPhe: 3.345 ± 0.056
11.372AlaGly: 11.372 ± 0.108
2.764AlaHis: 2.764 ± 0.048
3.736AlaIle: 3.736 ± 0.063
2.448AlaLys: 2.448 ± 0.049
13.071AlaLeu: 13.071 ± 0.119
2.617AlaMet: 2.617 ± 0.041
2.092AlaAsn: 2.092 ± 0.04
5.969AlaPro: 5.969 ± 0.082
3.758AlaGln: 3.758 ± 0.052
9.023AlaArg: 9.023 ± 0.086
6.185AlaSer: 6.185 ± 0.07
7.18AlaThr: 7.18 ± 0.077
11.655AlaVal: 11.655 ± 0.1
1.693AlaTrp: 1.693 ± 0.037
2.06AlaTyr: 2.06 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.093CysAla: 1.093 ± 0.032
0.116CysCys: 0.116 ± 0.011
0.501CysAsp: 0.501 ± 0.016
0.435CysGlu: 0.435 ± 0.017
0.234CysPhe: 0.234 ± 0.012
1.03CysGly: 1.03 ± 0.03
0.216CysHis: 0.216 ± 0.013
0.171CysIle: 0.171 ± 0.011
0.102CysLys: 0.102 ± 0.008
0.717CysLeu: 0.717 ± 0.024
0.131CysMet: 0.131 ± 0.01
0.136CysAsn: 0.136 ± 0.011
0.536CysPro: 0.536 ± 0.02
0.197CysGln: 0.197 ± 0.011
0.618CysArg: 0.618 ± 0.023
0.528CysSer: 0.528 ± 0.02
0.527CysThr: 0.527 ± 0.022
0.75CysVal: 0.75 ± 0.027
0.13CysTrp: 0.13 ± 0.01
0.162CysTyr: 0.162 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.558AspAla: 7.558 ± 0.078
0.422AspCys: 0.422 ± 0.018
4.298AspAsp: 4.298 ± 0.061
5.072AspGlu: 5.072 ± 0.08
1.557AspPhe: 1.557 ± 0.037
6.216AspGly: 6.216 ± 0.076
1.499AspHis: 1.499 ± 0.034
1.727AspIle: 1.727 ± 0.036
1.129AspLys: 1.129 ± 0.034
6.281AspLeu: 6.281 ± 0.071
0.936AspMet: 0.936 ± 0.026
1.055AspAsn: 1.055 ± 0.026
4.392AspPro: 4.392 ± 0.054
1.777AspGln: 1.777 ± 0.035
5.001AspArg: 5.001 ± 0.066
3.076AspSer: 3.076 ± 0.051
3.544AspThr: 3.544 ± 0.051
5.828AspVal: 5.828 ± 0.068
0.857AspTrp: 0.857 ± 0.026
1.182AspTyr: 1.182 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
6.787GluAla: 6.787 ± 0.082
0.428GluCys: 0.428 ± 0.018
3.064GluAsp: 3.064 ± 0.051
2.976GluGlu: 2.976 ± 0.061
1.914GluPhe: 1.914 ± 0.041
4.046GluGly: 4.046 ± 0.061
2.111GluHis: 2.111 ± 0.044
2.538GluIle: 2.538 ± 0.05
1.23GluLys: 1.23 ± 0.038
7.34GluLeu: 7.34 ± 0.082
1.037GluMet: 1.037 ± 0.029
1.269GluAsn: 1.269 ± 0.031
3.776GluPro: 3.776 ± 0.059
3.206GluGln: 3.206 ± 0.056
5.583GluArg: 5.583 ± 0.074
3.413GluSer: 3.413 ± 0.052
3.169GluThr: 3.169 ± 0.046
5.433GluVal: 5.433 ± 0.077
0.854GluTrp: 0.854 ± 0.027
1.077GluTyr: 1.077 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
3.782PheAla: 3.782 ± 0.057
0.288PheCys: 0.288 ± 0.014
2.169PheAsp: 2.169 ± 0.042
1.54PheGlu: 1.54 ± 0.033
0.87PhePhe: 0.87 ± 0.029
3.38PheGly: 3.38 ± 0.064
0.684PheHis: 0.684 ± 0.024
0.69PheIle: 0.69 ± 0.028
0.387PheLys: 0.387 ± 0.017
2.588PheLeu: 2.588 ± 0.051
0.365PheMet: 0.365 ± 0.017
0.521PheAsn: 0.521 ± 0.02
1.318PhePro: 1.318 ± 0.031
0.661PheGln: 0.661 ± 0.024
1.82PheArg: 1.82 ± 0.041
1.572PheSer: 1.572 ± 0.032
1.952PheThr: 1.952 ± 0.042
2.728PheVal: 2.728 ± 0.047
0.433PheTrp: 0.433 ± 0.02
0.604PheTyr: 0.604 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
10.243GlyAla: 10.243 ± 0.108
0.866GlyCys: 0.866 ± 0.027
5.022GlyAsp: 5.022 ± 0.065
5.525GlyGlu: 5.525 ± 0.073
3.056GlyPhe: 3.056 ± 0.05
8.274GlyGly: 8.274 ± 0.118
2.276GlyHis: 2.276 ± 0.048
3.404GlyIle: 3.404 ± 0.055
2.227GlyLys: 2.227 ± 0.049
9.046GlyLeu: 9.046 ± 0.101
2.181GlyMet: 2.181 ± 0.042
1.794GlyAsn: 1.794 ± 0.04
4.401GlyPro: 4.401 ± 0.074
2.901GlyGln: 2.901 ± 0.054
6.7GlyArg: 6.7 ± 0.075
5.634GlySer: 5.634 ± 0.083
5.725GlyThr: 5.725 ± 0.071
8.358GlyVal: 8.358 ± 0.084
1.665GlyTrp: 1.665 ± 0.033
2.145GlyTyr: 2.145 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.769HisAla: 2.769 ± 0.051
0.247HisCys: 0.247 ± 0.014
1.574HisAsp: 1.574 ± 0.038
1.51HisGlu: 1.51 ± 0.034
0.632HisPhe: 0.632 ± 0.022
2.577HisGly: 2.577 ± 0.045
0.81HisHis: 0.81 ± 0.024
0.552HisIle: 0.552 ± 0.021
0.323HisLys: 0.323 ± 0.018
2.343HisLeu: 2.343 ± 0.041
0.345HisMet: 0.345 ± 0.019
0.406HisAsn: 0.406 ± 0.02
1.737HisPro: 1.737 ± 0.038
0.734HisGln: 0.734 ± 0.025
2.262HisArg: 2.262 ± 0.043
1.188HisSer: 1.188 ± 0.032
1.321HisThr: 1.321 ± 0.03
2.083HisVal: 2.083 ± 0.042
0.365HisTrp: 0.365 ± 0.015
0.512HisTyr: 0.512 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
4.681IleAla: 4.681 ± 0.063
0.276IleCys: 0.276 ± 0.014
2.447IleAsp: 2.447 ± 0.04
2.098IleGlu: 2.098 ± 0.041
0.673IlePhe: 0.673 ± 0.022
3.616IleGly: 3.616 ± 0.059
0.614IleHis: 0.614 ± 0.02
0.872IleIle: 0.872 ± 0.031
0.614IleLys: 0.614 ± 0.025
2.381IleLeu: 2.381 ± 0.044
0.474IleMet: 0.474 ± 0.019
0.749IleAsn: 0.749 ± 0.026
1.74IlePro: 1.74 ± 0.034
0.705IleGln: 0.705 ± 0.025
2.142IleArg: 2.142 ± 0.037
1.716IleSer: 1.716 ± 0.035
2.304IleThr: 2.304 ± 0.042
3.099IleVal: 3.099 ± 0.053
0.323IleTrp: 0.323 ± 0.015
0.529IleTyr: 0.529 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
2.203LysAla: 2.203 ± 0.053
0.095LysCys: 0.095 ± 0.008
1.002LysAsp: 1.002 ± 0.032
0.924LysGlu: 0.924 ± 0.029
0.483LysPhe: 0.483 ± 0.018
1.336LysGly: 1.336 ± 0.036
0.442LysHis: 0.442 ± 0.02
0.874LysIle: 0.874 ± 0.027
0.596LysLys: 0.596 ± 0.029
1.952LysLeu: 1.952 ± 0.039
0.357LysMet: 0.357 ± 0.016
0.445LysAsn: 0.445 ± 0.02
1.236LysPro: 1.236 ± 0.038
0.755LysGln: 0.755 ± 0.028
1.469LysArg: 1.469 ± 0.039
1.094LysSer: 1.094 ± 0.035
1.142LysThr: 1.142 ± 0.032
1.753LysVal: 1.753 ± 0.045
0.238LysTrp: 0.238 ± 0.014
0.37LysTyr: 0.37 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
14.247LeuAla: 14.247 ± 0.13
0.826LeuCys: 0.826 ± 0.027
7.375LeuAsp: 7.375 ± 0.094
4.704LeuGlu: 4.704 ± 0.066
2.729LeuPhe: 2.729 ± 0.046
9.484LeuGly: 9.484 ± 0.104
2.4LeuHis: 2.4 ± 0.046
2.953LeuIle: 2.953 ± 0.052
1.444LeuLys: 1.444 ± 0.041
10.476LeuLeu: 10.476 ± 0.139
1.505LeuMet: 1.505 ± 0.035
1.789LeuAsn: 1.789 ± 0.038
5.88LeuPro: 5.88 ± 0.07
2.445LeuGln: 2.445 ± 0.044
8.665LeuArg: 8.665 ± 0.081
5.53LeuSer: 5.53 ± 0.067
6.101LeuThr: 6.101 ± 0.065
9.627LeuVal: 9.627 ± 0.1
1.187LeuTrp: 1.187 ± 0.029
1.665LeuTyr: 1.665 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.21MetAla: 2.21 ± 0.041
0.168MetCys: 0.168 ± 0.012
0.883MetAsp: 0.883 ± 0.027
0.72MetGlu: 0.72 ± 0.024
0.531MetPhe: 0.531 ± 0.019
1.356MetGly: 1.356 ± 0.038
0.421MetHis: 0.421 ± 0.019
0.773MetIle: 0.773 ± 0.026
0.34MetLys: 0.34 ± 0.015
2.051MetLeu: 2.051 ± 0.037
0.341MetMet: 0.341 ± 0.019
0.468MetAsn: 0.468 ± 0.019
1.136MetPro: 1.136 ± 0.03
0.586MetGln: 0.586 ± 0.017
1.657MetArg: 1.657 ± 0.035
1.456MetSer: 1.456 ± 0.03
1.595MetThr: 1.595 ± 0.031
1.461MetVal: 1.461 ± 0.037
0.221MetTrp: 0.221 ± 0.013
0.261MetTyr: 0.261 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.349AsnAla: 2.349 ± 0.039
0.173AsnCys: 0.173 ± 0.012
1.101AsnAsp: 1.101 ± 0.03
0.968AsnGlu: 0.968 ± 0.026
0.497AsnPhe: 0.497 ± 0.02
1.866AsnGly: 1.866 ± 0.04
0.43AsnHis: 0.43 ± 0.017
0.624AsnIle: 0.624 ± 0.024
0.397AsnLys: 0.397 ± 0.016
1.854AsnLeu: 1.854 ± 0.033
0.34AsnMet: 0.34 ± 0.017
0.445AsnAsn: 0.445 ± 0.02
1.481AsnPro: 1.481 ± 0.038
0.588AsnGln: 0.588 ± 0.023
1.428AsnArg: 1.428 ± 0.033
1.0AsnSer: 1.0 ± 0.029
1.2AsnThr: 1.2 ± 0.029
1.54AsnVal: 1.54 ± 0.038
0.319AsnTrp: 0.319 ± 0.014
0.418AsnTyr: 0.418 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
6.659ProAla: 6.659 ± 0.085
0.406ProCys: 0.406 ± 0.017
4.499ProAsp: 4.499 ± 0.06
4.61ProGlu: 4.61 ± 0.066
1.546ProPhe: 1.546 ± 0.034
5.671ProGly: 5.671 ± 0.077
1.371ProHis: 1.371 ± 0.034
1.548ProIle: 1.548 ± 0.036
1.115ProLys: 1.115 ± 0.029
4.815ProLeu: 4.815 ± 0.065
1.072ProMet: 1.072 ± 0.029
1.146ProAsn: 1.146 ± 0.029
3.42ProPro: 3.42 ± 0.096
1.895ProGln: 1.895 ± 0.051
3.703ProArg: 3.703 ± 0.055
3.172ProSer: 3.172 ± 0.048
3.327ProThr: 3.327 ± 0.055
5.213ProVal: 5.213 ± 0.055
0.917ProTrp: 0.917 ± 0.029
1.052ProTyr: 1.052 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.866GlnAla: 3.866 ± 0.058
0.205GlnCys: 0.205 ± 0.014
1.594GlnAsp: 1.594 ± 0.034
1.567GlnGlu: 1.567 ± 0.032
0.79GlnPhe: 0.79 ± 0.024
2.375GlnGly: 2.375 ± 0.05
0.866GlnHis: 0.866 ± 0.025
1.111GlnIle: 1.111 ± 0.026
0.542GlnLys: 0.542 ± 0.019
3.28GlnLeu: 3.28 ± 0.058
0.586GlnMet: 0.586 ± 0.022
0.638GlnAsn: 0.638 ± 0.022
1.921GlnPro: 1.921 ± 0.051
1.776GlnGln: 1.776 ± 0.053
3.14GlnArg: 3.14 ± 0.051
1.456GlnSer: 1.456 ± 0.034
1.36GlnThr: 1.36 ± 0.032
2.664GlnVal: 2.664 ± 0.046
0.544GlnTrp: 0.544 ± 0.02
0.612GlnTyr: 0.612 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
8.912ArgAla: 8.912 ± 0.091
0.687ArgCys: 0.687 ± 0.026
4.664ArgAsp: 4.664 ± 0.066
5.04ArgGlu: 5.04 ± 0.061
2.352ArgPhe: 2.352 ± 0.045
5.758ArgGly: 5.758 ± 0.069
2.054ArgHis: 2.054 ± 0.042
2.958ArgIle: 2.958 ± 0.048
1.732ArgLys: 1.732 ± 0.042
7.864ArgLeu: 7.864 ± 0.085
1.952ArgMet: 1.952 ± 0.036
1.533ArgAsn: 1.533 ± 0.035
4.311ArgPro: 4.311 ± 0.062
2.316ArgGln: 2.316 ± 0.045
7.472ArgArg: 7.472 ± 0.095
4.76ArgSer: 4.76 ± 0.061
5.121ArgThr: 5.121 ± 0.052
6.25ArgVal: 6.25 ± 0.072
1.422ArgTrp: 1.422 ± 0.034
1.759ArgTyr: 1.759 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.915SerAla: 6.915 ± 0.085
0.471SerCys: 0.471 ± 0.02
3.153SerAsp: 3.153 ± 0.048
3.419SerGlu: 3.419 ± 0.051
1.617SerPhe: 1.617 ± 0.038
6.261SerGly: 6.261 ± 0.087
1.026SerHis: 1.026 ± 0.029
1.683SerIle: 1.683 ± 0.036
1.09SerLys: 1.09 ± 0.034
5.037SerLeu: 5.037 ± 0.058
1.301SerMet: 1.301 ± 0.031
0.981SerAsn: 0.981 ± 0.03
3.07SerPro: 3.07 ± 0.052
1.467SerGln: 1.467 ± 0.035
3.982SerArg: 3.982 ± 0.052
3.391SerSer: 3.391 ± 0.061
3.779SerThr: 3.779 ± 0.065
4.923SerVal: 4.923 ± 0.066
0.968SerTrp: 0.968 ± 0.026
1.1SerTyr: 1.1 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
7.589ThrAla: 7.589 ± 0.077
0.47ThrCys: 0.47 ± 0.019
3.837ThrAsp: 3.837 ± 0.059
3.825ThrGlu: 3.825 ± 0.062
1.715ThrPhe: 1.715 ± 0.04
6.219ThrGly: 6.219 ± 0.07
1.277ThrHis: 1.277 ± 0.033
1.981ThrIle: 1.981 ± 0.042
1.108ThrLys: 1.108 ± 0.034
5.589ThrLeu: 5.589 ± 0.07
1.137ThrMet: 1.137 ± 0.024
1.079ThrAsn: 1.079 ± 0.025
3.757ThrPro: 3.757 ± 0.055
1.501ThrGln: 1.501 ± 0.033
3.956ThrArg: 3.956 ± 0.047
3.484ThrSer: 3.484 ± 0.053
4.056ThrThr: 4.056 ± 0.067
6.366ThrVal: 6.366 ± 0.072
0.936ThrTrp: 0.936 ± 0.032
1.155ThrTyr: 1.155 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
11.425ValAla: 11.425 ± 0.112
0.769ValCys: 0.769 ± 0.024
6.246ValAsp: 6.246 ± 0.073
5.598ValGlu: 5.598 ± 0.073
2.619ValPhe: 2.619 ± 0.045
7.58ValGly: 7.58 ± 0.089
2.269ValHis: 2.269 ± 0.041
2.824ValIle: 2.824 ± 0.046
1.353ValLys: 1.353 ± 0.034
10.496ValLeu: 10.496 ± 0.113
1.356ValMet: 1.356 ± 0.036
1.753ValAsn: 1.753 ± 0.035
5.215ValPro: 5.215 ± 0.067
2.426ValGln: 2.426 ± 0.043
7.29ValArg: 7.29 ± 0.083
5.001ValSer: 5.001 ± 0.063
5.636ValThr: 5.636 ± 0.072
9.45ValVal: 9.45 ± 0.106
1.116ValTrp: 1.116 ± 0.031
1.443ValTyr: 1.443 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.487TrpAla: 1.487 ± 0.036
0.17TrpCys: 0.17 ± 0.012
0.776TrpAsp: 0.776 ± 0.027
0.717TrpGlu: 0.717 ± 0.025
0.562TrpPhe: 0.562 ± 0.021
1.072TrpGly: 1.072 ± 0.029
0.369TrpHis: 0.369 ± 0.018
0.602TrpIle: 0.602 ± 0.019
0.285TrpLys: 0.285 ± 0.014
1.814TrpLeu: 1.814 ± 0.041
0.37TrpMet: 0.37 ± 0.016
0.375TrpAsn: 0.375 ± 0.018
0.811TrpPro: 0.811 ± 0.025
0.587TrpGln: 0.587 ± 0.021
1.227TrpArg: 1.227 ± 0.034
0.951TrpSer: 0.951 ± 0.027
0.921TrpThr: 0.921 ± 0.031
1.125TrpVal: 1.125 ± 0.029
0.41TrpTrp: 0.41 ± 0.017
0.263TrpTyr: 0.263 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.135TyrAla: 2.135 ± 0.041
0.182TyrCys: 0.182 ± 0.01
1.238TyrAsp: 1.238 ± 0.035
1.096TyrGlu: 1.096 ± 0.029
0.63TyrPhe: 0.63 ± 0.022
1.957TyrGly: 1.957 ± 0.041
0.394TyrHis: 0.394 ± 0.017
0.431TyrIle: 0.431 ± 0.018
0.3TyrLys: 0.3 ± 0.014
2.037TyrLeu: 2.037 ± 0.044
0.232TyrMet: 0.232 ± 0.013
0.34TyrAsn: 0.34 ± 0.017
1.049TyrPro: 1.049 ± 0.031
0.611TyrGln: 0.611 ± 0.023
1.778TyrArg: 1.778 ± 0.036
1.027TyrSer: 1.027 ± 0.026
1.076TyrThr: 1.076 ± 0.031
1.559TyrVal: 1.559 ± 0.031
0.296TyrTrp: 0.296 ± 0.016
0.431TyrTyr: 0.431 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4296 proteins (1342545 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski