Amino acid dipepetide frequency for Burkholderia sp. TSV86

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.313AlaAla: 21.313 ± 0.221
1.517AlaCys: 1.517 ± 0.039
7.246AlaAsp: 7.246 ± 0.084
5.778AlaGlu: 5.778 ± 0.064
4.503AlaPhe: 4.503 ± 0.051
11.33AlaGly: 11.33 ± 0.112
3.374AlaHis: 3.374 ± 0.059
5.881AlaIle: 5.881 ± 0.066
3.81AlaLys: 3.81 ± 0.061
15.685AlaLeu: 15.685 ± 0.159
3.149AlaMet: 3.149 ± 0.046
3.496AlaAsn: 3.496 ± 0.069
6.748AlaPro: 6.748 ± 0.098
5.914AlaGln: 5.914 ± 0.073
10.685AlaArg: 10.685 ± 0.11
7.99AlaSer: 7.99 ± 0.104
6.207AlaThr: 6.207 ± 0.078
8.551AlaVal: 8.551 ± 0.085
1.811AlaTrp: 1.811 ± 0.035
2.96AlaTyr: 2.96 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.459CysAla: 1.459 ± 0.033
0.123CysCys: 0.123 ± 0.01
0.605CysAsp: 0.605 ± 0.02
0.521CysGlu: 0.521 ± 0.02
0.329CysPhe: 0.329 ± 0.017
1.047CysGly: 1.047 ± 0.028
0.241CysHis: 0.241 ± 0.012
0.419CysIle: 0.419 ± 0.016
0.2CysLys: 0.2 ± 0.011
0.71CysLeu: 0.71 ± 0.024
0.193CysMet: 0.193 ± 0.012
0.245CysAsn: 0.245 ± 0.012
0.42CysPro: 0.42 ± 0.016
0.194CysGln: 0.194 ± 0.01
0.712CysArg: 0.712 ± 0.024
0.528CysSer: 0.528 ± 0.018
0.479CysThr: 0.479 ± 0.016
0.879CysVal: 0.879 ± 0.026
0.129CysTrp: 0.129 ± 0.01
0.243CysTyr: 0.243 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
9.628AspAla: 9.628 ± 0.118
0.461AspCys: 0.461 ± 0.017
3.507AspAsp: 3.507 ± 0.051
3.637AspGlu: 3.637 ± 0.053
1.898AspPhe: 1.898 ± 0.037
4.967AspGly: 4.967 ± 0.062
1.117AspHis: 1.117 ± 0.028
2.49AspIle: 2.49 ± 0.04
1.639AspLys: 1.639 ± 0.031
4.954AspLeu: 4.954 ± 0.06
1.101AspMet: 1.101 ± 0.031
1.258AspAsn: 1.258 ± 0.034
2.954AspPro: 2.954 ± 0.044
1.452AspGln: 1.452 ± 0.03
3.191AspArg: 3.191 ± 0.05
2.406AspSer: 2.406 ± 0.043
2.938AspThr: 2.938 ± 0.049
4.415AspVal: 4.415 ± 0.055
0.984AspTrp: 0.984 ± 0.025
1.632AspTyr: 1.632 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
5.654GluAla: 5.654 ± 0.067
0.422GluCys: 0.422 ± 0.019
1.656GluAsp: 1.656 ± 0.039
1.71GluGlu: 1.71 ± 0.045
1.744GluPhe: 1.744 ± 0.037
2.842GluGly: 2.842 ± 0.051
1.51GluHis: 1.51 ± 0.033
2.848GluIle: 2.848 ± 0.051
1.487GluLys: 1.487 ± 0.038
5.343GluLeu: 5.343 ± 0.071
1.107GluMet: 1.107 ± 0.028
1.255GluAsn: 1.255 ± 0.038
2.732GluPro: 2.732 ± 0.045
2.286GluGln: 2.286 ± 0.044
5.418GluArg: 5.418 ± 0.072
2.31GluSer: 2.31 ± 0.042
2.611GluThr: 2.611 ± 0.045
2.868GluVal: 2.868 ± 0.06
0.699GluTrp: 0.699 ± 0.02
1.166GluTyr: 1.166 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
5.015PheAla: 5.015 ± 0.071
0.41PheCys: 0.41 ± 0.015
2.901PheAsp: 2.901 ± 0.045
1.95PheGlu: 1.95 ± 0.04
1.37PhePhe: 1.37 ± 0.032
3.679PheGly: 3.679 ± 0.04
0.757PheHis: 0.757 ± 0.023
1.525PheIle: 1.525 ± 0.029
0.996PheLys: 0.996 ± 0.029
2.59PheLeu: 2.59 ± 0.049
0.731PheMet: 0.731 ± 0.023
1.109PheAsn: 1.109 ± 0.031
1.414PhePro: 1.414 ± 0.031
0.893PheGln: 0.893 ± 0.022
1.921PheArg: 1.921 ± 0.036
2.151PheSer: 2.151 ± 0.036
1.815PheThr: 1.815 ± 0.034
3.28PheVal: 3.28 ± 0.044
0.5PheTrp: 0.5 ± 0.02
0.936PheTyr: 0.936 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
10.588GlyAla: 10.588 ± 0.129
0.898GlyCys: 0.898 ± 0.023
4.224GlyAsp: 4.224 ± 0.065
4.143GlyGlu: 4.143 ± 0.058
3.315GlyPhe: 3.315 ± 0.049
7.177GlyGly: 7.177 ± 0.105
1.802GlyHis: 1.802 ± 0.038
4.132GlyIle: 4.132 ± 0.059
2.965GlyLys: 2.965 ± 0.055
7.596GlyLeu: 7.596 ± 0.074
2.108GlyMet: 2.108 ± 0.041
2.395GlyAsn: 2.395 ± 0.048
2.876GlyPro: 2.876 ± 0.047
2.547GlyGln: 2.547 ± 0.039
5.534GlyArg: 5.534 ± 0.067
4.499GlySer: 4.499 ± 0.071
4.425GlyThr: 4.425 ± 0.067
6.808GlyVal: 6.808 ± 0.071
1.393GlyTrp: 1.393 ± 0.038
2.548GlyTyr: 2.548 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
3.6HisAla: 3.6 ± 0.062
0.282HisCys: 0.282 ± 0.013
1.459HisAsp: 1.459 ± 0.033
1.109HisGlu: 1.109 ± 0.028
0.942HisPhe: 0.942 ± 0.027
2.292HisGly: 2.292 ± 0.043
0.621HisHis: 0.621 ± 0.021
0.843HisIle: 0.843 ± 0.026
0.444HisLys: 0.444 ± 0.018
2.114HisLeu: 2.114 ± 0.042
0.437HisMet: 0.437 ± 0.018
0.492HisAsn: 0.492 ± 0.019
1.515HisPro: 1.515 ± 0.034
0.603HisGln: 0.603 ± 0.02
1.697HisArg: 1.697 ± 0.038
1.004HisSer: 1.004 ± 0.026
1.102HisThr: 1.102 ± 0.026
1.725HisVal: 1.725 ± 0.035
0.43HisTrp: 0.43 ± 0.019
0.703HisTyr: 0.703 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.607IleAla: 7.607 ± 0.075
0.438IleCys: 0.438 ± 0.018
3.915IleAsp: 3.915 ± 0.059
3.214IleGlu: 3.214 ± 0.056
1.32IlePhe: 1.32 ± 0.032
4.92IleGly: 4.92 ± 0.064
0.909IleHis: 0.909 ± 0.027
1.418IleIle: 1.418 ± 0.038
1.319IleLys: 1.319 ± 0.036
3.032IleLeu: 3.032 ± 0.05
0.672IleMet: 0.672 ± 0.022
1.326IleAsn: 1.326 ± 0.035
1.917IlePro: 1.917 ± 0.037
1.21IleGln: 1.21 ± 0.032
2.823IleArg: 2.823 ± 0.041
2.278IleSer: 2.278 ± 0.041
2.231IleThr: 2.231 ± 0.04
4.499IleVal: 4.499 ± 0.063
0.499IleTrp: 0.499 ± 0.018
1.026IleTyr: 1.026 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.184LysAla: 3.184 ± 0.053
0.158LysCys: 0.158 ± 0.009
1.285LysAsp: 1.285 ± 0.038
1.23LysGlu: 1.23 ± 0.04
0.882LysPhe: 0.882 ± 0.026
1.885LysGly: 1.885 ± 0.039
0.698LysHis: 0.698 ± 0.019
1.593LysIle: 1.593 ± 0.038
1.164LysLys: 1.164 ± 0.045
3.412LysLeu: 3.412 ± 0.056
0.731LysMet: 0.731 ± 0.023
0.895LysAsn: 0.895 ± 0.026
1.978LysPro: 1.978 ± 0.039
1.291LysGln: 1.291 ± 0.032
2.526LysArg: 2.526 ± 0.041
1.615LysSer: 1.615 ± 0.032
1.813LysThr: 1.813 ± 0.04
1.969LysVal: 1.969 ± 0.041
0.374LysTrp: 0.374 ± 0.017
0.692LysTyr: 0.692 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
14.736LeuAla: 14.736 ± 0.142
0.982LeuCys: 0.982 ± 0.026
6.52LeuAsp: 6.52 ± 0.072
4.609LeuGlu: 4.609 ± 0.072
3.479LeuPhe: 3.479 ± 0.053
7.883LeuGly: 7.883 ± 0.093
2.228LeuHis: 2.228 ± 0.039
4.523LeuIle: 4.523 ± 0.062
3.222LeuLys: 3.222 ± 0.052
9.292LeuLeu: 9.292 ± 0.103
2.114LeuMet: 2.114 ± 0.044
2.757LeuAsn: 2.757 ± 0.044
5.878LeuPro: 5.878 ± 0.061
2.976LeuGln: 2.976 ± 0.045
7.132LeuArg: 7.132 ± 0.079
6.219LeuSer: 6.219 ± 0.077
5.401LeuThr: 5.401 ± 0.065
7.27LeuVal: 7.27 ± 0.073
1.109LeuTrp: 1.109 ± 0.028
2.241LeuTyr: 2.241 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
2.249MetAla: 2.249 ± 0.04
0.164MetCys: 0.164 ± 0.01
0.804MetAsp: 0.804 ± 0.023
0.761MetGlu: 0.761 ± 0.024
0.715MetPhe: 0.715 ± 0.021
1.35MetGly: 1.35 ± 0.03
0.543MetHis: 0.543 ± 0.019
1.072MetIle: 1.072 ± 0.03
0.978MetLys: 0.978 ± 0.026
2.654MetLeu: 2.654 ± 0.044
0.578MetMet: 0.578 ± 0.024
0.803MetAsn: 0.803 ± 0.024
1.497MetPro: 1.497 ± 0.03
0.988MetGln: 0.988 ± 0.027
1.851MetArg: 1.851 ± 0.038
1.571MetSer: 1.571 ± 0.031
1.517MetThr: 1.517 ± 0.034
1.28MetVal: 1.28 ± 0.03
0.211MetTrp: 0.211 ± 0.012
0.381MetTyr: 0.381 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.715AsnAla: 3.715 ± 0.06
0.262AsnCys: 0.262 ± 0.012
1.481AsnAsp: 1.481 ± 0.031
1.25AsnGlu: 1.25 ± 0.03
0.965AsnPhe: 0.965 ± 0.026
2.686AsnGly: 2.686 ± 0.058
0.535AsnHis: 0.535 ± 0.02
1.14AsnIle: 1.14 ± 0.031
0.652AsnLys: 0.652 ± 0.022
2.684AsnLeu: 2.684 ± 0.047
0.537AsnMet: 0.537 ± 0.019
0.814AsnAsn: 0.814 ± 0.032
1.834AsnPro: 1.834 ± 0.041
0.976AsnGln: 0.976 ± 0.034
1.833AsnArg: 1.833 ± 0.04
1.335AsnSer: 1.335 ± 0.041
1.468AsnThr: 1.468 ± 0.038
2.244AsnVal: 2.244 ± 0.041
0.433AsnTrp: 0.433 ± 0.016
0.783AsnTyr: 0.783 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
7.572ProAla: 7.572 ± 0.086
0.394ProCys: 0.394 ± 0.017
3.324ProAsp: 3.324 ± 0.049
2.62ProGlu: 2.62 ± 0.041
1.992ProPhe: 1.992 ± 0.038
4.329ProGly: 4.329 ± 0.054
1.342ProHis: 1.342 ± 0.031
2.142ProIle: 2.142 ± 0.038
1.457ProLys: 1.457 ± 0.033
5.191ProLeu: 5.191 ± 0.063
1.04ProMet: 1.04 ± 0.026
1.542ProAsn: 1.542 ± 0.033
2.665ProPro: 2.665 ± 0.054
1.876ProGln: 1.876 ± 0.036
3.266ProArg: 3.266 ± 0.048
2.943ProSer: 2.943 ± 0.044
2.411ProThr: 2.411 ± 0.038
4.146ProVal: 4.146 ± 0.052
0.634ProTrp: 0.634 ± 0.02
1.25ProTyr: 1.25 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.663GlnAla: 4.663 ± 0.066
0.284GlnCys: 0.284 ± 0.014
1.293GlnAsp: 1.293 ± 0.025
1.144GlnGlu: 1.144 ± 0.029
1.204GlnPhe: 1.204 ± 0.029
2.23GlnGly: 2.23 ± 0.041
0.878GlnHis: 0.878 ± 0.026
2.027GlnIle: 2.027 ± 0.034
0.973GlnLys: 0.973 ± 0.029
3.579GlnLeu: 3.579 ± 0.05
0.961GlnMet: 0.961 ± 0.024
0.938GlnAsn: 0.938 ± 0.028
2.181GlnPro: 2.181 ± 0.038
1.849GlnGln: 1.849 ± 0.051
3.055GlnArg: 3.055 ± 0.047
1.91GlnSer: 1.91 ± 0.04
2.073GlnThr: 2.073 ± 0.036
2.28GlnVal: 2.28 ± 0.042
0.58GlnTrp: 0.58 ± 0.021
0.958GlnTyr: 0.958 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
9.816ArgAla: 9.816 ± 0.109
0.721ArgCys: 0.721 ± 0.024
4.513ArgAsp: 4.513 ± 0.062
4.162ArgGlu: 4.162 ± 0.066
3.032ArgPhe: 3.032 ± 0.049
5.045ArgGly: 5.045 ± 0.073
2.011ArgHis: 2.011 ± 0.043
3.943ArgIle: 3.943 ± 0.052
1.871ArgLys: 1.871 ± 0.038
7.278ArgLeu: 7.278 ± 0.079
1.832ArgMet: 1.832 ± 0.039
1.937ArgAsn: 1.937 ± 0.038
3.246ArgPro: 3.246 ± 0.047
2.558ArgGln: 2.558 ± 0.043
5.955ArgArg: 5.955 ± 0.076
3.324ArgSer: 3.324 ± 0.046
3.539ArgThr: 3.539 ± 0.049
5.497ArgVal: 5.497 ± 0.069
1.09ArgTrp: 1.09 ± 0.03
2.211ArgTyr: 2.211 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
7.34SerAla: 7.34 ± 0.096
0.446SerCys: 0.446 ± 0.017
2.765SerAsp: 2.765 ± 0.044
2.233SerGlu: 2.233 ± 0.044
2.084SerPhe: 2.084 ± 0.038
5.225SerGly: 5.225 ± 0.076
1.172SerHis: 1.172 ± 0.028
2.771SerIle: 2.771 ± 0.044
1.487SerLys: 1.487 ± 0.033
5.523SerLeu: 5.523 ± 0.063
1.25SerMet: 1.25 ± 0.027
1.693SerAsn: 1.693 ± 0.039
2.846SerPro: 2.846 ± 0.045
1.725SerGln: 1.725 ± 0.041
3.658SerArg: 3.658 ± 0.052
3.257SerSer: 3.257 ± 0.062
2.97SerThr: 2.97 ± 0.065
4.183SerVal: 4.183 ± 0.054
0.681SerTrp: 0.681 ± 0.023
1.381SerTyr: 1.381 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
5.909ThrAla: 5.909 ± 0.071
0.433ThrCys: 0.433 ± 0.018
2.611ThrAsp: 2.611 ± 0.043
2.037ThrGlu: 2.037 ± 0.038
1.93ThrPhe: 1.93 ± 0.038
4.739ThrGly: 4.739 ± 0.067
1.266ThrHis: 1.266 ± 0.029
2.684ThrIle: 2.684 ± 0.044
1.255ThrLys: 1.255 ± 0.032
6.6ThrLeu: 6.6 ± 0.069
1.016ThrMet: 1.016 ± 0.026
1.394ThrAsn: 1.394 ± 0.044
3.419ThrPro: 3.419 ± 0.046
1.908ThrGln: 1.908 ± 0.036
3.453ThrArg: 3.453 ± 0.045
2.837ThrSer: 2.837 ± 0.054
2.642ThrThr: 2.642 ± 0.056
3.962ThrVal: 3.962 ± 0.055
0.617ThrTrp: 0.617 ± 0.019
1.265ThrTyr: 1.265 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
9.585ValAla: 9.585 ± 0.085
0.858ValCys: 0.858 ± 0.024
4.44ValAsp: 4.44 ± 0.058
3.913ValGlu: 3.913 ± 0.058
2.661ValPhe: 2.661 ± 0.044
5.247ValGly: 5.247 ± 0.067
1.489ValHis: 1.489 ± 0.034
3.574ValIle: 3.574 ± 0.059
2.431ValLys: 2.431 ± 0.044
7.659ValLeu: 7.659 ± 0.081
1.628ValMet: 1.628 ± 0.031
2.177ValAsn: 2.177 ± 0.043
3.991ValPro: 3.991 ± 0.058
2.27ValGln: 2.27 ± 0.041
5.278ValArg: 5.278 ± 0.056
4.462ValSer: 4.462 ± 0.062
4.334ValThr: 4.334 ± 0.056
5.687ValVal: 5.687 ± 0.073
0.932ValTrp: 0.932 ± 0.025
1.702ValTyr: 1.702 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.232TrpAla: 1.232 ± 0.028
0.152TrpCys: 0.152 ± 0.01
0.592TrpAsp: 0.592 ± 0.024
0.466TrpGlu: 0.466 ± 0.018
0.559TrpPhe: 0.559 ± 0.022
0.844TrpGly: 0.844 ± 0.024
0.397TrpHis: 0.397 ± 0.016
0.723TrpIle: 0.723 ± 0.022
0.397TrpLys: 0.397 ± 0.014
2.03TrpLeu: 2.03 ± 0.042
0.338TrpMet: 0.338 ± 0.018
0.45TrpAsn: 0.45 ± 0.017
0.737TrpPro: 0.737 ± 0.023
0.637TrpGln: 0.637 ± 0.02
1.432TrpArg: 1.432 ± 0.033
0.763TrpSer: 0.763 ± 0.025
0.643TrpThr: 0.643 ± 0.02
0.831TrpVal: 0.831 ± 0.024
0.216TrpTrp: 0.216 ± 0.014
0.326TrpTyr: 0.326 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.084TyrAla: 3.084 ± 0.049
0.273TyrCys: 0.273 ± 0.013
1.49TyrAsp: 1.49 ± 0.033
1.181TyrGlu: 1.181 ± 0.029
1.015TyrPhe: 1.015 ± 0.025
2.254TyrGly: 2.254 ± 0.037
0.528TyrHis: 0.528 ± 0.02
0.826TyrIle: 0.826 ± 0.024
0.627TyrLys: 0.627 ± 0.022
2.644TyrLeu: 2.644 ± 0.041
0.444TyrMet: 0.444 ± 0.017
0.651TyrAsn: 0.651 ± 0.023
1.289TyrPro: 1.289 ± 0.03
0.908TyrGln: 0.908 ± 0.026
2.162TyrArg: 2.162 ± 0.044
1.287TyrSer: 1.287 ± 0.032
1.358TyrThr: 1.358 ± 0.032
1.941TyrVal: 1.941 ± 0.035
0.442TyrTrp: 0.442 ± 0.018
0.705TyrTyr: 0.705 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4805 proteins (1537092 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski