Amino acid dipepetide frequency for Methyloceanibacter marginalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.692AlaAla: 15.692 ± 0.254	1.198AlaCys: 1.198 ± 0.049	6.431AlaAsp: 6.431 ± 0.105	7.908AlaGlu: 7.908 ± 0.126	4.425AlaPhe: 4.425 ± 0.091	9.75AlaGly: 9.75 ± 0.119	2.288AlaHis: 2.288 ± 0.06	5.844AlaIle: 5.844 ± 0.091	4.986AlaLys: 4.986 ± 0.103	13.251AlaLeu: 13.251 ± 0.171	3.36AlaMet: 3.36 ± 0.072	2.785AlaAsn: 2.785 ± 0.067	5.926AlaPro: 5.926 ± 0.115	3.731AlaGln: 3.731 ± 0.082	8.072AlaArg: 8.072 ± 0.136	6.238AlaSer: 6.238 ± 0.097	5.672AlaThr: 5.672 ± 0.103	8.429AlaVal: 8.429 ± 0.13	1.664AlaTrp: 1.664 ± 0.053	2.712AlaTyr: 2.712 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	1.129CysAla: 1.129 ± 0.047	0.145CysCys: 0.145 ± 0.016	0.528CysAsp: 0.528 ± 0.028	0.479CysGlu: 0.479 ± 0.027	0.366CysPhe: 0.366 ± 0.021	1.031CysGly: 1.031 ± 0.04	0.29CysHis: 0.29 ± 0.023	0.375CysIle: 0.375 ± 0.026	0.296CysLys: 0.296 ± 0.022	0.834CysLeu: 0.834 ± 0.043	0.211CysMet: 0.211 ± 0.017	0.246CysAsn: 0.246 ± 0.019	0.566CysPro: 0.566 ± 0.039	0.248CysGln: 0.248 ± 0.018	0.735CysArg: 0.735 ± 0.036	0.612CysSer: 0.612 ± 0.031	0.43CysThr: 0.43 ± 0.027	0.684CysVal: 0.684 ± 0.032	0.137CysTrp: 0.137 ± 0.016	0.218CysTyr: 0.218 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	6.76AspAla: 6.76 ± 0.103	0.587AspCys: 0.587 ± 0.029	3.4AspAsp: 3.4 ± 0.081	3.931AspGlu: 3.931 ± 0.094	2.236AspPhe: 2.236 ± 0.065	5.234AspGly: 5.234 ± 0.097	1.194AspHis: 1.194 ± 0.042	2.812AspIle: 2.812 ± 0.061	2.124AspLys: 2.124 ± 0.061	5.86AspLeu: 5.86 ± 0.112	1.246AspMet: 1.246 ± 0.041	1.347AspAsn: 1.347 ± 0.052	3.323AspPro: 3.323 ± 0.073	1.847AspGln: 1.847 ± 0.062	4.05AspArg: 4.05 ± 0.082	2.279AspSer: 2.279 ± 0.063	2.89AspThr: 2.89 ± 0.071	4.266AspVal: 4.266 ± 0.077	0.995AspTrp: 0.995 ± 0.042	1.616AspTyr: 1.616 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	8.064GluAla: 8.064 ± 0.144	0.401GluCys: 0.401 ± 0.025	3.498GluAsp: 3.498 ± 0.081	3.837GluGlu: 3.837 ± 0.099	1.749GluPhe: 1.749 ± 0.06	4.622GluGly: 4.622 ± 0.081	1.288GluHis: 1.288 ± 0.046	3.576GluIle: 3.576 ± 0.071	2.488GluLys: 2.488 ± 0.068	5.721GluLeu: 5.721 ± 0.115	1.503GluMet: 1.503 ± 0.054	1.591GluAsn: 1.591 ± 0.054	3.307GluPro: 3.307 ± 0.086	2.126GluGln: 2.126 ± 0.056	5.089GluArg: 5.089 ± 0.11	2.712GluSer: 2.712 ± 0.066	4.046GluThr: 4.046 ± 0.089	4.048GluVal: 4.048 ± 0.091	0.746GluTrp: 0.746 ± 0.034	1.072GluTyr: 1.072 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	4.598PheAla: 4.598 ± 0.093	0.388PheCys: 0.388 ± 0.024	2.607PheAsp: 2.607 ± 0.066	2.335PheGlu: 2.335 ± 0.065	1.449PhePhe: 1.449 ± 0.058	3.649PheGly: 3.649 ± 0.084	0.729PheHis: 0.729 ± 0.036	1.686PheIle: 1.686 ± 0.068	1.151PheLys: 1.151 ± 0.041	3.479PheLeu: 3.479 ± 0.086	0.834PheMet: 0.834 ± 0.04	0.992PheAsn: 0.992 ± 0.039	1.642PhePro: 1.642 ± 0.056	0.937PheGln: 0.937 ± 0.038	2.294PheArg: 2.294 ± 0.069	2.16PheSer: 2.16 ± 0.059	1.886PheThr: 1.886 ± 0.049	3.006PheVal: 3.006 ± 0.067	0.629PheTrp: 0.629 ± 0.035	0.979PheTyr: 0.979 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	9.239GlyAla: 9.239 ± 0.138	0.929GlyCys: 0.929 ± 0.039	4.65GlyAsp: 4.65 ± 0.082	5.037GlyGlu: 5.037 ± 0.097	3.635GlyPhe: 3.635 ± 0.073	7.011GlyGly: 7.011 ± 0.123	1.892GlyHis: 1.892 ± 0.061	4.158GlyIle: 4.158 ± 0.086	3.558GlyLys: 3.558 ± 0.079	8.965GlyLeu: 8.965 ± 0.151	2.036GlyMet: 2.036 ± 0.067	2.16GlyAsn: 2.16 ± 0.062	3.715GlyPro: 3.715 ± 0.074	2.643GlyGln: 2.643 ± 0.071	5.912GlyArg: 5.912 ± 0.111	4.497GlySer: 4.497 ± 0.088	4.53GlyThr: 4.53 ± 0.096	6.076GlyVal: 6.076 ± 0.097	1.328GlyTrp: 1.328 ± 0.054	2.282GlyTyr: 2.282 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	2.441HisAla: 2.441 ± 0.066	0.23HisCys: 0.23 ± 0.019	1.249HisAsp: 1.249 ± 0.043	1.216HisGlu: 1.216 ± 0.048	0.823HisPhe: 0.823 ± 0.04	1.949HisGly: 1.949 ± 0.061	0.561HisHis: 0.561 ± 0.03	0.919HisIle: 0.919 ± 0.04	0.645HisLys: 0.645 ± 0.032	2.039HisLeu: 2.039 ± 0.058	0.426HisMet: 0.426 ± 0.025	0.459HisAsn: 0.459 ± 0.026	1.321HisPro: 1.321 ± 0.047	0.566HisGln: 0.566 ± 0.036	1.392HisArg: 1.392 ± 0.047	0.814HisSer: 0.814 ± 0.034	0.795HisThr: 0.795 ± 0.04	1.539HisVal: 1.539 ± 0.051	0.317HisTrp: 0.317 ± 0.023	0.632HisTyr: 0.632 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.767IleAla: 6.767 ± 0.112	0.522IleCys: 0.522 ± 0.029	3.458IleAsp: 3.458 ± 0.07	3.679IleGlu: 3.679 ± 0.075	1.706IlePhe: 1.706 ± 0.055	4.691IleGly: 4.691 ± 0.099	0.881IleHis: 0.881 ± 0.038	2.107IleIle: 2.107 ± 0.07	1.708IleLys: 1.708 ± 0.049	4.27IleLeu: 4.27 ± 0.094	0.945IleMet: 0.945 ± 0.041	1.277IleAsn: 1.277 ± 0.047	2.309IlePro: 2.309 ± 0.055	1.099IleGln: 1.099 ± 0.041	2.775IleArg: 2.775 ± 0.072	2.616IleSer: 2.616 ± 0.07	2.463IleThr: 2.463 ± 0.064	4.217IleVal: 4.217 ± 0.09	0.594IleTrp: 0.594 ± 0.033	1.151IleTyr: 1.151 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.597LysAla: 4.597 ± 0.093	0.225LysCys: 0.225 ± 0.02	2.288LysAsp: 2.288 ± 0.063	2.25LysGlu: 2.25 ± 0.07	1.058LysPhe: 1.058 ± 0.043	3.007LysGly: 3.007 ± 0.084	0.7LysHis: 0.7 ± 0.038	1.886LysIle: 1.886 ± 0.051	1.779LysLys: 1.779 ± 0.065	3.789LysLeu: 3.789 ± 0.09	0.736LysMet: 0.736 ± 0.038	1.034LysAsn: 1.034 ± 0.042	2.521LysPro: 2.521 ± 0.072	1.203LysGln: 1.203 ± 0.044	2.993LysArg: 2.993 ± 0.067	2.217LysSer: 2.217 ± 0.049	2.324LysThr: 2.324 ± 0.071	2.717LysVal: 2.717 ± 0.077	0.445LysTrp: 0.445 ± 0.026	0.706LysTyr: 0.706 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	13.109LeuAla: 13.109 ± 0.17	0.913LeuCys: 0.913 ± 0.036	6.126LeuAsp: 6.126 ± 0.106	5.478LeuGlu: 5.478 ± 0.105	3.715LeuPhe: 3.715 ± 0.087	8.53LeuGly: 8.53 ± 0.137	1.875LeuHis: 1.875 ± 0.057	5.314LeuIle: 5.314 ± 0.103	4.321LeuLys: 4.321 ± 0.083	9.638LeuLeu: 9.638 ± 0.167	2.175LeuMet: 2.175 ± 0.058	2.447LeuAsn: 2.447 ± 0.061	5.399LeuPro: 5.399 ± 0.088	2.581LeuGln: 2.581 ± 0.06	6.612LeuArg: 6.612 ± 0.115	5.954LeuSer: 5.954 ± 0.088	5.548LeuThr: 5.548 ± 0.091	7.443LeuVal: 7.443 ± 0.121	1.195LeuTrp: 1.195 ± 0.044	2.246LeuTyr: 2.246 ± 0.074	0.0LeuXaa: 0.0 ± 0.0
Met	2.827MetAla: 2.827 ± 0.074	0.178MetCys: 0.178 ± 0.015	1.06MetAsp: 1.06 ± 0.039	1.186MetGlu: 1.186 ± 0.039	0.755MetPhe: 0.755 ± 0.032	1.686MetGly: 1.686 ± 0.064	0.495MetHis: 0.495 ± 0.024	1.224MetIle: 1.224 ± 0.044	0.993MetLys: 0.993 ± 0.043	2.406MetLeu: 2.406 ± 0.066	0.587MetMet: 0.587 ± 0.036	0.676MetAsn: 0.676 ± 0.031	1.531MetPro: 1.531 ± 0.054	0.714MetGln: 0.714 ± 0.031	1.954MetArg: 1.954 ± 0.062	1.571MetSer: 1.571 ± 0.045	1.69MetThr: 1.69 ± 0.057	1.596MetVal: 1.596 ± 0.057	0.244MetTrp: 0.244 ± 0.021	0.326MetTyr: 0.326 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.802AsnAla: 2.802 ± 0.078	0.301AsnCys: 0.301 ± 0.025	1.448AsnAsp: 1.448 ± 0.051	1.43AsnGlu: 1.43 ± 0.051	0.989AsnPhe: 0.989 ± 0.041	2.246AsnGly: 2.246 ± 0.06	0.471AsnHis: 0.471 ± 0.03	1.213AsnIle: 1.213 ± 0.048	0.889AsnLys: 0.889 ± 0.04	2.387AsnLeu: 2.387 ± 0.07	0.62AsnMet: 0.62 ± 0.033	0.708AsnAsn: 0.708 ± 0.038	1.802AsnPro: 1.802 ± 0.057	0.692AsnGln: 0.692 ± 0.037	1.724AsnArg: 1.724 ± 0.062	1.23AsnSer: 1.23 ± 0.057	1.208AsnThr: 1.208 ± 0.05	2.026AsnVal: 2.026 ± 0.068	0.413AsnTrp: 0.413 ± 0.026	0.708AsnTyr: 0.708 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	5.898ProAla: 5.898 ± 0.119	0.451ProCys: 0.451 ± 0.027	3.77ProAsp: 3.77 ± 0.078	4.251ProGlu: 4.251 ± 0.095	2.083ProPhe: 2.083 ± 0.052	4.513ProGly: 4.513 ± 0.097	1.083ProHis: 1.083 ± 0.039	2.392ProIle: 2.392 ± 0.062	2.233ProLys: 2.233 ± 0.065	4.672ProLeu: 4.672 ± 0.088	1.255ProMet: 1.255 ± 0.046	1.413ProAsn: 1.413 ± 0.049	3.095ProPro: 3.095 ± 0.077	1.741ProGln: 1.741 ± 0.063	3.371ProArg: 3.371 ± 0.08	3.107ProSer: 3.107 ± 0.062	2.539ProThr: 2.539 ± 0.063	3.859ProVal: 3.859 ± 0.074	0.738ProTrp: 0.738 ± 0.037	1.336ProTyr: 1.336 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	3.835GlnAla: 3.835 ± 0.074	0.219GlnCys: 0.219 ± 0.019	1.549GlnAsp: 1.549 ± 0.048	1.768GlnGlu: 1.768 ± 0.058	1.023GlnPhe: 1.023 ± 0.037	2.46GlnGly: 2.46 ± 0.059	0.635GlnHis: 0.635 ± 0.031	1.522GlnIle: 1.522 ± 0.046	1.129GlnLys: 1.129 ± 0.05	2.726GlnLeu: 2.726 ± 0.068	0.811GlnMet: 0.811 ± 0.037	0.792GlnAsn: 0.792 ± 0.035	1.613GlnPro: 1.613 ± 0.058	1.06GlnGln: 1.06 ± 0.046	2.253GlnArg: 2.253 ± 0.076	1.73GlnSer: 1.73 ± 0.048	1.588GlnThr: 1.588 ± 0.055	2.148GlnVal: 2.148 ± 0.057	0.404GlnTrp: 0.404 ± 0.025	0.555GlnTyr: 0.555 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.926ArgAla: 7.926 ± 0.134	0.681ArgCys: 0.681 ± 0.036	3.857ArgAsp: 3.857 ± 0.087	4.108ArgGlu: 4.108 ± 0.083	2.796ArgPhe: 2.796 ± 0.069	5.008ArgGly: 5.008 ± 0.095	1.664ArgHis: 1.664 ± 0.054	3.485ArgIle: 3.485 ± 0.077	2.622ArgLys: 2.622 ± 0.068	7.572ArgLeu: 7.572 ± 0.134	1.758ArgMet: 1.758 ± 0.055	1.859ArgAsn: 1.859 ± 0.056	3.662ArgPro: 3.662 ± 0.08	2.301ArgGln: 2.301 ± 0.062	5.819ArgArg: 5.819 ± 0.136	3.977ArgSer: 3.977 ± 0.09	3.272ArgThr: 3.272 ± 0.067	4.676ArgVal: 4.676 ± 0.084	0.979ArgTrp: 0.979 ± 0.041	1.888ArgTyr: 1.888 ± 0.062	0.0ArgXaa: 0.0 ± 0.0
Ser	6.193SerAla: 6.193 ± 0.106	0.528SerCys: 0.528 ± 0.029	2.914SerAsp: 2.914 ± 0.068	2.999SerGlu: 2.999 ± 0.062	2.282SerPhe: 2.282 ± 0.064	5.218SerGly: 5.218 ± 0.117	1.086SerHis: 1.086 ± 0.04	2.465SerIle: 2.465 ± 0.066	1.922SerLys: 1.922 ± 0.052	5.387SerLeu: 5.387 ± 0.095	1.396SerMet: 1.396 ± 0.052	1.336SerAsn: 1.336 ± 0.047	3.124SerPro: 3.124 ± 0.076	1.629SerGln: 1.629 ± 0.058	3.74SerArg: 3.74 ± 0.079	3.053SerSer: 3.053 ± 0.081	2.58SerThr: 2.58 ± 0.062	3.843SerVal: 3.843 ± 0.076	0.839SerTrp: 0.839 ± 0.038	1.359SerTyr: 1.359 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	6.088ThrAla: 6.088 ± 0.115	0.494ThrCys: 0.494 ± 0.03	2.761ThrAsp: 2.761 ± 0.061	2.946ThrGlu: 2.946 ± 0.074	2.003ThrPhe: 2.003 ± 0.058	4.958ThrGly: 4.958 ± 0.094	0.981ThrHis: 0.981 ± 0.042	2.637ThrIle: 2.637 ± 0.065	1.785ThrLys: 1.785 ± 0.061	5.614ThrLeu: 5.614 ± 0.085	1.2ThrMet: 1.2 ± 0.046	1.244ThrAsn: 1.244 ± 0.044	3.218ThrPro: 3.218 ± 0.074	1.418ThrGln: 1.418 ± 0.048	3.337ThrArg: 3.337 ± 0.073	2.79ThrSer: 2.79 ± 0.055	2.622ThrThr: 2.622 ± 0.074	4.28ThrVal: 4.28 ± 0.087	0.676ThrTrp: 0.676 ± 0.036	1.342ThrTyr: 1.342 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	8.642ValAla: 8.642 ± 0.114	0.678ValCys: 0.678 ± 0.031	4.092ValAsp: 4.092 ± 0.087	4.549ValGlu: 4.549 ± 0.091	2.717ValPhe: 2.717 ± 0.07	5.434ValGly: 5.434 ± 0.104	1.397ValHis: 1.397 ± 0.049	3.933ValIle: 3.933 ± 0.077	2.572ValLys: 2.572 ± 0.065	7.814ValLeu: 7.814 ± 0.116	1.728ValMet: 1.728 ± 0.056	1.91ValAsn: 1.91 ± 0.062	3.892ValPro: 3.892 ± 0.072	1.905ValGln: 1.905 ± 0.053	4.635ValArg: 4.635 ± 0.089	4.354ValSer: 4.354 ± 0.085	4.398ValThr: 4.398 ± 0.087	5.868ValVal: 5.868 ± 0.111	1.072ValTrp: 1.072 ± 0.042	1.741ValTyr: 1.741 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	1.26TrpAla: 1.26 ± 0.046	0.175TrpCys: 0.175 ± 0.017	0.675TrpAsp: 0.675 ± 0.038	0.68TrpGlu: 0.68 ± 0.034	0.609TrpPhe: 0.609 ± 0.037	1.019TrpGly: 1.019 ± 0.044	0.32TrpHis: 0.32 ± 0.024	0.711TrpIle: 0.711 ± 0.031	0.497TrpLys: 0.497 ± 0.032	1.695TrpLeu: 1.695 ± 0.054	0.367TrpMet: 0.367 ± 0.023	0.435TrpAsn: 0.435 ± 0.025	0.746TrpPro: 0.746 ± 0.038	0.609TrpGln: 0.609 ± 0.027	1.266TrpArg: 1.266 ± 0.045	0.823TrpSer: 0.823 ± 0.039	0.768TrpThr: 0.768 ± 0.036	0.831TrpVal: 0.831 ± 0.034	0.27TrpTrp: 0.27 ± 0.022	0.369TrpTyr: 0.369 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.496TyrAla: 2.496 ± 0.072	0.319TyrCys: 0.319 ± 0.024	1.634TyrAsp: 1.634 ± 0.052	1.416TyrGlu: 1.416 ± 0.049	1.011TyrPhe: 1.011 ± 0.045	2.239TyrGly: 2.239 ± 0.075	0.501TyrHis: 0.501 ± 0.028	0.978TyrIle: 0.978 ± 0.042	0.779TyrLys: 0.779 ± 0.034	2.499TyrLeu: 2.499 ± 0.07	0.506TyrMet: 0.506 ± 0.03	0.596TyrAsn: 0.596 ± 0.037	1.088TyrPro: 1.088 ± 0.045	0.771TyrGln: 0.771 ± 0.033	1.886TyrArg: 1.886 ± 0.06	1.159TyrSer: 1.159 ± 0.041	1.142TyrThr: 1.142 ± 0.046	1.78TyrVal: 1.78 ± 0.051	0.438TyrTrp: 0.438 ± 0.027	0.727TyrTyr: 0.727 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2602 proteins (634150 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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