Amino acid dipepetide frequency for Clostridium homopropionicum DSM 5847

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.565AlaAla: 4.565 ± 0.099	0.756AlaCys: 0.756 ± 0.032	2.699AlaAsp: 2.699 ± 0.064	3.866AlaGlu: 3.866 ± 0.068	2.694AlaPhe: 2.694 ± 0.056	3.956AlaGly: 3.956 ± 0.079	0.855AlaHis: 0.855 ± 0.028	6.067AlaIle: 6.067 ± 0.088	4.892AlaLys: 4.892 ± 0.074	6.27AlaLeu: 6.27 ± 0.095	1.675AlaMet: 1.675 ± 0.043	2.575AlaAsn: 2.575 ± 0.049	1.503AlaPro: 1.503 ± 0.055	1.497AlaGln: 1.497 ± 0.038	1.992AlaArg: 1.992 ± 0.046	3.576AlaSer: 3.576 ± 0.065	2.815AlaThr: 2.815 ± 0.065	4.418AlaVal: 4.418 ± 0.076	0.352AlaTrp: 0.352 ± 0.023	2.241AlaTyr: 2.241 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.615CysAla: 0.615 ± 0.025	0.218CysCys: 0.218 ± 0.015	0.619CysAsp: 0.619 ± 0.02	0.76CysGlu: 0.76 ± 0.028	0.506CysPhe: 0.506 ± 0.023	1.061CysGly: 1.061 ± 0.034	0.199CysHis: 0.199 ± 0.013	1.116CysIle: 1.116 ± 0.034	0.922CysLys: 0.922 ± 0.033	0.817CysLeu: 0.817 ± 0.025	0.276CysMet: 0.276 ± 0.018	0.686CysAsn: 0.686 ± 0.025	0.491CysPro: 0.491 ± 0.024	0.216CysGln: 0.216 ± 0.016	0.418CysArg: 0.418 ± 0.022	0.818CysSer: 0.818 ± 0.032	0.548CysThr: 0.548 ± 0.023	0.605CysVal: 0.605 ± 0.02	0.064CysTrp: 0.064 ± 0.007	0.415CysTyr: 0.415 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.853AspAla: 2.853 ± 0.064	0.547AspCys: 0.547 ± 0.023	2.335AspAsp: 2.335 ± 0.058	4.193AspGlu: 4.193 ± 0.065	2.646AspPhe: 2.646 ± 0.05	3.207AspGly: 3.207 ± 0.076	0.554AspHis: 0.554 ± 0.025	5.925AspIle: 5.925 ± 0.083	5.382AspLys: 5.382 ± 0.086	4.704AspLeu: 4.704 ± 0.069	1.514AspMet: 1.514 ± 0.036	3.104AspAsn: 3.104 ± 0.058	1.369AspPro: 1.369 ± 0.042	0.8AspGln: 0.8 ± 0.03	1.8AspArg: 1.8 ± 0.045	3.208AspSer: 3.208 ± 0.072	2.538AspThr: 2.538 ± 0.057	3.245AspVal: 3.245 ± 0.055	0.354AspTrp: 0.354 ± 0.02	2.484AspTyr: 2.484 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	4.717GluAla: 4.717 ± 0.076	0.666GluCys: 0.666 ± 0.024	4.299GluAsp: 4.299 ± 0.068	7.398GluGlu: 7.398 ± 0.117	2.949GluPhe: 2.949 ± 0.059	4.235GluGly: 4.235 ± 0.061	0.948GluHis: 0.948 ± 0.033	7.565GluIle: 7.565 ± 0.082	8.019GluLys: 8.019 ± 0.103	6.749GluLeu: 6.749 ± 0.079	2.019GluMet: 2.019 ± 0.042	5.206GluAsn: 5.206 ± 0.073	1.494GluPro: 1.494 ± 0.037	1.936GluGln: 1.936 ± 0.04	2.774GluArg: 2.774 ± 0.068	3.426GluSer: 3.426 ± 0.063	3.057GluThr: 3.057 ± 0.058	4.969GluVal: 4.969 ± 0.079	0.453GluTrp: 0.453 ± 0.022	3.036GluTyr: 3.036 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	2.398PheAla: 2.398 ± 0.055	0.527PheCys: 0.527 ± 0.02	2.349PheAsp: 2.349 ± 0.05	2.652PheGlu: 2.652 ± 0.053	1.878PhePhe: 1.878 ± 0.047	2.908PheGly: 2.908 ± 0.056	0.589PheHis: 0.589 ± 0.026	4.66PheIle: 4.66 ± 0.088	3.731PheLys: 3.731 ± 0.06	3.933PheLeu: 3.933 ± 0.075	1.149PheMet: 1.149 ± 0.039	2.919PheAsn: 2.919 ± 0.056	1.215PhePro: 1.215 ± 0.034	1.133PheGln: 1.133 ± 0.032	1.328PheArg: 1.328 ± 0.035	3.153PheSer: 3.153 ± 0.058	2.343PheThr: 2.343 ± 0.05	2.461PheVal: 2.461 ± 0.047	0.299PheTrp: 0.299 ± 0.017	1.752PheTyr: 1.752 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.151GlyAla: 4.151 ± 0.081	0.891GlyCys: 0.891 ± 0.031	3.116GlyAsp: 3.116 ± 0.059	4.39GlyGlu: 4.39 ± 0.061	3.032GlyPhe: 3.032 ± 0.056	4.27GlyGly: 4.27 ± 0.087	1.031GlyHis: 1.031 ± 0.033	6.825GlyIle: 6.825 ± 0.085	5.762GlyLys: 5.762 ± 0.08	5.383GlyLeu: 5.383 ± 0.09	1.71GlyMet: 1.71 ± 0.046	3.339GlyAsn: 3.339 ± 0.09	1.229GlyPro: 1.229 ± 0.043	1.549GlyGln: 1.549 ± 0.044	2.203GlyArg: 2.203 ± 0.05	3.744GlySer: 3.744 ± 0.079	3.613GlyThr: 3.613 ± 0.086	4.433GlyVal: 4.433 ± 0.071	0.46GlyTrp: 0.46 ± 0.022	2.875GlyTyr: 2.875 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	0.691HisAla: 0.691 ± 0.026	0.197HisCys: 0.197 ± 0.013	0.681HisAsp: 0.681 ± 0.028	0.924HisGlu: 0.924 ± 0.032	0.593HisPhe: 0.593 ± 0.021	0.994HisGly: 0.994 ± 0.036	0.277HisHis: 0.277 ± 0.016	1.317HisIle: 1.317 ± 0.035	1.16HisLys: 1.16 ± 0.036	1.187HisLeu: 1.187 ± 0.036	0.359HisMet: 0.359 ± 0.018	0.81HisAsn: 0.81 ± 0.028	0.589HisPro: 0.589 ± 0.026	0.335HisGln: 0.335 ± 0.018	0.532HisArg: 0.532 ± 0.022	0.893HisSer: 0.893 ± 0.033	0.646HisThr: 0.646 ± 0.03	0.767HisVal: 0.767 ± 0.027	0.125HisTrp: 0.125 ± 0.012	0.535HisTyr: 0.535 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.87IleAla: 5.87 ± 0.089	1.176IleCys: 1.176 ± 0.036	5.807IleAsp: 5.807 ± 0.085	7.301IleGlu: 7.301 ± 0.095	4.307IlePhe: 4.307 ± 0.091	6.158IleGly: 6.158 ± 0.095	1.312IleHis: 1.312 ± 0.039	9.943IleIle: 9.943 ± 0.148	9.0IleLys: 9.0 ± 0.101	9.316IleLeu: 9.316 ± 0.127	2.283IleMet: 2.283 ± 0.049	6.532IleAsn: 6.532 ± 0.095	3.455IlePro: 3.455 ± 0.065	2.428IleGln: 2.428 ± 0.055	3.181IleArg: 3.181 ± 0.059	7.307IleSer: 7.307 ± 0.096	5.09IleThr: 5.09 ± 0.07	6.115IleVal: 6.115 ± 0.083	0.52IleTrp: 0.52 ± 0.023	3.626IleTyr: 3.626 ± 0.068	0.0IleXaa: 0.0 ± 0.0
Lys	5.453LysAla: 5.453 ± 0.083	0.822LysCys: 0.822 ± 0.033	5.692LysAsp: 5.692 ± 0.094	8.727LysGlu: 8.727 ± 0.124	3.215LysPhe: 3.215 ± 0.054	5.32LysGly: 5.32 ± 0.064	1.16LysHis: 1.16 ± 0.034	8.526LysIle: 8.526 ± 0.093	7.518LysLys: 7.518 ± 0.095	7.876LysLeu: 7.876 ± 0.081	2.369LysMet: 2.369 ± 0.045	6.026LysAsn: 6.026 ± 0.078	2.212LysPro: 2.212 ± 0.042	2.259LysGln: 2.259 ± 0.05	3.076LysArg: 3.076 ± 0.056	5.068LysSer: 5.068 ± 0.071	4.162LysThr: 4.162 ± 0.067	6.096LysVal: 6.096 ± 0.086	0.617LysTrp: 0.617 ± 0.024	3.974LysTyr: 3.974 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	5.253LeuAla: 5.253 ± 0.085	1.032LeuCys: 1.032 ± 0.034	4.848LeuAsp: 4.848 ± 0.072	6.611LeuGlu: 6.611 ± 0.098	3.779LeuPhe: 3.779 ± 0.077	6.014LeuGly: 6.014 ± 0.096	1.151LeuHis: 1.151 ± 0.034	8.677LeuIle: 8.677 ± 0.122	8.545LeuLys: 8.545 ± 0.091	7.981LeuLeu: 7.981 ± 0.107	2.352LeuMet: 2.352 ± 0.046	5.977LeuAsn: 5.977 ± 0.081	2.88LeuPro: 2.88 ± 0.053	2.268LeuGln: 2.268 ± 0.053	3.14LeuArg: 3.14 ± 0.057	6.584LeuSer: 6.584 ± 0.084	4.443LeuThr: 4.443 ± 0.073	5.381LeuVal: 5.381 ± 0.082	0.576LeuTrp: 0.576 ± 0.023	3.308LeuTyr: 3.308 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.79MetAla: 1.79 ± 0.042	0.246MetCys: 0.246 ± 0.016	1.577MetAsp: 1.577 ± 0.038	1.957MetGlu: 1.957 ± 0.046	0.94MetPhe: 0.94 ± 0.031	1.823MetGly: 1.823 ± 0.047	0.349MetHis: 0.349 ± 0.019	2.142MetIle: 2.142 ± 0.046	2.421MetLys: 2.421 ± 0.048	2.326MetLeu: 2.326 ± 0.051	0.636MetMet: 0.636 ± 0.028	1.705MetAsn: 1.705 ± 0.042	0.947MetPro: 0.947 ± 0.027	0.688MetGln: 0.688 ± 0.027	0.875MetArg: 0.875 ± 0.032	1.682MetSer: 1.682 ± 0.044	1.19MetThr: 1.19 ± 0.032	1.533MetVal: 1.533 ± 0.039	0.141MetTrp: 0.141 ± 0.012	0.859MetTyr: 0.859 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.05AsnAla: 3.05 ± 0.057	0.749AsnCys: 0.749 ± 0.03	2.671AsnAsp: 2.671 ± 0.053	4.249AsnGlu: 4.249 ± 0.077	2.541AsnPhe: 2.541 ± 0.053	3.561AsnGly: 3.561 ± 0.088	0.773AsnHis: 0.773 ± 0.028	6.928AsnIle: 6.928 ± 0.089	6.129AsnLys: 6.129 ± 0.096	5.775AsnLeu: 5.775 ± 0.068	1.556AsnMet: 1.556 ± 0.043	4.156AsnAsn: 4.156 ± 0.074	2.098AsnPro: 2.098 ± 0.05	1.427AsnGln: 1.427 ± 0.035	2.126AsnArg: 2.126 ± 0.052	4.252AsnSer: 4.252 ± 0.079	2.887AsnThr: 2.887 ± 0.061	3.409AsnVal: 3.409 ± 0.065	0.446AsnTrp: 0.446 ± 0.02	2.665AsnTyr: 2.665 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	1.503ProAla: 1.503 ± 0.049	0.314ProCys: 0.314 ± 0.018	1.375ProAsp: 1.375 ± 0.041	2.4ProGlu: 2.4 ± 0.047	1.437ProPhe: 1.437 ± 0.038	1.84ProGly: 1.84 ± 0.044	0.46ProHis: 0.46 ± 0.019	2.854ProIle: 2.854 ± 0.055	2.304ProLys: 2.304 ± 0.046	2.548ProLeu: 2.548 ± 0.048	0.762ProMet: 0.762 ± 0.028	1.566ProAsn: 1.566 ± 0.041	0.704ProPro: 0.704 ± 0.025	0.836ProGln: 0.836 ± 0.027	0.856ProArg: 0.856 ± 0.033	1.83ProSer: 1.83 ± 0.046	1.485ProThr: 1.485 ± 0.047	2.099ProVal: 2.099 ± 0.057	0.233ProTrp: 0.233 ± 0.014	1.253ProTyr: 1.253 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	1.46GlnAla: 1.46 ± 0.041	0.287GlnCys: 0.287 ± 0.017	1.253GlnAsp: 1.253 ± 0.035	1.838GlnGlu: 1.838 ± 0.048	0.994GlnPhe: 0.994 ± 0.027	1.602GlnGly: 1.602 ± 0.041	0.352GlnHis: 0.352 ± 0.022	2.283GlnIle: 2.283 ± 0.048	2.048GlnLys: 2.048 ± 0.046	2.331GlnLeu: 2.331 ± 0.045	0.76GlnMet: 0.76 ± 0.031	1.483GlnAsn: 1.483 ± 0.037	0.623GlnPro: 0.623 ± 0.026	0.752GlnGln: 0.752 ± 0.029	0.91GlnArg: 0.91 ± 0.029	1.351GlnSer: 1.351 ± 0.033	0.994GlnThr: 0.994 ± 0.033	1.743GlnVal: 1.743 ± 0.037	0.261GlnTrp: 0.261 ± 0.016	1.07GlnTyr: 1.07 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	1.939ArgAla: 1.939 ± 0.044	0.363ArgCys: 0.363 ± 0.021	1.796ArgAsp: 1.796 ± 0.041	3.09ArgGlu: 3.09 ± 0.062	1.449ArgPhe: 1.449 ± 0.038	1.999ArgGly: 1.999 ± 0.042	0.452ArgHis: 0.452 ± 0.019	3.387ArgIle: 3.387 ± 0.055	3.135ArgLys: 3.135 ± 0.065	3.034ArgLeu: 3.034 ± 0.059	0.947ArgMet: 0.947 ± 0.029	2.016ArgAsn: 2.016 ± 0.044	0.97ArgPro: 0.97 ± 0.031	0.93ArgGln: 0.93 ± 0.033	1.528ArgArg: 1.528 ± 0.047	1.583ArgSer: 1.583 ± 0.038	1.58ArgThr: 1.58 ± 0.038	2.298ArgVal: 2.298 ± 0.052	0.244ArgTrp: 0.244 ± 0.015	1.406ArgTyr: 1.406 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.305SerAla: 3.305 ± 0.067	0.665SerCys: 0.665 ± 0.024	2.98SerAsp: 2.98 ± 0.061	4.449SerGlu: 4.449 ± 0.065	3.072SerPhe: 3.072 ± 0.058	4.209SerGly: 4.209 ± 0.062	0.899SerHis: 0.899 ± 0.029	6.908SerIle: 6.908 ± 0.088	5.983SerLys: 5.983 ± 0.094	6.004SerLeu: 6.004 ± 0.091	1.657SerMet: 1.657 ± 0.036	3.872SerAsn: 3.872 ± 0.065	1.708SerPro: 1.708 ± 0.041	1.585SerGln: 1.585 ± 0.04	2.056SerArg: 2.056 ± 0.043	4.481SerSer: 4.481 ± 0.08	3.19SerThr: 3.19 ± 0.071	3.811SerVal: 3.811 ± 0.058	0.435SerTrp: 0.435 ± 0.024	2.524SerTyr: 2.524 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	3.231ThrAla: 3.231 ± 0.072	0.509ThrCys: 0.509 ± 0.024	2.357ThrAsp: 2.357 ± 0.052	3.261ThrGlu: 3.261 ± 0.058	2.166ThrPhe: 2.166 ± 0.049	3.764ThrGly: 3.764 ± 0.075	0.733ThrHis: 0.733 ± 0.024	4.863ThrIle: 4.863 ± 0.067	3.627ThrLys: 3.627 ± 0.062	4.702ThrLeu: 4.702 ± 0.068	1.12ThrMet: 1.12 ± 0.034	2.649ThrAsn: 2.649 ± 0.055	1.754ThrPro: 1.754 ± 0.053	1.139ThrGln: 1.139 ± 0.035	1.566ThrArg: 1.566 ± 0.039	3.273ThrSer: 3.273 ± 0.073	2.679ThrThr: 2.679 ± 0.07	3.349ThrVal: 3.349 ± 0.07	0.339ThrTrp: 0.339 ± 0.02	1.892ThrTyr: 1.892 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	3.977ValAla: 3.977 ± 0.07	0.773ValCys: 0.773 ± 0.026	3.636ValAsp: 3.636 ± 0.067	4.56ValGlu: 4.56 ± 0.074	2.867ValPhe: 2.867 ± 0.056	4.084ValGly: 4.084 ± 0.075	0.825ValHis: 0.825 ± 0.026	6.181ValIle: 6.181 ± 0.09	5.438ValLys: 5.438 ± 0.078	5.781ValLeu: 5.781 ± 0.083	1.547ValMet: 1.547 ± 0.042	3.616ValAsn: 3.616 ± 0.066	2.0ValPro: 2.0 ± 0.044	1.578ValGln: 1.578 ± 0.043	2.021ValArg: 2.021 ± 0.05	4.233ValSer: 4.233 ± 0.082	3.373ValThr: 3.373 ± 0.067	4.392ValVal: 4.392 ± 0.075	0.418ValTrp: 0.418 ± 0.02	2.355ValTyr: 2.355 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.369TrpAla: 0.369 ± 0.021	0.099TrpCys: 0.099 ± 0.009	0.399TrpAsp: 0.399 ± 0.02	0.465TrpGlu: 0.465 ± 0.024	0.288TrpPhe: 0.288 ± 0.019	0.49TrpGly: 0.49 ± 0.023	0.12TrpHis: 0.12 ± 0.012	0.644TrpIle: 0.644 ± 0.03	0.504TrpLys: 0.504 ± 0.025	0.595TrpLeu: 0.595 ± 0.022	0.185TrpMet: 0.185 ± 0.014	0.46TrpAsn: 0.46 ± 0.022	0.166TrpPro: 0.166 ± 0.013	0.222TrpGln: 0.222 ± 0.015	0.232TrpArg: 0.232 ± 0.016	0.42TrpSer: 0.42 ± 0.023	0.322TrpThr: 0.322 ± 0.019	0.396TrpVal: 0.396 ± 0.021	0.071TrpTrp: 0.071 ± 0.009	0.244TrpTyr: 0.244 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.075TyrAla: 2.075 ± 0.04	0.533TyrCys: 0.533 ± 0.022	2.273TyrAsp: 2.273 ± 0.07	2.823TyrGlu: 2.823 ± 0.057	2.024TyrPhe: 2.024 ± 0.044	2.51TyrGly: 2.51 ± 0.055	0.574TyrHis: 0.574 ± 0.024	3.917TyrIle: 3.917 ± 0.077	3.647TyrLys: 3.647 ± 0.064	3.49TyrLeu: 3.49 ± 0.071	0.95TyrMet: 0.95 ± 0.032	2.753TyrAsn: 2.753 ± 0.057	1.253TyrPro: 1.253 ± 0.033	0.816TyrGln: 0.816 ± 0.029	1.531TyrArg: 1.531 ± 0.035	2.913TyrSer: 2.913 ± 0.057	2.018TyrThr: 2.018 ± 0.055	2.133TyrVal: 2.133 ± 0.045	0.281TyrTrp: 0.281 ± 0.018	1.894TyrTyr: 1.894 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3499 proteins (1063634 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---