Amino acid dipepetide frequency for Pediculus humanus subsp. corporis (Body louse)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.522AlaAla: 3.522 ± 0.045	0.88AlaCys: 0.88 ± 0.015	2.205AlaAsp: 2.205 ± 0.022	3.125AlaGlu: 3.125 ± 0.034	2.035AlaPhe: 2.035 ± 0.023	2.607AlaGly: 2.607 ± 0.033	0.99AlaHis: 0.99 ± 0.016	2.957AlaIle: 2.957 ± 0.032	3.218AlaLys: 3.218 ± 0.03	4.76AlaLeu: 4.76 ± 0.046	1.112AlaMet: 1.112 ± 0.017	2.201AlaAsn: 2.201 ± 0.023	1.999AlaPro: 1.999 ± 0.032	1.774AlaGln: 1.774 ± 0.023	2.079AlaArg: 2.079 ± 0.022	3.607AlaSer: 3.607 ± 0.031	2.738AlaThr: 2.738 ± 0.028	3.213AlaVal: 3.213 ± 0.028	0.481AlaTrp: 0.481 ± 0.01	1.372AlaTyr: 1.372 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.83CysAla: 0.83 ± 0.015	0.499CysCys: 0.499 ± 0.011	1.197CysAsp: 1.197 ± 0.029	1.258CysGlu: 1.258 ± 0.026	0.883CysPhe: 0.883 ± 0.021	1.301CysGly: 1.301 ± 0.031	0.513CysHis: 0.513 ± 0.013	1.113CysIle: 1.113 ± 0.018	1.422CysLys: 1.422 ± 0.022	1.915CysLeu: 1.915 ± 0.027	0.364CysMet: 0.364 ± 0.008	1.07CysAsn: 1.07 ± 0.018	0.991CysPro: 0.991 ± 0.027	0.822CysGln: 0.822 ± 0.013	0.939CysArg: 0.939 ± 0.018	1.638CysSer: 1.638 ± 0.023	0.961CysThr: 0.961 ± 0.016	1.118CysVal: 1.118 ± 0.017	0.218CysTrp: 0.218 ± 0.008	0.631CysTyr: 0.631 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	2.325AspAla: 2.325 ± 0.024	1.036AspCys: 1.036 ± 0.017	4.604AspAsp: 4.604 ± 0.065	4.566AspGlu: 4.566 ± 0.049	2.581AspPhe: 2.581 ± 0.022	3.156AspGly: 3.156 ± 0.031	1.02AspHis: 1.02 ± 0.015	3.342AspIle: 3.342 ± 0.028	4.096AspLys: 4.096 ± 0.075	5.051AspLeu: 5.051 ± 0.038	1.097AspMet: 1.097 ± 0.027	3.171AspAsn: 3.171 ± 0.033	2.204AspPro: 2.204 ± 0.036	1.438AspGln: 1.438 ± 0.018	2.189AspArg: 2.189 ± 0.031	4.512AspSer: 4.512 ± 0.039	2.301AspThr: 2.301 ± 0.02	3.857AspVal: 3.857 ± 0.032	0.629AspTrp: 0.629 ± 0.013	1.948AspTyr: 1.948 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	3.107GluAla: 3.107 ± 0.031	1.254GluCys: 1.254 ± 0.026	4.047GluAsp: 4.047 ± 0.042	6.962GluGlu: 6.962 ± 0.09	2.584GluPhe: 2.584 ± 0.032	3.119GluGly: 3.119 ± 0.032	1.178GluHis: 1.178 ± 0.017	4.942GluIle: 4.942 ± 0.039	7.46GluLys: 7.46 ± 0.091	5.689GluLeu: 5.689 ± 0.05	1.699GluMet: 1.699 ± 0.02	5.644GluAsn: 5.644 ± 0.049	2.378GluPro: 2.378 ± 0.043	2.222GluGln: 2.222 ± 0.025	3.24GluArg: 3.24 ± 0.038	5.208GluSer: 5.208 ± 0.046	3.854GluThr: 3.854 ± 0.036	3.557GluVal: 3.557 ± 0.033	0.657GluTrp: 0.657 ± 0.014	2.058GluTyr: 2.058 ± 0.025	0.001GluXaa: 0.001 ± 0.0
Phe	1.86PheAla: 1.86 ± 0.022	0.912PheCys: 0.912 ± 0.015	2.432PheAsp: 2.432 ± 0.031	2.609PheGlu: 2.609 ± 0.028	2.237PhePhe: 2.237 ± 0.028	2.466PheGly: 2.466 ± 0.029	1.039PheHis: 1.039 ± 0.015	2.658PheIle: 2.658 ± 0.027	3.011PheLys: 3.011 ± 0.028	4.145PheLeu: 4.145 ± 0.038	0.87PheMet: 0.87 ± 0.013	2.43PheAsn: 2.43 ± 0.023	1.861PhePro: 1.861 ± 0.028	1.706PheGln: 1.706 ± 0.016	1.804PheArg: 1.804 ± 0.021	3.606PheSer: 3.606 ± 0.028	2.315PheThr: 2.315 ± 0.024	2.535PheVal: 2.535 ± 0.026	0.497PheTrp: 0.497 ± 0.01	1.619PheTyr: 1.619 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	2.428GlyAla: 2.428 ± 0.037	1.027GlyCys: 1.027 ± 0.019	2.831GlyAsp: 2.831 ± 0.031	3.373GlyGlu: 3.373 ± 0.04	2.405GlyPhe: 2.405 ± 0.032	4.496GlyGly: 4.496 ± 0.091	1.24GlyHis: 1.24 ± 0.023	3.283GlyIle: 3.283 ± 0.029	4.327GlyLys: 4.327 ± 0.048	4.375GlyLeu: 4.375 ± 0.041	1.121GlyMet: 1.121 ± 0.019	3.159GlyAsn: 3.159 ± 0.033	2.149GlyPro: 2.149 ± 0.044	1.799GlyGln: 1.799 ± 0.038	2.548GlyArg: 2.548 ± 0.033	4.614GlySer: 4.614 ± 0.062	2.871GlyThr: 2.871 ± 0.032	3.162GlyVal: 3.162 ± 0.031	0.585GlyTrp: 0.585 ± 0.012	1.878GlyTyr: 1.878 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	0.92HisAla: 0.92 ± 0.015	0.536HisCys: 0.536 ± 0.013	0.999HisAsp: 0.999 ± 0.016	1.238HisGlu: 1.238 ± 0.019	1.05HisPhe: 1.05 ± 0.015	1.231HisGly: 1.231 ± 0.023	0.965HisHis: 0.965 ± 0.029	1.264HisIle: 1.264 ± 0.017	1.444HisLys: 1.444 ± 0.039	2.281HisLeu: 2.281 ± 0.024	0.492HisMet: 0.492 ± 0.012	1.129HisAsn: 1.129 ± 0.016	1.21HisPro: 1.21 ± 0.02	0.961HisGln: 0.961 ± 0.017	1.133HisArg: 1.133 ± 0.018	1.905HisSer: 1.905 ± 0.026	1.032HisThr: 1.032 ± 0.021	1.378HisVal: 1.378 ± 0.018	0.268HisTrp: 0.268 ± 0.006	0.826HisTyr: 0.826 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	2.847IleAla: 2.847 ± 0.028	1.327IleCys: 1.327 ± 0.026	3.308IleAsp: 3.308 ± 0.038	4.061IleGlu: 4.061 ± 0.036	2.898IlePhe: 2.898 ± 0.026	2.856IleGly: 2.856 ± 0.027	1.438IleHis: 1.438 ± 0.02	4.327IleIle: 4.327 ± 0.038	4.972IleLys: 4.972 ± 0.037	6.053IleLeu: 6.053 ± 0.053	1.277IleMet: 1.277 ± 0.015	3.859IleAsn: 3.859 ± 0.038	3.033IlePro: 3.033 ± 0.027	2.453IleGln: 2.453 ± 0.026	2.713IleArg: 2.713 ± 0.024	4.989IleSer: 4.989 ± 0.034	3.377IleThr: 3.377 ± 0.033	3.542IleVal: 3.542 ± 0.03	0.648IleTrp: 0.648 ± 0.012	2.022IleTyr: 2.022 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.148LysAla: 3.148 ± 0.03	1.544LysCys: 1.544 ± 0.026	3.948LysAsp: 3.948 ± 0.05	6.205LysGlu: 6.205 ± 0.066	3.096LysPhe: 3.096 ± 0.032	3.306LysGly: 3.306 ± 0.036	1.564LysHis: 1.564 ± 0.041	5.911LysIle: 5.911 ± 0.043	8.729LysLys: 8.729 ± 0.091	7.005LysLeu: 7.005 ± 0.053	1.907LysMet: 1.907 ± 0.021	6.126LysAsn: 6.126 ± 0.047	3.442LysPro: 3.442 ± 0.099	2.747LysGln: 2.747 ± 0.029	3.733LysArg: 3.733 ± 0.039	6.224LysSer: 6.224 ± 0.053	4.847LysThr: 4.847 ± 0.043	3.972LysVal: 3.972 ± 0.042	0.802LysTrp: 0.802 ± 0.015	2.686LysTyr: 2.686 ± 0.025	0.001LysXaa: 0.001 ± 0.0
Leu	4.568LeuAla: 4.568 ± 0.041	1.755LeuCys: 1.755 ± 0.024	4.631LeuAsp: 4.631 ± 0.045	6.417LeuGlu: 6.417 ± 0.06	3.646LeuPhe: 3.646 ± 0.03	4.395LeuGly: 4.395 ± 0.04	2.077LeuHis: 2.077 ± 0.025	5.436LeuIle: 5.436 ± 0.046	7.858LeuLys: 7.858 ± 0.063	8.691LeuLeu: 8.691 ± 0.069	1.992LeuMet: 1.992 ± 0.022	5.605LeuAsn: 5.605 ± 0.044	4.515LeuPro: 4.515 ± 0.037	4.045LeuGln: 4.045 ± 0.04	4.195LeuArg: 4.195 ± 0.038	7.407LeuSer: 7.407 ± 0.043	5.097LeuThr: 5.097 ± 0.037	4.621LeuVal: 4.621 ± 0.038	0.897LeuTrp: 0.897 ± 0.014	2.728LeuTyr: 2.728 ± 0.027	0.001LeuXaa: 0.001 ± 0.0
Met	1.35MetAla: 1.35 ± 0.018	0.399MetCys: 0.399 ± 0.01	1.216MetAsp: 1.216 ± 0.016	1.677MetGlu: 1.677 ± 0.021	0.833MetPhe: 0.833 ± 0.014	1.092MetGly: 1.092 ± 0.019	0.387MetHis: 0.387 ± 0.008	1.26MetIle: 1.26 ± 0.016	1.835MetLys: 1.835 ± 0.029	1.739MetLeu: 1.739 ± 0.021	0.571MetMet: 0.571 ± 0.011	1.224MetAsn: 1.224 ± 0.016	0.934MetPro: 0.934 ± 0.015	0.756MetGln: 0.756 ± 0.014	0.943MetArg: 0.943 ± 0.015	1.75MetSer: 1.75 ± 0.018	1.292MetThr: 1.292 ± 0.017	1.137MetVal: 1.137 ± 0.015	0.225MetTrp: 0.225 ± 0.008	0.635MetTyr: 0.635 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.546AsnAla: 2.546 ± 0.027	1.225AsnCys: 1.225 ± 0.017	3.739AsnAsp: 3.739 ± 0.035	4.402AsnGlu: 4.402 ± 0.034	2.99AsnPhe: 2.99 ± 0.028	3.301AsnGly: 3.301 ± 0.039	1.337AsnHis: 1.337 ± 0.02	3.814AsnIle: 3.814 ± 0.035	4.749AsnLys: 4.749 ± 0.036	5.877AsnLeu: 5.877 ± 0.047	1.163AsnMet: 1.163 ± 0.015	5.626AsnAsn: 5.626 ± 0.07	2.515AsnPro: 2.515 ± 0.028	2.274AsnGln: 2.274 ± 0.03	2.383AsnArg: 2.383 ± 0.027	5.578AsnSer: 5.578 ± 0.04	2.772AsnThr: 2.772 ± 0.028	4.006AsnVal: 4.006 ± 0.031	0.609AsnTrp: 0.609 ± 0.01	2.36AsnTyr: 2.36 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	2.116ProAla: 2.116 ± 0.033	0.788ProCys: 0.788 ± 0.02	2.544ProAsp: 2.544 ± 0.05	3.374ProGlu: 3.374 ± 0.058	1.841ProPhe: 1.841 ± 0.024	2.808ProGly: 2.808 ± 0.101	1.054ProHis: 1.054 ± 0.025	2.549ProIle: 2.549 ± 0.024	3.216ProLys: 3.216 ± 0.055	3.903ProLeu: 3.903 ± 0.041	0.842ProMet: 0.842 ± 0.014	2.511ProAsn: 2.511 ± 0.027	3.91ProPro: 3.91 ± 0.063	1.869ProGln: 1.869 ± 0.036	1.949ProArg: 1.949 ± 0.037	4.157ProSer: 4.157 ± 0.042	2.766ProThr: 2.766 ± 0.039	3.057ProVal: 3.057 ± 0.033	0.461ProTrp: 0.461 ± 0.01	1.462ProTyr: 1.462 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	1.745GlnAla: 1.745 ± 0.025	0.757GlnCys: 0.757 ± 0.024	1.71GlnAsp: 1.71 ± 0.02	2.628GlnGlu: 2.628 ± 0.028	1.405GlnPhe: 1.405 ± 0.017	1.746GlnGly: 1.746 ± 0.024	0.903GlnHis: 0.903 ± 0.017	2.496GlnIle: 2.496 ± 0.027	2.98GlnLys: 2.98 ± 0.03	3.373GlnLeu: 3.373 ± 0.033	0.935GlnMet: 0.935 ± 0.015	2.651GlnAsn: 2.651 ± 0.028	1.761GlnPro: 1.761 ± 0.054	2.499GlnGln: 2.499 ± 0.055	1.842GlnArg: 1.842 ± 0.027	2.887GlnSer: 2.887 ± 0.028	2.164GlnThr: 2.164 ± 0.023	2.103GlnVal: 2.103 ± 0.024	0.395GlnTrp: 0.395 ± 0.009	1.217GlnTyr: 1.217 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	2.054ArgAla: 2.054 ± 0.026	0.867ArgCys: 0.867 ± 0.023	2.43ArgAsp: 2.43 ± 0.035	3.162ArgGlu: 3.162 ± 0.034	1.805ArgPhe: 1.805 ± 0.021	2.34ArgGly: 2.34 ± 0.028	1.184ArgHis: 1.184 ± 0.019	2.698ArgIle: 2.698 ± 0.026	4.065ArgLys: 4.065 ± 0.036	4.055ArgLeu: 4.055 ± 0.035	0.991ArgMet: 0.991 ± 0.016	2.659ArgAsn: 2.659 ± 0.022	2.039ArgPro: 2.039 ± 0.04	1.849ArgGln: 1.849 ± 0.024	3.003ArgArg: 3.003 ± 0.041	3.387ArgSer: 3.387 ± 0.038	2.235ArgThr: 2.235 ± 0.019	2.3ArgVal: 2.3 ± 0.025	0.449ArgTrp: 0.449 ± 0.01	1.442ArgTyr: 1.442 ± 0.02	0.001ArgXaa: 0.001 ± 0.0
Ser	3.746SerAla: 3.746 ± 0.035	1.554SerCys: 1.554 ± 0.023	4.799SerAsp: 4.799 ± 0.039	5.441SerGlu: 5.441 ± 0.043	3.428SerPhe: 3.428 ± 0.025	4.918SerGly: 4.918 ± 0.055	1.861SerHis: 1.861 ± 0.024	4.477SerIle: 4.477 ± 0.03	6.043SerLys: 6.043 ± 0.042	7.322SerLeu: 7.322 ± 0.046	1.546SerMet: 1.546 ± 0.017	5.201SerAsn: 5.201 ± 0.044	4.401SerPro: 4.401 ± 0.063	3.168SerGln: 3.168 ± 0.035	3.58SerArg: 3.58 ± 0.038	9.738SerSer: 9.738 ± 0.098	4.748SerThr: 4.748 ± 0.055	4.794SerVal: 4.794 ± 0.034	0.82SerTrp: 0.82 ± 0.014	2.453SerTyr: 2.453 ± 0.024	0.001SerXaa: 0.001 ± 0.0
Thr	2.779ThrAla: 2.779 ± 0.029	1.151ThrCys: 1.151 ± 0.019	2.871ThrAsp: 2.871 ± 0.04	3.608ThrGlu: 3.608 ± 0.044	2.289ThrPhe: 2.289 ± 0.027	3.152ThrGly: 3.152 ± 0.035	1.137ThrHis: 1.137 ± 0.018	3.372ThrIle: 3.372 ± 0.027	3.806ThrLys: 3.806 ± 0.038	4.909ThrLeu: 4.909 ± 0.035	1.105ThrMet: 1.105 ± 0.016	3.217ThrAsn: 3.217 ± 0.025	3.05ThrPro: 3.05 ± 0.039	1.891ThrGln: 1.891 ± 0.027	2.166ThrArg: 2.166 ± 0.022	4.924ThrSer: 4.924 ± 0.042	4.274ThrThr: 4.274 ± 0.062	3.532ThrVal: 3.532 ± 0.033	0.554ThrTrp: 0.554 ± 0.011	1.612ThrTyr: 1.612 ± 0.02	0.001ThrXaa: 0.001 ± 0.0
Val	3.097ValAla: 3.097 ± 0.031	1.205ValCys: 1.205 ± 0.025	3.142ValAsp: 3.142 ± 0.031	3.995ValGlu: 3.995 ± 0.039	2.488ValPhe: 2.488 ± 0.029	2.983ValGly: 2.983 ± 0.027	1.296ValHis: 1.296 ± 0.018	3.624ValIle: 3.624 ± 0.031	4.536ValLys: 4.536 ± 0.04	5.247ValLeu: 5.247 ± 0.041	1.232ValMet: 1.232 ± 0.013	3.267ValAsn: 3.267 ± 0.029	2.94ValPro: 2.94 ± 0.032	2.243ValGln: 2.243 ± 0.021	2.53ValArg: 2.53 ± 0.024	4.517ValSer: 4.517 ± 0.034	3.609ValThr: 3.609 ± 0.038	3.867ValVal: 3.867 ± 0.035	0.618ValTrp: 0.618 ± 0.012	1.767ValTyr: 1.767 ± 0.019	0.001ValXaa: 0.001 ± 0.0
Trp	0.466TrpAla: 0.466 ± 0.009	0.218TrpCys: 0.218 ± 0.007	0.586TrpAsp: 0.586 ± 0.013	0.672TrpGlu: 0.672 ± 0.013	0.474TrpPhe: 0.474 ± 0.01	0.527TrpGly: 0.527 ± 0.013	0.221TrpHis: 0.221 ± 0.007	0.689TrpIle: 0.689 ± 0.012	0.883TrpLys: 0.883 ± 0.014	0.994TrpLeu: 0.994 ± 0.019	0.275TrpMet: 0.275 ± 0.006	0.676TrpAsn: 0.676 ± 0.011	0.37TrpPro: 0.37 ± 0.009	0.371TrpGln: 0.371 ± 0.009	0.532TrpArg: 0.532 ± 0.013	0.805TrpSer: 0.805 ± 0.015	0.561TrpThr: 0.561 ± 0.009	0.551TrpVal: 0.551 ± 0.01	0.162TrpTrp: 0.162 ± 0.005	0.338TrpTyr: 0.338 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.419TyrAla: 1.419 ± 0.017	0.747TyrCys: 0.747 ± 0.013	1.883TyrAsp: 1.883 ± 0.02	2.086TyrGlu: 2.086 ± 0.022	1.644TyrPhe: 1.644 ± 0.019	1.87TyrGly: 1.87 ± 0.027	0.857TyrHis: 0.857 ± 0.014	1.787TyrIle: 1.787 ± 0.021	2.297TyrLys: 2.297 ± 0.022	3.193TyrLeu: 3.193 ± 0.027	0.663TyrMet: 0.663 ± 0.011	1.841TyrAsn: 1.841 ± 0.023	1.474TyrPro: 1.474 ± 0.037	1.309TyrGln: 1.309 ± 0.019	1.512TyrArg: 1.512 ± 0.02	2.586TyrSer: 2.586 ± 0.024	1.587TyrThr: 1.587 ± 0.02	1.903TyrVal: 1.903 ± 0.023	0.397TyrTrp: 0.397 ± 0.01	1.402TyrTyr: 1.402 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.009XaaXaa: 0.009 ± 0.002

Statistics based on 10788 proteins (5547409 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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