Amino acid dipepetide frequency for Roseovarius tolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.232AlaAla: 16.232 ± 0.172	1.199AlaCys: 1.199 ± 0.04	6.768AlaAsp: 6.768 ± 0.084	8.285AlaGlu: 8.285 ± 0.113	4.065AlaPhe: 4.065 ± 0.075	10.823AlaGly: 10.823 ± 0.111	2.65AlaHis: 2.65 ± 0.053	5.589AlaIle: 5.589 ± 0.075	3.419AlaLys: 3.419 ± 0.068	14.105AlaLeu: 14.105 ± 0.145	3.947AlaMet: 3.947 ± 0.065	2.531AlaAsn: 2.531 ± 0.055	6.074AlaPro: 6.074 ± 0.084	4.849AlaGln: 4.849 ± 0.075	10.075AlaArg: 10.075 ± 0.135	5.199AlaSer: 5.199 ± 0.073	6.174AlaThr: 6.174 ± 0.082	8.443AlaVal: 8.443 ± 0.109	1.472AlaTrp: 1.472 ± 0.041	2.56AlaTyr: 2.56 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.186CysAla: 1.186 ± 0.033	0.115CysCys: 0.115 ± 0.009	0.707CysAsp: 0.707 ± 0.027	0.474CysGlu: 0.474 ± 0.022	0.336CysPhe: 0.336 ± 0.018	1.006CysGly: 1.006 ± 0.032	0.294CysHis: 0.294 ± 0.019	0.428CysIle: 0.428 ± 0.02	0.2CysLys: 0.2 ± 0.014	0.919CysLeu: 0.919 ± 0.031	0.188CysMet: 0.188 ± 0.014	0.212CysAsn: 0.212 ± 0.014	0.546CysPro: 0.546 ± 0.024	0.241CysGln: 0.241 ± 0.016	0.611CysArg: 0.611 ± 0.024	0.411CysSer: 0.411 ± 0.019	0.472CysThr: 0.472 ± 0.023	0.645CysVal: 0.645 ± 0.025	0.118CysTrp: 0.118 ± 0.01	0.227CysTyr: 0.227 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.428AspAla: 7.428 ± 0.08	0.596AspCys: 0.596 ± 0.022	3.304AspAsp: 3.304 ± 0.072	3.58AspGlu: 3.58 ± 0.062	2.098AspPhe: 2.098 ± 0.041	5.46AspGly: 5.46 ± 0.085	1.503AspHis: 1.503 ± 0.04	3.106AspIle: 3.106 ± 0.058	1.623AspLys: 1.623 ± 0.04	6.805AspLeu: 6.805 ± 0.083	1.813AspMet: 1.813 ± 0.045	1.258AspAsn: 1.258 ± 0.034	3.625AspPro: 3.625 ± 0.065	1.891AspGln: 1.891 ± 0.038	4.371AspArg: 4.371 ± 0.066	2.093AspSer: 2.093 ± 0.043	3.103AspThr: 3.103 ± 0.059	4.23AspVal: 4.23 ± 0.063	1.295AspTrp: 1.295 ± 0.035	1.566AspTyr: 1.566 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.656GluAla: 8.656 ± 0.117	0.396GluCys: 0.396 ± 0.021	3.444GluAsp: 3.444 ± 0.066	3.577GluGlu: 3.577 ± 0.072	1.853GluPhe: 1.853 ± 0.047	5.124GluGly: 5.124 ± 0.07	1.204GluHis: 1.204 ± 0.033	3.665GluIle: 3.665 ± 0.056	1.997GluLys: 1.997 ± 0.051	4.614GluLeu: 4.614 ± 0.069	2.033GluMet: 2.033 ± 0.044	1.631GluAsn: 1.631 ± 0.037	2.511GluPro: 2.511 ± 0.048	1.851GluGln: 1.851 ± 0.044	4.54GluArg: 4.54 ± 0.064	2.226GluSer: 2.226 ± 0.045	4.068GluThr: 4.068 ± 0.06	4.533GluVal: 4.533 ± 0.07	0.759GluTrp: 0.759 ± 0.028	1.03GluTyr: 1.03 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.307PheAla: 4.307 ± 0.074	0.433PheCys: 0.433 ± 0.019	2.758PheAsp: 2.758 ± 0.054	2.231PheGlu: 2.231 ± 0.047	1.372PhePhe: 1.372 ± 0.047	3.577PheGly: 3.577 ± 0.07	0.744PheHis: 0.744 ± 0.026	1.607PheIle: 1.607 ± 0.044	0.859PheLys: 0.859 ± 0.03	3.352PheLeu: 3.352 ± 0.071	0.846PheMet: 0.846 ± 0.026	1.058PheAsn: 1.058 ± 0.035	1.41PhePro: 1.41 ± 0.038	0.985PheGln: 0.985 ± 0.032	2.119PheArg: 2.119 ± 0.045	2.002PheSer: 2.002 ± 0.048	2.058PheThr: 2.058 ± 0.051	2.464PheVal: 2.464 ± 0.052	0.562PheTrp: 0.562 ± 0.023	0.912PheTyr: 0.912 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	10.283GlyAla: 10.283 ± 0.111	0.943GlyCys: 0.943 ± 0.032	5.049GlyAsp: 5.049 ± 0.083	4.82GlyGlu: 4.82 ± 0.071	3.663GlyPhe: 3.663 ± 0.059	7.463GlyGly: 7.463 ± 0.114	2.164GlyHis: 2.164 ± 0.053	4.308GlyIle: 4.308 ± 0.07	2.826GlyLys: 2.826 ± 0.057	9.692GlyLeu: 9.692 ± 0.111	2.779GlyMet: 2.779 ± 0.05	1.996GlyAsn: 1.996 ± 0.046	3.796GlyPro: 3.796 ± 0.067	3.275GlyGln: 3.275 ± 0.061	6.109GlyArg: 6.109 ± 0.078	3.945GlySer: 3.945 ± 0.067	4.67GlyThr: 4.67 ± 0.067	6.437GlyVal: 6.437 ± 0.075	1.579GlyTrp: 1.579 ± 0.037	2.369GlyTyr: 2.369 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.572HisAla: 2.572 ± 0.052	0.26HisCys: 0.26 ± 0.015	1.481HisAsp: 1.481 ± 0.04	1.192HisGlu: 1.192 ± 0.031	0.832HisPhe: 0.832 ± 0.029	2.061HisGly: 2.061 ± 0.045	0.58HisHis: 0.58 ± 0.026	1.021HisIle: 1.021 ± 0.033	0.513HisLys: 0.513 ± 0.024	2.387HisLeu: 2.387 ± 0.05	0.568HisMet: 0.568 ± 0.025	0.471HisAsn: 0.471 ± 0.021	1.437HisPro: 1.437 ± 0.038	0.608HisGln: 0.608 ± 0.026	1.418HisArg: 1.418 ± 0.038	0.899HisSer: 0.899 ± 0.028	0.836HisThr: 0.836 ± 0.028	1.678HisVal: 1.678 ± 0.043	0.385HisTrp: 0.385 ± 0.018	0.583HisTyr: 0.583 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.827IleAla: 6.827 ± 0.086	0.589IleCys: 0.589 ± 0.021	3.299IleAsp: 3.299 ± 0.06	3.629IleGlu: 3.629 ± 0.06	1.794IlePhe: 1.794 ± 0.049	4.727IleGly: 4.727 ± 0.072	0.896IleHis: 0.896 ± 0.026	2.104IleIle: 2.104 ± 0.046	1.371IleLys: 1.371 ± 0.042	4.76IleLeu: 4.76 ± 0.082	1.103IleMet: 1.103 ± 0.04	1.378IleAsn: 1.378 ± 0.038	2.296IlePro: 2.296 ± 0.051	1.046IleGln: 1.046 ± 0.033	3.237IleArg: 3.237 ± 0.053	2.76IleSer: 2.76 ± 0.053	3.093IleThr: 3.093 ± 0.054	3.563IleVal: 3.563 ± 0.064	0.748IleTrp: 0.748 ± 0.029	1.119IleTyr: 1.119 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.487LysAla: 3.487 ± 0.067	0.182LysCys: 0.182 ± 0.012	1.547LysAsp: 1.547 ± 0.044	1.38LysGlu: 1.38 ± 0.043	0.85LysPhe: 0.85 ± 0.032	2.576LysGly: 2.576 ± 0.054	0.606LysHis: 0.606 ± 0.027	1.496LysIle: 1.496 ± 0.038	1.133LysLys: 1.133 ± 0.039	2.702LysLeu: 2.702 ± 0.053	0.821LysMet: 0.821 ± 0.036	0.649LysAsn: 0.649 ± 0.024	1.815LysPro: 1.815 ± 0.05	0.812LysGln: 0.812 ± 0.029	2.225LysArg: 2.225 ± 0.05	1.723LysSer: 1.723 ± 0.041	1.878LysThr: 1.878 ± 0.044	2.019LysVal: 2.019 ± 0.046	0.361LysTrp: 0.361 ± 0.02	0.629LysTyr: 0.629 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.079LeuAla: 13.079 ± 0.148	1.021LeuCys: 1.021 ± 0.032	6.312LeuAsp: 6.312 ± 0.078	5.253LeuGlu: 5.253 ± 0.077	3.382LeuPhe: 3.382 ± 0.064	8.645LeuGly: 8.645 ± 0.099	2.056LeuHis: 2.056 ± 0.048	5.475LeuIle: 5.475 ± 0.089	2.966LeuLys: 2.966 ± 0.064	8.888LeuLeu: 8.888 ± 0.119	2.914LeuMet: 2.914 ± 0.058	2.529LeuAsn: 2.529 ± 0.048	5.646LeuPro: 5.646 ± 0.072	2.717LeuGln: 2.717 ± 0.044	7.873LeuArg: 7.873 ± 0.099	6.577LeuSer: 6.577 ± 0.081	5.991LeuThr: 5.991 ± 0.078	6.869LeuVal: 6.869 ± 0.099	1.455LeuTrp: 1.455 ± 0.038	2.009LeuTyr: 2.009 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.751MetAla: 3.751 ± 0.065	0.202MetCys: 0.202 ± 0.012	1.38MetAsp: 1.38 ± 0.037	1.369MetGlu: 1.369 ± 0.041	0.817MetPhe: 0.817 ± 0.027	2.425MetGly: 2.425 ± 0.05	0.49MetHis: 0.49 ± 0.023	1.629MetIle: 1.629 ± 0.043	0.991MetLys: 0.991 ± 0.032	2.732MetLeu: 2.732 ± 0.051	0.81MetMet: 0.81 ± 0.025	0.776MetAsn: 0.776 ± 0.032	1.584MetPro: 1.584 ± 0.037	1.085MetGln: 1.085 ± 0.033	2.153MetArg: 2.153 ± 0.048	1.809MetSer: 1.809 ± 0.038	2.127MetThr: 2.127 ± 0.042	1.931MetVal: 1.931 ± 0.043	0.262MetTrp: 0.262 ± 0.017	0.349MetTyr: 0.349 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.955AsnAla: 2.955 ± 0.055	0.245AsnCys: 0.245 ± 0.014	1.332AsnAsp: 1.332 ± 0.039	1.158AsnGlu: 1.158 ± 0.033	0.844AsnPhe: 0.844 ± 0.031	2.195AsnGly: 2.195 ± 0.051	0.477AsnHis: 0.477 ± 0.02	1.259AsnIle: 1.259 ± 0.037	0.622AsnLys: 0.622 ± 0.022	2.438AsnLeu: 2.438 ± 0.048	0.655AsnMet: 0.655 ± 0.026	0.603AsnAsn: 0.603 ± 0.026	1.811AsnPro: 1.811 ± 0.041	0.627AsnGln: 0.627 ± 0.027	1.721AsnArg: 1.721 ± 0.041	1.074AsnSer: 1.074 ± 0.033	1.329AsnThr: 1.329 ± 0.033	1.679AsnVal: 1.679 ± 0.039	0.412AsnTrp: 0.412 ± 0.019	0.577AsnTyr: 0.577 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.641ProAla: 5.641 ± 0.074	0.404ProCys: 0.404 ± 0.021	4.205ProAsp: 4.205 ± 0.064	4.42ProGlu: 4.42 ± 0.073	1.882ProPhe: 1.882 ± 0.038	4.757ProGly: 4.757 ± 0.067	1.114ProHis: 1.114 ± 0.034	2.111ProIle: 2.111 ± 0.044	1.572ProLys: 1.572 ± 0.046	4.682ProLeu: 4.682 ± 0.07	1.39ProMet: 1.39 ± 0.032	1.236ProAsn: 1.236 ± 0.033	2.387ProPro: 2.387 ± 0.056	1.672ProGln: 1.672 ± 0.037	3.225ProArg: 3.225 ± 0.056	2.306ProSer: 2.306 ± 0.043	2.295ProThr: 2.295 ± 0.044	4.374ProVal: 4.374 ± 0.073	0.692ProTrp: 0.692 ± 0.026	1.172ProTyr: 1.172 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.312GlnAla: 4.312 ± 0.065	0.227GlnCys: 0.227 ± 0.015	1.753GlnAsp: 1.753 ± 0.046	1.696GlnGlu: 1.696 ± 0.038	1.064GlnPhe: 1.064 ± 0.029	2.876GlnGly: 2.876 ± 0.054	0.589GlnHis: 0.589 ± 0.025	1.848GlnIle: 1.848 ± 0.041	0.96GlnLys: 0.96 ± 0.032	2.621GlnLeu: 2.621 ± 0.049	1.036GlnMet: 1.036 ± 0.033	0.806GlnAsn: 0.806 ± 0.029	1.65GlnPro: 1.65 ± 0.039	1.022GlnGln: 1.022 ± 0.037	2.08GlnArg: 2.08 ± 0.05	1.764GlnSer: 1.764 ± 0.044	1.817GlnThr: 1.817 ± 0.043	2.46GlnVal: 2.46 ± 0.048	0.414GlnTrp: 0.414 ± 0.017	0.608GlnTyr: 0.608 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.44ArgAla: 9.44 ± 0.126	0.535ArgCys: 0.535 ± 0.023	4.818ArgAsp: 4.818 ± 0.064	4.104ArgGlu: 4.104 ± 0.074	2.696ArgPhe: 2.696 ± 0.044	5.104ArgGly: 5.104 ± 0.065	1.789ArgHis: 1.789 ± 0.046	3.863ArgIle: 3.863 ± 0.065	2.192ArgLys: 2.192 ± 0.051	8.054ArgLeu: 8.054 ± 0.107	2.059ArgMet: 2.059 ± 0.039	1.734ArgAsn: 1.734 ± 0.04	3.487ArgPro: 3.487 ± 0.057	2.29ArgGln: 2.29 ± 0.052	5.512ArgArg: 5.512 ± 0.089	3.092ArgSer: 3.092 ± 0.056	2.917ArgThr: 2.917 ± 0.048	5.122ArgVal: 5.122 ± 0.078	0.99ArgTrp: 0.99 ± 0.028	1.596ArgTyr: 1.596 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.463SerAla: 5.463 ± 0.066	0.434SerCys: 0.434 ± 0.021	3.272SerAsp: 3.272 ± 0.062	2.98SerGlu: 2.98 ± 0.054	1.967SerPhe: 1.967 ± 0.047	5.254SerGly: 5.254 ± 0.082	1.096SerHis: 1.096 ± 0.03	2.244SerIle: 2.244 ± 0.048	1.325SerLys: 1.325 ± 0.038	4.853SerLeu: 4.853 ± 0.073	1.241SerMet: 1.241 ± 0.036	1.209SerAsn: 1.209 ± 0.032	2.379SerPro: 2.379 ± 0.045	1.445SerGln: 1.445 ± 0.037	3.171SerArg: 3.171 ± 0.055	2.277SerSer: 2.277 ± 0.05	2.384SerThr: 2.384 ± 0.051	3.659SerVal: 3.659 ± 0.059	0.625SerTrp: 0.625 ± 0.026	1.266SerTyr: 1.266 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.12ThrAla: 6.12 ± 0.076	0.523ThrCys: 0.523 ± 0.021	3.135ThrAsp: 3.135 ± 0.054	3.019ThrGlu: 3.019 ± 0.059	1.929ThrPhe: 1.929 ± 0.048	5.607ThrGly: 5.607 ± 0.077	1.176ThrHis: 1.176 ± 0.032	2.537ThrIle: 2.537 ± 0.057	1.348ThrLys: 1.348 ± 0.031	6.272ThrLeu: 6.272 ± 0.077	1.255ThrMet: 1.255 ± 0.035	1.204ThrAsn: 1.204 ± 0.037	3.595ThrPro: 3.595 ± 0.059	1.642ThrGln: 1.642 ± 0.04	3.841ThrArg: 3.841 ± 0.062	2.558ThrSer: 2.558 ± 0.048	2.789ThrThr: 2.789 ± 0.059	4.186ThrVal: 4.186 ± 0.068	0.748ThrTrp: 0.748 ± 0.027	1.205ThrTyr: 1.205 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.779ValAla: 8.779 ± 0.096	0.641ValCys: 0.641 ± 0.026	3.86ValAsp: 3.86 ± 0.055	4.537ValGlu: 4.537 ± 0.069	2.733ValPhe: 2.733 ± 0.058	5.289ValGly: 5.289 ± 0.081	1.38ValHis: 1.38 ± 0.039	4.392ValIle: 4.392 ± 0.067	2.0ValLys: 2.0 ± 0.042	7.746ValLeu: 7.746 ± 0.1	2.291ValMet: 2.291 ± 0.045	1.799ValAsn: 1.799 ± 0.047	3.624ValPro: 3.624 ± 0.068	2.138ValGln: 2.138 ± 0.048	4.286ValArg: 4.286 ± 0.057	3.952ValSer: 3.952 ± 0.07	4.829ValThr: 4.829 ± 0.071	5.525ValVal: 5.525 ± 0.099	0.993ValTrp: 0.993 ± 0.029	1.47ValTyr: 1.47 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.46TrpAla: 1.46 ± 0.044	0.141TrpCys: 0.141 ± 0.011	0.72TrpAsp: 0.72 ± 0.029	0.698TrpGlu: 0.698 ± 0.025	0.573TrpPhe: 0.573 ± 0.024	1.092TrpGly: 1.092 ± 0.032	0.409TrpHis: 0.409 ± 0.017	0.73TrpIle: 0.73 ± 0.025	0.387TrpLys: 0.387 ± 0.021	1.724TrpLeu: 1.724 ± 0.046	0.416TrpMet: 0.416 ± 0.023	0.373TrpAsn: 0.373 ± 0.019	0.802TrpPro: 0.802 ± 0.031	0.729TrpGln: 0.729 ± 0.028	1.213TrpArg: 1.213 ± 0.035	0.801TrpSer: 0.801 ± 0.029	0.774TrpThr: 0.774 ± 0.029	0.925TrpVal: 0.925 ± 0.029	0.229TrpTrp: 0.229 ± 0.014	0.261TrpTyr: 0.261 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.48TyrAla: 2.48 ± 0.051	0.25TyrCys: 0.25 ± 0.015	1.603TyrAsp: 1.603 ± 0.037	1.31TyrGlu: 1.31 ± 0.042	0.906TyrPhe: 0.906 ± 0.029	2.107TyrGly: 2.107 ± 0.047	0.566TyrHis: 0.566 ± 0.025	0.926TyrIle: 0.926 ± 0.032	0.585TyrLys: 0.585 ± 0.02	2.309TyrLeu: 2.309 ± 0.044	0.506TyrMet: 0.506 ± 0.024	0.559TyrAsn: 0.559 ± 0.023	1.064TyrPro: 1.064 ± 0.033	0.677TyrGln: 0.677 ± 0.026	1.616TyrArg: 1.616 ± 0.041	1.079TyrSer: 1.079 ± 0.034	1.083TyrThr: 1.083 ± 0.029	1.523TyrVal: 1.523 ± 0.042	0.356TyrTrp: 0.356 ± 0.023	0.578TyrTyr: 0.578 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3684 proteins (1107601 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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