Amino acid dipepetide frequency for Acinetobacter phage AP205

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.431AlaAla: 5.431 ± 1.186
1.552AlaCys: 1.552 ± 1.533
5.431AlaAsp: 5.431 ± 1.186
4.655AlaGlu: 4.655 ± 4.264
3.879AlaPhe: 3.879 ± 1.896
7.758AlaGly: 7.758 ± 2.224
2.327AlaHis: 2.327 ± 0.853
4.655AlaIle: 4.655 ± 0.876
3.103AlaLys: 3.103 ± 1.357
4.655AlaLeu: 4.655 ± 6.936
3.103AlaMet: 3.103 ± 1.854
3.103AlaAsn: 3.103 ± 2.829
2.327AlaPro: 2.327 ± 1.637
2.327AlaGln: 2.327 ± 0.853
3.103AlaArg: 3.103 ± 1.004
8.534AlaSer: 8.534 ± 1.797
5.431AlaThr: 5.431 ± 0.758
1.552AlaVal: 1.552 ± 3.654
0.776AlaTrp: 0.776 ± 0.642
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.776CysAla: 0.776 ± 1.632
0.0CysCys: 0.0 ± 0.0
0.776CysAsp: 0.776 ± 0.565
0.776CysGlu: 0.776 ± 0.565
0.0CysPhe: 0.0 ± 0.0
1.552CysGly: 1.552 ± 0.502
0.776CysHis: 0.776 ± 0.565
0.776CysIle: 0.776 ± 0.565
0.776CysLys: 0.776 ± 0.565
0.776CysLeu: 0.776 ± 0.565
0.0CysMet: 0.0 ± 0.0
1.552CysAsn: 1.552 ± 1.129
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.776CysArg: 0.776 ± 0.565
0.0CysSer: 0.0 ± 0.0
0.776CysThr: 0.776 ± 0.565
0.776CysVal: 0.776 ± 1.632
0.0CysTrp: 0.0 ± 0.0
1.552CysTyr: 1.552 ± 1.129
0.0CysXaa: 0.0 ± 0.0
Asp
4.655AspAla: 4.655 ± 0.876
0.0AspCys: 0.0 ± 0.0
4.655AspAsp: 4.655 ± 1.707
0.0AspGlu: 0.0 ± 0.0
4.655AspPhe: 4.655 ± 1.505
1.552AspGly: 1.552 ± 1.285
0.0AspHis: 0.0 ± 0.0
4.655AspIle: 4.655 ± 2.01
2.327AspLys: 2.327 ± 1.005
3.879AspLeu: 3.879 ± 2.823
0.0AspMet: 0.0 ± 0.0
2.327AspAsn: 2.327 ± 0.853
3.879AspPro: 3.879 ± 2.67
1.552AspGln: 1.552 ± 0.502
1.552AspArg: 1.552 ± 0.502
5.431AspSer: 5.431 ± 2.607
3.879AspThr: 3.879 ± 2.686
8.534AspVal: 8.534 ± 2.965
0.776AspTrp: 0.776 ± 0.642
3.103AspTyr: 3.103 ± 1.611
0.0AspXaa: 0.0 ± 0.0
Glu
0.776GluAla: 0.776 ± 0.565
0.776GluCys: 0.776 ± 0.565
0.0GluAsp: 0.0 ± 0.0
1.552GluGlu: 1.552 ± 0.502
3.879GluPhe: 3.879 ± 1.281
3.103GluGly: 3.103 ± 1.143
0.0GluHis: 0.0 ± 0.0
3.103GluIle: 3.103 ± 1.611
1.552GluLys: 1.552 ± 1.285
3.879GluLeu: 3.879 ± 1.337
0.776GluMet: 0.776 ± 0.565
3.103GluAsn: 3.103 ± 3.006
2.327GluPro: 2.327 ± 1.694
0.776GluGln: 0.776 ± 0.565
2.327GluArg: 2.327 ± 1.927
3.103GluSer: 3.103 ± 1.357
1.552GluThr: 1.552 ± 1.533
1.552GluVal: 1.552 ± 1.129
3.103GluTrp: 3.103 ± 1.185
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
3.103PheAla: 3.103 ± 1.185
0.0PheCys: 0.0 ± 0.0
3.879PheAsp: 3.879 ± 1.896
3.103PheGlu: 3.103 ± 2.259
3.103PhePhe: 3.103 ± 1.357
1.552PheGly: 1.552 ± 0.502
1.552PheHis: 1.552 ± 0.502
3.103PheIle: 3.103 ± 3.352
1.552PheLys: 1.552 ± 0.502
5.431PheLeu: 5.431 ± 0.758
2.327PheMet: 2.327 ± 6.186
3.103PheAsn: 3.103 ± 1.357
0.776PhePro: 0.776 ± 0.565
3.879PheGln: 3.879 ± 3.171
2.327PheArg: 2.327 ± 1.005
3.879PheSer: 3.879 ± 1.337
6.206PheThr: 6.206 ± 2.007
3.879PheVal: 3.879 ± 2.237
0.0PheTrp: 0.0 ± 0.0
1.552PheTyr: 1.552 ± 1.285
0.0PheXaa: 0.0 ± 0.0
Gly
3.879GlyAla: 3.879 ± 1.896
0.776GlyCys: 0.776 ± 1.632
3.103GlyAsp: 3.103 ± 1.611
5.431GlyGlu: 5.431 ± 2.196
4.655GlyPhe: 4.655 ± 0.876
1.552GlyGly: 1.552 ± 1.285
0.776GlyHis: 0.776 ± 0.565
2.327GlyIle: 2.327 ± 1.637
5.431GlyLys: 5.431 ± 2.196
4.655GlyLeu: 4.655 ± 0.876
0.0GlyMet: 0.0 ± 0.0
2.327GlyAsn: 2.327 ± 1.21
3.103GlyPro: 3.103 ± 1.611
3.103GlyGln: 3.103 ± 1.185
1.552GlyArg: 1.552 ± 0.502
4.655GlySer: 4.655 ± 1.704
0.776GlyThr: 0.776 ± 0.642
1.552GlyVal: 1.552 ± 0.502
0.776GlyTrp: 0.776 ± 0.642
2.327GlyTyr: 2.327 ± 1.927
0.0GlyXaa: 0.0 ± 0.0
His
0.776HisAla: 0.776 ± 0.565
0.0HisCys: 0.0 ± 0.0
0.776HisAsp: 0.776 ± 0.565
0.0HisGlu: 0.0 ± 0.0
0.776HisPhe: 0.776 ± 0.642
0.0HisGly: 0.0 ± 0.0
1.552HisHis: 1.552 ± 1.129
0.776HisIle: 0.776 ± 0.565
1.552HisLys: 1.552 ± 1.533
3.879HisLeu: 3.879 ± 1.896
0.0HisMet: 0.0 ± 0.0
0.776HisAsn: 0.776 ± 0.642
0.776HisPro: 0.776 ± 0.565
1.552HisGln: 1.552 ± 0.502
0.776HisArg: 0.776 ± 0.565
0.0HisSer: 0.0 ± 0.0
1.552HisThr: 1.552 ± 0.502
1.552HisVal: 1.552 ± 1.129
1.552HisTrp: 1.552 ± 1.129
0.776HisTyr: 0.776 ± 3.755
0.0HisXaa: 0.0 ± 0.0
Ile
5.431IleAla: 5.431 ± 0.758
1.552IleCys: 1.552 ± 1.129
3.879IleAsp: 3.879 ± 1.281
1.552IleGlu: 1.552 ± 1.129
1.552IlePhe: 1.552 ± 0.502
5.431IleGly: 5.431 ± 1.928
0.776IleHis: 0.776 ± 0.642
3.879IleIle: 3.879 ± 3.171
1.552IleLys: 1.552 ± 0.502
2.327IleLeu: 2.327 ± 3.639
2.327IleMet: 2.327 ± 1.637
3.103IleAsn: 3.103 ± 1.004
6.206IlePro: 6.206 ± 2.007
0.776IleGln: 0.776 ± 0.565
4.655IleArg: 4.655 ± 1.027
3.103IleSer: 3.103 ± 1.185
6.206IleThr: 6.206 ± 2.656
6.982IleVal: 6.982 ± 2.596
0.0IleTrp: 0.0 ± 0.0
0.776IleTyr: 0.776 ± 0.565
0.0IleXaa: 0.0 ± 0.0
Lys
8.534LysAla: 8.534 ± 2.77
0.0LysCys: 0.0 ± 0.0
2.327LysAsp: 2.327 ± 1.927
3.103LysGlu: 3.103 ± 1.004
1.552LysPhe: 1.552 ± 0.502
2.327LysGly: 2.327 ± 1.694
2.327LysHis: 2.327 ± 1.694
3.103LysIle: 3.103 ± 1.981
4.655LysLys: 4.655 ± 3.102
9.31LysLeu: 9.31 ± 3.025
1.552LysMet: 1.552 ± 1.285
2.327LysAsn: 2.327 ± 0.853
3.103LysPro: 3.103 ± 3.006
1.552LysGln: 1.552 ± 1.129
4.655LysArg: 4.655 ± 5.073
3.103LysSer: 3.103 ± 1.357
2.327LysThr: 2.327 ± 0.853
2.327LysVal: 2.327 ± 1.21
2.327LysTrp: 2.327 ± 0.853
1.552LysTyr: 1.552 ± 1.285
0.0LysXaa: 0.0 ± 0.0
Leu
4.655LeuAla: 4.655 ± 0.876
2.327LeuCys: 2.327 ± 0.853
6.206LeuAsp: 6.206 ± 2.026
0.776LeuGlu: 0.776 ± 0.642
6.206LeuPhe: 6.206 ± 3.904
6.206LeuGly: 6.206 ± 0.856
0.776LeuHis: 0.776 ± 0.565
3.103LeuIle: 3.103 ± 1.357
7.758LeuLys: 7.758 ± 1.096
6.982LeuLeu: 6.982 ± 7.351
1.552LeuMet: 1.552 ± 1.129
3.879LeuAsn: 3.879 ± 0.876
1.552LeuPro: 1.552 ± 3.654
0.776LeuGln: 0.776 ± 0.565
5.431LeuArg: 5.431 ± 1.186
13.189LeuSer: 13.189 ± 2.418
4.655LeuThr: 4.655 ± 6.878
4.655LeuVal: 4.655 ± 2.01
2.327LeuTrp: 2.327 ± 0.853
1.552LeuTyr: 1.552 ± 0.502
0.0LeuXaa: 0.0 ± 0.0
Met
1.552MetAla: 1.552 ± 1.503
0.0MetCys: 0.0 ± 0.0
0.776MetAsp: 0.776 ± 0.642
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
1.552MetGly: 1.552 ± 1.129
0.0MetHis: 0.0 ± 0.0
2.327MetIle: 2.327 ± 0.853
1.552MetLys: 1.552 ± 3.654
0.776MetLeu: 0.776 ± 0.565
0.0MetMet: 0.0 ± 0.0
0.776MetAsn: 0.776 ± 0.642
3.103MetPro: 3.103 ± 1.981
0.776MetGln: 0.776 ± 1.632
2.327MetArg: 2.327 ± 1.927
0.776MetSer: 0.776 ± 0.642
2.327MetThr: 2.327 ± 0.853
3.103MetVal: 3.103 ± 1.611
0.0MetTrp: 0.0 ± 0.0
1.552MetTyr: 1.552 ± 3.613
0.0MetXaa: 0.0 ± 0.0
Asn
3.103AsnAla: 3.103 ± 1.906
0.0AsnCys: 0.0 ± 0.0
0.0AsnAsp: 0.0 ± 0.0
1.552AsnGlu: 1.552 ± 1.533
3.103AsnPhe: 3.103 ± 1.611
3.103AsnGly: 3.103 ± 1.004
0.776AsnHis: 0.776 ± 0.565
4.655AsnIle: 4.655 ± 1.505
6.206AsnLys: 6.206 ± 2.052
7.758AsnLeu: 7.758 ± 1.721
1.552AsnMet: 1.552 ± 0.502
4.655AsnAsn: 4.655 ± 1.027
0.776AsnPro: 0.776 ± 0.642
1.552AsnGln: 1.552 ± 1.533
3.103AsnArg: 3.103 ± 1.004
2.327AsnSer: 2.327 ± 1.005
1.552AsnThr: 1.552 ± 0.502
3.879AsnVal: 3.879 ± 2.686
1.552AsnTrp: 1.552 ± 0.502
0.776AsnTyr: 0.776 ± 0.565
0.0AsnXaa: 0.0 ± 0.0
Pro
3.879ProAla: 3.879 ± 0.876
0.0ProCys: 0.0 ± 0.0
3.879ProAsp: 3.879 ± 2.237
3.879ProGlu: 3.879 ± 1.473
0.776ProPhe: 0.776 ± 0.642
1.552ProGly: 1.552 ± 1.129
1.552ProHis: 1.552 ± 1.129
1.552ProIle: 1.552 ± 1.533
4.655ProLys: 4.655 ± 1.027
1.552ProLeu: 1.552 ± 1.285
0.776ProMet: 0.776 ± 1.632
2.327ProAsn: 2.327 ± 1.634
0.776ProPro: 0.776 ± 0.565
3.103ProGln: 3.103 ± 1.004
3.103ProArg: 3.103 ± 1.611
2.327ProSer: 2.327 ± 1.927
4.655ProThr: 4.655 ± 2.657
3.103ProVal: 3.103 ± 1.357
0.776ProTrp: 0.776 ± 0.642
1.552ProTyr: 1.552 ± 3.613
0.0ProXaa: 0.0 ± 0.0
Gln
1.552GlnAla: 1.552 ± 1.285
0.776GlnCys: 0.776 ± 0.565
0.776GlnAsp: 0.776 ± 0.642
3.103GlnGlu: 3.103 ± 1.357
0.776GlnPhe: 0.776 ± 0.565
0.0GlnGly: 0.0 ± 0.0
0.776GlnHis: 0.776 ± 0.565
1.552GlnIle: 1.552 ± 0.502
0.776GlnLys: 0.776 ± 0.642
3.879GlnLeu: 3.879 ± 3.865
0.776GlnMet: 0.776 ± 0.565
1.552GlnAsn: 1.552 ± 0.502
3.103GlnPro: 3.103 ± 1.185
1.552GlnGln: 1.552 ± 0.502
3.879GlnArg: 3.879 ± 1.473
3.879GlnSer: 3.879 ± 0.876
0.776GlnThr: 0.776 ± 0.642
1.552GlnVal: 1.552 ± 1.285
0.776GlnTrp: 0.776 ± 0.565
3.103GlnTyr: 3.103 ± 1.906
0.0GlnXaa: 0.0 ± 0.0
Arg
1.552ArgAla: 1.552 ± 0.502
0.776ArgCys: 0.776 ± 0.565
5.431ArgAsp: 5.431 ± 1.928
2.327ArgGlu: 2.327 ± 1.005
3.879ArgPhe: 3.879 ± 1.453
2.327ArgGly: 2.327 ± 1.694
2.327ArgHis: 2.327 ± 1.005
3.879ArgIle: 3.879 ± 1.281
4.655ArgLys: 4.655 ± 2.01
3.879ArgLeu: 3.879 ± 1.473
1.552ArgMet: 1.552 ± 1.285
3.879ArgAsn: 3.879 ± 0.876
1.552ArgPro: 1.552 ± 1.503
3.103ArgGln: 3.103 ± 1.185
6.206ArgArg: 6.206 ± 4.145
2.327ArgSer: 2.327 ± 1.005
1.552ArgThr: 1.552 ± 4.477
3.103ArgVal: 3.103 ± 1.185
1.552ArgTrp: 1.552 ± 0.502
2.327ArgTyr: 2.327 ± 1.927
0.0ArgXaa: 0.0 ± 0.0
Ser
5.431SerAla: 5.431 ± 2.308
0.776SerCys: 0.776 ± 0.565
6.982SerAsp: 6.982 ± 2.422
0.776SerGlu: 0.776 ± 0.642
4.655SerPhe: 4.655 ± 3.493
5.431SerGly: 5.431 ± 4.16
0.0SerHis: 0.0 ± 0.0
7.758SerIle: 7.758 ± 2.673
2.327SerLys: 2.327 ± 1.005
6.982SerLeu: 6.982 ± 2.62
2.327SerMet: 2.327 ± 0.781
4.655SerAsn: 4.655 ± 1.707
3.103SerPro: 3.103 ± 1.611
3.103SerGln: 3.103 ± 1.611
4.655SerArg: 4.655 ± 1.505
6.982SerSer: 6.982 ± 0.941
5.431SerThr: 5.431 ± 2.285
5.431SerVal: 5.431 ± 1.186
1.552SerTrp: 1.552 ± 1.285
3.103SerTyr: 3.103 ± 1.357
0.0SerXaa: 0.0 ± 0.0
Thr
6.982ThrAla: 6.982 ± 5.855
2.327ThrCys: 2.327 ± 1.694
1.552ThrAsp: 1.552 ± 1.129
0.0ThrGlu: 0.0 ± 0.0
6.982ThrPhe: 6.982 ± 4.071
3.879ThrGly: 3.879 ± 2.237
1.552ThrHis: 1.552 ± 1.533
0.776ThrIle: 0.776 ± 0.565
3.879ThrLys: 3.879 ± 3.171
6.206ThrLeu: 6.206 ± 4.412
1.552ThrMet: 1.552 ± 1.142
1.552ThrAsn: 1.552 ± 1.129
3.103ThrPro: 3.103 ± 1.004
2.327ThrGln: 2.327 ± 1.005
2.327ThrArg: 2.327 ± 1.21
5.431ThrSer: 5.431 ± 0.758
2.327ThrThr: 2.327 ± 3.071
6.982ThrVal: 6.982 ± 2.144
0.0ThrTrp: 0.0 ± 0.0
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
6.206ValAla: 6.206 ± 2.448
0.776ValCys: 0.776 ± 0.565
4.655ValAsp: 4.655 ± 0.876
2.327ValGlu: 2.327 ± 0.853
3.103ValPhe: 3.103 ± 3.352
1.552ValGly: 1.552 ± 1.533
0.776ValHis: 0.776 ± 0.565
10.085ValIle: 10.085 ± 1.714
4.655ValLys: 4.655 ± 1.94
4.655ValLeu: 4.655 ± 2.446
2.327ValMet: 2.327 ± 1.005
3.879ValAsn: 3.879 ± 1.453
5.431ValPro: 5.431 ± 2.196
1.552ValGln: 1.552 ± 1.129
1.552ValArg: 1.552 ± 0.502
8.534ValSer: 8.534 ± 3.253
3.103ValThr: 3.103 ± 1.611
4.655ValVal: 4.655 ± 1.505
1.552ValTrp: 1.552 ± 1.503
3.879ValTyr: 3.879 ± 2.287
0.0ValXaa: 0.0 ± 0.0
Trp
1.552TrpAla: 1.552 ± 0.502
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.552TrpGlu: 1.552 ± 1.503
0.776TrpPhe: 0.776 ± 0.642
1.552TrpGly: 1.552 ± 0.502
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.776TrpLys: 0.776 ± 0.565
1.552TrpLeu: 1.552 ± 0.502
0.0TrpMet: 0.0 ± 0.0
1.552TrpAsn: 1.552 ± 1.285
0.0TrpPro: 0.0 ± 0.0
0.776TrpGln: 0.776 ± 0.565
1.552TrpArg: 1.552 ± 1.285
1.552TrpSer: 1.552 ± 1.533
0.776TrpThr: 0.776 ± 0.565
5.431TrpVal: 5.431 ± 1.749
0.0TrpTrp: 0.0 ± 0.0
0.776TrpTyr: 0.776 ± 0.642
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.879TyrAla: 3.879 ± 3.171
0.0TyrCys: 0.0 ± 0.0
2.327TyrAsp: 2.327 ± 1.005
0.776TyrGlu: 0.776 ± 0.642
0.776TyrPhe: 0.776 ± 0.642
0.776TyrGly: 0.776 ± 0.565
0.776TyrHis: 0.776 ± 3.755
0.0TyrIle: 0.0 ± 0.0
2.327TyrLys: 2.327 ± 1.21
1.552TyrLeu: 1.552 ± 1.285
0.0TyrMet: 0.0 ± 0.0
1.552TyrAsn: 1.552 ± 1.129
0.776TyrPro: 0.776 ± 0.565
0.776TyrGln: 0.776 ± 0.642
2.327TyrArg: 2.327 ± 0.853
2.327TyrSer: 2.327 ± 1.927
3.879TyrThr: 3.879 ± 3.354
4.655TyrVal: 4.655 ± 1.704
0.776TyrTrp: 0.776 ± 0.565
3.103TyrTyr: 3.103 ± 3.336
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1290 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski