Amino acid dipepetide frequency for Bifidobacterium pullorum subsp. gallinarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.726AlaAla: 14.726 ± 0.24	1.206AlaCys: 1.206 ± 0.053	8.053AlaAsp: 8.053 ± 0.141	6.811AlaGlu: 6.811 ± 0.107	3.545AlaPhe: 3.545 ± 0.084	9.24AlaGly: 9.24 ± 0.156	2.125AlaHis: 2.125 ± 0.072	5.635AlaIle: 5.635 ± 0.101	3.659AlaLys: 3.659 ± 0.095	10.354AlaLeu: 10.354 ± 0.172	3.48AlaMet: 3.48 ± 0.081	2.996AlaAsn: 2.996 ± 0.076	4.333AlaPro: 4.333 ± 0.098	4.093AlaGln: 4.093 ± 0.095	6.821AlaArg: 6.821 ± 0.131	6.062AlaSer: 6.062 ± 0.111	5.906AlaThr: 5.906 ± 0.112	9.483AlaVal: 9.483 ± 0.152	1.546AlaTrp: 1.546 ± 0.051	2.649AlaTyr: 2.649 ± 0.075	0.0AlaXaa: 0.0 ± 0.0
Cys	1.113CysAla: 1.113 ± 0.05	0.145CysCys: 0.145 ± 0.018	0.614CysAsp: 0.614 ± 0.033	0.523CysGlu: 0.523 ± 0.033	0.331CysPhe: 0.331 ± 0.026	1.108CysGly: 1.108 ± 0.048	0.219CysHis: 0.219 ± 0.017	0.396CysIle: 0.396 ± 0.028	0.232CysLys: 0.232 ± 0.021	0.885CysLeu: 0.885 ± 0.042	0.267CysMet: 0.267 ± 0.021	0.254CysAsn: 0.254 ± 0.022	0.556CysPro: 0.556 ± 0.033	0.244CysGln: 0.244 ± 0.021	0.658CysArg: 0.658 ± 0.033	0.579CysSer: 0.579 ± 0.031	0.555CysThr: 0.555 ± 0.028	0.851CysVal: 0.851 ± 0.038	0.13CysTrp: 0.13 ± 0.013	0.248CysTyr: 0.248 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	8.157AspAla: 8.157 ± 0.137	0.61AspCys: 0.61 ± 0.034	4.9AspAsp: 4.9 ± 0.102	5.24AspGlu: 5.24 ± 0.103	2.163AspPhe: 2.163 ± 0.06	6.559AspGly: 6.559 ± 0.117	1.375AspHis: 1.375 ± 0.046	3.164AspIle: 3.164 ± 0.072	1.862AspLys: 1.862 ± 0.065	5.561AspLeu: 5.561 ± 0.103	1.685AspMet: 1.685 ± 0.045	1.652AspAsn: 1.652 ± 0.052	3.878AspPro: 3.878 ± 0.083	1.887AspGln: 1.887 ± 0.052	4.178AspArg: 4.178 ± 0.103	3.091AspSer: 3.091 ± 0.073	3.553AspThr: 3.553 ± 0.081	5.251AspVal: 5.251 ± 0.099	1.105AspTrp: 1.105 ± 0.046	1.977AspTyr: 1.977 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	6.489GluAla: 6.489 ± 0.125	0.486GluCys: 0.486 ± 0.031	3.498GluAsp: 3.498 ± 0.077	3.524GluGlu: 3.524 ± 0.087	1.88GluPhe: 1.88 ± 0.054	4.268GluGly: 4.268 ± 0.097	1.8GluHis: 1.8 ± 0.062	2.823GluIle: 2.823 ± 0.068	1.682GluLys: 1.682 ± 0.059	5.607GluLeu: 5.607 ± 0.113	1.459GluMet: 1.459 ± 0.052	1.785GluAsn: 1.785 ± 0.051	3.03GluPro: 3.03 ± 0.082	2.876GluGln: 2.876 ± 0.069	5.245GluArg: 5.245 ± 0.114	3.382GluSer: 3.382 ± 0.067	3.318GluThr: 3.318 ± 0.083	3.722GluVal: 3.722 ± 0.081	0.69GluTrp: 0.69 ± 0.034	1.772GluTyr: 1.772 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	3.913PheAla: 3.913 ± 0.083	0.378PheCys: 0.378 ± 0.026	2.702PheAsp: 2.702 ± 0.068	1.888PheGlu: 1.888 ± 0.059	1.139PhePhe: 1.139 ± 0.047	3.279PheGly: 3.279 ± 0.08	0.721PheHis: 0.721 ± 0.034	1.663PheIle: 1.663 ± 0.055	0.897PheLys: 0.897 ± 0.037	2.652PheLeu: 2.652 ± 0.074	0.756PheMet: 0.756 ± 0.036	1.142PheAsn: 1.142 ± 0.043	1.402PhePro: 1.402 ± 0.048	0.88PheGln: 0.88 ± 0.036	1.803PheArg: 1.803 ± 0.052	2.12PheSer: 2.12 ± 0.062	2.163PheThr: 2.163 ± 0.07	2.663PheVal: 2.663 ± 0.07	0.413PheTrp: 0.413 ± 0.027	0.852PheTyr: 0.852 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	7.993GlyAla: 7.993 ± 0.127	0.873GlyCys: 0.873 ± 0.044	4.9GlyAsp: 4.9 ± 0.091	5.089GlyGlu: 5.089 ± 0.1	3.199GlyPhe: 3.199 ± 0.082	6.452GlyGly: 6.452 ± 0.152	1.814GlyHis: 1.814 ± 0.06	4.733GlyIle: 4.733 ± 0.1	3.164GlyLys: 3.164 ± 0.071	7.352GlyLeu: 7.352 ± 0.125	2.38GlyMet: 2.38 ± 0.065	2.56GlyAsn: 2.56 ± 0.071	2.797GlyPro: 2.797 ± 0.07	2.567GlyGln: 2.567 ± 0.071	5.288GlyArg: 5.288 ± 0.103	4.855GlySer: 4.855 ± 0.119	5.237GlyThr: 5.237 ± 0.099	6.999GlyVal: 6.999 ± 0.121	1.227GlyTrp: 1.227 ± 0.05	2.805GlyTyr: 2.805 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	2.347HisAla: 2.347 ± 0.068	0.224HisCys: 0.224 ± 0.019	1.618HisAsp: 1.618 ± 0.048	1.246HisGlu: 1.246 ± 0.049	0.565HisPhe: 0.565 ± 0.033	2.088HisGly: 2.088 ± 0.062	0.547HisHis: 0.547 ± 0.033	1.082HisIle: 1.082 ± 0.039	0.495HisLys: 0.495 ± 0.028	1.661HisLeu: 1.661 ± 0.05	0.523HisMet: 0.523 ± 0.027	0.584HisAsn: 0.584 ± 0.03	1.295HisPro: 1.295 ± 0.05	0.605HisGln: 0.605 ± 0.031	1.603HisArg: 1.603 ± 0.052	0.881HisSer: 0.881 ± 0.04	1.306HisThr: 1.306 ± 0.05	1.777HisVal: 1.777 ± 0.054	0.317HisTrp: 0.317 ± 0.026	0.632HisTyr: 0.632 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.517IleAla: 6.517 ± 0.099	0.621IleCys: 0.621 ± 0.029	4.286IleAsp: 4.286 ± 0.082	3.226IleGlu: 3.226 ± 0.073	1.364IlePhe: 1.364 ± 0.055	4.741IleGly: 4.741 ± 0.097	0.967IleHis: 0.967 ± 0.04	2.692IleIle: 2.692 ± 0.078	1.364IleLys: 1.364 ± 0.049	3.815IleLeu: 3.815 ± 0.094	1.103IleMet: 1.103 ± 0.042	1.64IleAsn: 1.64 ± 0.055	2.699IlePro: 2.699 ± 0.062	1.259IleGln: 1.259 ± 0.045	3.255IleArg: 3.255 ± 0.07	2.66IleSer: 2.66 ± 0.066	3.213IleThr: 3.213 ± 0.076	4.833IleVal: 4.833 ± 0.1	0.59IleTrp: 0.59 ± 0.028	1.148IleTyr: 1.148 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	3.91LysAla: 3.91 ± 0.093	0.145LysCys: 0.145 ± 0.015	1.978LysAsp: 1.978 ± 0.073	1.684LysGlu: 1.684 ± 0.056	0.769LysPhe: 0.769 ± 0.045	2.247LysGly: 2.247 ± 0.072	0.661LysHis: 0.661 ± 0.034	1.415LysIle: 1.415 ± 0.057	1.185LysLys: 1.185 ± 0.059	2.713LysLeu: 2.713 ± 0.082	0.645LysMet: 0.645 ± 0.034	0.997LysAsn: 0.997 ± 0.045	1.832LysPro: 1.832 ± 0.057	1.107LysGln: 1.107 ± 0.045	2.232LysArg: 2.232 ± 0.059	1.616LysSer: 1.616 ± 0.056	2.03LysThr: 2.03 ± 0.063	2.319LysVal: 2.319 ± 0.074	0.351LysTrp: 0.351 ± 0.027	0.809LysTyr: 0.809 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	10.158LeuAla: 10.158 ± 0.144	0.997LeuCys: 0.997 ± 0.041	6.536LeuAsp: 6.536 ± 0.107	4.526LeuGlu: 4.526 ± 0.086	3.127LeuPhe: 3.127 ± 0.079	7.221LeuGly: 7.221 ± 0.103	1.878LeuHis: 1.878 ± 0.063	4.653LeuIle: 4.653 ± 0.099	3.078LeuLys: 3.078 ± 0.078	8.025LeuLeu: 8.025 ± 0.145	2.298LeuMet: 2.298 ± 0.068	2.901LeuAsn: 2.901 ± 0.057	4.616LeuPro: 4.616 ± 0.092	2.496LeuGln: 2.496 ± 0.068	5.705LeuArg: 5.705 ± 0.115	5.301LeuSer: 5.301 ± 0.09	5.524LeuThr: 5.524 ± 0.097	6.764LeuVal: 6.764 ± 0.108	1.076LeuTrp: 1.076 ± 0.045	2.071LeuTyr: 2.071 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	3.083MetAla: 3.083 ± 0.071	0.254MetCys: 0.254 ± 0.022	1.494MetAsp: 1.494 ± 0.045	1.224MetGlu: 1.224 ± 0.046	0.846MetPhe: 0.846 ± 0.038	1.858MetGly: 1.858 ± 0.057	0.56MetHis: 0.56 ± 0.035	1.309MetIle: 1.309 ± 0.048	0.828MetLys: 0.828 ± 0.042	2.589MetLeu: 2.589 ± 0.062	0.759MetMet: 0.759 ± 0.036	0.896MetAsn: 0.896 ± 0.039	1.497MetPro: 1.497 ± 0.048	0.851MetGln: 0.851 ± 0.037	1.94MetArg: 1.94 ± 0.053	1.722MetSer: 1.722 ± 0.056	2.125MetThr: 2.125 ± 0.058	1.938MetVal: 1.938 ± 0.062	0.326MetTrp: 0.326 ± 0.022	0.486MetTyr: 0.486 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.62AsnAla: 3.62 ± 0.086	0.219AsnCys: 0.219 ± 0.019	1.805AsnAsp: 1.805 ± 0.056	1.711AsnGlu: 1.711 ± 0.054	0.827AsnPhe: 0.827 ± 0.044	2.996AsnGly: 2.996 ± 0.081	0.605AsnHis: 0.605 ± 0.03	1.435AsnIle: 1.435 ± 0.054	0.893AsnLys: 0.893 ± 0.046	2.58AsnLeu: 2.58 ± 0.069	0.73AsnMet: 0.73 ± 0.035	0.965AsnAsn: 0.965 ± 0.046	2.08AsnPro: 2.08 ± 0.062	0.939AsnGln: 0.939 ± 0.041	1.954AsnArg: 1.954 ± 0.06	1.359AsnSer: 1.359 ± 0.046	1.761AsnThr: 1.761 ± 0.062	2.314AsnVal: 2.314 ± 0.061	0.417AsnTrp: 0.417 ± 0.026	0.82AsnTyr: 0.82 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	5.139ProAla: 5.139 ± 0.114	0.362ProCys: 0.362 ± 0.028	4.005ProAsp: 4.005 ± 0.097	3.762ProGlu: 3.762 ± 0.086	1.687ProPhe: 1.687 ± 0.049	3.736ProGly: 3.736 ± 0.079	0.984ProHis: 0.984 ± 0.039	2.24ProIle: 2.24 ± 0.054	1.597ProLys: 1.597 ± 0.057	3.844ProLeu: 3.844 ± 0.089	1.235ProMet: 1.235 ± 0.041	1.579ProAsn: 1.579 ± 0.044	1.451ProPro: 1.451 ± 0.048	1.808ProGln: 1.808 ± 0.052	2.593ProArg: 2.593 ± 0.067	2.86ProSer: 2.86 ± 0.08	2.829ProThr: 2.829 ± 0.076	4.159ProVal: 4.159 ± 0.087	0.783ProTrp: 0.783 ± 0.035	1.377ProTyr: 1.377 ± 0.052	0.0ProXaa: 0.0 ± 0.0
Gln	3.863GlnAla: 3.863 ± 0.09	0.238GlnCys: 0.238 ± 0.02	1.703GlnAsp: 1.703 ± 0.058	1.642GlnGlu: 1.642 ± 0.064	1.008GlnPhe: 1.008 ± 0.043	2.301GlnGly: 2.301 ± 0.069	0.669GlnHis: 0.669 ± 0.036	1.924GlnIle: 1.924 ± 0.06	0.758GlnLys: 0.758 ± 0.035	3.189GlnLeu: 3.189 ± 0.079	0.976GlnMet: 0.976 ± 0.034	0.877GlnAsn: 0.877 ± 0.043	1.668GlnPro: 1.668 ± 0.065	1.529GlnGln: 1.529 ± 0.063	2.491GlnArg: 2.491 ± 0.067	1.885GlnSer: 1.885 ± 0.06	1.933GlnThr: 1.933 ± 0.057	2.615GlnVal: 2.615 ± 0.061	0.56GlnTrp: 0.56 ± 0.026	1.082GlnTyr: 1.082 ± 0.049	0.0GlnXaa: 0.0 ± 0.0
Arg	5.931ArgAla: 5.931 ± 0.109	0.619ArgCys: 0.619 ± 0.04	3.866ArgAsp: 3.866 ± 0.092	4.323ArgGlu: 4.323 ± 0.107	2.552ArgPhe: 2.552 ± 0.061	4.362ArgGly: 4.362 ± 0.079	1.747ArgHis: 1.747 ± 0.059	4.061ArgIle: 4.061 ± 0.071	2.215ArgLys: 2.215 ± 0.073	6.271ArgLeu: 6.271 ± 0.143	2.104ArgMet: 2.104 ± 0.05	2.133ArgAsn: 2.133 ± 0.067	2.996ArgPro: 2.996 ± 0.072	2.474ArgGln: 2.474 ± 0.061	5.946ArgArg: 5.946 ± 0.14	3.329ArgSer: 3.329 ± 0.09	3.841ArgThr: 3.841 ± 0.084	4.677ArgVal: 4.677 ± 0.093	1.01ArgTrp: 1.01 ± 0.04	2.297ArgTyr: 2.297 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	5.809SerAla: 5.809 ± 0.112	0.507SerCys: 0.507 ± 0.031	3.659SerAsp: 3.659 ± 0.091	2.995SerGlu: 2.995 ± 0.069	2.002SerPhe: 2.002 ± 0.059	5.378SerGly: 5.378 ± 0.092	1.113SerHis: 1.113 ± 0.047	2.905SerIle: 2.905 ± 0.076	1.657SerLys: 1.657 ± 0.053	4.983SerLeu: 4.983 ± 0.093	1.566SerMet: 1.566 ± 0.051	1.571SerAsn: 1.571 ± 0.047	2.461SerPro: 2.461 ± 0.06	1.912SerGln: 1.912 ± 0.054	3.64SerArg: 3.64 ± 0.095	3.482SerSer: 3.482 ± 0.102	3.152SerThr: 3.152 ± 0.072	4.404SerVal: 4.404 ± 0.085	0.812SerTrp: 0.812 ± 0.035	1.557SerTyr: 1.557 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	6.665ThrAla: 6.665 ± 0.099	0.56ThrCys: 0.56 ± 0.029	3.897ThrAsp: 3.897 ± 0.094	2.906ThrGlu: 2.906 ± 0.071	2.02ThrPhe: 2.02 ± 0.067	5.151ThrGly: 5.151 ± 0.096	1.197ThrHis: 1.197 ± 0.047	3.381ThrIle: 3.381 ± 0.069	1.623ThrLys: 1.623 ± 0.06	5.701ThrLeu: 5.701 ± 0.101	1.513ThrMet: 1.513 ± 0.052	1.668ThrAsn: 1.668 ± 0.046	3.459ThrPro: 3.459 ± 0.083	1.703ThrGln: 1.703 ± 0.067	3.21ThrArg: 3.21 ± 0.081	3.096ThrSer: 3.096 ± 0.07	3.537ThrThr: 3.537 ± 0.086	5.864ThrVal: 5.864 ± 0.108	0.777ThrTrp: 0.777 ± 0.04	1.623ThrTyr: 1.623 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	9.076ValAla: 9.076 ± 0.166	0.962ValCys: 0.962 ± 0.047	5.499ValAsp: 5.499 ± 0.1	4.711ValGlu: 4.711 ± 0.083	2.897ValPhe: 2.897 ± 0.066	5.735ValGly: 5.735 ± 0.128	1.531ValHis: 1.531 ± 0.052	4.629ValIle: 4.629 ± 0.108	2.359ValLys: 2.359 ± 0.068	7.253ValLeu: 7.253 ± 0.115	2.047ValMet: 2.047 ± 0.06	2.42ValAsn: 2.42 ± 0.069	4.164ValPro: 4.164 ± 0.077	2.149ValGln: 2.149 ± 0.058	5.04ValArg: 5.04 ± 0.089	5.007ValSer: 5.007 ± 0.081	5.126ValThr: 5.126 ± 0.092	7.036ValVal: 7.036 ± 0.146	1.113ValTrp: 1.113 ± 0.045	1.89ValTyr: 1.89 ± 0.07	0.0ValXaa: 0.0 ± 0.0
Trp	1.168TrpAla: 1.168 ± 0.043	0.204TrpCys: 0.204 ± 0.018	0.841TrpAsp: 0.841 ± 0.04	0.658TrpGlu: 0.658 ± 0.035	0.545TrpPhe: 0.545 ± 0.031	0.955TrpGly: 0.955 ± 0.036	0.354TrpHis: 0.354 ± 0.024	0.674TrpIle: 0.674 ± 0.035	0.426TrpLys: 0.426 ± 0.023	1.441TrpLeu: 1.441 ± 0.053	0.489TrpMet: 0.489 ± 0.027	0.532TrpAsn: 0.532 ± 0.032	0.565TrpPro: 0.565 ± 0.032	0.624TrpGln: 0.624 ± 0.027	1.164TrpArg: 1.164 ± 0.048	0.846TrpSer: 0.846 ± 0.035	0.801TrpThr: 0.801 ± 0.035	0.86TrpVal: 0.86 ± 0.036	0.323TrpTrp: 0.323 ± 0.021	0.494TrpTyr: 0.494 ± 0.032	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.043TyrAla: 3.043 ± 0.081	0.299TyrCys: 0.299 ± 0.023	1.993TyrAsp: 1.993 ± 0.063	1.649TyrGlu: 1.649 ± 0.051	0.962TyrPhe: 0.962 ± 0.041	2.609TyrGly: 2.609 ± 0.071	0.531TyrHis: 0.531 ± 0.029	1.182TyrIle: 1.182 ± 0.044	0.671TyrLys: 0.671 ± 0.033	2.477TyrLeu: 2.477 ± 0.067	0.568TyrMet: 0.568 ± 0.033	0.875TyrAsn: 0.875 ± 0.041	1.251TyrPro: 1.251 ± 0.049	0.91TyrGln: 0.91 ± 0.038	1.986TyrArg: 1.986 ± 0.047	1.43TyrSer: 1.43 ± 0.05	1.642TyrThr: 1.642 ± 0.06	2.113TyrVal: 2.113 ± 0.069	0.399TyrTrp: 0.399 ± 0.03	0.873TyrTyr: 0.873 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1652 proteins (621777 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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