Amino acid dipepetide frequency for Cryptococcus depauperatus CBS 7841

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.872AlaAla: 6.872 ± 0.069	0.853AlaCys: 0.853 ± 0.017	3.395AlaAsp: 3.395 ± 0.035	4.717AlaGlu: 4.717 ± 0.047	2.819AlaPhe: 2.819 ± 0.033	5.042AlaGly: 5.042 ± 0.047	1.698AlaHis: 1.698 ± 0.025	4.18AlaIle: 4.18 ± 0.038	4.263AlaLys: 4.263 ± 0.041	7.399AlaLeu: 7.399 ± 0.059	1.806AlaMet: 1.806 ± 0.026	2.775AlaAsn: 2.775 ± 0.032	4.139AlaPro: 4.139 ± 0.052	3.205AlaGln: 3.205 ± 0.039	4.464AlaArg: 4.464 ± 0.047	7.336AlaSer: 7.336 ± 0.06	4.688AlaThr: 4.688 ± 0.037	4.708AlaVal: 4.708 ± 0.042	0.997AlaTrp: 0.997 ± 0.018	1.96AlaTyr: 1.96 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.711CysAla: 0.711 ± 0.017	0.188CysCys: 0.188 ± 0.007	0.544CysAsp: 0.544 ± 0.015	0.589CysGlu: 0.589 ± 0.015	0.469CysPhe: 0.469 ± 0.011	0.767CysGly: 0.767 ± 0.019	0.297CysHis: 0.297 ± 0.011	0.629CysIle: 0.629 ± 0.016	0.54CysLys: 0.54 ± 0.014	1.176CysLeu: 1.176 ± 0.02	0.235CysMet: 0.235 ± 0.009	0.37CysAsn: 0.37 ± 0.012	0.645CysPro: 0.645 ± 0.017	0.43CysGln: 0.43 ± 0.011	0.63CysArg: 0.63 ± 0.014	0.869CysSer: 0.869 ± 0.019	0.61CysThr: 0.61 ± 0.014	0.726CysVal: 0.726 ± 0.015	0.174CysTrp: 0.174 ± 0.007	0.294CysTyr: 0.294 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	3.788AspAla: 3.788 ± 0.03	0.562AspCys: 0.562 ± 0.013	3.693AspAsp: 3.693 ± 0.05	4.657AspGlu: 4.657 ± 0.047	1.909AspPhe: 1.909 ± 0.028	3.743AspGly: 3.743 ± 0.038	1.119AspHis: 1.119 ± 0.018	2.997AspIle: 2.997 ± 0.034	2.763AspLys: 2.763 ± 0.033	4.861AspLeu: 4.861 ± 0.044	1.232AspMet: 1.232 ± 0.02	1.886AspAsn: 1.886 ± 0.024	2.994AspPro: 2.994 ± 0.034	1.892AspGln: 1.892 ± 0.026	2.807AspArg: 2.807 ± 0.034	4.044AspSer: 4.044 ± 0.038	2.708AspThr: 2.708 ± 0.029	3.564AspVal: 3.564 ± 0.03	0.86AspTrp: 0.86 ± 0.017	1.411AspTyr: 1.411 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	5.01GluAla: 5.01 ± 0.041	0.594GluCys: 0.594 ± 0.015	4.324GluAsp: 4.324 ± 0.047	6.478GluGlu: 6.478 ± 0.073	1.737GluPhe: 1.737 ± 0.024	4.432GluGly: 4.432 ± 0.047	1.3GluHis: 1.3 ± 0.018	3.316GluIle: 3.316 ± 0.037	4.589GluLys: 4.589 ± 0.052	5.263GluLeu: 5.263 ± 0.052	1.677GluMet: 1.677 ± 0.025	2.584GluAsn: 2.584 ± 0.029	2.533GluPro: 2.533 ± 0.027	2.599GluGln: 2.599 ± 0.031	4.481GluArg: 4.481 ± 0.047	4.57GluSer: 4.57 ± 0.038	3.422GluThr: 3.422 ± 0.036	3.61GluVal: 3.61 ± 0.042	0.995GluTrp: 0.995 ± 0.021	1.582GluTyr: 1.582 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	2.718PheAla: 2.718 ± 0.033	0.465PheCys: 0.465 ± 0.011	2.053PheAsp: 2.053 ± 0.025	2.083PheGlu: 2.083 ± 0.026	1.39PhePhe: 1.39 ± 0.023	2.581PheGly: 2.581 ± 0.038	0.85PheHis: 0.85 ± 0.015	1.733PheIle: 1.733 ± 0.027	1.635PheLys: 1.635 ± 0.022	3.153PheLeu: 3.153 ± 0.038	0.702PheMet: 0.702 ± 0.014	1.351PheAsn: 1.351 ± 0.022	1.94PhePro: 1.94 ± 0.024	1.246PheGln: 1.246 ± 0.019	1.716PheArg: 1.716 ± 0.023	3.169PheSer: 3.169 ± 0.036	1.97PheThr: 1.97 ± 0.024	2.21PheVal: 2.21 ± 0.027	0.498PheTrp: 0.498 ± 0.013	0.968PheTyr: 0.968 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	4.357GlyAla: 4.357 ± 0.047	0.79GlyCys: 0.79 ± 0.016	3.331GlyAsp: 3.331 ± 0.036	4.134GlyGlu: 4.134 ± 0.043	2.418GlyPhe: 2.418 ± 0.033	5.446GlyGly: 5.446 ± 0.075	1.542GlyHis: 1.542 ± 0.024	3.459GlyIle: 3.459 ± 0.036	4.297GlyLys: 4.297 ± 0.042	5.967GlyLeu: 5.967 ± 0.051	1.7GlyMet: 1.7 ± 0.027	2.464GlyAsn: 2.464 ± 0.026	2.923GlyPro: 2.923 ± 0.035	2.733GlyGln: 2.733 ± 0.032	4.001GlyArg: 4.001 ± 0.041	5.626GlySer: 5.626 ± 0.055	3.484GlyThr: 3.484 ± 0.036	4.19GlyVal: 4.19 ± 0.034	1.257GlyTrp: 1.257 ± 0.022	1.892GlyTyr: 1.892 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	1.659HisAla: 1.659 ± 0.018	0.288HisCys: 0.288 ± 0.009	1.145HisAsp: 1.145 ± 0.021	1.263HisGlu: 1.263 ± 0.02	0.877HisPhe: 0.877 ± 0.017	1.486HisGly: 1.486 ± 0.02	0.867HisHis: 0.867 ± 0.02	1.264HisIle: 1.264 ± 0.021	0.991HisLys: 0.991 ± 0.018	2.584HisLeu: 2.584 ± 0.031	0.44HisMet: 0.44 ± 0.012	0.838HisAsn: 0.838 ± 0.016	1.896HisPro: 1.896 ± 0.027	0.997HisGln: 0.997 ± 0.019	1.403HisArg: 1.403 ± 0.026	2.293HisSer: 2.293 ± 0.025	1.386HisThr: 1.386 ± 0.023	1.394HisVal: 1.394 ± 0.021	0.28HisTrp: 0.28 ± 0.009	0.668HisTyr: 0.668 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.963IleAla: 3.963 ± 0.046	0.676IleCys: 0.676 ± 0.017	2.927IleAsp: 2.927 ± 0.028	3.148IleGlu: 3.148 ± 0.038	1.821IlePhe: 1.821 ± 0.028	3.242IleGly: 3.242 ± 0.034	1.315IleHis: 1.315 ± 0.023	2.694IleIle: 2.694 ± 0.035	2.765IleLys: 2.765 ± 0.032	4.728IleLeu: 4.728 ± 0.049	1.028IleMet: 1.028 ± 0.02	2.002IleAsn: 2.002 ± 0.028	3.417IlePro: 3.417 ± 0.039	1.974IleGln: 1.974 ± 0.024	2.88IleArg: 2.88 ± 0.035	4.494IleSer: 4.494 ± 0.043	2.827IleThr: 2.827 ± 0.03	3.248IleVal: 3.248 ± 0.037	0.702IleTrp: 0.702 ± 0.013	1.346IleTyr: 1.346 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	4.501LysAla: 4.501 ± 0.047	0.474LysCys: 0.474 ± 0.013	3.173LysAsp: 3.173 ± 0.036	4.385LysGlu: 4.385 ± 0.044	1.423LysPhe: 1.423 ± 0.022	3.574LysGly: 3.574 ± 0.036	1.215LysHis: 1.215 ± 0.021	2.611LysIle: 2.611 ± 0.031	4.077LysLys: 4.077 ± 0.055	4.437LysLeu: 4.437 ± 0.04	1.19LysMet: 1.19 ± 0.018	1.986LysAsn: 1.986 ± 0.026	2.903LysPro: 2.903 ± 0.033	2.123LysGln: 2.123 ± 0.024	3.981LysArg: 3.981 ± 0.043	4.266LysSer: 4.266 ± 0.044	3.258LysThr: 3.258 ± 0.035	3.173LysVal: 3.173 ± 0.035	0.721LysTrp: 0.721 ± 0.017	1.306LysTyr: 1.306 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	7.635LeuAla: 7.635 ± 0.06	1.094LeuCys: 1.094 ± 0.019	4.973LeuAsp: 4.973 ± 0.045	5.757LeuGlu: 5.757 ± 0.047	3.185LeuPhe: 3.185 ± 0.035	5.863LeuGly: 5.863 ± 0.052	2.26LeuHis: 2.26 ± 0.027	4.268LeuIle: 4.268 ± 0.051	4.704LeuLys: 4.704 ± 0.043	8.72LeuLeu: 8.72 ± 0.081	1.691LeuMet: 1.691 ± 0.027	3.362LeuAsn: 3.362 ± 0.033	6.513LeuPro: 6.513 ± 0.051	3.77LeuGln: 3.77 ± 0.039	5.369LeuArg: 5.369 ± 0.049	8.924LeuSer: 8.924 ± 0.063	5.033LeuThr: 5.033 ± 0.041	5.433LeuVal: 5.433 ± 0.047	1.077LeuTrp: 1.077 ± 0.019	2.288LeuTyr: 2.288 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	1.93MetAla: 1.93 ± 0.024	0.218MetCys: 0.218 ± 0.008	1.233MetAsp: 1.233 ± 0.019	1.399MetGlu: 1.399 ± 0.021	0.676MetPhe: 0.676 ± 0.014	1.579MetGly: 1.579 ± 0.024	0.339MetHis: 0.339 ± 0.009	1.009MetIle: 1.009 ± 0.017	1.076MetLys: 1.076 ± 0.017	1.835MetLeu: 1.835 ± 0.024	0.566MetMet: 0.566 ± 0.016	0.785MetAsn: 0.785 ± 0.018	1.346MetPro: 1.346 ± 0.023	0.742MetGln: 0.742 ± 0.018	1.267MetArg: 1.267 ± 0.02	2.238MetSer: 2.238 ± 0.027	1.329MetThr: 1.329 ± 0.021	1.267MetVal: 1.267 ± 0.02	0.256MetTrp: 0.256 ± 0.01	0.465MetTyr: 0.465 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.951AsnAla: 2.951 ± 0.031	0.358AsnCys: 0.358 ± 0.01	2.085AsnAsp: 2.085 ± 0.028	2.327AsnGlu: 2.327 ± 0.027	1.275AsnPhe: 1.275 ± 0.02	2.768AsnGly: 2.768 ± 0.034	0.926AsnHis: 0.926 ± 0.017	2.034AsnIle: 2.034 ± 0.027	1.911AsnLys: 1.911 ± 0.027	3.462AsnLeu: 3.462 ± 0.032	0.804AsnMet: 0.804 ± 0.015	1.529AsnAsn: 1.529 ± 0.023	2.499AsnPro: 2.499 ± 0.032	1.485AsnGln: 1.485 ± 0.023	1.947AsnArg: 1.947 ± 0.024	3.111AsnSer: 3.111 ± 0.031	2.232AsnThr: 2.232 ± 0.03	2.44AsnVal: 2.44 ± 0.027	0.467AsnTrp: 0.467 ± 0.013	0.962AsnTyr: 0.962 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	4.535ProAla: 4.535 ± 0.052	0.491ProCys: 0.491 ± 0.013	2.659ProAsp: 2.659 ± 0.029	3.351ProGlu: 3.351 ± 0.031	2.202ProPhe: 2.202 ± 0.032	3.328ProGly: 3.328 ± 0.038	1.509ProHis: 1.509 ± 0.025	3.129ProIle: 3.129 ± 0.032	2.73ProLys: 2.73 ± 0.028	5.704ProLeu: 5.704 ± 0.049	1.06ProMet: 1.06 ± 0.019	2.36ProAsn: 2.36 ± 0.033	5.673ProPro: 5.673 ± 0.086	2.476ProGln: 2.476 ± 0.038	3.116ProArg: 3.116 ± 0.035	7.582ProSer: 7.582 ± 0.071	4.34ProThr: 4.34 ± 0.051	3.57ProVal: 3.57 ± 0.038	0.598ProTrp: 0.598 ± 0.015	1.548ProTyr: 1.548 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.396GlnAla: 3.396 ± 0.037	0.403GlnCys: 0.403 ± 0.012	1.997GlnAsp: 1.997 ± 0.027	2.569GlnGlu: 2.569 ± 0.03	1.132GlnPhe: 1.132 ± 0.019	2.485GlnGly: 2.485 ± 0.033	1.084GlnHis: 1.084 ± 0.017	1.971GlnIle: 1.971 ± 0.025	2.092GlnLys: 2.092 ± 0.027	3.531GlnLeu: 3.531 ± 0.042	0.903GlnMet: 0.903 ± 0.017	1.62GlnAsn: 1.62 ± 0.024	2.622GlnPro: 2.622 ± 0.039	2.254GlnGln: 2.254 ± 0.053	2.504GlnArg: 2.504 ± 0.03	3.605GlnSer: 3.605 ± 0.037	2.523GlnThr: 2.523 ± 0.03	2.321GlnVal: 2.321 ± 0.028	0.515GlnTrp: 0.515 ± 0.014	1.056GlnTyr: 1.056 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	4.311ArgAla: 4.311 ± 0.041	0.62ArgCys: 0.62 ± 0.015	3.07ArgAsp: 3.07 ± 0.038	4.086ArgGlu: 4.086 ± 0.045	1.867ArgPhe: 1.867 ± 0.027	3.66ArgGly: 3.66 ± 0.042	1.489ArgHis: 1.489 ± 0.023	2.971ArgIle: 2.971 ± 0.031	3.784ArgLys: 3.784 ± 0.041	5.478ArgLeu: 5.478 ± 0.041	1.377ArgMet: 1.377 ± 0.022	2.12ArgAsn: 2.12 ± 0.026	3.437ArgPro: 3.437 ± 0.042	2.662ArgGln: 2.662 ± 0.031	4.807ArgArg: 4.807 ± 0.052	4.858ArgSer: 4.858 ± 0.05	2.971ArgThr: 2.971 ± 0.03	3.188ArgVal: 3.188 ± 0.033	0.863ArgTrp: 0.863 ± 0.016	1.536ArgTyr: 1.536 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	6.88SerAla: 6.88 ± 0.056	0.916SerCys: 0.916 ± 0.017	4.238SerAsp: 4.238 ± 0.044	4.508SerGlu: 4.508 ± 0.045	3.353SerPhe: 3.353 ± 0.033	5.524SerGly: 5.524 ± 0.048	2.386SerHis: 2.386 ± 0.03	4.606SerIle: 4.606 ± 0.043	4.454SerLys: 4.454 ± 0.046	8.758SerLeu: 8.758 ± 0.059	1.773SerMet: 1.773 ± 0.027	3.529SerAsn: 3.529 ± 0.035	6.361SerPro: 6.361 ± 0.071	3.977SerGln: 3.977 ± 0.041	5.173SerArg: 5.173 ± 0.05	11.188SerSer: 11.188 ± 0.109	6.369SerThr: 6.369 ± 0.061	5.114SerVal: 5.114 ± 0.045	1.043SerTrp: 1.043 ± 0.017	2.097SerTyr: 2.097 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	4.552ThrAla: 4.552 ± 0.038	0.65ThrCys: 0.65 ± 0.014	2.656ThrAsp: 2.656 ± 0.03	3.03ThrGlu: 3.03 ± 0.034	2.225ThrPhe: 2.225 ± 0.024	3.783ThrGly: 3.783 ± 0.042	1.423ThrHis: 1.423 ± 0.024	3.151ThrIle: 3.151 ± 0.03	2.773ThrLys: 2.773 ± 0.036	5.603ThrLeu: 5.603 ± 0.042	1.125ThrMet: 1.125 ± 0.015	2.147ThrAsn: 2.147 ± 0.031	4.559ThrPro: 4.559 ± 0.05	2.159ThrGln: 2.159 ± 0.028	3.08ThrArg: 3.08 ± 0.031	6.137ThrSer: 6.137 ± 0.06	3.898ThrThr: 3.898 ± 0.044	3.534ThrVal: 3.534 ± 0.038	0.69ThrTrp: 0.69 ± 0.015	1.456ThrTyr: 1.456 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	4.656ValAla: 4.656 ± 0.044	0.74ValCys: 0.74 ± 0.016	3.605ValAsp: 3.605 ± 0.036	4.199ValGlu: 4.199 ± 0.042	2.239ValPhe: 2.239 ± 0.03	4.018ValGly: 4.018 ± 0.038	1.341ValHis: 1.341 ± 0.021	3.115ValIle: 3.115 ± 0.036	3.331ValLys: 3.331 ± 0.035	5.53ValLeu: 5.53 ± 0.045	1.323ValMet: 1.323 ± 0.023	2.26ValAsn: 2.26 ± 0.031	3.447ValPro: 3.447 ± 0.037	2.354ValGln: 2.354 ± 0.027	3.168ValArg: 3.168 ± 0.034	4.887ValSer: 4.887 ± 0.041	3.29ValThr: 3.29 ± 0.033	4.086ValVal: 4.086 ± 0.039	0.864ValTrp: 0.864 ± 0.018	1.625ValTyr: 1.625 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	0.983TrpAla: 0.983 ± 0.018	0.183TrpCys: 0.183 ± 0.008	0.871TrpAsp: 0.871 ± 0.018	0.951TrpGlu: 0.951 ± 0.019	0.441TrpPhe: 0.441 ± 0.011	0.865TrpGly: 0.865 ± 0.019	0.297TrpHis: 0.297 ± 0.011	0.715TrpIle: 0.715 ± 0.013	0.845TrpLys: 0.845 ± 0.017	1.205TrpLeu: 1.205 ± 0.021	0.37TrpMet: 0.37 ± 0.011	0.56TrpAsn: 0.56 ± 0.014	0.551TrpPro: 0.551 ± 0.015	0.52TrpGln: 0.52 ± 0.013	0.893TrpArg: 0.893 ± 0.02	1.015TrpSer: 1.015 ± 0.018	0.787TrpThr: 0.787 ± 0.015	0.813TrpVal: 0.813 ± 0.017	0.298TrpTrp: 0.298 ± 0.01	0.35TrpTyr: 0.35 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.91TyrAla: 1.91 ± 0.025	0.331TyrCys: 0.331 ± 0.01	1.52TyrAsp: 1.52 ± 0.023	1.465TyrGlu: 1.465 ± 0.023	0.972TyrPhe: 0.972 ± 0.018	1.828TyrGly: 1.828 ± 0.029	0.761TyrHis: 0.761 ± 0.017	1.347TyrIle: 1.347 ± 0.019	1.156TyrLys: 1.156 ± 0.02	2.526TyrLeu: 2.526 ± 0.031	0.555TyrMet: 0.555 ± 0.013	1.046TyrAsn: 1.046 ± 0.019	1.563TyrPro: 1.563 ± 0.024	0.985TyrGln: 0.985 ± 0.017	1.468TyrArg: 1.468 ± 0.019	2.033TyrSer: 2.033 ± 0.027	1.504TyrThr: 1.504 ± 0.023	1.486TyrVal: 1.486 ± 0.021	0.356TyrTrp: 0.356 ± 0.01	0.751TyrTyr: 0.751 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6530 proteins (3229921 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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