Amino acid dipepetide frequency for Prevotella sp. OH937_COT-195

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.913AlaAla: 5.913 ± 0.12
1.017AlaCys: 1.017 ± 0.033
4.437AlaAsp: 4.437 ± 0.086
4.978AlaGlu: 4.978 ± 0.086
3.161AlaPhe: 3.161 ± 0.073
5.152AlaGly: 5.152 ± 0.098
1.216AlaHis: 1.216 ± 0.041
4.551AlaIle: 4.551 ± 0.09
4.451AlaLys: 4.451 ± 0.094
6.192AlaLeu: 6.192 ± 0.103
2.279AlaMet: 2.279 ± 0.056
3.074AlaAsn: 3.074 ± 0.066
2.018AlaPro: 2.018 ± 0.049
2.479AlaGln: 2.479 ± 0.065
3.558AlaArg: 3.558 ± 0.082
3.73AlaSer: 3.73 ± 0.079
3.948AlaThr: 3.948 ± 0.084
5.124AlaVal: 5.124 ± 0.102
0.717AlaTrp: 0.717 ± 0.029
2.638AlaTyr: 2.638 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.848CysAla: 0.848 ± 0.033
0.228CysCys: 0.228 ± 0.016
0.765CysAsp: 0.765 ± 0.034
0.757CysGlu: 0.757 ± 0.033
0.6CysPhe: 0.6 ± 0.028
1.255CysGly: 1.255 ± 0.042
0.378CysHis: 0.378 ± 0.027
1.006CysIle: 1.006 ± 0.04
0.728CysLys: 0.728 ± 0.031
0.992CysLeu: 0.992 ± 0.036
0.342CysMet: 0.342 ± 0.022
0.733CysAsn: 0.733 ± 0.033
0.546CysPro: 0.546 ± 0.031
0.328CysGln: 0.328 ± 0.021
0.859CysArg: 0.859 ± 0.037
0.791CysSer: 0.791 ± 0.036
0.714CysThr: 0.714 ± 0.034
0.826CysVal: 0.826 ± 0.032
0.144CysTrp: 0.144 ± 0.014
0.567CysTyr: 0.567 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.012AspAla: 4.012 ± 0.082
0.753AspCys: 0.753 ± 0.032
3.297AspAsp: 3.297 ± 0.08
4.236AspGlu: 4.236 ± 0.088
3.127AspPhe: 3.127 ± 0.077
4.289AspGly: 4.289 ± 0.103
0.772AspHis: 0.772 ± 0.031
4.76AspIle: 4.76 ± 0.088
4.201AspLys: 4.201 ± 0.076
4.058AspLeu: 4.058 ± 0.075
1.971AspMet: 1.971 ± 0.052
3.436AspAsn: 3.436 ± 0.074
1.693AspPro: 1.693 ± 0.053
0.953AspGln: 0.953 ± 0.037
2.671AspArg: 2.671 ± 0.064
2.997AspSer: 2.997 ± 0.082
3.038AspThr: 3.038 ± 0.07
3.746AspVal: 3.746 ± 0.081
0.693AspTrp: 0.693 ± 0.029
2.638AspTyr: 2.638 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
4.43GluAla: 4.43 ± 0.091
0.753GluCys: 0.753 ± 0.032
3.329GluAsp: 3.329 ± 0.069
4.973GluGlu: 4.973 ± 0.102
2.417GluPhe: 2.417 ± 0.064
4.17GluGly: 4.17 ± 0.089
1.379GluHis: 1.379 ± 0.052
5.018GluIle: 5.018 ± 0.092
5.422GluLys: 5.422 ± 0.103
5.624GluLeu: 5.624 ± 0.097
2.348GluMet: 2.348 ± 0.059
3.99GluAsn: 3.99 ± 0.083
1.75GluPro: 1.75 ± 0.055
2.647GluGln: 2.647 ± 0.066
3.69GluArg: 3.69 ± 0.086
2.969GluSer: 2.969 ± 0.054
3.69GluThr: 3.69 ± 0.067
3.892GluVal: 3.892 ± 0.086
0.823GluTrp: 0.823 ± 0.035
2.804GluTyr: 2.804 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
3.222PheAla: 3.222 ± 0.081
0.797PheCys: 0.797 ± 0.033
2.829PheAsp: 2.829 ± 0.064
2.417PheGlu: 2.417 ± 0.059
2.32PhePhe: 2.32 ± 0.067
3.381PheGly: 3.381 ± 0.07
0.872PheHis: 0.872 ± 0.035
3.019PheIle: 3.019 ± 0.074
2.512PheLys: 2.512 ± 0.051
3.564PheLeu: 3.564 ± 0.078
1.278PheMet: 1.278 ± 0.048
2.396PheAsn: 2.396 ± 0.064
1.548PhePro: 1.548 ± 0.039
0.995PheGln: 0.995 ± 0.04
2.18PheArg: 2.18 ± 0.061
3.21PheSer: 3.21 ± 0.076
2.673PheThr: 2.673 ± 0.055
3.262PheVal: 3.262 ± 0.074
0.484PheTrp: 0.484 ± 0.029
1.789PheTyr: 1.789 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
4.262GlyAla: 4.262 ± 0.101
0.977GlyCys: 0.977 ± 0.045
3.658GlyAsp: 3.658 ± 0.08
4.249GlyGlu: 4.249 ± 0.083
3.128GlyPhe: 3.128 ± 0.07
4.979GlyGly: 4.979 ± 0.105
1.341GlyHis: 1.341 ± 0.04
5.532GlyIle: 5.532 ± 0.094
5.747GlyLys: 5.747 ± 0.093
5.351GlyLeu: 5.351 ± 0.094
2.38GlyMet: 2.38 ± 0.058
3.842GlyAsn: 3.842 ± 0.082
1.042GlyPro: 1.042 ± 0.039
1.982GlyGln: 1.982 ± 0.049
3.342GlyArg: 3.342 ± 0.075
3.923GlySer: 3.923 ± 0.096
4.398GlyThr: 4.398 ± 0.085
4.749GlyVal: 4.749 ± 0.077
0.86GlyTrp: 0.86 ± 0.036
2.985GlyTyr: 2.985 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
1.251HisAla: 1.251 ± 0.042
0.347HisCys: 0.347 ± 0.02
1.062HisAsp: 1.062 ± 0.048
1.134HisGlu: 1.134 ± 0.037
1.018HisPhe: 1.018 ± 0.037
1.345HisGly: 1.345 ± 0.053
0.481HisHis: 0.481 ± 0.029
1.476HisIle: 1.476 ± 0.048
1.144HisLys: 1.144 ± 0.04
1.761HisLeu: 1.761 ± 0.058
0.285HisMet: 0.285 ± 0.019
1.028HisAsn: 1.028 ± 0.039
0.892HisPro: 0.892 ± 0.037
0.459HisGln: 0.459 ± 0.027
1.11HisArg: 1.11 ± 0.042
1.152HisSer: 1.152 ± 0.04
1.056HisThr: 1.056 ± 0.036
1.228HisVal: 1.228 ± 0.045
0.22HisTrp: 0.22 ± 0.018
0.825HisTyr: 0.825 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.209IleAla: 5.209 ± 0.079
0.992IleCys: 0.992 ± 0.037
5.023IleAsp: 5.023 ± 0.07
4.788IleGlu: 4.788 ± 0.078
2.709IlePhe: 2.709 ± 0.078
4.734IleGly: 4.734 ± 0.096
1.252IleHis: 1.252 ± 0.046
5.188IleIle: 5.188 ± 0.104
4.623IleLys: 4.623 ± 0.088
5.578IleLeu: 5.578 ± 0.104
1.977IleMet: 1.977 ± 0.053
3.904IleAsn: 3.904 ± 0.084
2.998IlePro: 2.998 ± 0.069
1.682IleGln: 1.682 ± 0.053
3.167IleArg: 3.167 ± 0.062
4.493IleSer: 4.493 ± 0.097
4.351IleThr: 4.351 ± 0.098
4.897IleVal: 4.897 ± 0.092
0.569IleTrp: 0.569 ± 0.027
2.911IleTyr: 2.911 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
4.738LysAla: 4.738 ± 0.097
0.659LysCys: 0.659 ± 0.036
3.889LysAsp: 3.889 ± 0.086
5.56LysGlu: 5.56 ± 0.104
2.424LysPhe: 2.424 ± 0.066
4.604LysGly: 4.604 ± 0.078
1.347LysHis: 1.347 ± 0.045
4.76LysIle: 4.76 ± 0.078
5.48LysLys: 5.48 ± 0.102
5.153LysLeu: 5.153 ± 0.09
2.465LysMet: 2.465 ± 0.06
3.846LysAsn: 3.846 ± 0.076
2.251LysPro: 2.251 ± 0.057
2.432LysGln: 2.432 ± 0.064
3.677LysArg: 3.677 ± 0.073
3.609LysSer: 3.609 ± 0.072
4.159LysThr: 4.159 ± 0.09
4.343LysVal: 4.343 ± 0.084
0.8LysTrp: 0.8 ± 0.031
2.949LysTyr: 2.949 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
6.093LeuAla: 6.093 ± 0.113
1.311LeuCys: 1.311 ± 0.053
4.491LeuAsp: 4.491 ± 0.093
4.603LeuGlu: 4.603 ± 0.09
3.896LeuPhe: 3.896 ± 0.088
5.502LeuGly: 5.502 ± 0.101
1.745LeuHis: 1.745 ± 0.057
4.864LeuIle: 4.864 ± 0.087
5.813LeuLys: 5.813 ± 0.088
7.938LeuLeu: 7.938 ± 0.147
2.555LeuMet: 2.555 ± 0.053
4.33LeuAsn: 4.33 ± 0.096
3.756LeuPro: 3.756 ± 0.07
2.904LeuGln: 2.904 ± 0.076
4.492LeuArg: 4.492 ± 0.085
5.978LeuSer: 5.978 ± 0.111
5.047LeuThr: 5.047 ± 0.084
5.178LeuVal: 5.178 ± 0.096
0.902LeuTrp: 0.902 ± 0.037
3.163LeuTyr: 3.163 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.498MetAla: 2.498 ± 0.067
0.309MetCys: 0.309 ± 0.021
1.347MetAsp: 1.347 ± 0.039
1.985MetGlu: 1.985 ± 0.053
1.296MetPhe: 1.296 ± 0.047
1.927MetGly: 1.927 ± 0.05
0.54MetHis: 0.54 ± 0.031
1.828MetIle: 1.828 ± 0.046
2.702MetLys: 2.702 ± 0.058
3.024MetLeu: 3.024 ± 0.074
1.054MetMet: 1.054 ± 0.035
1.588MetAsn: 1.588 ± 0.036
1.577MetPro: 1.577 ± 0.046
1.248MetGln: 1.248 ± 0.04
1.762MetArg: 1.762 ± 0.049
1.839MetSer: 1.839 ± 0.045
1.808MetThr: 1.808 ± 0.053
1.823MetVal: 1.823 ± 0.043
0.232MetTrp: 0.232 ± 0.019
0.908MetTyr: 0.908 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.85AsnAla: 3.85 ± 0.076
0.595AsnCys: 0.595 ± 0.031
3.304AsnAsp: 3.304 ± 0.072
3.291AsnGlu: 3.291 ± 0.074
2.198AsnPhe: 2.198 ± 0.06
4.307AsnGly: 4.307 ± 0.085
0.992AsnHis: 0.992 ± 0.037
4.413AsnIle: 4.413 ± 0.095
3.503AsnLys: 3.503 ± 0.075
3.987AsnLeu: 3.987 ± 0.071
1.511AsnMet: 1.511 ± 0.05
3.246AsnAsn: 3.246 ± 0.099
2.229AsnPro: 2.229 ± 0.057
1.285AsnGln: 1.285 ± 0.049
2.569AsnArg: 2.569 ± 0.061
2.85AsnSer: 2.85 ± 0.076
2.775AsnThr: 2.775 ± 0.069
3.724AsnVal: 3.724 ± 0.078
0.528AsnTrp: 0.528 ± 0.033
2.128AsnTyr: 2.128 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
2.53ProAla: 2.53 ± 0.069
0.418ProCys: 0.418 ± 0.023
2.303ProAsp: 2.303 ± 0.06
2.994ProGlu: 2.994 ± 0.069
1.668ProPhe: 1.668 ± 0.052
2.049ProGly: 2.049 ± 0.061
0.735ProHis: 0.735 ± 0.031
2.103ProIle: 2.103 ± 0.056
2.063ProLys: 2.063 ± 0.053
2.967ProLeu: 2.967 ± 0.067
1.09ProMet: 1.09 ± 0.033
1.594ProAsn: 1.594 ± 0.053
0.812ProPro: 0.812 ± 0.036
1.309ProGln: 1.309 ± 0.045
1.46ProArg: 1.46 ± 0.045
2.07ProSer: 2.07 ± 0.06
1.989ProThr: 1.989 ± 0.057
2.741ProVal: 2.741 ± 0.069
0.357ProTrp: 0.357 ± 0.026
1.565ProTyr: 1.565 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
1.977GlnAla: 1.977 ± 0.064
0.362GlnCys: 0.362 ± 0.025
1.349GlnAsp: 1.349 ± 0.043
2.039GlnGlu: 2.039 ± 0.06
1.258GlnPhe: 1.258 ± 0.042
1.823GlnGly: 1.823 ± 0.058
0.563GlnHis: 0.563 ± 0.027
2.191GlnIle: 2.191 ± 0.062
2.338GlnLys: 2.338 ± 0.062
2.973GlnLeu: 2.973 ± 0.071
1.121GlnMet: 1.121 ± 0.038
1.599GlnAsn: 1.599 ± 0.052
1.188GlnPro: 1.188 ± 0.054
1.399GlnGln: 1.399 ± 0.06
1.679GlnArg: 1.679 ± 0.047
1.713GlnSer: 1.713 ± 0.053
1.923GlnThr: 1.923 ± 0.057
1.8GlnVal: 1.8 ± 0.058
0.423GlnTrp: 0.423 ± 0.025
1.357GlnTyr: 1.357 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.811ArgAla: 2.811 ± 0.064
0.618ArgCys: 0.618 ± 0.034
2.493ArgAsp: 2.493 ± 0.057
3.493ArgGlu: 3.493 ± 0.074
2.417ArgPhe: 2.417 ± 0.062
2.825ArgGly: 2.825 ± 0.069
1.291ArgHis: 1.291 ± 0.046
3.817ArgIle: 3.817 ± 0.075
3.811ArgLys: 3.811 ± 0.078
4.821ArgLeu: 4.821 ± 0.094
1.794ArgMet: 1.794 ± 0.053
2.843ArgAsn: 2.843 ± 0.066
1.554ArgPro: 1.554 ± 0.048
2.198ArgGln: 2.198 ± 0.055
3.121ArgArg: 3.121 ± 0.088
2.421ArgSer: 2.421 ± 0.059
2.591ArgThr: 2.591 ± 0.063
2.86ArgVal: 2.86 ± 0.056
0.591ArgTrp: 0.591 ± 0.034
2.314ArgTyr: 2.314 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
4.128SerAla: 4.128 ± 0.08
0.789SerCys: 0.789 ± 0.03
3.244SerAsp: 3.244 ± 0.068
3.508SerGlu: 3.508 ± 0.063
3.013SerPhe: 3.013 ± 0.072
4.309SerGly: 4.309 ± 0.09
1.188SerHis: 1.188 ± 0.044
4.283SerIle: 4.283 ± 0.083
3.421SerLys: 3.421 ± 0.075
5.348SerLeu: 5.348 ± 0.099
1.671SerMet: 1.671 ± 0.053
2.753SerAsn: 2.753 ± 0.064
2.146SerPro: 2.146 ± 0.058
1.754SerGln: 1.754 ± 0.04
2.795SerArg: 2.795 ± 0.069
3.425SerSer: 3.425 ± 0.086
2.976SerThr: 2.976 ± 0.067
4.207SerVal: 4.207 ± 0.079
0.688SerTrp: 0.688 ± 0.031
2.392SerTyr: 2.392 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
4.524ThrAla: 4.524 ± 0.086
0.653ThrCys: 0.653 ± 0.027
3.73ThrAsp: 3.73 ± 0.072
3.566ThrGlu: 3.566 ± 0.074
2.666ThrPhe: 2.666 ± 0.058
4.225ThrGly: 4.225 ± 0.082
1.015ThrHis: 1.015 ± 0.036
4.189ThrIle: 4.189 ± 0.084
3.212ThrLys: 3.212 ± 0.082
5.326ThrLeu: 5.326 ± 0.082
1.639ThrMet: 1.639 ± 0.049
2.554ThrAsn: 2.554 ± 0.073
2.604ThrPro: 2.604 ± 0.075
1.547ThrGln: 1.547 ± 0.051
2.344ThrArg: 2.344 ± 0.065
3.288ThrSer: 3.288 ± 0.073
3.477ThrThr: 3.477 ± 0.08
4.088ThrVal: 4.088 ± 0.093
0.578ThrTrp: 0.578 ± 0.031
2.176ThrTyr: 2.176 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
4.921ValAla: 4.921 ± 0.09
1.087ValCys: 1.087 ± 0.035
3.457ValAsp: 3.457 ± 0.081
4.48ValGlu: 4.48 ± 0.084
3.028ValPhe: 3.028 ± 0.074
4.289ValGly: 4.289 ± 0.093
1.076ValHis: 1.076 ± 0.044
4.459ValIle: 4.459 ± 0.081
4.571ValLys: 4.571 ± 0.092
5.617ValLeu: 5.617 ± 0.1
2.133ValMet: 2.133 ± 0.051
3.36ValAsn: 3.36 ± 0.074
2.468ValPro: 2.468 ± 0.068
1.829ValGln: 1.829 ± 0.058
3.376ValArg: 3.376 ± 0.073
4.478ValSer: 4.478 ± 0.07
3.984ValThr: 3.984 ± 0.086
4.878ValVal: 4.878 ± 0.092
0.685ValTrp: 0.685 ± 0.031
2.443ValTyr: 2.443 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.636TrpAla: 0.636 ± 0.034
0.17TrpCys: 0.17 ± 0.016
0.558TrpAsp: 0.558 ± 0.028
0.645TrpGlu: 0.645 ± 0.034
0.537TrpPhe: 0.537 ± 0.031
0.728TrpGly: 0.728 ± 0.036
0.285TrpHis: 0.285 ± 0.02
0.74TrpIle: 0.74 ± 0.029
0.826TrpLys: 0.826 ± 0.036
1.115TrpLeu: 1.115 ± 0.041
0.291TrpMet: 0.291 ± 0.022
0.696TrpAsn: 0.696 ± 0.03
0.206TrpPro: 0.206 ± 0.016
0.537TrpGln: 0.537 ± 0.027
0.587TrpArg: 0.587 ± 0.033
0.551TrpSer: 0.551 ± 0.028
0.542TrpThr: 0.542 ± 0.028
0.647TrpVal: 0.647 ± 0.028
0.151TrpTrp: 0.151 ± 0.014
0.455TrpTyr: 0.455 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.779TyrAla: 2.779 ± 0.068
0.573TyrCys: 0.573 ± 0.027
2.778TyrAsp: 2.778 ± 0.07
2.418TyrGlu: 2.418 ± 0.06
1.866TyrPhe: 1.866 ± 0.045
2.836TyrGly: 2.836 ± 0.066
0.808TyrHis: 0.808 ± 0.029
2.846TyrIle: 2.846 ± 0.064
2.577TyrLys: 2.577 ± 0.066
3.169TyrLeu: 3.169 ± 0.066
1.112TyrMet: 1.112 ± 0.045
2.472TyrAsn: 2.472 ± 0.071
1.537TyrPro: 1.537 ± 0.05
1.11TyrGln: 1.11 ± 0.041
2.247TyrArg: 2.247 ± 0.064
2.554TyrSer: 2.554 ± 0.057
2.263TyrThr: 2.263 ± 0.063
2.605TyrVal: 2.605 ± 0.061
0.457TyrTrp: 0.457 ± 0.023
1.879TyrTyr: 1.879 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2205 proteins (722840 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski