Amino acid dipepetide frequency for Acinetobacter phage AB1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.492AlaAla: 4.492 ± 0.877
0.663AlaCys: 0.663 ± 0.196
3.608AlaAsp: 3.608 ± 0.514
3.534AlaGlu: 3.534 ± 0.548
3.387AlaPhe: 3.387 ± 0.635
3.829AlaGly: 3.829 ± 0.539
1.546AlaHis: 1.546 ± 0.337
5.964AlaIle: 5.964 ± 0.567
5.743AlaLys: 5.743 ± 0.676
6.921AlaLeu: 6.921 ± 0.73
2.135AlaMet: 2.135 ± 0.425
3.093AlaAsn: 3.093 ± 0.476
2.724AlaPro: 2.724 ± 0.41
3.387AlaGln: 3.387 ± 0.584
2.43AlaArg: 2.43 ± 0.384
4.123AlaSer: 4.123 ± 0.498
4.565AlaThr: 4.565 ± 0.695
4.197AlaVal: 4.197 ± 0.562
0.957AlaTrp: 0.957 ± 0.221
2.651AlaTyr: 2.651 ± 0.446
0.0AlaXaa: 0.0 ± 0.0
Cys
1.104CysAla: 1.104 ± 0.309
0.147CysCys: 0.147 ± 0.104
0.663CysAsp: 0.663 ± 0.261
0.884CysGlu: 0.884 ± 0.283
0.663CysPhe: 0.663 ± 0.233
0.81CysGly: 0.81 ± 0.223
0.147CysHis: 0.147 ± 0.109
0.515CysIle: 0.515 ± 0.177
1.104CysLys: 1.104 ± 0.296
1.399CysLeu: 1.399 ± 0.29
0.147CysMet: 0.147 ± 0.096
0.295CysAsn: 0.295 ± 0.14
0.515CysPro: 0.515 ± 0.183
0.295CysGln: 0.295 ± 0.136
0.442CysArg: 0.442 ± 0.171
0.368CysSer: 0.368 ± 0.17
0.442CysThr: 0.442 ± 0.173
1.178CysVal: 1.178 ± 0.267
0.221CysTrp: 0.221 ± 0.129
0.221CysTyr: 0.221 ± 0.123
0.0CysXaa: 0.0 ± 0.0
Asp
4.492AspAla: 4.492 ± 0.445
1.031AspCys: 1.031 ± 0.295
4.786AspAsp: 4.786 ± 0.584
4.712AspGlu: 4.712 ± 0.691
3.166AspPhe: 3.166 ± 0.408
5.67AspGly: 5.67 ± 0.743
0.589AspHis: 0.589 ± 0.247
3.534AspIle: 3.534 ± 0.543
5.081AspLys: 5.081 ± 0.763
4.86AspLeu: 4.86 ± 0.659
1.62AspMet: 1.62 ± 0.366
2.798AspAsn: 2.798 ± 0.415
1.767AspPro: 1.767 ± 0.343
2.503AspGln: 2.503 ± 0.394
2.43AspArg: 2.43 ± 0.401
3.829AspSer: 3.829 ± 0.504
2.798AspThr: 2.798 ± 0.486
4.639AspVal: 4.639 ± 0.465
1.031AspTrp: 1.031 ± 0.296
2.651AspTyr: 2.651 ± 0.419
0.0AspXaa: 0.0 ± 0.0
Glu
4.197GluAla: 4.197 ± 0.629
0.663GluCys: 0.663 ± 0.196
3.903GluAsp: 3.903 ± 0.794
4.712GluGlu: 4.712 ± 0.831
3.829GluPhe: 3.829 ± 0.796
3.903GluGly: 3.903 ± 0.591
0.81GluHis: 0.81 ± 0.243
4.639GluIle: 4.639 ± 0.677
4.86GluLys: 4.86 ± 0.653
5.375GluLeu: 5.375 ± 0.673
1.841GluMet: 1.841 ± 0.34
3.976GluAsn: 3.976 ± 0.463
1.62GluPro: 1.62 ± 0.347
2.945GluGln: 2.945 ± 0.554
2.062GluArg: 2.062 ± 0.414
4.933GluSer: 4.933 ± 0.437
2.577GluThr: 2.577 ± 0.45
4.418GluVal: 4.418 ± 0.552
0.957GluTrp: 0.957 ± 0.234
3.461GluTyr: 3.461 ± 0.495
0.0GluXaa: 0.0 ± 0.0
Phe
3.682PheAla: 3.682 ± 0.55
0.442PheCys: 0.442 ± 0.163
3.019PheAsp: 3.019 ± 0.455
3.24PheGlu: 3.24 ± 0.666
1.694PhePhe: 1.694 ± 0.325
3.24PheGly: 3.24 ± 0.491
0.589PheHis: 0.589 ± 0.187
3.166PheIle: 3.166 ± 0.487
3.387PheLys: 3.387 ± 0.46
3.461PheLeu: 3.461 ± 0.503
1.399PheMet: 1.399 ± 0.356
2.577PheAsn: 2.577 ± 0.476
1.031PhePro: 1.031 ± 0.239
1.325PheGln: 1.325 ± 0.38
1.325PheArg: 1.325 ± 0.319
2.577PheSer: 2.577 ± 0.459
2.062PheThr: 2.062 ± 0.345
3.166PheVal: 3.166 ± 0.58
0.736PheTrp: 0.736 ± 0.267
2.651PheTyr: 2.651 ± 0.409
0.0PheXaa: 0.0 ± 0.0
Gly
4.86GlyAla: 4.86 ± 0.643
0.663GlyCys: 0.663 ± 0.253
3.682GlyAsp: 3.682 ± 0.644
4.05GlyGlu: 4.05 ± 0.529
4.786GlyPhe: 4.786 ± 0.612
4.271GlyGly: 4.271 ± 0.547
1.399GlyHis: 1.399 ± 0.314
4.86GlyIle: 4.86 ± 0.64
4.344GlyLys: 4.344 ± 0.609
5.449GlyLeu: 5.449 ± 0.574
2.283GlyMet: 2.283 ± 0.511
3.461GlyAsn: 3.461 ± 0.513
0.442GlyPro: 0.442 ± 0.225
2.503GlyGln: 2.503 ± 0.408
1.694GlyArg: 1.694 ± 0.322
4.565GlySer: 4.565 ± 0.518
3.755GlyThr: 3.755 ± 0.644
5.964GlyVal: 5.964 ± 0.716
1.104GlyTrp: 1.104 ± 0.265
3.534GlyTyr: 3.534 ± 0.495
0.0GlyXaa: 0.0 ± 0.0
His
1.62HisAla: 1.62 ± 0.35
0.147HisCys: 0.147 ± 0.106
1.031HisAsp: 1.031 ± 0.255
1.178HisGlu: 1.178 ± 0.319
0.295HisPhe: 0.295 ± 0.169
0.81HisGly: 0.81 ± 0.242
0.295HisHis: 0.295 ± 0.156
1.546HisIle: 1.546 ± 0.338
1.252HisLys: 1.252 ± 0.393
1.252HisLeu: 1.252 ± 0.297
0.368HisMet: 0.368 ± 0.168
0.81HisAsn: 0.81 ± 0.232
0.589HisPro: 0.589 ± 0.218
0.589HisGln: 0.589 ± 0.21
0.295HisArg: 0.295 ± 0.228
1.178HisSer: 1.178 ± 0.343
0.515HisThr: 0.515 ± 0.166
0.957HisVal: 0.957 ± 0.242
0.221HisTrp: 0.221 ± 0.117
0.81HisTyr: 0.81 ± 0.259
0.0HisXaa: 0.0 ± 0.0
Ile
4.197IleAla: 4.197 ± 0.562
0.957IleCys: 0.957 ± 0.302
5.449IleAsp: 5.449 ± 0.74
5.449IleGlu: 5.449 ± 0.727
1.841IlePhe: 1.841 ± 0.411
3.976IleGly: 3.976 ± 0.528
1.767IleHis: 1.767 ± 0.419
4.344IleIle: 4.344 ± 0.61
6.774IleLys: 6.774 ± 0.751
5.007IleLeu: 5.007 ± 0.623
1.546IleMet: 1.546 ± 0.301
4.344IleAsn: 4.344 ± 0.499
3.313IlePro: 3.313 ± 0.474
2.945IleGln: 2.945 ± 0.417
2.503IleArg: 2.503 ± 0.448
4.933IleSer: 4.933 ± 0.556
4.418IleThr: 4.418 ± 0.568
5.007IleVal: 5.007 ± 0.69
0.515IleTrp: 0.515 ± 0.207
2.651IleTyr: 2.651 ± 0.509
0.0IleXaa: 0.0 ± 0.0
Lys
6.48LysAla: 6.48 ± 0.753
1.031LysCys: 1.031 ± 0.276
4.933LysAsp: 4.933 ± 0.698
5.007LysGlu: 5.007 ± 0.762
2.724LysPhe: 2.724 ± 0.508
5.522LysGly: 5.522 ± 0.629
0.81LysHis: 0.81 ± 0.231
5.302LysIle: 5.302 ± 0.619
5.228LysLys: 5.228 ± 0.791
5.449LysLeu: 5.449 ± 0.582
2.503LysMet: 2.503 ± 0.447
4.271LysAsn: 4.271 ± 0.557
2.283LysPro: 2.283 ± 0.511
2.503LysGln: 2.503 ± 0.513
4.271LysArg: 4.271 ± 0.607
4.712LysSer: 4.712 ± 0.625
4.933LysThr: 4.933 ± 0.462
5.154LysVal: 5.154 ± 0.821
1.031LysTrp: 1.031 ± 0.288
1.914LysTyr: 1.914 ± 0.39
0.0LysXaa: 0.0 ± 0.0
Leu
6.48LeuAla: 6.48 ± 0.659
0.515LeuCys: 0.515 ± 0.187
4.933LeuAsp: 4.933 ± 0.693
5.596LeuGlu: 5.596 ± 0.54
2.945LeuPhe: 2.945 ± 0.479
5.522LeuGly: 5.522 ± 0.61
0.884LeuHis: 0.884 ± 0.254
6.259LeuIle: 6.259 ± 0.695
6.553LeuLys: 6.553 ± 0.671
5.081LeuLeu: 5.081 ± 0.585
1.841LeuMet: 1.841 ± 0.395
5.596LeuAsn: 5.596 ± 0.631
1.767LeuPro: 1.767 ± 0.327
1.473LeuGln: 1.473 ± 0.333
3.755LeuArg: 3.755 ± 0.492
5.522LeuSer: 5.522 ± 0.571
4.712LeuThr: 4.712 ± 0.518
5.007LeuVal: 5.007 ± 0.539
0.81LeuTrp: 0.81 ± 0.24
2.724LeuTyr: 2.724 ± 0.462
0.0LeuXaa: 0.0 ± 0.0
Met
1.841MetAla: 1.841 ± 0.387
0.442MetCys: 0.442 ± 0.184
1.178MetAsp: 1.178 ± 0.42
1.62MetGlu: 1.62 ± 0.304
1.178MetPhe: 1.178 ± 0.324
1.914MetGly: 1.914 ± 0.455
0.368MetHis: 0.368 ± 0.156
1.767MetIle: 1.767 ± 0.37
2.283MetLys: 2.283 ± 0.403
1.841MetLeu: 1.841 ± 0.439
0.663MetMet: 0.663 ± 0.175
2.577MetAsn: 2.577 ± 0.421
1.252MetPro: 1.252 ± 0.362
1.694MetGln: 1.694 ± 0.39
1.104MetArg: 1.104 ± 0.276
2.724MetSer: 2.724 ± 0.509
1.62MetThr: 1.62 ± 0.245
1.178MetVal: 1.178 ± 0.325
0.147MetTrp: 0.147 ± 0.105
0.368MetTyr: 0.368 ± 0.147
0.0MetXaa: 0.0 ± 0.0
Asn
4.197AsnAla: 4.197 ± 0.551
0.957AsnCys: 0.957 ± 0.32
3.461AsnAsp: 3.461 ± 0.418
4.492AsnGlu: 4.492 ± 0.554
2.356AsnPhe: 2.356 ± 0.367
5.596AsnGly: 5.596 ± 0.795
1.325AsnHis: 1.325 ± 0.321
4.712AsnIle: 4.712 ± 0.655
2.872AsnLys: 2.872 ± 0.495
4.123AsnLeu: 4.123 ± 0.638
1.546AsnMet: 1.546 ± 0.392
4.271AsnAsn: 4.271 ± 0.722
3.093AsnPro: 3.093 ± 0.476
2.209AsnGln: 2.209 ± 0.397
1.252AsnArg: 1.252 ± 0.253
3.608AsnSer: 3.608 ± 0.516
3.534AsnThr: 3.534 ± 0.458
2.945AsnVal: 2.945 ± 0.443
0.589AsnTrp: 0.589 ± 0.205
2.577AsnTyr: 2.577 ± 0.338
0.0AsnXaa: 0.0 ± 0.0
Pro
1.62ProAla: 1.62 ± 0.343
0.442ProCys: 0.442 ± 0.161
2.651ProAsp: 2.651 ± 0.41
2.209ProGlu: 2.209 ± 0.326
1.473ProPhe: 1.473 ± 0.349
0.515ProGly: 0.515 ± 0.203
0.442ProHis: 0.442 ± 0.177
1.988ProIle: 1.988 ± 0.42
3.387ProLys: 3.387 ± 0.598
2.135ProLeu: 2.135 ± 0.343
1.178ProMet: 1.178 ± 0.275
2.43ProAsn: 2.43 ± 0.46
0.663ProPro: 0.663 ± 0.213
1.399ProGln: 1.399 ± 0.328
1.104ProArg: 1.104 ± 0.274
2.43ProSer: 2.43 ± 0.459
1.546ProThr: 1.546 ± 0.37
1.988ProVal: 1.988 ± 0.286
0.074ProTrp: 0.074 ± 0.072
1.841ProTyr: 1.841 ± 0.383
0.0ProXaa: 0.0 ± 0.0
Gln
3.093GlnAla: 3.093 ± 0.526
0.368GlnCys: 0.368 ± 0.179
2.43GlnAsp: 2.43 ± 0.439
2.503GlnGlu: 2.503 ± 0.442
1.914GlnPhe: 1.914 ± 0.474
2.577GlnGly: 2.577 ± 0.544
0.957GlnHis: 0.957 ± 0.269
2.209GlnIle: 2.209 ± 0.445
2.724GlnLys: 2.724 ± 0.472
3.755GlnLeu: 3.755 ± 0.616
1.104GlnMet: 1.104 ± 0.295
1.914GlnAsn: 1.914 ± 0.354
1.031GlnPro: 1.031 ± 0.293
1.473GlnGln: 1.473 ± 0.35
1.694GlnArg: 1.694 ± 0.351
2.798GlnSer: 2.798 ± 0.382
2.209GlnThr: 2.209 ± 0.406
2.43GlnVal: 2.43 ± 0.365
0.957GlnTrp: 0.957 ± 0.229
1.767GlnTyr: 1.767 ± 0.324
0.0GlnXaa: 0.0 ± 0.0
Arg
1.914ArgAla: 1.914 ± 0.432
0.736ArgCys: 0.736 ± 0.284
2.43ArgAsp: 2.43 ± 0.433
2.283ArgGlu: 2.283 ± 0.384
1.62ArgPhe: 1.62 ± 0.345
1.988ArgGly: 1.988 ± 0.411
0.81ArgHis: 0.81 ± 0.233
2.356ArgIle: 2.356 ± 0.498
3.755ArgLys: 3.755 ± 0.566
3.093ArgLeu: 3.093 ± 0.488
0.663ArgMet: 0.663 ± 0.194
2.062ArgAsn: 2.062 ± 0.411
1.325ArgPro: 1.325 ± 0.286
1.546ArgGln: 1.546 ± 0.362
1.031ArgArg: 1.031 ± 0.273
2.724ArgSer: 2.724 ± 0.416
1.694ArgThr: 1.694 ± 0.311
2.724ArgVal: 2.724 ± 0.41
0.442ArgTrp: 0.442 ± 0.153
1.399ArgTyr: 1.399 ± 0.367
0.0ArgXaa: 0.0 ± 0.0
Ser
3.313SerAla: 3.313 ± 0.445
0.736SerCys: 0.736 ± 0.232
4.123SerAsp: 4.123 ± 0.593
4.492SerGlu: 4.492 ± 0.672
3.387SerPhe: 3.387 ± 0.633
5.081SerGly: 5.081 ± 0.556
0.515SerHis: 0.515 ± 0.179
6.48SerIle: 6.48 ± 0.59
5.375SerLys: 5.375 ± 0.715
5.302SerLeu: 5.302 ± 0.67
1.841SerMet: 1.841 ± 0.375
4.197SerAsn: 4.197 ± 0.508
1.694SerPro: 1.694 ± 0.327
2.43SerGln: 2.43 ± 0.489
2.43SerArg: 2.43 ± 0.409
3.682SerSer: 3.682 ± 0.493
3.534SerThr: 3.534 ± 0.5
4.123SerVal: 4.123 ± 0.595
0.81SerTrp: 0.81 ± 0.261
2.283SerTyr: 2.283 ± 0.375
0.0SerXaa: 0.0 ± 0.0
Thr
3.755ThrAla: 3.755 ± 0.586
0.663ThrCys: 0.663 ± 0.213
3.461ThrAsp: 3.461 ± 0.501
1.841ThrGlu: 1.841 ± 0.333
2.209ThrPhe: 2.209 ± 0.401
4.418ThrGly: 4.418 ± 0.678
0.515ThrHis: 0.515 ± 0.201
3.682ThrIle: 3.682 ± 0.602
3.461ThrLys: 3.461 ± 0.55
4.639ThrLeu: 4.639 ± 0.754
1.546ThrMet: 1.546 ± 0.258
2.651ThrAsn: 2.651 ± 0.493
2.283ThrPro: 2.283 ± 0.384
2.503ThrGln: 2.503 ± 0.426
1.694ThrArg: 1.694 ± 0.357
3.093ThrSer: 3.093 ± 0.587
2.798ThrThr: 2.798 ± 0.596
4.492ThrVal: 4.492 ± 0.708
1.473ThrTrp: 1.473 ± 0.371
1.104ThrTyr: 1.104 ± 0.262
0.0ThrXaa: 0.0 ± 0.0
Val
4.86ValAla: 4.86 ± 0.588
0.368ValCys: 0.368 ± 0.169
4.123ValAsp: 4.123 ± 0.445
5.007ValGlu: 5.007 ± 0.759
2.872ValPhe: 2.872 ± 0.393
4.418ValGly: 4.418 ± 0.57
1.104ValHis: 1.104 ± 0.305
5.375ValIle: 5.375 ± 0.84
4.123ValLys: 4.123 ± 0.467
4.786ValLeu: 4.786 ± 0.725
2.577ValMet: 2.577 ± 0.425
4.565ValAsn: 4.565 ± 0.588
2.283ValPro: 2.283 ± 0.395
3.093ValGln: 3.093 ± 0.543
2.209ValArg: 2.209 ± 0.458
4.492ValSer: 4.492 ± 0.515
2.724ValThr: 2.724 ± 0.555
4.712ValVal: 4.712 ± 0.645
0.884ValTrp: 0.884 ± 0.219
2.945ValTyr: 2.945 ± 0.513
0.0ValXaa: 0.0 ± 0.0
Trp
0.884TrpAla: 0.884 ± 0.302
0.147TrpCys: 0.147 ± 0.124
0.957TrpAsp: 0.957 ± 0.268
0.81TrpGlu: 0.81 ± 0.212
0.81TrpPhe: 0.81 ± 0.212
0.663TrpGly: 0.663 ± 0.173
0.147TrpHis: 0.147 ± 0.096
0.663TrpIle: 0.663 ± 0.213
0.81TrpLys: 0.81 ± 0.232
1.178TrpLeu: 1.178 ± 0.282
0.221TrpMet: 0.221 ± 0.118
0.884TrpAsn: 0.884 ± 0.234
0.147TrpPro: 0.147 ± 0.097
0.957TrpGln: 0.957 ± 0.258
0.884TrpArg: 0.884 ± 0.243
1.252TrpSer: 1.252 ± 0.321
0.368TrpThr: 0.368 ± 0.142
1.325TrpVal: 1.325 ± 0.308
0.368TrpTrp: 0.368 ± 0.169
0.589TrpTyr: 0.589 ± 0.213
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.872TyrAla: 2.872 ± 0.39
0.442TyrCys: 0.442 ± 0.2
3.166TyrAsp: 3.166 ± 0.431
2.062TyrGlu: 2.062 ± 0.367
1.62TyrPhe: 1.62 ± 0.396
3.019TyrGly: 3.019 ± 0.497
0.736TyrHis: 0.736 ± 0.281
2.577TyrIle: 2.577 ± 0.382
2.945TyrLys: 2.945 ± 0.551
2.872TyrLeu: 2.872 ± 0.399
0.663TyrMet: 0.663 ± 0.221
2.945TyrAsn: 2.945 ± 0.523
1.694TyrPro: 1.694 ± 0.342
2.135TyrGln: 2.135 ± 0.344
1.988TyrArg: 1.988 ± 0.406
2.283TyrSer: 2.283 ± 0.396
1.473TyrThr: 1.473 ± 0.331
1.914TyrVal: 1.914 ± 0.363
0.736TyrTrp: 0.736 ± 0.234
1.325TyrTyr: 1.325 ± 0.321
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 85 proteins (13582 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski