Amino acid dipepetide frequency for Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.308AlaAla: 20.308 ± 0.137	1.048AlaCys: 1.048 ± 0.02	8.287AlaAsp: 8.287 ± 0.061	9.089AlaGlu: 9.089 ± 0.083	3.49AlaPhe: 3.49 ± 0.036	11.934AlaGly: 11.934 ± 0.08	2.96AlaHis: 2.96 ± 0.032	3.42AlaIle: 3.42 ± 0.038	2.834AlaLys: 2.834 ± 0.042	14.651AlaLeu: 14.651 ± 0.094	2.432AlaMet: 2.432 ± 0.034	1.983AlaAsn: 1.983 ± 0.027	6.786AlaPro: 6.786 ± 0.066	3.848AlaGln: 3.848 ± 0.042	10.045AlaArg: 10.045 ± 0.066	5.831AlaSer: 5.831 ± 0.057	6.986AlaThr: 6.986 ± 0.056	11.994AlaVal: 11.994 ± 0.083	1.931AlaTrp: 1.931 ± 0.025	2.832AlaTyr: 2.832 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.092CysAla: 1.092 ± 0.016	0.092CysCys: 0.092 ± 0.006	0.469CysAsp: 0.469 ± 0.013	0.421CysGlu: 0.421 ± 0.011	0.221CysPhe: 0.221 ± 0.009	0.958CysGly: 0.958 ± 0.018	0.186CysHis: 0.186 ± 0.007	0.159CysIle: 0.159 ± 0.007	0.11CysLys: 0.11 ± 0.006	0.795CysLeu: 0.795 ± 0.016	0.126CysMet: 0.126 ± 0.006	0.131CysAsn: 0.131 ± 0.008	0.497CysPro: 0.497 ± 0.015	0.174CysGln: 0.174 ± 0.008	0.607CysArg: 0.607 ± 0.015	0.423CysSer: 0.423 ± 0.013	0.543CysThr: 0.543 ± 0.015	0.679CysVal: 0.679 ± 0.016	0.14CysTrp: 0.14 ± 0.007	0.15CysTyr: 0.15 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.547AspAla: 7.547 ± 0.067	0.462AspCys: 0.462 ± 0.013	3.693AspAsp: 3.693 ± 0.041	3.928AspGlu: 3.928 ± 0.041	1.759AspPhe: 1.759 ± 0.027	6.359AspGly: 6.359 ± 0.056	1.444AspHis: 1.444 ± 0.024	1.953AspIle: 1.953 ± 0.025	1.248AspLys: 1.248 ± 0.027	6.369AspLeu: 6.369 ± 0.049	0.831AspMet: 0.831 ± 0.017	1.005AspAsn: 1.005 ± 0.023	4.553AspPro: 4.553 ± 0.051	1.57AspGln: 1.57 ± 0.023	4.93AspArg: 4.93 ± 0.045	2.715AspSer: 2.715 ± 0.035	3.304AspThr: 3.304 ± 0.034	4.692AspVal: 4.692 ± 0.038	1.1AspTrp: 1.1 ± 0.021	1.167AspTyr: 1.167 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.419GluAla: 7.419 ± 0.065	0.382GluCys: 0.382 ± 0.012	3.008GluAsp: 3.008 ± 0.037	3.776GluGlu: 3.776 ± 0.051	1.561GluPhe: 1.561 ± 0.025	4.439GluGly: 4.439 ± 0.038	1.574GluHis: 1.574 ± 0.024	2.32GluIle: 2.32 ± 0.032	1.454GluLys: 1.454 ± 0.024	7.153GluLeu: 7.153 ± 0.061	0.844GluMet: 0.844 ± 0.02	1.052GluAsn: 1.052 ± 0.021	3.667GluPro: 3.667 ± 0.045	2.33GluGln: 2.33 ± 0.032	5.579GluArg: 5.579 ± 0.055	2.726GluSer: 2.726 ± 0.031	2.967GluThr: 2.967 ± 0.035	4.55GluVal: 4.55 ± 0.049	0.835GluTrp: 0.835 ± 0.017	1.165GluTyr: 1.165 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.626PheAla: 3.626 ± 0.043	0.258PheCys: 0.258 ± 0.01	1.967PheAsp: 1.967 ± 0.03	1.535PheGlu: 1.535 ± 0.022	0.865PhePhe: 0.865 ± 0.022	2.983PheGly: 2.983 ± 0.036	0.614PheHis: 0.614 ± 0.016	0.699PheIle: 0.699 ± 0.016	0.524PheLys: 0.524 ± 0.014	2.609PheLeu: 2.609 ± 0.034	0.412PheMet: 0.412 ± 0.014	0.601PheAsn: 0.601 ± 0.016	1.403PhePro: 1.403 ± 0.023	0.709PheGln: 0.709 ± 0.015	1.898PheArg: 1.898 ± 0.025	1.427PheSer: 1.427 ± 0.022	2.029PheThr: 2.029 ± 0.027	2.234PheVal: 2.234 ± 0.029	0.441PheTrp: 0.441 ± 0.015	0.587PheTyr: 0.587 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.611GlyAla: 10.611 ± 0.073	0.839GlyCys: 0.839 ± 0.019	5.157GlyAsp: 5.157 ± 0.048	5.212GlyGlu: 5.212 ± 0.046	2.826GlyPhe: 2.826 ± 0.036	8.28GlyGly: 8.28 ± 0.084	2.281GlyHis: 2.281 ± 0.031	3.43GlyIle: 3.43 ± 0.038	2.402GlyLys: 2.402 ± 0.03	9.303GlyLeu: 9.303 ± 0.061	1.919GlyMet: 1.919 ± 0.029	1.747GlyAsn: 1.747 ± 0.029	4.98GlyPro: 4.98 ± 0.047	2.638GlyGln: 2.638 ± 0.028	7.43GlyArg: 7.43 ± 0.066	5.267GlySer: 5.267 ± 0.054	6.264GlyThr: 6.264 ± 0.053	7.36GlyVal: 7.36 ± 0.052	1.75GlyTrp: 1.75 ± 0.025	2.253GlyTyr: 2.253 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.762HisAla: 2.762 ± 0.032	0.229HisCys: 0.229 ± 0.009	1.382HisAsp: 1.382 ± 0.021	1.28HisGlu: 1.28 ± 0.022	0.673HisPhe: 0.673 ± 0.016	2.38HisGly: 2.38 ± 0.031	0.712HisHis: 0.712 ± 0.019	0.698HisIle: 0.698 ± 0.017	0.376HisLys: 0.376 ± 0.013	2.486HisLeu: 2.486 ± 0.029	0.332HisMet: 0.332 ± 0.01	0.401HisAsn: 0.401 ± 0.011	1.81HisPro: 1.81 ± 0.027	0.677HisGln: 0.677 ± 0.016	2.147HisArg: 2.147 ± 0.03	1.084HisSer: 1.084 ± 0.019	1.363HisThr: 1.363 ± 0.024	1.688HisVal: 1.688 ± 0.027	0.386HisTrp: 0.386 ± 0.012	0.51HisTyr: 0.51 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.759IleAla: 4.759 ± 0.044	0.289IleCys: 0.289 ± 0.01	2.261IleAsp: 2.261 ± 0.032	2.045IleGlu: 2.045 ± 0.031	0.693IlePhe: 0.693 ± 0.016	3.531IleGly: 3.531 ± 0.04	0.637IleHis: 0.637 ± 0.014	0.847IleIle: 0.847 ± 0.018	0.75IleLys: 0.75 ± 0.019	2.44IleLeu: 2.44 ± 0.032	0.438IleMet: 0.438 ± 0.014	0.712IleAsn: 0.712 ± 0.017	1.857IlePro: 1.857 ± 0.024	0.768IleGln: 0.768 ± 0.016	2.353IleArg: 2.353 ± 0.031	1.681IleSer: 1.681 ± 0.024	2.272IleThr: 2.272 ± 0.032	2.645IleVal: 2.645 ± 0.037	0.396IleTrp: 0.396 ± 0.011	0.545IleTyr: 0.545 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.94LysAla: 2.94 ± 0.041	0.131LysCys: 0.131 ± 0.008	1.398LysAsp: 1.398 ± 0.028	1.252LysGlu: 1.252 ± 0.025	0.478LysPhe: 0.478 ± 0.013	1.847LysGly: 1.847 ± 0.03	0.44LysHis: 0.44 ± 0.014	0.843LysIle: 0.843 ± 0.021	0.864LysLys: 0.864 ± 0.028	2.055LysLeu: 2.055 ± 0.03	0.383LysMet: 0.383 ± 0.013	0.536LysAsn: 0.536 ± 0.015	1.39LysPro: 1.39 ± 0.022	0.732LysGln: 0.732 ± 0.019	1.459LysArg: 1.459 ± 0.021	1.238LysSer: 1.238 ± 0.026	1.31LysThr: 1.31 ± 0.026	1.95LysVal: 1.95 ± 0.027	0.304LysTrp: 0.304 ± 0.011	0.489LysTyr: 0.489 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.116LeuAla: 15.116 ± 0.089	0.867LeuCys: 0.867 ± 0.019	6.883LeuAsp: 6.883 ± 0.059	4.731LeuGlu: 4.731 ± 0.044	2.669LeuPhe: 2.669 ± 0.036	9.254LeuGly: 9.254 ± 0.062	2.41LeuHis: 2.41 ± 0.034	3.407LeuIle: 3.407 ± 0.036	2.215LeuLys: 2.215 ± 0.032	11.54LeuLeu: 11.54 ± 0.095	1.657LeuMet: 1.657 ± 0.026	1.786LeuAsn: 1.786 ± 0.031	6.607LeuPro: 6.607 ± 0.051	2.193LeuGln: 2.193 ± 0.03	8.725LeuArg: 8.725 ± 0.067	5.408LeuSer: 5.408 ± 0.05	7.197LeuThr: 7.197 ± 0.059	8.677LeuVal: 8.677 ± 0.062	1.355LeuTrp: 1.355 ± 0.025	1.969LeuTyr: 1.969 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.194MetAla: 2.194 ± 0.031	0.133MetCys: 0.133 ± 0.007	0.895MetAsp: 0.895 ± 0.016	0.768MetGlu: 0.768 ± 0.014	0.453MetPhe: 0.453 ± 0.016	1.292MetGly: 1.292 ± 0.024	0.363MetHis: 0.363 ± 0.011	0.644MetIle: 0.644 ± 0.015	0.424MetLys: 0.424 ± 0.014	1.651MetLeu: 1.651 ± 0.027	0.283MetMet: 0.283 ± 0.011	0.43MetAsn: 0.43 ± 0.012	1.103MetPro: 1.103 ± 0.023	0.452MetGln: 0.452 ± 0.013	1.421MetArg: 1.421 ± 0.022	1.314MetSer: 1.314 ± 0.023	1.573MetThr: 1.573 ± 0.022	1.218MetVal: 1.218 ± 0.023	0.216MetTrp: 0.216 ± 0.007	0.322MetTyr: 0.322 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.192AsnAla: 2.192 ± 0.03	0.185AsnCys: 0.185 ± 0.008	1.002AsnAsp: 1.002 ± 0.02	0.839AsnGlu: 0.839 ± 0.017	0.509AsnPhe: 0.509 ± 0.014	1.942AsnGly: 1.942 ± 0.032	0.422AsnHis: 0.422 ± 0.013	0.665AsnIle: 0.665 ± 0.017	0.427AsnLys: 0.427 ± 0.014	1.703AsnLeu: 1.703 ± 0.023	0.305AsnMet: 0.305 ± 0.011	0.462AsnAsn: 0.462 ± 0.017	1.412AsnPro: 1.412 ± 0.023	0.573AsnGln: 0.573 ± 0.014	1.312AsnArg: 1.312 ± 0.022	1.03AsnSer: 1.03 ± 0.021	1.182AsnThr: 1.182 ± 0.025	1.358AsnVal: 1.358 ± 0.025	0.326AsnTrp: 0.326 ± 0.011	0.418AsnTyr: 0.418 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.134ProAla: 8.134 ± 0.073	0.338ProCys: 0.338 ± 0.011	4.552ProAsp: 4.552 ± 0.044	4.675ProGlu: 4.675 ± 0.043	1.545ProPhe: 1.545 ± 0.026	6.303ProGly: 6.303 ± 0.056	1.383ProHis: 1.383 ± 0.025	1.332ProIle: 1.332 ± 0.02	1.236ProLys: 1.236 ± 0.024	5.519ProLeu: 5.519 ± 0.05	1.016ProMet: 1.016 ± 0.018	0.963ProAsn: 0.963 ± 0.02	3.506ProPro: 3.506 ± 0.05	1.816ProGln: 1.816 ± 0.036	3.916ProArg: 3.916 ± 0.042	3.226ProSer: 3.226 ± 0.035	3.406ProThr: 3.406 ± 0.036	5.474ProVal: 5.474 ± 0.045	0.906ProTrp: 0.906 ± 0.02	1.448ProTyr: 1.448 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.767GlnAla: 3.767 ± 0.039	0.178GlnCys: 0.178 ± 0.009	1.466GlnAsp: 1.466 ± 0.023	1.542GlnGlu: 1.542 ± 0.024	0.685GlnPhe: 0.685 ± 0.014	2.366GlnGly: 2.366 ± 0.025	0.686GlnHis: 0.686 ± 0.016	1.094GlnIle: 1.094 ± 0.02	0.603GlnLys: 0.603 ± 0.018	3.146GlnLeu: 3.146 ± 0.033	0.481GlnMet: 0.481 ± 0.015	0.528GlnAsn: 0.528 ± 0.014	1.749GlnPro: 1.749 ± 0.032	1.298GlnGln: 1.298 ± 0.029	2.399GlnArg: 2.399 ± 0.029	1.352GlnSer: 1.352 ± 0.021	1.352GlnThr: 1.352 ± 0.022	2.433GlnVal: 2.433 ± 0.03	0.526GlnTrp: 0.526 ± 0.014	0.641GlnTyr: 0.641 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.701ArgAla: 9.701 ± 0.069	0.598ArgCys: 0.598 ± 0.017	4.164ArgAsp: 4.164 ± 0.04	4.771ArgGlu: 4.771 ± 0.045	2.31ArgPhe: 2.31 ± 0.029	5.685ArgGly: 5.685 ± 0.051	2.161ArgHis: 2.161 ± 0.031	3.306ArgIle: 3.306 ± 0.031	1.663ArgLys: 1.663 ± 0.028	8.988ArgLeu: 8.988 ± 0.073	1.724ArgMet: 1.724 ± 0.027	1.356ArgAsn: 1.356 ± 0.024	4.954ArgPro: 4.954 ± 0.049	2.34ArgGln: 2.34 ± 0.031	7.627ArgArg: 7.627 ± 0.075	3.958ArgSer: 3.958 ± 0.039	5.509ArgThr: 5.509 ± 0.05	5.761ArgVal: 5.761 ± 0.047	1.416ArgTrp: 1.416 ± 0.026	1.825ArgTyr: 1.825 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.778SerAla: 6.778 ± 0.058	0.42SerCys: 0.42 ± 0.014	2.758SerAsp: 2.758 ± 0.031	2.535SerGlu: 2.535 ± 0.032	1.541SerPhe: 1.541 ± 0.024	5.943SerGly: 5.943 ± 0.049	1.015SerHis: 1.015 ± 0.018	1.405SerIle: 1.405 ± 0.025	1.071SerLys: 1.071 ± 0.022	4.911SerLeu: 4.911 ± 0.049	1.069SerMet: 1.069 ± 0.019	0.932SerAsn: 0.932 ± 0.018	3.172SerPro: 3.172 ± 0.033	1.267SerGln: 1.267 ± 0.021	3.676SerArg: 3.676 ± 0.035	2.828SerSer: 2.828 ± 0.041	3.1SerThr: 3.1 ± 0.042	4.346SerVal: 4.346 ± 0.039	0.953SerTrp: 0.953 ± 0.017	1.288SerTyr: 1.288 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.937ThrAla: 8.937 ± 0.062	0.441ThrCys: 0.441 ± 0.013	3.818ThrAsp: 3.818 ± 0.035	3.502ThrGlu: 3.502 ± 0.039	1.597ThrPhe: 1.597 ± 0.025	6.649ThrGly: 6.649 ± 0.051	1.298ThrHis: 1.298 ± 0.022	1.766ThrIle: 1.766 ± 0.026	1.245ThrLys: 1.245 ± 0.026	5.914ThrLeu: 5.914 ± 0.059	0.933ThrMet: 0.933 ± 0.019	1.069ThrAsn: 1.069 ± 0.023	4.2ThrPro: 4.2 ± 0.042	1.425ThrGln: 1.425 ± 0.024	3.915ThrArg: 3.915 ± 0.041	3.173ThrSer: 3.173 ± 0.036	3.972ThrThr: 3.972 ± 0.051	6.093ThrVal: 6.093 ± 0.049	0.992ThrTrp: 0.992 ± 0.018	1.43ThrTyr: 1.43 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.314ValAla: 10.314 ± 0.071	0.752ValCys: 0.752 ± 0.018	4.991ValAsp: 4.991 ± 0.045	4.793ValGlu: 4.793 ± 0.04	2.339ValPhe: 2.339 ± 0.032	6.363ValGly: 6.363 ± 0.055	1.999ValHis: 1.999 ± 0.026	2.846ValIle: 2.846 ± 0.034	1.777ValLys: 1.777 ± 0.03	9.406ValLeu: 9.406 ± 0.069	1.415ValMet: 1.415 ± 0.022	1.681ValAsn: 1.681 ± 0.027	5.17ValPro: 5.17 ± 0.047	2.147ValGln: 2.147 ± 0.029	7.115ValArg: 7.115 ± 0.053	4.34ValSer: 4.34 ± 0.039	5.698ValThr: 5.698 ± 0.05	7.707ValVal: 7.707 ± 0.065	1.165ValTrp: 1.165 ± 0.023	1.596ValTyr: 1.596 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.709TrpAla: 1.709 ± 0.025	0.152TrpCys: 0.152 ± 0.007	0.87TrpAsp: 0.87 ± 0.016	0.778TrpGlu: 0.778 ± 0.015	0.523TrpPhe: 0.523 ± 0.014	1.07TrpGly: 1.07 ± 0.021	0.408TrpHis: 0.408 ± 0.012	0.576TrpIle: 0.576 ± 0.015	0.39TrpLys: 0.39 ± 0.012	1.871TrpLeu: 1.871 ± 0.032	0.297TrpMet: 0.297 ± 0.011	0.452TrpAsn: 0.452 ± 0.014	0.811TrpPro: 0.811 ± 0.016	0.683TrpGln: 0.683 ± 0.016	1.401TrpArg: 1.401 ± 0.024	0.982TrpSer: 0.982 ± 0.019	1.125TrpThr: 1.125 ± 0.021	1.026TrpVal: 1.026 ± 0.019	0.346TrpTrp: 0.346 ± 0.011	0.379TrpTyr: 0.379 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.783TyrAla: 2.783 ± 0.032	0.177TyrCys: 0.177 ± 0.007	1.61TyrAsp: 1.61 ± 0.028	1.331TyrGlu: 1.331 ± 0.019	0.683TyrPhe: 0.683 ± 0.016	2.371TyrGly: 2.371 ± 0.033	0.384TyrHis: 0.384 ± 0.012	0.508TyrIle: 0.508 ± 0.013	0.427TyrLys: 0.427 ± 0.013	2.153TyrLeu: 2.153 ± 0.03	0.249TyrMet: 0.249 ± 0.01	0.435TyrAsn: 0.435 ± 0.014	1.069TyrPro: 1.069 ± 0.018	0.65TyrGln: 0.65 ± 0.016	1.864TyrArg: 1.864 ± 0.03	1.003TyrSer: 1.003 ± 0.022	1.22TyrThr: 1.22 ± 0.023	1.73TyrVal: 1.73 ± 0.024	0.367TyrTrp: 0.367 ± 0.011	0.468TyrTyr: 0.468 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8553 proteins (2841216 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---