Amino acid dipepetide frequency for Xenorhabdus bovienii (strain SS-2004)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.316AlaAla: 7.316 ± 0.119	1.003AlaCys: 1.003 ± 0.03	4.459AlaAsp: 4.459 ± 0.087	5.479AlaGlu: 5.479 ± 0.079	3.206AlaPhe: 3.206 ± 0.059	6.285AlaGly: 6.285 ± 0.095	1.65AlaHis: 1.65 ± 0.047	5.75AlaIle: 5.75 ± 0.078	4.119AlaLys: 4.119 ± 0.074	9.437AlaLeu: 9.437 ± 0.133	2.263AlaMet: 2.263 ± 0.047	3.176AlaAsn: 3.176 ± 0.054	2.811AlaPro: 2.811 ± 0.06	3.677AlaGln: 3.677 ± 0.086	4.147AlaArg: 4.147 ± 0.064	4.646AlaSer: 4.646 ± 0.064	4.09AlaThr: 4.09 ± 0.062	5.385AlaVal: 5.385 ± 0.075	0.965AlaTrp: 0.965 ± 0.028	2.388AlaTyr: 2.388 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.806CysAla: 0.806 ± 0.028	0.195CysCys: 0.195 ± 0.014	0.596CysAsp: 0.596 ± 0.022	0.578CysGlu: 0.578 ± 0.021	0.445CysPhe: 0.445 ± 0.021	0.928CysGly: 0.928 ± 0.027	0.397CysHis: 0.397 ± 0.022	0.67CysIle: 0.67 ± 0.023	0.392CysLys: 0.392 ± 0.02	1.07CysLeu: 1.07 ± 0.037	0.231CysMet: 0.231 ± 0.016	0.381CysAsn: 0.381 ± 0.019	0.466CysPro: 0.466 ± 0.021	0.612CysGln: 0.612 ± 0.023	0.671CysArg: 0.671 ± 0.025	0.712CysSer: 0.712 ± 0.026	0.499CysThr: 0.499 ± 0.023	0.646CysVal: 0.646 ± 0.023	0.192CysTrp: 0.192 ± 0.013	0.405CysTyr: 0.405 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.168AspAla: 4.168 ± 0.081	0.56AspCys: 0.56 ± 0.023	2.772AspAsp: 2.772 ± 0.057	3.528AspGlu: 3.528 ± 0.068	2.279AspPhe: 2.279 ± 0.048	3.677AspGly: 3.677 ± 0.07	1.055AspHis: 1.055 ± 0.031	4.187AspIle: 4.187 ± 0.067	2.927AspLys: 2.927 ± 0.066	4.797AspLeu: 4.797 ± 0.075	1.273AspMet: 1.273 ± 0.034	2.521AspAsn: 2.521 ± 0.055	2.166AspPro: 2.166 ± 0.057	1.696AspGln: 1.696 ± 0.037	2.532AspArg: 2.532 ± 0.05	3.079AspSer: 3.079 ± 0.053	2.674AspThr: 2.674 ± 0.05	3.363AspVal: 3.363 ± 0.059	0.852AspTrp: 0.852 ± 0.026	1.998AspTyr: 1.998 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.586GluAla: 4.586 ± 0.072	0.565GluCys: 0.565 ± 0.022	2.442GluAsp: 2.442 ± 0.055	3.43GluGlu: 3.43 ± 0.068	2.035GluPhe: 2.035 ± 0.047	3.364GluGly: 3.364 ± 0.07	1.593GluHis: 1.593 ± 0.041	4.048GluIle: 4.048 ± 0.072	4.079GluLys: 4.079 ± 0.088	6.622GluLeu: 6.622 ± 0.084	1.745GluMet: 1.745 ± 0.047	2.891GluAsn: 2.891 ± 0.058	2.091GluPro: 2.091 ± 0.046	3.813GluGln: 3.813 ± 0.078	3.767GluArg: 3.767 ± 0.064	3.287GluSer: 3.287 ± 0.062	3.045GluThr: 3.045 ± 0.048	3.393GluVal: 3.393 ± 0.057	0.835GluTrp: 0.835 ± 0.029	1.788GluTyr: 1.788 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.065PheAla: 3.065 ± 0.054	0.536PheCys: 0.536 ± 0.023	2.46PheAsp: 2.46 ± 0.047	2.089PheGlu: 2.089 ± 0.049	1.751PhePhe: 1.751 ± 0.043	2.977PheGly: 2.977 ± 0.058	0.914PheHis: 0.914 ± 0.031	2.918PheIle: 2.918 ± 0.061	1.652PheLys: 1.652 ± 0.039	3.393PheLeu: 3.393 ± 0.069	1.104PheMet: 1.104 ± 0.03	1.967PheAsn: 1.967 ± 0.046	1.55PhePro: 1.55 ± 0.04	1.266PheGln: 1.266 ± 0.035	1.886PheArg: 1.886 ± 0.039	3.316PheSer: 3.316 ± 0.065	2.341PheThr: 2.341 ± 0.053	2.39PheVal: 2.39 ± 0.051	0.596PheTrp: 0.596 ± 0.026	1.414PheTyr: 1.414 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.124GlyAla: 5.124 ± 0.079	0.844GlyCys: 0.844 ± 0.026	3.399GlyAsp: 3.399 ± 0.075	4.237GlyGlu: 4.237 ± 0.061	3.022GlyPhe: 3.022 ± 0.059	4.809GlyGly: 4.809 ± 0.094	1.675GlyHis: 1.675 ± 0.043	5.224GlyIle: 5.224 ± 0.074	4.351GlyLys: 4.351 ± 0.079	6.728GlyLeu: 6.728 ± 0.076	2.047GlyMet: 2.047 ± 0.048	2.957GlyAsn: 2.957 ± 0.074	1.467GlyPro: 1.467 ± 0.036	2.921GlyGln: 2.921 ± 0.055	3.571GlyArg: 3.571 ± 0.059	4.05GlySer: 4.05 ± 0.067	3.535GlyThr: 3.535 ± 0.068	4.854GlyVal: 4.854 ± 0.072	1.143GlyTrp: 1.143 ± 0.031	2.675GlyTyr: 2.675 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.619HisAla: 1.619 ± 0.038	0.377HisCys: 0.377 ± 0.021	1.248HisAsp: 1.248 ± 0.037	1.198HisGlu: 1.198 ± 0.038	1.136HisPhe: 1.136 ± 0.036	1.657HisGly: 1.657 ± 0.039	0.857HisHis: 0.857 ± 0.038	1.602HisIle: 1.602 ± 0.032	0.984HisLys: 0.984 ± 0.033	2.417HisLeu: 2.417 ± 0.058	0.556HisMet: 0.556 ± 0.023	0.947HisAsn: 0.947 ± 0.033	1.276HisPro: 1.276 ± 0.036	1.367HisGln: 1.367 ± 0.04	1.322HisArg: 1.322 ± 0.035	1.55HisSer: 1.55 ± 0.039	1.178HisThr: 1.178 ± 0.034	1.237HisVal: 1.237 ± 0.032	0.434HisTrp: 0.434 ± 0.019	1.031HisTyr: 1.031 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	6.249IleAla: 6.249 ± 0.077	0.837IleCys: 0.837 ± 0.025	3.964IleAsp: 3.964 ± 0.076	4.19IleGlu: 4.19 ± 0.061	2.536IlePhe: 2.536 ± 0.053	4.872IleGly: 4.872 ± 0.079	1.44IleHis: 1.44 ± 0.037	4.297IleIle: 4.297 ± 0.083	3.385IleLys: 3.385 ± 0.073	5.927IleLeu: 5.927 ± 0.081	1.447IleMet: 1.447 ± 0.043	3.422IleAsn: 3.422 ± 0.054	3.157IlePro: 3.157 ± 0.055	2.448IleGln: 2.448 ± 0.048	3.477IleArg: 3.477 ± 0.052	4.771IleSer: 4.771 ± 0.076	4.05IleThr: 4.05 ± 0.068	3.952IleVal: 3.952 ± 0.065	0.818IleTrp: 0.818 ± 0.027	1.973IleTyr: 1.973 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.168LysAla: 4.168 ± 0.078	0.317LysCys: 0.317 ± 0.019	2.362LysAsp: 2.362 ± 0.063	3.123LysGlu: 3.123 ± 0.071	1.468LysPhe: 1.468 ± 0.043	3.341LysGly: 3.341 ± 0.063	1.081LysHis: 1.081 ± 0.033	3.442LysIle: 3.442 ± 0.069	3.142LysLys: 3.142 ± 0.069	5.168LysLeu: 5.168 ± 0.087	1.484LysMet: 1.484 ± 0.042	2.709LysAsn: 2.709 ± 0.061	2.293LysPro: 2.293 ± 0.052	2.629LysGln: 2.629 ± 0.056	2.693LysArg: 2.693 ± 0.057	3.051LysSer: 3.051 ± 0.067	3.176LysThr: 3.176 ± 0.063	3.219LysVal: 3.219 ± 0.073	0.583LysTrp: 0.583 ± 0.025	1.474LysTyr: 1.474 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	9.585LeuAla: 9.585 ± 0.139	1.168LeuCys: 1.168 ± 0.033	5.469LeuAsp: 5.469 ± 0.083	5.611LeuGlu: 5.611 ± 0.097	4.296LeuPhe: 4.296 ± 0.073	6.692LeuGly: 6.692 ± 0.097	2.312LeuHis: 2.312 ± 0.05	6.59LeuIle: 6.59 ± 0.094	5.171LeuLys: 5.171 ± 0.091	11.261LeuLeu: 11.261 ± 0.144	2.722LeuMet: 2.722 ± 0.05	4.831LeuAsn: 4.831 ± 0.067	5.508LeuPro: 5.508 ± 0.088	4.257LeuGln: 4.257 ± 0.075	5.485LeuArg: 5.485 ± 0.072	8.209LeuSer: 8.209 ± 0.104	6.33LeuThr: 6.33 ± 0.104	6.371LeuVal: 6.371 ± 0.08	1.225LeuTrp: 1.225 ± 0.038	2.866LeuTyr: 2.866 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.491MetAla: 2.491 ± 0.052	0.213MetCys: 0.213 ± 0.013	1.14MetAsp: 1.14 ± 0.034	1.357MetGlu: 1.357 ± 0.039	0.819MetPhe: 0.819 ± 0.028	1.748MetGly: 1.748 ± 0.047	0.47MetHis: 0.47 ± 0.02	1.564MetIle: 1.564 ± 0.04	1.508MetLys: 1.508 ± 0.043	2.888MetLeu: 2.888 ± 0.053	0.775MetMet: 0.775 ± 0.03	1.183MetAsn: 1.183 ± 0.026	1.256MetPro: 1.256 ± 0.036	1.102MetGln: 1.102 ± 0.032	1.315MetArg: 1.315 ± 0.035	1.805MetSer: 1.805 ± 0.04	1.691MetThr: 1.691 ± 0.042	1.736MetVal: 1.736 ± 0.038	0.23MetTrp: 0.23 ± 0.014	0.566MetTyr: 0.566 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.364AsnAla: 3.364 ± 0.074	0.376AsnCys: 0.376 ± 0.017	2.214AsnAsp: 2.214 ± 0.04	2.404AsnGlu: 2.404 ± 0.048	1.562AsnPhe: 1.562 ± 0.036	3.155AsnGly: 3.155 ± 0.071	1.075AsnHis: 1.075 ± 0.036	3.199AsnIle: 3.199 ± 0.065	2.415AsnLys: 2.415 ± 0.065	4.047AsnLeu: 4.047 ± 0.064	1.092AsnMet: 1.092 ± 0.03	2.183AsnAsn: 2.183 ± 0.056	2.233AsnPro: 2.233 ± 0.049	2.146AsnGln: 2.146 ± 0.045	2.396AsnArg: 2.396 ± 0.051	2.609AsnSer: 2.609 ± 0.047	2.433AsnThr: 2.433 ± 0.048	2.498AsnVal: 2.498 ± 0.054	0.582AsnTrp: 0.582 ± 0.026	1.478AsnTyr: 1.478 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.735ProAla: 3.735 ± 0.078	0.375ProCys: 0.375 ± 0.021	2.937ProAsp: 2.937 ± 0.067	3.466ProGlu: 3.466 ± 0.057	1.839ProPhe: 1.839 ± 0.039	2.346ProGly: 2.346 ± 0.048	1.001ProHis: 1.001 ± 0.029	2.501ProIle: 2.501 ± 0.05	1.911ProLys: 1.911 ± 0.043	4.732ProLeu: 4.732 ± 0.089	1.007ProMet: 1.007 ± 0.029	1.604ProAsn: 1.604 ± 0.042	1.53ProPro: 1.53 ± 0.042	1.929ProGln: 1.929 ± 0.045	1.693ProArg: 1.693 ± 0.038	2.388ProSer: 2.388 ± 0.042	2.232ProThr: 2.232 ± 0.051	3.512ProVal: 3.512 ± 0.059	0.579ProTrp: 0.579 ± 0.021	1.338ProTyr: 1.338 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.134GlnAla: 4.134 ± 0.075	0.456GlnCys: 0.456 ± 0.021	2.008GlnAsp: 2.008 ± 0.039	2.432GlnGlu: 2.432 ± 0.056	1.692GlnPhe: 1.692 ± 0.035	3.058GlnGly: 3.058 ± 0.053	1.27GlnHis: 1.27 ± 0.035	2.878GlnIle: 2.878 ± 0.053	2.347GlnLys: 2.347 ± 0.049	5.403GlnLeu: 5.403 ± 0.106	1.074GlnMet: 1.074 ± 0.029	1.873GlnAsn: 1.873 ± 0.052	2.124GlnPro: 2.124 ± 0.051	3.328GlnGln: 3.328 ± 0.094	2.869GlnArg: 2.869 ± 0.054	2.692GlnSer: 2.692 ± 0.053	2.271GlnThr: 2.271 ± 0.065	3.019GlnVal: 3.019 ± 0.06	0.736GlnTrp: 0.736 ± 0.029	1.362GlnTyr: 1.362 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.612ArgAla: 3.612 ± 0.055	0.57ArgCys: 0.57 ± 0.021	2.665ArgAsp: 2.665 ± 0.05	3.462ArgGlu: 3.462 ± 0.062	2.42ArgPhe: 2.42 ± 0.053	3.038ArgGly: 3.038 ± 0.056	1.634ArgHis: 1.634 ± 0.053	3.621ArgIle: 3.621 ± 0.056	2.674ArgLys: 2.674 ± 0.056	6.124ArgLeu: 6.124 ± 0.094	1.419ArgMet: 1.419 ± 0.036	2.137ArgAsn: 2.137 ± 0.05	2.074ArgPro: 2.074 ± 0.048	2.998ArgGln: 2.998 ± 0.053	3.065ArgArg: 3.065 ± 0.066	2.79ArgSer: 2.79 ± 0.058	2.543ArgThr: 2.543 ± 0.052	3.29ArgVal: 3.29 ± 0.062	0.871ArgTrp: 0.871 ± 0.031	2.141ArgTyr: 2.141 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.115SerAla: 5.115 ± 0.074	0.667SerCys: 0.667 ± 0.026	3.386SerAsp: 3.386 ± 0.055	3.73SerGlu: 3.73 ± 0.069	2.492SerPhe: 2.492 ± 0.052	5.184SerGly: 5.184 ± 0.072	1.655SerHis: 1.655 ± 0.041	4.081SerIle: 4.081 ± 0.064	2.679SerLys: 2.679 ± 0.066	7.089SerLeu: 7.089 ± 0.088	1.555SerMet: 1.555 ± 0.036	2.322SerAsn: 2.322 ± 0.051	2.857SerPro: 2.857 ± 0.048	2.979SerGln: 2.979 ± 0.058	3.353SerArg: 3.353 ± 0.058	4.045SerSer: 4.045 ± 0.079	3.097SerThr: 3.097 ± 0.057	4.32SerVal: 4.32 ± 0.063	0.901SerTrp: 0.901 ± 0.027	2.034SerTyr: 2.034 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.636ThrAla: 4.636 ± 0.072	0.504ThrCys: 0.504 ± 0.022	2.897ThrAsp: 2.897 ± 0.056	3.275ThrGlu: 3.275 ± 0.062	2.063ThrPhe: 2.063 ± 0.04	4.267ThrGly: 4.267 ± 0.069	1.338ThrHis: 1.338 ± 0.037	3.299ThrIle: 3.299 ± 0.067	2.082ThrLys: 2.082 ± 0.047	6.708ThrLeu: 6.708 ± 0.082	1.055ThrMet: 1.055 ± 0.034	1.739ThrAsn: 1.739 ± 0.043	3.009ThrPro: 3.009 ± 0.057	2.541ThrGln: 2.541 ± 0.057	2.658ThrArg: 2.658 ± 0.05	3.087ThrSer: 3.087 ± 0.062	2.865ThrThr: 2.865 ± 0.064	3.819ThrVal: 3.819 ± 0.065	0.631ThrTrp: 0.631 ± 0.027	1.495ThrTyr: 1.495 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	5.376ValAla: 5.376 ± 0.087	0.71ValCys: 0.71 ± 0.026	3.389ValAsp: 3.389 ± 0.05	3.701ValGlu: 3.701 ± 0.058	2.561ValPhe: 2.561 ± 0.055	4.237ValGly: 4.237 ± 0.078	1.201ValHis: 1.201 ± 0.035	4.729ValIle: 4.729 ± 0.075	3.286ValLys: 3.286 ± 0.057	6.506ValLeu: 6.506 ± 0.085	1.94ValMet: 1.94 ± 0.041	2.868ValAsn: 2.868 ± 0.059	2.728ValPro: 2.728 ± 0.066	2.266ValGln: 2.266 ± 0.055	3.222ValArg: 3.222 ± 0.055	4.522ValSer: 4.522 ± 0.057	3.863ValThr: 3.863 ± 0.065	4.404ValVal: 4.404 ± 0.069	0.805ValTrp: 0.805 ± 0.028	1.755ValTyr: 1.755 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.819TrpAla: 0.819 ± 0.025	0.182TrpCys: 0.182 ± 0.013	0.609TrpAsp: 0.609 ± 0.026	0.701TrpGlu: 0.701 ± 0.027	0.578TrpPhe: 0.578 ± 0.026	0.807TrpGly: 0.807 ± 0.028	0.432TrpHis: 0.432 ± 0.022	0.757TrpIle: 0.757 ± 0.029	0.606TrpLys: 0.606 ± 0.022	2.015TrpLeu: 2.015 ± 0.05	0.346TrpMet: 0.346 ± 0.017	0.505TrpAsn: 0.505 ± 0.024	0.557TrpPro: 0.557 ± 0.023	1.128TrpGln: 1.128 ± 0.036	0.885TrpArg: 0.885 ± 0.027	0.812TrpSer: 0.812 ± 0.029	0.47TrpThr: 0.47 ± 0.021	0.909TrpVal: 0.909 ± 0.031	0.197TrpTrp: 0.197 ± 0.013	0.355TrpTyr: 0.355 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.282TyrAla: 2.282 ± 0.045	0.437TyrCys: 0.437 ± 0.019	1.69TyrAsp: 1.69 ± 0.05	1.428TyrGlu: 1.428 ± 0.035	1.385TyrPhe: 1.385 ± 0.04	2.192TyrGly: 2.192 ± 0.054	0.943TyrHis: 0.943 ± 0.028	1.857TyrIle: 1.857 ± 0.045	1.214TyrLys: 1.214 ± 0.033	3.628TyrLeu: 3.628 ± 0.053	0.724TyrMet: 0.724 ± 0.026	1.243TyrAsn: 1.243 ± 0.044	1.503TyrPro: 1.503 ± 0.033	1.926TyrGln: 1.926 ± 0.046	2.138TyrArg: 2.138 ± 0.045	2.117TyrSer: 2.117 ± 0.044	1.584TyrThr: 1.584 ± 0.038	1.748TyrVal: 1.748 ± 0.04	0.497TyrTrp: 0.497 ± 0.025	1.091TyrTyr: 1.091 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4102 proteins (1169299 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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