Amino acid dipepetide frequency for Mycobacterium kansasii 824

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.778AlaAla: 21.778 ± 0.194
1.173AlaCys: 1.173 ± 0.027
7.729AlaAsp: 7.729 ± 0.071
7.26AlaGlu: 7.26 ± 0.075
3.355AlaPhe: 3.355 ± 0.045
13.12AlaGly: 13.12 ± 0.131
2.66AlaHis: 2.66 ± 0.038
5.134AlaIle: 5.134 ± 0.059
2.756AlaLys: 2.756 ± 0.036
12.243AlaLeu: 12.243 ± 0.096
3.027AlaMet: 3.027 ± 0.044
2.888AlaAsn: 2.888 ± 0.057
6.507AlaPro: 6.507 ± 0.073
4.188AlaGln: 4.188 ± 0.057
9.059AlaArg: 9.059 ± 0.097
6.373AlaSer: 6.373 ± 0.062
7.656AlaThr: 7.656 ± 0.097
11.384AlaVal: 11.384 ± 0.094
1.71AlaTrp: 1.71 ± 0.031
2.315AlaTyr: 2.315 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
1.29CysAla: 1.29 ± 0.026
0.262CysCys: 0.262 ± 0.013
0.578CysAsp: 0.578 ± 0.021
0.426CysGlu: 0.426 ± 0.017
0.263CysPhe: 0.263 ± 0.011
1.182CysGly: 1.182 ± 0.026
0.242CysHis: 0.242 ± 0.011
0.274CysIle: 0.274 ± 0.012
0.139CysLys: 0.139 ± 0.009
0.746CysLeu: 0.746 ± 0.02
0.234CysMet: 0.234 ± 0.01
0.202CysAsn: 0.202 ± 0.01
0.71CysPro: 0.71 ± 0.022
0.247CysGln: 0.247 ± 0.009
1.035CysArg: 1.035 ± 0.025
0.738CysSer: 0.738 ± 0.024
0.561CysThr: 0.561 ± 0.02
0.67CysVal: 0.67 ± 0.019
0.263CysTrp: 0.263 ± 0.012
0.211CysTyr: 0.211 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.921AspAla: 6.921 ± 0.08
0.501AspCys: 0.501 ± 0.018
3.661AspAsp: 3.661 ± 0.055
3.502AspGlu: 3.502 ± 0.048
1.718AspPhe: 1.718 ± 0.03
5.476AspGly: 5.476 ± 0.058
1.411AspHis: 1.411 ± 0.027
2.506AspIle: 2.506 ± 0.038
1.168AspLys: 1.168 ± 0.023
5.417AspLeu: 5.417 ± 0.051
0.986AspMet: 0.986 ± 0.023
1.204AspAsn: 1.204 ± 0.026
4.083AspPro: 4.083 ± 0.051
1.739AspGln: 1.739 ± 0.032
4.388AspArg: 4.388 ± 0.055
2.67AspSer: 2.67 ± 0.041
2.947AspThr: 2.947 ± 0.043
4.843AspVal: 4.843 ± 0.053
0.938AspTrp: 0.938 ± 0.022
1.383AspTyr: 1.383 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
5.51GluAla: 5.51 ± 0.062
0.402GluCys: 0.402 ± 0.015
1.954GluAsp: 1.954 ± 0.034
2.058GluGlu: 2.058 ± 0.046
1.679GluPhe: 1.679 ± 0.034
2.792GluGly: 2.792 ± 0.037
1.468GluHis: 1.468 ± 0.027
2.39GluIle: 2.39 ± 0.037
1.087GluLys: 1.087 ± 0.025
6.085GluLeu: 6.085 ± 0.067
0.985GluMet: 0.985 ± 0.024
0.976GluAsn: 0.976 ± 0.024
2.781GluPro: 2.781 ± 0.046
2.076GluGln: 2.076 ± 0.033
3.978GluArg: 3.978 ± 0.057
2.452GluSer: 2.452 ± 0.032
2.363GluThr: 2.363 ± 0.046
3.826GluVal: 3.826 ± 0.048
0.661GluTrp: 0.661 ± 0.017
1.038GluTyr: 1.038 ± 0.023
0.0GluXaa: 0.0 ± 0.0
Phe
3.905PheAla: 3.905 ± 0.052
0.316PheCys: 0.316 ± 0.012
2.276PheAsp: 2.276 ± 0.035
1.399PheGlu: 1.399 ± 0.027
1.041PhePhe: 1.041 ± 0.025
3.712PheGly: 3.712 ± 0.067
0.654PheHis: 0.654 ± 0.022
1.024PheIle: 1.024 ± 0.023
0.471PheLys: 0.471 ± 0.019
2.363PheLeu: 2.363 ± 0.04
0.503PheMet: 0.503 ± 0.016
0.963PheAsn: 0.963 ± 0.05
1.477PhePro: 1.477 ± 0.028
0.696PheGln: 0.696 ± 0.018
1.786PheArg: 1.786 ± 0.031
1.72PheSer: 1.72 ± 0.029
1.918PheThr: 1.918 ± 0.038
2.44PheVal: 2.44 ± 0.036
0.454PheTrp: 0.454 ± 0.018
0.662PheTyr: 0.662 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
10.52GlyAla: 10.52 ± 0.11
1.118GlyCys: 1.118 ± 0.023
4.907GlyAsp: 4.907 ± 0.065
3.835GlyGlu: 3.835 ± 0.044
3.264GlyPhe: 3.264 ± 0.073
9.277GlyGly: 9.277 ± 0.241
2.184GlyHis: 2.184 ± 0.034
4.162GlyIle: 4.162 ± 0.059
2.152GlyLys: 2.152 ± 0.035
8.678GlyLeu: 8.678 ± 0.081
2.282GlyMet: 2.282 ± 0.032
3.074GlyAsn: 3.074 ± 0.144
4.848GlyPro: 4.848 ± 0.058
3.032GlyGln: 3.032 ± 0.048
6.638GlyArg: 6.638 ± 0.064
6.025GlySer: 6.025 ± 0.092
5.377GlyThr: 5.377 ± 0.06
7.177GlyVal: 7.177 ± 0.067
1.816GlyTrp: 1.816 ± 0.036
2.39GlyTyr: 2.39 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.534HisAla: 2.534 ± 0.036
0.303HisCys: 0.303 ± 0.014
1.404HisAsp: 1.404 ± 0.027
0.997HisGlu: 0.997 ± 0.023
0.676HisPhe: 0.676 ± 0.019
2.176HisGly: 2.176 ± 0.032
0.758HisHis: 0.758 ± 0.023
0.843HisIle: 0.843 ± 0.022
0.359HisLys: 0.359 ± 0.015
2.094HisLeu: 2.094 ± 0.035
0.372HisMet: 0.372 ± 0.015
0.553HisAsn: 0.553 ± 0.018
1.783HisPro: 1.783 ± 0.034
0.772HisGln: 0.772 ± 0.022
2.248HisArg: 2.248 ± 0.038
1.18HisSer: 1.18 ± 0.025
1.303HisThr: 1.303 ± 0.026
1.695HisVal: 1.695 ± 0.029
0.414HisTrp: 0.414 ± 0.016
0.572HisTyr: 0.572 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
6.111IleAla: 6.111 ± 0.062
0.448IleCys: 0.448 ± 0.015
3.142IleAsp: 3.142 ± 0.039
2.296IleGlu: 2.296 ± 0.037
0.996IlePhe: 0.996 ± 0.025
4.593IleGly: 4.593 ± 0.068
0.805IleHis: 0.805 ± 0.02
1.371IleIle: 1.371 ± 0.028
0.838IleLys: 0.838 ± 0.022
2.798IleLeu: 2.798 ± 0.039
0.637IleMet: 0.637 ± 0.017
1.181IleAsn: 1.181 ± 0.027
2.532IlePro: 2.532 ± 0.047
0.934IleGln: 0.934 ± 0.02
2.748IleArg: 2.748 ± 0.042
2.429IleSer: 2.429 ± 0.039
2.755IleThr: 2.755 ± 0.039
3.362IleVal: 3.362 ± 0.047
0.485IleTrp: 0.485 ± 0.017
0.792IleTyr: 0.792 ± 0.02
0.0IleXaa: 0.0 ± 0.0
Lys
2.424LysAla: 2.424 ± 0.045
0.143LysCys: 0.143 ± 0.009
0.961LysAsp: 0.961 ± 0.026
0.795LysGlu: 0.795 ± 0.021
0.557LysPhe: 0.557 ± 0.016
1.37LysGly: 1.37 ± 0.03
0.505LysHis: 0.505 ± 0.017
0.89LysIle: 0.89 ± 0.022
0.54LysLys: 0.54 ± 0.021
2.103LysLeu: 2.103 ± 0.041
0.441LysMet: 0.441 ± 0.015
0.474LysAsn: 0.474 ± 0.015
1.463LysPro: 1.463 ± 0.027
0.652LysGln: 0.652 ± 0.018
1.508LysArg: 1.508 ± 0.031
1.151LysSer: 1.151 ± 0.027
1.299LysThr: 1.299 ± 0.026
1.755LysVal: 1.755 ± 0.03
0.299LysTrp: 0.299 ± 0.013
0.433LysTyr: 0.433 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
13.753LeuAla: 13.753 ± 0.102
0.846LeuCys: 0.846 ± 0.023
6.057LeuAsp: 6.057 ± 0.067
3.867LeuGlu: 3.867 ± 0.054
2.624LeuPhe: 2.624 ± 0.043
8.485LeuGly: 8.485 ± 0.078
2.071LeuHis: 2.071 ± 0.037
3.823LeuIle: 3.823 ± 0.048
1.693LeuLys: 1.693 ± 0.031
9.501LeuLeu: 9.501 ± 0.097
1.665LeuMet: 1.665 ± 0.032
2.245LeuAsn: 2.245 ± 0.038
6.126LeuPro: 6.126 ± 0.071
2.674LeuGln: 2.674 ± 0.036
7.679LeuArg: 7.679 ± 0.077
5.7LeuSer: 5.7 ± 0.052
6.219LeuThr: 6.219 ± 0.052
7.891LeuVal: 7.891 ± 0.063
1.188LeuTrp: 1.188 ± 0.027
1.608LeuTyr: 1.608 ± 0.029
0.0LeuXaa: 0.0 ± 0.0
Met
2.772MetAla: 2.772 ± 0.039
0.212MetCys: 0.212 ± 0.011
0.873MetAsp: 0.873 ± 0.025
0.651MetGlu: 0.651 ± 0.02
0.689MetPhe: 0.689 ± 0.02
1.55MetGly: 1.55 ± 0.031
0.445MetHis: 0.445 ± 0.017
0.947MetIle: 0.947 ± 0.024
0.415MetLys: 0.415 ± 0.015
2.252MetLeu: 2.252 ± 0.035
0.48MetMet: 0.48 ± 0.018
0.494MetAsn: 0.494 ± 0.017
1.348MetPro: 1.348 ± 0.027
0.58MetGln: 0.58 ± 0.018
1.554MetArg: 1.554 ± 0.028
1.579MetSer: 1.579 ± 0.028
1.678MetThr: 1.678 ± 0.032
1.673MetVal: 1.673 ± 0.032
0.341MetTrp: 0.341 ± 0.012
0.382MetTyr: 0.382 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.857AsnAla: 2.857 ± 0.05
0.215AsnCys: 0.215 ± 0.01
1.177AsnAsp: 1.177 ± 0.025
0.947AsnGlu: 0.947 ± 0.02
0.823AsnPhe: 0.823 ± 0.032
2.576AsnGly: 2.576 ± 0.069
0.532AsnHis: 0.532 ± 0.016
1.161AsnIle: 1.161 ± 0.058
0.428AsnLys: 0.428 ± 0.017
2.184AsnLeu: 2.184 ± 0.037
0.422AsnMet: 0.422 ± 0.017
0.709AsnAsn: 0.709 ± 0.038
1.817AsnPro: 1.817 ± 0.03
0.733AsnGln: 0.733 ± 0.021
1.714AsnArg: 1.714 ± 0.027
1.588AsnSer: 1.588 ± 0.065
1.641AsnThr: 1.641 ± 0.074
1.893AsnVal: 1.893 ± 0.047
0.402AsnTrp: 0.402 ± 0.016
0.559AsnTyr: 0.559 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
8.196ProAla: 8.196 ± 0.081
0.435ProCys: 0.435 ± 0.018
4.088ProAsp: 4.088 ± 0.05
3.356ProGlu: 3.356 ± 0.042
1.645ProPhe: 1.645 ± 0.033
6.215ProGly: 6.215 ± 0.071
1.349ProHis: 1.349 ± 0.027
2.263ProIle: 2.263 ± 0.039
1.249ProLys: 1.249 ± 0.026
4.929ProLeu: 4.929 ± 0.058
1.298ProMet: 1.298 ± 0.025
1.352ProAsn: 1.352 ± 0.031
4.381ProPro: 4.381 ± 0.093
1.95ProGln: 1.95 ± 0.038
4.066ProArg: 4.066 ± 0.055
3.485ProSer: 3.485 ± 0.048
3.842ProThr: 3.842 ± 0.054
5.03ProVal: 5.03 ± 0.055
0.95ProTrp: 0.95 ± 0.025
1.165ProTyr: 1.165 ± 0.022
0.0ProXaa: 0.0 ± 0.0
Gln
4.044GlnAla: 4.044 ± 0.051
0.263GlnCys: 0.263 ± 0.013
1.182GlnAsp: 1.182 ± 0.024
1.086GlnGlu: 1.086 ± 0.026
0.972GlnPhe: 0.972 ± 0.022
1.992GlnGly: 1.992 ± 0.036
0.873GlnHis: 0.873 ± 0.021
1.439GlnIle: 1.439 ± 0.026
0.509GlnLys: 0.509 ± 0.019
3.89GlnLeu: 3.89 ± 0.049
0.686GlnMet: 0.686 ± 0.019
0.625GlnAsn: 0.625 ± 0.019
2.059GlnPro: 2.059 ± 0.038
1.417GlnGln: 1.417 ± 0.032
3.039GlnArg: 3.039 ± 0.038
1.585GlnSer: 1.585 ± 0.029
1.668GlnThr: 1.668 ± 0.031
2.493GlnVal: 2.493 ± 0.037
0.553GlnTrp: 0.553 ± 0.015
0.644GlnTyr: 0.644 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
8.574ArgAla: 8.574 ± 0.084
1.149ArgCys: 1.149 ± 0.027
4.052ArgAsp: 4.052 ± 0.045
3.415ArgGlu: 3.415 ± 0.047
2.459ArgPhe: 2.459 ± 0.046
5.263ArgGly: 5.263 ± 0.063
2.114ArgHis: 2.114 ± 0.035
3.434ArgIle: 3.434 ± 0.044
1.529ArgLys: 1.529 ± 0.031
7.847ArgLeu: 7.847 ± 0.078
1.972ArgMet: 1.972 ± 0.032
1.789ArgAsn: 1.789 ± 0.028
4.794ArgPro: 4.794 ± 0.064
2.591ArgGln: 2.591 ± 0.041
8.305ArgArg: 8.305 ± 0.112
4.635ArgSer: 4.635 ± 0.061
3.995ArgThr: 3.995 ± 0.051
5.416ArgVal: 5.416 ± 0.063
1.646ArgTrp: 1.646 ± 0.03
1.966ArgTyr: 1.966 ± 0.027
0.0ArgXaa: 0.0 ± 0.0
Ser
7.688SerAla: 7.688 ± 0.081
0.628SerCys: 0.628 ± 0.022
2.933SerAsp: 2.933 ± 0.04
2.33SerGlu: 2.33 ± 0.036
1.653SerPhe: 1.653 ± 0.03
6.411SerGly: 6.411 ± 0.121
1.098SerHis: 1.098 ± 0.025
2.157SerIle: 2.157 ± 0.036
1.108SerLys: 1.108 ± 0.024
4.879SerLeu: 4.879 ± 0.055
1.436SerMet: 1.436 ± 0.026
1.263SerAsn: 1.263 ± 0.028
3.625SerPro: 3.625 ± 0.045
1.624SerGln: 1.624 ± 0.024
4.223SerArg: 4.223 ± 0.052
3.665SerSer: 3.665 ± 0.063
3.665SerThr: 3.665 ± 0.044
4.477SerVal: 4.477 ± 0.051
1.074SerTrp: 1.074 ± 0.025
1.355SerTyr: 1.355 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
8.192ThrAla: 8.192 ± 0.092
0.55ThrCys: 0.55 ± 0.017
3.283ThrAsp: 3.283 ± 0.043
2.727ThrGlu: 2.727 ± 0.043
1.71ThrPhe: 1.71 ± 0.034
6.538ThrGly: 6.538 ± 0.106
1.238ThrHis: 1.238 ± 0.029
2.455ThrIle: 2.455 ± 0.036
1.173ThrLys: 1.173 ± 0.025
5.327ThrLeu: 5.327 ± 0.054
1.304ThrMet: 1.304 ± 0.027
1.382ThrAsn: 1.382 ± 0.03
3.979ThrPro: 3.979 ± 0.052
1.543ThrGln: 1.543 ± 0.031
3.802ThrArg: 3.802 ± 0.05
3.407ThrSer: 3.407 ± 0.048
4.071ThrThr: 4.071 ± 0.068
5.446ThrVal: 5.446 ± 0.061
0.891ThrTrp: 0.891 ± 0.024
1.202ThrTyr: 1.202 ± 0.025
0.0ThrXaa: 0.0 ± 0.0
Val
11.148ValAla: 11.148 ± 0.088
0.848ValCys: 0.848 ± 0.024
5.144ValAsp: 5.144 ± 0.057
4.007ValGlu: 4.007 ± 0.053
2.439ValPhe: 2.439 ± 0.037
7.004ValGly: 7.004 ± 0.082
1.715ValHis: 1.715 ± 0.035
3.715ValIle: 3.715 ± 0.045
1.511ValLys: 1.511 ± 0.032
8.286ValLeu: 8.286 ± 0.081
1.519ValMet: 1.519 ± 0.032
2.036ValAsn: 2.036 ± 0.035
4.595ValPro: 4.595 ± 0.049
2.08ValGln: 2.08 ± 0.04
5.72ValArg: 5.72 ± 0.067
4.72ValSer: 4.72 ± 0.06
5.215ValThr: 5.215 ± 0.055
8.025ValVal: 8.025 ± 0.093
1.05ValTrp: 1.05 ± 0.02
1.442ValTyr: 1.442 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.651TrpAla: 1.651 ± 0.03
0.228TrpCys: 0.228 ± 0.011
0.78TrpAsp: 0.78 ± 0.02
0.613TrpGlu: 0.613 ± 0.018
0.484TrpPhe: 0.484 ± 0.017
1.021TrpGly: 1.021 ± 0.025
0.393TrpHis: 0.393 ± 0.016
0.662TrpIle: 0.662 ± 0.018
0.322TrpLys: 0.322 ± 0.013
1.824TrpLeu: 1.824 ± 0.036
0.394TrpMet: 0.394 ± 0.015
0.43TrpAsn: 0.43 ± 0.018
1.067TrpPro: 1.067 ± 0.028
0.696TrpGln: 0.696 ± 0.019
1.519TrpArg: 1.519 ± 0.031
1.046TrpSer: 1.046 ± 0.021
0.919TrpThr: 0.919 ± 0.022
1.127TrpVal: 1.127 ± 0.023
0.404TrpTrp: 0.404 ± 0.015
0.326TrpTyr: 0.326 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.447TyrAla: 2.447 ± 0.035
0.236TyrCys: 0.236 ± 0.012
1.284TyrAsp: 1.284 ± 0.026
0.992TyrGlu: 0.992 ± 0.021
0.737TyrPhe: 0.737 ± 0.021
2.0TyrGly: 2.0 ± 0.036
0.52TyrHis: 0.52 ± 0.019
0.603TyrIle: 0.603 ± 0.018
0.314TyrLys: 0.314 ± 0.013
2.271TyrLeu: 2.271 ± 0.038
0.275TyrMet: 0.275 ± 0.012
0.536TyrAsn: 0.536 ± 0.027
1.266TyrPro: 1.266 ± 0.028
0.793TyrGln: 0.793 ± 0.023
1.937TyrArg: 1.937 ± 0.037
1.144TyrSer: 1.144 ± 0.027
1.128TyrThr: 1.128 ± 0.024
1.596TyrVal: 1.596 ± 0.031
0.365TyrTrp: 0.365 ± 0.014
0.512TyrTyr: 0.512 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7684 proteins (1907453 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski