Amino acid dipepetide frequency for Pseudopropionibacterium propionicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.871AlaAla: 15.871 ± 0.192	1.117AlaCys: 1.117 ± 0.031	6.543AlaAsp: 6.543 ± 0.094	7.437AlaGlu: 7.437 ± 0.121	3.393AlaPhe: 3.393 ± 0.07	10.837AlaGly: 10.837 ± 0.119	2.292AlaHis: 2.292 ± 0.048	4.968AlaIle: 4.968 ± 0.068	3.102AlaLys: 3.102 ± 0.064	12.608AlaLeu: 12.608 ± 0.136	2.784AlaMet: 2.784 ± 0.053	2.33AlaAsn: 2.33 ± 0.052	5.208AlaPro: 5.208 ± 0.089	3.353AlaGln: 3.353 ± 0.062	8.533AlaArg: 8.533 ± 0.109	6.5AlaSer: 6.5 ± 0.09	6.859AlaThr: 6.859 ± 0.084	9.897AlaVal: 9.897 ± 0.124	1.932AlaTrp: 1.932 ± 0.05	1.921AlaTyr: 1.921 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.876CysAla: 0.876 ± 0.024	0.135CysCys: 0.135 ± 0.014	0.543CysAsp: 0.543 ± 0.024	0.429CysGlu: 0.429 ± 0.023	0.284CysPhe: 0.284 ± 0.015	0.913CysGly: 0.913 ± 0.032	0.201CysHis: 0.201 ± 0.016	0.333CysIle: 0.333 ± 0.018	0.121CysLys: 0.121 ± 0.012	0.919CysLeu: 0.919 ± 0.035	0.179CysMet: 0.179 ± 0.014	0.179CysAsn: 0.179 ± 0.014	0.487CysPro: 0.487 ± 0.024	0.211CysGln: 0.211 ± 0.014	0.623CysArg: 0.623 ± 0.027	0.566CysSer: 0.566 ± 0.024	0.475CysThr: 0.475 ± 0.025	0.676CysVal: 0.676 ± 0.026	0.168CysTrp: 0.168 ± 0.013	0.183CysTyr: 0.183 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.512AspAla: 6.512 ± 0.088	0.396AspCys: 0.396 ± 0.022	3.426AspAsp: 3.426 ± 0.06	4.11AspGlu: 4.11 ± 0.071	1.712AspPhe: 1.712 ± 0.039	5.342AspGly: 5.342 ± 0.08	1.338AspHis: 1.338 ± 0.037	2.241AspIle: 2.241 ± 0.054	1.229AspLys: 1.229 ± 0.036	6.55AspLeu: 6.55 ± 0.089	0.917AspMet: 0.917 ± 0.031	1.015AspAsn: 1.015 ± 0.032	4.186AspPro: 4.186 ± 0.068	1.614AspGln: 1.614 ± 0.039	3.904AspArg: 3.904 ± 0.068	2.886AspSer: 2.886 ± 0.059	2.403AspThr: 2.403 ± 0.054	4.7AspVal: 4.7 ± 0.079	0.983AspTrp: 0.983 ± 0.033	1.221AspTyr: 1.221 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.275GluAla: 7.275 ± 0.11	0.408GluCys: 0.408 ± 0.019	2.808GluAsp: 2.808 ± 0.061	3.818GluGlu: 3.818 ± 0.088	1.78GluPhe: 1.78 ± 0.048	4.179GluGly: 4.179 ± 0.063	1.487GluHis: 1.487 ± 0.04	2.96GluIle: 2.96 ± 0.064	1.922GluLys: 1.922 ± 0.056	7.215GluLeu: 7.215 ± 0.106	1.173GluMet: 1.173 ± 0.032	1.514GluAsn: 1.514 ± 0.038	3.16GluPro: 3.16 ± 0.062	2.405GluGln: 2.405 ± 0.05	4.825GluArg: 4.825 ± 0.082	2.841GluSer: 2.841 ± 0.051	3.639GluThr: 3.639 ± 0.072	5.131GluVal: 5.131 ± 0.077	0.803GluTrp: 0.803 ± 0.027	1.071GluTyr: 1.071 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.461PheAla: 3.461 ± 0.061	0.32PheCys: 0.32 ± 0.018	2.07PheAsp: 2.07 ± 0.05	1.769PheGlu: 1.769 ± 0.045	1.001PhePhe: 1.001 ± 0.039	3.206PheGly: 3.206 ± 0.076	0.662PheHis: 0.662 ± 0.027	1.224PheIle: 1.224 ± 0.037	0.71PheLys: 0.71 ± 0.029	3.071PheLeu: 3.071 ± 0.065	0.561PheMet: 0.561 ± 0.027	0.804PheAsn: 0.804 ± 0.03	1.531PhePro: 1.531 ± 0.039	0.877PheGln: 0.877 ± 0.032	1.932PheArg: 1.932 ± 0.044	1.945PheSer: 1.945 ± 0.055	2.14PheThr: 2.14 ± 0.05	2.589PheVal: 2.589 ± 0.062	0.477PheTrp: 0.477 ± 0.021	0.629PheTyr: 0.629 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.882GlyAla: 8.882 ± 0.106	0.893GlyCys: 0.893 ± 0.025	4.651GlyAsp: 4.651 ± 0.068	5.222GlyGlu: 5.222 ± 0.081	3.386GlyPhe: 3.386 ± 0.07	7.146GlyGly: 7.146 ± 0.113	1.969GlyHis: 1.969 ± 0.043	4.791GlyIle: 4.791 ± 0.073	2.835GlyLys: 2.835 ± 0.063	9.429GlyLeu: 9.429 ± 0.107	2.174GlyMet: 2.174 ± 0.055	2.167GlyAsn: 2.167 ± 0.052	3.773GlyPro: 3.773 ± 0.067	2.865GlyGln: 2.865 ± 0.059	6.73GlyArg: 6.73 ± 0.105	5.32GlySer: 5.32 ± 0.074	5.282GlyThr: 5.282 ± 0.083	7.483GlyVal: 7.483 ± 0.108	1.798GlyTrp: 1.798 ± 0.051	2.13GlyTyr: 2.13 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.085HisAla: 2.085 ± 0.046	0.219HisCys: 0.219 ± 0.018	1.405HisAsp: 1.405 ± 0.039	1.261HisGlu: 1.261 ± 0.034	0.572HisPhe: 0.572 ± 0.023	1.883HisGly: 1.883 ± 0.045	0.587HisHis: 0.587 ± 0.023	0.841HisIle: 0.841 ± 0.029	0.354HisLys: 0.354 ± 0.019	2.348HisLeu: 2.348 ± 0.049	0.373HisMet: 0.373 ± 0.021	0.473HisAsn: 0.473 ± 0.022	1.614HisPro: 1.614 ± 0.035	0.679HisGln: 0.679 ± 0.026	1.802HisArg: 1.802 ± 0.044	1.008HisSer: 1.008 ± 0.032	1.137HisThr: 1.137 ± 0.04	1.651HisVal: 1.651 ± 0.04	0.338HisTrp: 0.338 ± 0.018	0.43HisTyr: 0.43 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.692IleAla: 5.692 ± 0.086	0.433IleCys: 0.433 ± 0.022	3.14IleAsp: 3.14 ± 0.062	2.627IleGlu: 2.627 ± 0.05	1.15IlePhe: 1.15 ± 0.041	4.365IleGly: 4.365 ± 0.082	0.937IleHis: 0.937 ± 0.028	1.897IleIle: 1.897 ± 0.054	1.012IleLys: 1.012 ± 0.034	3.804IleLeu: 3.804 ± 0.074	0.786IleMet: 0.786 ± 0.032	1.185IleAsn: 1.185 ± 0.034	2.53IlePro: 2.53 ± 0.05	1.107IleGln: 1.107 ± 0.035	3.115IleArg: 3.115 ± 0.062	2.68IleSer: 2.68 ± 0.051	3.076IleThr: 3.076 ± 0.058	3.525IleVal: 3.525 ± 0.077	0.577IleTrp: 0.577 ± 0.027	0.773IleTyr: 0.773 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.96LysAla: 2.96 ± 0.07	0.121LysCys: 0.121 ± 0.01	1.381LysAsp: 1.381 ± 0.04	1.571LysGlu: 1.571 ± 0.045	0.626LysPhe: 0.626 ± 0.027	1.974LysGly: 1.974 ± 0.053	0.579LysHis: 0.579 ± 0.024	1.048LysIle: 1.048 ± 0.038	1.029LysLys: 1.029 ± 0.041	2.617LysLeu: 2.617 ± 0.058	0.493LysMet: 0.493 ± 0.025	0.807LysAsn: 0.807 ± 0.034	1.589LysPro: 1.589 ± 0.047	0.992LysGln: 0.992 ± 0.038	1.894LysArg: 1.894 ± 0.049	1.427LysSer: 1.427 ± 0.046	1.593LysThr: 1.593 ± 0.049	2.366LysVal: 2.366 ± 0.056	0.313LysTrp: 0.313 ± 0.021	0.531LysTyr: 0.531 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.948LeuAla: 13.948 ± 0.141	0.851LeuCys: 0.851 ± 0.033	6.215LeuAsp: 6.215 ± 0.087	5.783LeuGlu: 5.783 ± 0.096	3.025LeuPhe: 3.025 ± 0.06	10.005LeuGly: 10.005 ± 0.131	1.946LeuHis: 1.946 ± 0.045	4.498LeuIle: 4.498 ± 0.081	2.571LeuLys: 2.571 ± 0.064	11.715LeuLeu: 11.715 ± 0.165	2.013LeuMet: 2.013 ± 0.052	2.314LeuAsn: 2.314 ± 0.045	6.121LeuPro: 6.121 ± 0.087	2.408LeuGln: 2.408 ± 0.055	7.962LeuArg: 7.962 ± 0.099	5.868LeuSer: 5.868 ± 0.077	6.889LeuThr: 6.889 ± 0.102	9.382LeuVal: 9.382 ± 0.117	1.266LeuTrp: 1.266 ± 0.039	1.483LeuTyr: 1.483 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.519MetAla: 2.519 ± 0.047	0.153MetCys: 0.153 ± 0.014	0.962MetAsp: 0.962 ± 0.033	0.921MetGlu: 0.921 ± 0.029	0.6MetPhe: 0.6 ± 0.024	1.548MetGly: 1.548 ± 0.041	0.355MetHis: 0.355 ± 0.018	1.05MetIle: 1.05 ± 0.033	0.648MetLys: 0.648 ± 0.025	2.17MetLeu: 2.17 ± 0.057	0.438MetMet: 0.438 ± 0.019	0.668MetAsn: 0.668 ± 0.026	1.145MetPro: 1.145 ± 0.036	0.554MetGln: 0.554 ± 0.024	1.589MetArg: 1.589 ± 0.04	1.551MetSer: 1.551 ± 0.034	1.677MetThr: 1.677 ± 0.047	1.706MetVal: 1.706 ± 0.042	0.267MetTrp: 0.267 ± 0.018	0.306MetTyr: 0.306 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.51AsnAla: 2.51 ± 0.057	0.165AsnCys: 0.165 ± 0.013	1.251AsnAsp: 1.251 ± 0.04	1.169AsnGlu: 1.169 ± 0.041	0.664AsnPhe: 0.664 ± 0.029	2.04AsnGly: 2.04 ± 0.051	0.575AsnHis: 0.575 ± 0.025	0.989AsnIle: 0.989 ± 0.032	0.605AsnLys: 0.605 ± 0.031	2.592AsnLeu: 2.592 ± 0.055	0.442AsnMet: 0.442 ± 0.022	0.672AsnAsn: 0.672 ± 0.031	1.971AsnPro: 1.971 ± 0.047	0.835AsnGln: 0.835 ± 0.03	1.743AsnArg: 1.743 ± 0.043	1.318AsnSer: 1.318 ± 0.037	1.396AsnThr: 1.396 ± 0.04	1.635AsnVal: 1.635 ± 0.042	0.403AsnTrp: 0.403 ± 0.023	0.582AsnTyr: 0.582 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.165ProAla: 6.165 ± 0.103	0.334ProCys: 0.334 ± 0.021	3.704ProAsp: 3.704 ± 0.063	4.626ProGlu: 4.626 ± 0.08	1.546ProPhe: 1.546 ± 0.041	6.041ProGly: 6.041 ± 0.096	1.131ProHis: 1.131 ± 0.037	1.803ProIle: 1.803 ± 0.045	1.414ProLys: 1.414 ± 0.041	4.77ProLeu: 4.77 ± 0.071	1.106ProMet: 1.106 ± 0.034	1.237ProAsn: 1.237 ± 0.037	2.474ProPro: 2.474 ± 0.07	1.683ProGln: 1.683 ± 0.043	3.558ProArg: 3.558 ± 0.062	3.282ProSer: 3.282 ± 0.067	3.322ProThr: 3.322 ± 0.059	4.859ProVal: 4.859 ± 0.091	0.88ProTrp: 0.88 ± 0.028	1.004ProTyr: 1.004 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.683GlnAla: 3.683 ± 0.056	0.178GlnCys: 0.178 ± 0.013	1.338GlnAsp: 1.338 ± 0.035	1.822GlnGlu: 1.822 ± 0.055	0.871GlnPhe: 0.871 ± 0.03	2.253GlnGly: 2.253 ± 0.06	0.606GlnHis: 0.606 ± 0.026	1.28GlnIle: 1.28 ± 0.039	0.724GlnLys: 0.724 ± 0.029	3.582GlnLeu: 3.582 ± 0.071	0.619GlnMet: 0.619 ± 0.025	0.694GlnAsn: 0.694 ± 0.028	1.784GlnPro: 1.784 ± 0.056	1.419GlnGln: 1.419 ± 0.048	2.467GlnArg: 2.467 ± 0.052	1.337GlnSer: 1.337 ± 0.037	1.403GlnThr: 1.403 ± 0.04	2.775GlnVal: 2.775 ± 0.058	0.455GlnTrp: 0.455 ± 0.021	0.591GlnTyr: 0.591 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.865ArgAla: 7.865 ± 0.104	0.645ArgCys: 0.645 ± 0.028	4.256ArgAsp: 4.256 ± 0.064	4.663ArgGlu: 4.663 ± 0.088	2.647ArgPhe: 2.647 ± 0.052	5.448ArgGly: 5.448 ± 0.092	1.661ArgHis: 1.661 ± 0.044	4.18ArgIle: 4.18 ± 0.067	1.901ArgLys: 1.901 ± 0.052	7.755ArgLeu: 7.755 ± 0.107	1.814ArgMet: 1.814 ± 0.048	1.859ArgAsn: 1.859 ± 0.046	3.672ArgPro: 3.672 ± 0.063	2.281ArgGln: 2.281 ± 0.055	6.866ArgArg: 6.866 ± 0.127	4.04ArgSer: 4.04 ± 0.063	4.027ArgThr: 4.027 ± 0.066	5.829ArgVal: 5.829 ± 0.086	1.241ArgTrp: 1.241 ± 0.034	1.636ArgTyr: 1.636 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.992SerAla: 5.992 ± 0.08	0.498SerCys: 0.498 ± 0.023	2.954SerAsp: 2.954 ± 0.054	3.057SerGlu: 3.057 ± 0.053	1.936SerPhe: 1.936 ± 0.048	6.14SerGly: 6.14 ± 0.08	1.168SerHis: 1.168 ± 0.03	2.304SerIle: 2.304 ± 0.054	1.296SerLys: 1.296 ± 0.045	5.765SerLeu: 5.765 ± 0.082	1.411SerMet: 1.411 ± 0.039	1.334SerAsn: 1.334 ± 0.037	3.477SerPro: 3.477 ± 0.065	1.707SerGln: 1.707 ± 0.042	4.29SerArg: 4.29 ± 0.068	3.703SerSer: 3.703 ± 0.077	3.185SerThr: 3.185 ± 0.067	4.272SerVal: 4.272 ± 0.064	1.018SerTrp: 1.018 ± 0.035	1.267SerTyr: 1.267 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.651ThrAla: 6.651 ± 0.088	0.544ThrCys: 0.544 ± 0.025	3.456ThrAsp: 3.456 ± 0.062	3.13ThrGlu: 3.13 ± 0.073	1.774ThrPhe: 1.774 ± 0.045	6.036ThrGly: 6.036 ± 0.088	1.277ThrHis: 1.277 ± 0.035	2.62ThrIle: 2.62 ± 0.057	1.536ThrLys: 1.536 ± 0.045	5.712ThrLeu: 5.712 ± 0.079	1.17ThrMet: 1.17 ± 0.035	1.447ThrAsn: 1.447 ± 0.039	3.941ThrPro: 3.941 ± 0.062	1.672ThrGln: 1.672 ± 0.044	4.122ThrArg: 4.122 ± 0.066	3.6ThrSer: 3.6 ± 0.069	3.959ThrThr: 3.959 ± 0.078	5.037ThrVal: 5.037 ± 0.079	1.019ThrTrp: 1.019 ± 0.035	1.12ThrTyr: 1.12 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.997ValAla: 10.997 ± 0.132	0.753ValCys: 0.753 ± 0.027	4.672ValAsp: 4.672 ± 0.073	5.042ValGlu: 5.042 ± 0.088	2.745ValPhe: 2.745 ± 0.062	6.62ValGly: 6.62 ± 0.086	1.574ValHis: 1.574 ± 0.042	4.15ValIle: 4.15 ± 0.071	2.09ValLys: 2.09 ± 0.047	9.334ValLeu: 9.334 ± 0.116	1.806ValMet: 1.806 ± 0.052	1.931ValAsn: 1.931 ± 0.046	4.459ValPro: 4.459 ± 0.064	1.975ValGln: 1.975 ± 0.049	5.334ValArg: 5.334 ± 0.073	4.938ValSer: 4.938 ± 0.075	5.556ValThr: 5.556 ± 0.104	8.407ValVal: 8.407 ± 0.129	1.069ValTrp: 1.069 ± 0.036	1.24ValTyr: 1.24 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.535TrpAla: 1.535 ± 0.041	0.168TrpCys: 0.168 ± 0.013	0.778TrpAsp: 0.778 ± 0.033	0.833TrpGlu: 0.833 ± 0.031	0.646TrpPhe: 0.646 ± 0.027	1.189TrpGly: 1.189 ± 0.033	0.328TrpHis: 0.328 ± 0.02	0.631TrpIle: 0.631 ± 0.029	0.411TrpLys: 0.411 ± 0.023	2.075TrpLeu: 2.075 ± 0.057	0.307TrpMet: 0.307 ± 0.02	0.473TrpAsn: 0.473 ± 0.025	0.721TrpPro: 0.721 ± 0.025	0.586TrpGln: 0.586 ± 0.021	1.382TrpArg: 1.382 ± 0.041	0.905TrpSer: 0.905 ± 0.042	0.779TrpThr: 0.779 ± 0.03	1.31TrpVal: 1.31 ± 0.039	0.416TrpTrp: 0.416 ± 0.022	0.275TrpTyr: 0.275 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.008TyrAla: 2.008 ± 0.042	0.172TyrCys: 0.172 ± 0.013	1.13TyrAsp: 1.13 ± 0.042	1.121TyrGlu: 1.121 ± 0.035	0.622TyrPhe: 0.622 ± 0.023	1.76TyrGly: 1.76 ± 0.054	0.387TyrHis: 0.387 ± 0.019	0.606TyrIle: 0.606 ± 0.028	0.401TyrLys: 0.401 ± 0.023	2.232TyrLeu: 2.232 ± 0.045	0.261TyrMet: 0.261 ± 0.016	0.452TyrAsn: 0.452 ± 0.025	1.098TyrPro: 1.098 ± 0.038	0.654TyrGln: 0.654 ± 0.026	1.618TyrArg: 1.618 ± 0.041	1.059TyrSer: 1.059 ± 0.027	1.026TyrThr: 1.026 ± 0.034	1.462TyrVal: 1.462 ± 0.037	0.325TyrTrp: 0.325 ± 0.019	0.436TyrTyr: 0.436 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3001 proteins (1008578 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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