Amino acid dipepetide frequency for Acidianus brierleyi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.097AlaAla: 3.097 ± 0.089	0.377AlaCys: 0.377 ± 0.024	2.3AlaAsp: 2.3 ± 0.055	3.286AlaGlu: 3.286 ± 0.067	2.802AlaPhe: 2.802 ± 0.066	3.606AlaGly: 3.606 ± 0.083	0.764AlaHis: 0.764 ± 0.036	5.999AlaIle: 5.999 ± 0.098	4.15AlaLys: 4.15 ± 0.075	6.084AlaLeu: 6.084 ± 0.099	1.389AlaMet: 1.389 ± 0.043	2.195AlaAsn: 2.195 ± 0.059	1.545AlaPro: 1.545 ± 0.056	1.099AlaGln: 1.099 ± 0.037	2.142AlaArg: 2.142 ± 0.059	3.843AlaSer: 3.843 ± 0.062	2.618AlaThr: 2.618 ± 0.062	3.773AlaVal: 3.773 ± 0.087	0.563AlaTrp: 0.563 ± 0.03	2.688AlaTyr: 2.688 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.28CysAla: 0.28 ± 0.02	0.091CysCys: 0.091 ± 0.012	0.357CysAsp: 0.357 ± 0.025	0.455CysGlu: 0.455 ± 0.025	0.22CysPhe: 0.22 ± 0.019	0.72CysGly: 0.72 ± 0.035	0.1CysHis: 0.1 ± 0.011	0.504CysIle: 0.504 ± 0.022	0.609CysLys: 0.609 ± 0.034	0.377CysLeu: 0.377 ± 0.022	0.173CysMet: 0.173 ± 0.015	0.424CysAsn: 0.424 ± 0.023	0.54CysPro: 0.54 ± 0.03	0.115CysGln: 0.115 ± 0.013	0.237CysArg: 0.237 ± 0.018	0.425CysSer: 0.425 ± 0.027	0.297CysThr: 0.297 ± 0.02	0.367CysVal: 0.367 ± 0.023	0.065CysTrp: 0.065 ± 0.009	0.288CysTyr: 0.288 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.414AspAla: 2.414 ± 0.061	0.361AspCys: 0.361 ± 0.025	2.206AspAsp: 2.206 ± 0.052	3.738AspGlu: 3.738 ± 0.082	2.649AspPhe: 2.649 ± 0.061	2.645AspGly: 2.645 ± 0.064	0.572AspHis: 0.572 ± 0.026	5.42AspIle: 5.42 ± 0.094	4.263AspLys: 4.263 ± 0.086	5.11AspLeu: 5.11 ± 0.084	1.091AspMet: 1.091 ± 0.035	2.599AspAsn: 2.599 ± 0.07	2.229AspPro: 2.229 ± 0.058	0.86AspGln: 0.86 ± 0.033	1.673AspArg: 1.673 ± 0.047	2.868AspSer: 2.868 ± 0.063	1.927AspThr: 1.927 ± 0.045	3.617AspVal: 3.617 ± 0.07	0.569AspTrp: 0.569 ± 0.031	2.604AspTyr: 2.604 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	3.659GluAla: 3.659 ± 0.069	0.405GluCys: 0.405 ± 0.024	3.651GluAsp: 3.651 ± 0.071	5.655GluGlu: 5.655 ± 0.105	2.838GluPhe: 2.838 ± 0.062	4.069GluGly: 4.069 ± 0.08	0.686GluHis: 0.686 ± 0.03	7.967GluIle: 7.967 ± 0.126	6.934GluLys: 6.934 ± 0.115	6.155GluLeu: 6.155 ± 0.088	1.567GluMet: 1.567 ± 0.043	4.027GluAsn: 4.027 ± 0.076	1.662GluPro: 1.662 ± 0.043	1.083GluGln: 1.083 ± 0.037	2.521GluArg: 2.521 ± 0.063	3.264GluSer: 3.264 ± 0.069	2.489GluThr: 2.489 ± 0.06	4.473GluVal: 4.473 ± 0.084	0.686GluTrp: 0.686 ± 0.03	2.869GluTyr: 2.869 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.444PheAla: 2.444 ± 0.063	0.281PheCys: 0.281 ± 0.019	2.249PheAsp: 2.249 ± 0.06	2.344PheGlu: 2.344 ± 0.059	2.287PhePhe: 2.287 ± 0.069	2.845PheGly: 2.845 ± 0.062	0.751PheHis: 0.751 ± 0.027	4.487PheIle: 4.487 ± 0.096	3.006PheLys: 3.006 ± 0.064	5.305PheLeu: 5.305 ± 0.104	1.188PheMet: 1.188 ± 0.042	2.701PheAsn: 2.701 ± 0.055	1.989PhePro: 1.989 ± 0.051	0.951PheGln: 0.951 ± 0.032	1.65PheArg: 1.65 ± 0.045	4.381PheSer: 4.381 ± 0.077	2.528PheThr: 2.528 ± 0.063	2.676PheVal: 2.676 ± 0.059	0.512PheTrp: 0.512 ± 0.026	2.611PheTyr: 2.611 ± 0.061	0.0PheXaa: 0.0 ± 0.0
Gly	3.38GlyAla: 3.38 ± 0.088	0.428GlyCys: 0.428 ± 0.024	2.976GlyAsp: 2.976 ± 0.063	4.064GlyGlu: 4.064 ± 0.08	3.345GlyPhe: 3.345 ± 0.073	4.196GlyGly: 4.196 ± 0.098	0.843GlyHis: 0.843 ± 0.035	7.965GlyIle: 7.965 ± 0.099	5.925GlyLys: 5.925 ± 0.086	5.899GlyLeu: 5.899 ± 0.089	1.385GlyMet: 1.385 ± 0.041	3.332GlyAsn: 3.332 ± 0.073	1.708GlyPro: 1.708 ± 0.051	1.058GlyGln: 1.058 ± 0.037	2.306GlyArg: 2.306 ± 0.052	3.918GlySer: 3.918 ± 0.073	2.992GlyThr: 2.992 ± 0.08	4.177GlyVal: 4.177 ± 0.072	0.844GlyTrp: 0.844 ± 0.031	3.475GlyTyr: 3.475 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	0.71HisAla: 0.71 ± 0.032	0.118HisCys: 0.118 ± 0.013	0.616HisAsp: 0.616 ± 0.026	0.831HisGlu: 0.831 ± 0.037	0.588HisPhe: 0.588 ± 0.027	1.002HisGly: 1.002 ± 0.038	0.261HisHis: 0.261 ± 0.018	1.029HisIle: 1.029 ± 0.036	0.792HisLys: 0.792 ± 0.038	1.178HisLeu: 1.178 ± 0.037	0.288HisMet: 0.288 ± 0.019	0.633HisAsn: 0.633 ± 0.032	0.705HisPro: 0.705 ± 0.031	0.228HisGln: 0.228 ± 0.018	0.459HisArg: 0.459 ± 0.029	0.797HisSer: 0.797 ± 0.036	0.586HisThr: 0.586 ± 0.031	0.934HisVal: 0.934 ± 0.037	0.132HisTrp: 0.132 ± 0.014	0.684HisTyr: 0.684 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.321IleAla: 6.321 ± 0.092	0.596IleCys: 0.596 ± 0.029	5.515IleAsp: 5.515 ± 0.089	6.403IleGlu: 6.403 ± 0.113	4.981IlePhe: 4.981 ± 0.107	6.507IleGly: 6.507 ± 0.114	1.266IleHis: 1.266 ± 0.043	10.953IleIle: 10.953 ± 0.141	8.122IleLys: 8.122 ± 0.118	10.236IleLeu: 10.236 ± 0.128	2.348IleMet: 2.348 ± 0.054	5.727IleAsn: 5.727 ± 0.09	4.439IlePro: 4.439 ± 0.073	2.017IleGln: 2.017 ± 0.048	3.936IleArg: 3.936 ± 0.078	8.604IleSer: 8.604 ± 0.126	5.006IleThr: 5.006 ± 0.089	6.647IleVal: 6.647 ± 0.1	0.72IleTrp: 0.72 ± 0.034	4.566IleTyr: 4.566 ± 0.09	0.0IleXaa: 0.0 ± 0.0
Lys	3.979LysAla: 3.979 ± 0.063	0.549LysCys: 0.549 ± 0.032	4.905LysAsp: 4.905 ± 0.092	7.218LysGlu: 7.218 ± 0.108	3.068LysPhe: 3.068 ± 0.059	5.114LysGly: 5.114 ± 0.084	0.735LysHis: 0.735 ± 0.028	9.652LysIle: 9.652 ± 0.134	6.613LysLys: 6.613 ± 0.113	7.277LysLeu: 7.277 ± 0.117	1.933LysMet: 1.933 ± 0.048	4.732LysAsn: 4.732 ± 0.094	2.468LysPro: 2.468 ± 0.058	1.26LysGln: 1.26 ± 0.044	3.162LysArg: 3.162 ± 0.064	4.387LysSer: 4.387 ± 0.079	3.323LysThr: 3.323 ± 0.063	5.828LysVal: 5.828 ± 0.095	0.817LysTrp: 0.817 ± 0.029	4.033LysTyr: 4.033 ± 0.075	0.0LysXaa: 0.0 ± 0.0
Leu	5.906LeuAla: 5.906 ± 0.098	0.529LeuCys: 0.529 ± 0.027	5.105LeuAsp: 5.105 ± 0.088	6.036LeuGlu: 6.036 ± 0.098	4.239LeuPhe: 4.239 ± 0.091	7.237LeuGly: 7.237 ± 0.098	1.271LeuHis: 1.271 ± 0.045	9.056LeuIle: 9.056 ± 0.143	7.691LeuLys: 7.691 ± 0.106	9.244LeuLeu: 9.244 ± 0.138	2.232LeuMet: 2.232 ± 0.054	5.42LeuAsn: 5.42 ± 0.092	3.918LeuPro: 3.918 ± 0.082	2.17LeuGln: 2.17 ± 0.057	4.35LeuArg: 4.35 ± 0.093	8.287LeuSer: 8.287 ± 0.126	4.835LeuThr: 4.835 ± 0.081	5.923LeuVal: 5.923 ± 0.089	0.903LeuTrp: 0.903 ± 0.04	4.184LeuTyr: 4.184 ± 0.075	0.0LeuXaa: 0.0 ± 0.0
Met	1.35MetAla: 1.35 ± 0.044	0.13MetCys: 0.13 ± 0.013	1.135MetAsp: 1.135 ± 0.032	1.774MetGlu: 1.774 ± 0.053	0.85MetPhe: 0.85 ± 0.032	1.473MetGly: 1.473 ± 0.049	0.305MetHis: 0.305 ± 0.016	2.253MetIle: 2.253 ± 0.054	2.257MetLys: 2.257 ± 0.048	2.203MetLeu: 2.203 ± 0.052	0.531MetMet: 0.531 ± 0.027	1.17MetAsn: 1.17 ± 0.036	0.872MetPro: 0.872 ± 0.034	0.547MetGln: 0.547 ± 0.029	1.08MetArg: 1.08 ± 0.036	1.707MetSer: 1.707 ± 0.049	1.059MetThr: 1.059 ± 0.034	1.245MetVal: 1.245 ± 0.042	0.224MetTrp: 0.224 ± 0.018	0.815MetTyr: 0.815 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	2.691AsnAla: 2.691 ± 0.06	0.424AsnCys: 0.424 ± 0.024	2.434AsnAsp: 2.434 ± 0.057	3.664AsnGlu: 3.664 ± 0.071	2.606AsnPhe: 2.606 ± 0.064	3.506AsnGly: 3.506 ± 0.082	0.512AsnHis: 0.512 ± 0.024	5.874AsnIle: 5.874 ± 0.108	4.186AsnLys: 4.186 ± 0.085	5.095AsnLeu: 5.095 ± 0.085	1.156AsnMet: 1.156 ± 0.039	3.1AsnAsn: 3.1 ± 0.077	2.468AsnPro: 2.468 ± 0.063	0.983AsnGln: 0.983 ± 0.036	1.716AsnArg: 1.716 ± 0.047	4.147AsnSer: 4.147 ± 0.081	2.394AsnThr: 2.394 ± 0.058	3.766AsnVal: 3.766 ± 0.074	0.572AsnTrp: 0.572 ± 0.031	2.886AsnTyr: 2.886 ± 0.079	0.0AsnXaa: 0.0 ± 0.0
Pro	1.814ProAla: 1.814 ± 0.052	0.233ProCys: 0.233 ± 0.017	1.781ProAsp: 1.781 ± 0.05	2.559ProGlu: 2.559 ± 0.058	2.115ProPhe: 2.115 ± 0.052	2.185ProGly: 2.185 ± 0.055	0.564ProHis: 0.564 ± 0.026	3.587ProIle: 3.587 ± 0.07	2.79ProLys: 2.79 ± 0.067	3.903ProLeu: 3.903 ± 0.074	0.719ProMet: 0.719 ± 0.031	1.838ProAsn: 1.838 ± 0.047	1.579ProPro: 1.579 ± 0.055	1.087ProGln: 1.087 ± 0.041	1.278ProArg: 1.278 ± 0.043	3.058ProSer: 3.058 ± 0.067	1.993ProThr: 1.993 ± 0.048	2.391ProVal: 2.391 ± 0.056	0.472ProTrp: 0.472 ± 0.027	2.084ProTyr: 2.084 ± 0.063	0.0ProXaa: 0.0 ± 0.0
Gln	1.103GlnAla: 1.103 ± 0.039	0.143GlnCys: 0.143 ± 0.017	0.993GlnAsp: 0.993 ± 0.037	1.436GlnGlu: 1.436 ± 0.041	0.827GlnPhe: 0.827 ± 0.032	1.412GlnGly: 1.412 ± 0.04	0.245GlnHis: 0.245 ± 0.019	1.939GlnIle: 1.939 ± 0.048	1.58GlnLys: 1.58 ± 0.051	2.031GlnLeu: 2.031 ± 0.057	0.534GlnMet: 0.534 ± 0.03	1.14GlnAsn: 1.14 ± 0.045	0.716GlnPro: 0.716 ± 0.039	0.591GlnGln: 0.591 ± 0.042	0.778GlnArg: 0.778 ± 0.031	1.16GlnSer: 1.16 ± 0.037	0.879GlnThr: 0.879 ± 0.034	1.304GlnVal: 1.304 ± 0.045	0.214GlnTrp: 0.214 ± 0.016	0.989GlnTyr: 0.989 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	1.919ArgAla: 1.919 ± 0.052	0.321ArgCys: 0.321 ± 0.022	1.953ArgAsp: 1.953 ± 0.056	3.027ArgGlu: 3.027 ± 0.078	1.717ArgPhe: 1.717 ± 0.046	2.43ArgGly: 2.43 ± 0.058	0.453ArgHis: 0.453 ± 0.023	3.784ArgIle: 3.784 ± 0.078	3.741ArgLys: 3.741 ± 0.073	3.59ArgLeu: 3.59 ± 0.071	0.894ArgMet: 0.894 ± 0.037	2.11ArgAsn: 2.11 ± 0.056	1.241ArgPro: 1.241 ± 0.042	0.763ArgGln: 0.763 ± 0.029	1.896ArgArg: 1.896 ± 0.058	2.181ArgSer: 2.181 ± 0.052	1.533ArgThr: 1.533 ± 0.042	2.387ArgVal: 2.387 ± 0.068	0.424ArgTrp: 0.424 ± 0.026	1.664ArgTyr: 1.664 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.535SerAla: 3.535 ± 0.075	0.468SerCys: 0.468 ± 0.027	2.979SerAsp: 2.979 ± 0.061	4.096SerGlu: 4.096 ± 0.083	3.712SerPhe: 3.712 ± 0.086	4.428SerGly: 4.428 ± 0.074	1.001SerHis: 1.001 ± 0.037	7.55SerIle: 7.55 ± 0.108	5.668SerLys: 5.668 ± 0.092	7.949SerLeu: 7.949 ± 0.12	1.799SerMet: 1.799 ± 0.048	3.579SerAsn: 3.579 ± 0.076	2.897SerPro: 2.897 ± 0.067	1.798SerGln: 1.798 ± 0.056	2.62SerArg: 2.62 ± 0.06	5.811SerSer: 5.811 ± 0.107	3.549SerThr: 3.549 ± 0.076	4.158SerVal: 4.158 ± 0.083	0.753SerTrp: 0.753 ± 0.036	3.159SerTyr: 3.159 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	2.9ThrAla: 2.9 ± 0.079	0.326ThrCys: 0.326 ± 0.022	1.905ThrAsp: 1.905 ± 0.049	2.659ThrGlu: 2.659 ± 0.063	2.258ThrPhe: 2.258 ± 0.06	3.103ThrGly: 3.103 ± 0.071	0.665ThrHis: 0.665 ± 0.03	4.709ThrIle: 4.709 ± 0.091	3.177ThrLys: 3.177 ± 0.071	5.167ThrLeu: 5.167 ± 0.093	1.054ThrMet: 1.054 ± 0.036	2.151ThrAsn: 2.151 ± 0.057	2.157ThrPro: 2.157 ± 0.063	1.154ThrGln: 1.154 ± 0.039	1.631ThrArg: 1.631 ± 0.044	3.41ThrSer: 3.41 ± 0.076	2.568ThrThr: 2.568 ± 0.078	3.064ThrVal: 3.064 ± 0.075	0.462ThrTrp: 0.462 ± 0.025	2.275ThrTyr: 2.275 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	3.642ValAla: 3.642 ± 0.07	0.411ValCys: 0.411 ± 0.025	3.432ValAsp: 3.432 ± 0.073	3.942ValGlu: 3.942 ± 0.076	3.024ValPhe: 3.024 ± 0.062	4.031ValGly: 4.031 ± 0.09	0.817ValHis: 0.817 ± 0.032	6.789ValIle: 6.789 ± 0.08	5.631ValLys: 5.631 ± 0.092	5.868ValLeu: 5.868 ± 0.097	1.412ValMet: 1.412 ± 0.039	3.725ValAsn: 3.725 ± 0.082	2.525ValPro: 2.525 ± 0.062	1.098ValGln: 1.098 ± 0.038	2.516ValArg: 2.516 ± 0.06	4.763ValSer: 4.763 ± 0.086	3.31ValThr: 3.31 ± 0.075	4.131ValVal: 4.131 ± 0.074	0.606ValTrp: 0.606 ± 0.027	3.016ValTyr: 3.016 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.541TrpAla: 0.541 ± 0.024	0.062TrpCys: 0.062 ± 0.009	0.505TrpAsp: 0.505 ± 0.026	0.645TrpGlu: 0.645 ± 0.031	0.511TrpPhe: 0.511 ± 0.026	0.678TrpGly: 0.678 ± 0.031	0.143TrpHis: 0.143 ± 0.014	1.051TrpIle: 1.051 ± 0.037	0.897TrpLys: 0.897 ± 0.031	1.016TrpLeu: 1.016 ± 0.043	0.244TrpMet: 0.244 ± 0.016	0.681TrpAsn: 0.681 ± 0.031	0.295TrpPro: 0.295 ± 0.02	0.178TrpGln: 0.178 ± 0.014	0.444TrpArg: 0.444 ± 0.025	0.583TrpSer: 0.583 ± 0.028	0.442TrpThr: 0.442 ± 0.02	0.595TrpVal: 0.595 ± 0.027	0.137TrpTrp: 0.137 ± 0.013	0.52TrpTyr: 0.52 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.635TyrAla: 2.635 ± 0.047	0.391TyrCys: 0.391 ± 0.024	2.416TyrAsp: 2.416 ± 0.056	2.826TyrGlu: 2.826 ± 0.062	2.549TyrPhe: 2.549 ± 0.06	3.033TyrGly: 3.033 ± 0.065	0.614TyrHis: 0.614 ± 0.031	4.342TyrIle: 4.342 ± 0.085	3.022TyrLys: 3.022 ± 0.068	4.849TyrLeu: 4.849 ± 0.084	1.039TyrMet: 1.039 ± 0.042	2.897TyrAsn: 2.897 ± 0.071	2.075TyrPro: 2.075 ± 0.056	0.977TyrGln: 0.977 ± 0.038	1.637TyrArg: 1.637 ± 0.054	3.914TyrSer: 3.914 ± 0.069	2.468TyrThr: 2.468 ± 0.062	3.231TyrVal: 3.231 ± 0.061	0.495TyrTrp: 0.495 ± 0.023	2.688TyrTyr: 2.688 ± 0.072	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2858 proteins (790434 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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