Amino acid dipepetide frequency for Polaromonas vacuolata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.537AlaAla: 14.537 ± 0.175	1.246AlaCys: 1.246 ± 0.04	5.742AlaAsp: 5.742 ± 0.087	5.715AlaGlu: 5.715 ± 0.08	3.831AlaPhe: 3.831 ± 0.059	8.963AlaGly: 8.963 ± 0.108	2.198AlaHis: 2.198 ± 0.055	5.673AlaIle: 5.673 ± 0.076	4.988AlaLys: 4.988 ± 0.08	14.241AlaLeu: 14.241 ± 0.142	3.51AlaMet: 3.51 ± 0.073	3.828AlaAsn: 3.828 ± 0.062	4.658AlaPro: 4.658 ± 0.089	5.903AlaGln: 5.903 ± 0.086	6.07AlaArg: 6.07 ± 0.093	7.586AlaSer: 7.586 ± 0.096	5.603AlaThr: 5.603 ± 0.09	8.321AlaVal: 8.321 ± 0.108	1.616AlaTrp: 1.616 ± 0.044	2.356AlaTyr: 2.356 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.156CysAla: 1.156 ± 0.033	0.124CysCys: 0.124 ± 0.009	0.523CysAsp: 0.523 ± 0.022	0.55CysGlu: 0.55 ± 0.025	0.326CysPhe: 0.326 ± 0.018	0.894CysGly: 0.894 ± 0.035	0.236CysHis: 0.236 ± 0.016	0.561CysIle: 0.561 ± 0.021	0.293CysLys: 0.293 ± 0.016	0.966CysLeu: 0.966 ± 0.03	0.244CysMet: 0.244 ± 0.014	0.289CysAsn: 0.289 ± 0.018	0.468CysPro: 0.468 ± 0.022	0.341CysGln: 0.341 ± 0.016	0.482CysArg: 0.482 ± 0.021	0.601CysSer: 0.601 ± 0.027	0.487CysThr: 0.487 ± 0.021	0.742CysVal: 0.742 ± 0.024	0.135CysTrp: 0.135 ± 0.012	0.215CysTyr: 0.215 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.02AspAla: 6.02 ± 0.083	0.503AspCys: 0.503 ± 0.024	2.325AspAsp: 2.325 ± 0.054	2.838AspGlu: 2.838 ± 0.056	2.181AspPhe: 2.181 ± 0.05	3.916AspGly: 3.916 ± 0.079	0.907AspHis: 0.907 ± 0.029	2.802AspIle: 2.802 ± 0.058	2.341AspLys: 2.341 ± 0.082	5.302AspLeu: 5.302 ± 0.072	1.385AspMet: 1.385 ± 0.04	1.55AspAsn: 1.55 ± 0.082	2.203AspPro: 2.203 ± 0.042	1.889AspGln: 1.889 ± 0.04	2.424AspArg: 2.424 ± 0.049	3.067AspSer: 3.067 ± 0.07	2.314AspThr: 2.314 ± 0.049	3.721AspVal: 3.721 ± 0.059	0.876AspTrp: 0.876 ± 0.027	1.429AspTyr: 1.429 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.241GluAla: 5.241 ± 0.082	0.386GluCys: 0.386 ± 0.018	2.031GluAsp: 2.031 ± 0.051	2.283GluGlu: 2.283 ± 0.051	1.935GluPhe: 1.935 ± 0.069	3.003GluGly: 3.003 ± 0.059	1.172GluHis: 1.172 ± 0.035	3.3GluIle: 3.3 ± 0.056	2.664GluLys: 2.664 ± 0.059	5.738GluLeu: 5.738 ± 0.085	1.356GluMet: 1.356 ± 0.036	1.699GluAsn: 1.699 ± 0.043	2.118GluPro: 2.118 ± 0.047	2.628GluGln: 2.628 ± 0.065	3.639GluArg: 3.639 ± 0.063	2.996GluSer: 2.996 ± 0.053	2.52GluThr: 2.52 ± 0.049	3.653GluVal: 3.653 ± 0.074	0.624GluTrp: 0.624 ± 0.023	0.989GluTyr: 0.989 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.239PheAla: 4.239 ± 0.066	0.481PheCys: 0.481 ± 0.022	2.483PheAsp: 2.483 ± 0.051	2.293PheGlu: 2.293 ± 0.041	1.672PhePhe: 1.672 ± 0.049	3.268PheGly: 3.268 ± 0.063	0.657PheHis: 0.657 ± 0.025	1.808PheIle: 1.808 ± 0.046	1.754PheLys: 1.754 ± 0.076	3.306PheLeu: 3.306 ± 0.066	0.971PheMet: 0.971 ± 0.034	1.442PheAsn: 1.442 ± 0.04	1.431PhePro: 1.431 ± 0.033	1.088PheGln: 1.088 ± 0.033	1.597PheArg: 1.597 ± 0.042	2.77PheSer: 2.77 ± 0.057	2.006PheThr: 2.006 ± 0.073	2.74PheVal: 2.74 ± 0.057	0.52PheTrp: 0.52 ± 0.026	0.986PheTyr: 0.986 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	7.545GlyAla: 7.545 ± 0.124	0.845GlyCys: 0.845 ± 0.027	3.381GlyAsp: 3.381 ± 0.066	3.716GlyGlu: 3.716 ± 0.057	3.348GlyPhe: 3.348 ± 0.056	5.793GlyGly: 5.793 ± 0.107	1.628GlyHis: 1.628 ± 0.043	4.024GlyIle: 4.024 ± 0.054	3.742GlyLys: 3.742 ± 0.058	8.861GlyLeu: 8.861 ± 0.103	2.218GlyMet: 2.218 ± 0.05	2.479GlyAsn: 2.479 ± 0.061	2.406GlyPro: 2.406 ± 0.052	3.665GlyGln: 3.665 ± 0.066	4.163GlyArg: 4.163 ± 0.073	4.715GlySer: 4.715 ± 0.086	3.809GlyThr: 3.809 ± 0.081	5.834GlyVal: 5.834 ± 0.083	1.223GlyTrp: 1.223 ± 0.039	2.137GlyTyr: 2.137 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.34HisAla: 2.34 ± 0.046	0.283HisCys: 0.283 ± 0.017	1.072HisAsp: 1.072 ± 0.033	1.007HisGlu: 1.007 ± 0.033	0.829HisPhe: 0.829 ± 0.029	1.698HisGly: 1.698 ± 0.047	0.499HisHis: 0.499 ± 0.022	1.041HisIle: 1.041 ± 0.028	0.686HisLys: 0.686 ± 0.028	2.073HisLeu: 2.073 ± 0.052	0.507HisMet: 0.507 ± 0.022	0.591HisAsn: 0.591 ± 0.025	1.147HisPro: 1.147 ± 0.035	0.869HisGln: 0.869 ± 0.029	1.049HisArg: 1.049 ± 0.03	1.242HisSer: 1.242 ± 0.036	1.087HisThr: 1.087 ± 0.037	1.288HisVal: 1.288 ± 0.035	0.332HisTrp: 0.332 ± 0.017	0.606HisTyr: 0.606 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.494IleAla: 6.494 ± 0.086	0.551IleCys: 0.551 ± 0.021	3.31IleAsp: 3.31 ± 0.05	3.348IleGlu: 3.348 ± 0.066	1.808IlePhe: 1.808 ± 0.046	4.256IleGly: 4.256 ± 0.071	0.994IleHis: 0.994 ± 0.034	2.134IleIle: 2.134 ± 0.044	2.456IleLys: 2.456 ± 0.053	4.072IleLeu: 4.072 ± 0.071	1.023IleMet: 1.023 ± 0.029	2.282IleAsn: 2.282 ± 0.054	2.226IlePro: 2.226 ± 0.048	1.581IleGln: 1.581 ± 0.037	2.591IleArg: 2.591 ± 0.06	3.702IleSer: 3.702 ± 0.064	3.172IleThr: 3.172 ± 0.063	3.505IleVal: 3.505 ± 0.06	0.569IleTrp: 0.569 ± 0.025	1.268IleTyr: 1.268 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.872LysAla: 4.872 ± 0.083	0.25LysCys: 0.25 ± 0.016	2.071LysAsp: 2.071 ± 0.045	1.719LysGlu: 1.719 ± 0.043	1.29LysPhe: 1.29 ± 0.04	2.692LysGly: 2.692 ± 0.055	0.831LysHis: 0.831 ± 0.029	2.403LysIle: 2.403 ± 0.058	2.117LysLys: 2.117 ± 0.055	4.688LysLeu: 4.688 ± 0.068	1.11LysMet: 1.11 ± 0.038	1.726LysAsn: 1.726 ± 0.041	2.607LysPro: 2.607 ± 0.055	1.599LysGln: 1.599 ± 0.038	2.527LysArg: 2.527 ± 0.045	2.885LysSer: 2.885 ± 0.075	2.853LysThr: 2.853 ± 0.057	2.912LysVal: 2.912 ± 0.052	0.405LysTrp: 0.405 ± 0.021	0.84LysTyr: 0.84 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	13.999LeuAla: 13.999 ± 0.146	1.071LeuCys: 1.071 ± 0.033	5.653LeuAsp: 5.653 ± 0.081	5.265LeuGlu: 5.265 ± 0.082	3.626LeuPhe: 3.626 ± 0.07	8.503LeuGly: 8.503 ± 0.101	2.152LeuHis: 2.152 ± 0.05	5.534LeuIle: 5.534 ± 0.084	4.776LeuLys: 4.776 ± 0.078	12.368LeuLeu: 12.368 ± 0.158	2.969LeuMet: 2.969 ± 0.071	3.642LeuAsn: 3.642 ± 0.059	5.773LeuPro: 5.773 ± 0.08	4.604LeuGln: 4.604 ± 0.075	6.537LeuArg: 6.537 ± 0.084	8.034LeuSer: 8.034 ± 0.108	6.117LeuThr: 6.117 ± 0.095	7.598LeuVal: 7.598 ± 0.109	1.313LeuTrp: 1.313 ± 0.045	2.062LeuTyr: 2.062 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.037MetAla: 3.037 ± 0.052	0.181MetCys: 0.181 ± 0.012	1.205MetAsp: 1.205 ± 0.041	1.054MetGlu: 1.054 ± 0.034	0.779MetPhe: 0.779 ± 0.029	1.959MetGly: 1.959 ± 0.049	0.577MetHis: 0.577 ± 0.024	1.168MetIle: 1.168 ± 0.035	1.161MetLys: 1.161 ± 0.04	3.213MetLeu: 3.213 ± 0.067	0.648MetMet: 0.648 ± 0.027	1.058MetAsn: 1.058 ± 0.032	1.572MetPro: 1.572 ± 0.04	1.408MetGln: 1.408 ± 0.039	1.7MetArg: 1.7 ± 0.043	1.789MetSer: 1.789 ± 0.042	1.752MetThr: 1.752 ± 0.043	1.71MetVal: 1.71 ± 0.041	0.188MetTrp: 0.188 ± 0.014	0.411MetTyr: 0.411 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	4.141AsnAla: 4.141 ± 0.068	0.354AsnCys: 0.354 ± 0.019	1.55AsnAsp: 1.55 ± 0.038	1.469AsnGlu: 1.469 ± 0.066	1.349AsnPhe: 1.349 ± 0.036	2.586AsnGly: 2.586 ± 0.056	0.68AsnHis: 0.68 ± 0.024	1.842AsnIle: 1.842 ± 0.039	1.293AsnLys: 1.293 ± 0.039	3.532AsnLeu: 3.532 ± 0.07	0.792AsnMet: 0.792 ± 0.033	1.234AsnAsn: 1.234 ± 0.052	2.231AsnPro: 2.231 ± 0.049	1.466AsnGln: 1.466 ± 0.047	1.702AsnArg: 1.702 ± 0.038	2.139AsnSer: 2.139 ± 0.047	2.064AsnThr: 2.064 ± 0.046	2.166AsnVal: 2.166 ± 0.058	0.52AsnTrp: 0.52 ± 0.022	0.949AsnTyr: 0.949 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.66ProAla: 5.66 ± 0.09	0.313ProCys: 0.313 ± 0.017	2.64ProAsp: 2.64 ± 0.051	2.979ProGlu: 2.979 ± 0.051	1.713ProPhe: 1.713 ± 0.046	3.535ProGly: 3.535 ± 0.057	0.912ProHis: 0.912 ± 0.032	2.135ProIle: 2.135 ± 0.049	1.814ProLys: 1.814 ± 0.044	4.886ProLeu: 4.886 ± 0.071	1.251ProMet: 1.251 ± 0.035	1.606ProAsn: 1.606 ± 0.044	1.832ProPro: 1.832 ± 0.046	2.034ProGln: 2.034 ± 0.045	2.177ProArg: 2.177 ± 0.05	3.052ProSer: 3.052 ± 0.059	2.494ProThr: 2.494 ± 0.048	3.758ProVal: 3.758 ± 0.067	0.624ProTrp: 0.624 ± 0.028	1.062ProTyr: 1.062 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.971GlnAla: 5.971 ± 0.094	0.301GlnCys: 0.301 ± 0.018	1.916GlnAsp: 1.916 ± 0.043	1.748GlnGlu: 1.748 ± 0.044	1.506GlnPhe: 1.506 ± 0.037	2.844GlnGly: 2.844 ± 0.057	0.962GlnHis: 0.962 ± 0.035	2.314GlnIle: 2.314 ± 0.054	1.573GlnLys: 1.573 ± 0.038	4.789GlnLeu: 4.789 ± 0.073	1.031GlnMet: 1.031 ± 0.03	1.357GlnAsn: 1.357 ± 0.035	2.052GlnPro: 2.052 ± 0.049	2.083GlnGln: 2.083 ± 0.052	2.978GlnArg: 2.978 ± 0.062	3.052GlnSer: 3.052 ± 0.056	2.668GlnThr: 2.668 ± 0.062	3.047GlnVal: 3.047 ± 0.048	0.643GlnTrp: 0.643 ± 0.025	0.859GlnTyr: 0.859 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.529ArgAla: 5.529 ± 0.086	0.536ArgCys: 0.536 ± 0.024	2.86ArgAsp: 2.86 ± 0.059	3.28ArgGlu: 3.28 ± 0.061	2.435ArgPhe: 2.435 ± 0.047	3.591ArgGly: 3.591 ± 0.059	1.299ArgHis: 1.299 ± 0.035	3.241ArgIle: 3.241 ± 0.05	2.185ArgLys: 2.185 ± 0.045	6.643ArgLeu: 6.643 ± 0.096	1.632ArgMet: 1.632 ± 0.04	1.813ArgAsn: 1.813 ± 0.041	2.357ArgPro: 2.357 ± 0.052	2.627ArgGln: 2.627 ± 0.057	3.218ArgArg: 3.218 ± 0.064	3.505ArgSer: 3.505 ± 0.067	2.481ArgThr: 2.481 ± 0.046	4.004ArgVal: 4.004 ± 0.067	0.874ArgTrp: 0.874 ± 0.032	1.529ArgTyr: 1.529 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	7.696SerAla: 7.696 ± 0.096	0.613SerCys: 0.613 ± 0.025	3.108SerAsp: 3.108 ± 0.051	3.056SerGlu: 3.056 ± 0.078	2.613SerPhe: 2.613 ± 0.062	5.568SerGly: 5.568 ± 0.072	1.365SerHis: 1.365 ± 0.033	3.394SerIle: 3.394 ± 0.062	2.376SerLys: 2.376 ± 0.052	7.436SerLeu: 7.436 ± 0.104	1.737SerMet: 1.737 ± 0.042	2.253SerAsn: 2.253 ± 0.053	3.119SerPro: 3.119 ± 0.06	2.93SerGln: 2.93 ± 0.06	3.73SerArg: 3.73 ± 0.062	4.844SerSer: 4.844 ± 0.101	3.564SerThr: 3.564 ± 0.067	4.839SerVal: 4.839 ± 0.151	0.881SerTrp: 0.881 ± 0.033	1.605SerTyr: 1.605 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	6.203ThrAla: 6.203 ± 0.1	0.409ThrCys: 0.409 ± 0.019	2.678ThrAsp: 2.678 ± 0.052	2.507ThrGlu: 2.507 ± 0.047	1.806ThrPhe: 1.806 ± 0.04	4.603ThrGly: 4.603 ± 0.089	1.173ThrHis: 1.173 ± 0.033	2.398ThrIle: 2.398 ± 0.053	1.747ThrLys: 1.747 ± 0.039	6.665ThrLeu: 6.665 ± 0.087	1.098ThrMet: 1.098 ± 0.037	1.708ThrAsn: 1.708 ± 0.055	3.366ThrPro: 3.366 ± 0.058	2.433ThrGln: 2.433 ± 0.054	2.863ThrArg: 2.863 ± 0.055	3.532ThrSer: 3.532 ± 0.081	3.038ThrThr: 3.038 ± 0.084	3.98ThrVal: 3.98 ± 0.079	0.594ThrTrp: 0.594 ± 0.021	1.065ThrTyr: 1.065 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.113ValAla: 8.113 ± 0.109	0.752ValCys: 0.752 ± 0.027	3.768ValAsp: 3.768 ± 0.182	3.563ValGlu: 3.563 ± 0.053	2.881ValPhe: 2.881 ± 0.08	5.17ValGly: 5.17 ± 0.075	1.312ValHis: 1.312 ± 0.043	3.938ValIle: 3.938 ± 0.058	3.03ValLys: 3.03 ± 0.055	8.146ValLeu: 8.146 ± 0.12	2.172ValMet: 2.172 ± 0.046	2.467ValAsn: 2.467 ± 0.059	3.164ValPro: 3.164 ± 0.056	2.759ValGln: 2.759 ± 0.053	3.731ValArg: 3.731 ± 0.06	4.821ValSer: 4.821 ± 0.091	3.924ValThr: 3.924 ± 0.077	5.725ValVal: 5.725 ± 0.095	0.982ValTrp: 0.982 ± 0.034	1.53ValTyr: 1.53 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.194TrpAla: 1.194 ± 0.037	0.173TrpCys: 0.173 ± 0.013	0.548TrpAsp: 0.548 ± 0.025	0.529TrpGlu: 0.529 ± 0.019	0.529TrpPhe: 0.529 ± 0.021	0.798TrpGly: 0.798 ± 0.027	0.319TrpHis: 0.319 ± 0.018	0.666TrpIle: 0.666 ± 0.027	0.45TrpLys: 0.45 ± 0.021	2.123TrpLeu: 2.123 ± 0.058	0.44TrpMet: 0.44 ± 0.019	0.384TrpAsn: 0.384 ± 0.02	0.623TrpPro: 0.623 ± 0.023	0.797TrpGln: 0.797 ± 0.031	1.011TrpArg: 1.011 ± 0.035	0.845TrpSer: 0.845 ± 0.027	0.702TrpThr: 0.702 ± 0.029	0.896TrpVal: 0.896 ± 0.033	0.238TrpTrp: 0.238 ± 0.017	0.243TrpTyr: 0.243 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.598TyrAla: 2.598 ± 0.051	0.259TyrCys: 0.259 ± 0.015	1.129TyrAsp: 1.129 ± 0.039	1.055TyrGlu: 1.055 ± 0.03	1.056TyrPhe: 1.056 ± 0.029	1.892TyrGly: 1.892 ± 0.048	0.373TyrHis: 0.373 ± 0.017	0.97TyrIle: 0.97 ± 0.029	0.952TyrLys: 0.952 ± 0.034	2.549TyrLeu: 2.549 ± 0.046	0.477TyrMet: 0.477 ± 0.02	0.651TyrAsn: 0.651 ± 0.027	1.125TyrPro: 1.125 ± 0.032	0.992TyrGln: 0.992 ± 0.032	1.449TyrArg: 1.449 ± 0.038	1.548TyrSer: 1.548 ± 0.043	1.211TyrThr: 1.211 ± 0.035	1.51TyrVal: 1.51 ± 0.04	0.346TyrTrp: 0.346 ± 0.019	0.556TyrTyr: 0.556 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3376 proteins (1095282 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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